Regulation of the activity of 5alpha-RA and the production of DHT in body hair
Figure 7. The relationships among the components of the insulin-related ovarian regulatory system. Insulin, IGF-I, and IGF-II, acting through insulin receptors or type I IGF receptors, increase pituitary responsiveness to GnRH; stimulate gonadotropin secretion directly; stimulate ovarian steroidogenesis; inhibit IGFBP-1 and SHBG production; and act synergistically with gonadotropins to promote ovarian growth and cyst formation (see also Tables 3–5).
Source: Endocr Rev 1999 Aug;20(4):535-82
Edited by Aldo Campana,