Obstetrics, gynecology and reproductive medicine guidelines

Maternal and neonatal infections

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Neonatal infections

International

• Cochrane Library
  • Vancomycin for prophylaxis against sepsis in preterm neonates
  • Topical umbilical cord care at birth
  • Topical ointment for preventing infection in preterm infants
  • Prophylactic versus selective antibiotics for term newborn infants of mothers with risk factors for neonatal infection
  • Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants
  • Prophylactic systemic antibiotics to reduce morbidity and mortality in neonates with central venous catheters
  • Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical venous catheters
  • Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical artery catheters
  • Pneumococcal vaccination during pregnancy for preventing infant infection
  • Pentoxifylline for neonatal sepsis
  • Oral immunoglobulin for the treatment of rotavirus diarrhoea in low birth weight infants
  • Oral immunoglobulin for the prevention of rotavirus infection in low birth weight infants
  • One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates
  • Intravenous immunoglobulin for suspected or subsequently proven infection in neonates
  • Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants
  • Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia
  • G-CSF and GM-CSF for treating or preventing neonatal infections
  • Early removal versus expectant management of central venous catheters in neonates with bloodstream infection
  • Diazepam for treating tetanus
  • Antibiotic regimens for suspected early neonatal sepsis

New Zealand

• Auckland District Health Board
  • Antibiotics for Neonatal Sepsis [2007]
  • Vaccination Schedule [2005]
  • Chickenpox Exposure [2005]
  • Congenital Infection [2000]
  • Severe Acute Respiratory Syndrome - Neonatal Protocol

Sub-Saharan Africa

• Lancet Infectious Diseases
  • Maternal and early onset neonatal bacterial sepsis: burden and strategies for prevention in sub-Saharan Africa [2009]

United Kingdom

• National Guideline Clearinghouse
  • Antibiotics for early-onset neonatal infection. Antibiotics for the prevention and treatment of early-onset neonatal infection. National Collaborating Centre for Women's and Children's Health [2012]

• National Institute for Health and Clinical Excellence
  • Antibiotics for early-onset neonatal infection [2012]

United States of America

• American Academy of Pediatrics
  • Strategies for Prevention of Health Care–Associated Infections in the NICU [2012]
  • Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis [2012]
  • Epidemiology and Diagnosis of Health Care–Associated Infections in the NICU [2012]

• Minnesota Department of Health
  • Neonatal Sepsis

• University of Michigan Evidence-Based Pediatrics
  • Asymptomatic, Full-Term Infants Born to Mothers Treated for Chorioamnionitis Require Conservative Evaluation and Treatment [2004]
  • There is Insufficient Evidence to Support the Use of G-CSF in Neonates with Sepsis [2003]
  • A Left-Shifted WBC Count is Modestly Effective at Diagnosing and Excluding Sepsis in Neonates [2001]

WHO

• WHO Reproductive Health Library
  • Topical umbilical cord care at birth [2004]

Articles in journals

• BMC Public Health
  • Effect of case management on neonatal mortality due to sepsis and pneumonia [2011]

• British Medical Journal
  • Infection in the preterm infant [2004]

• Clinical Chemistry
  • Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge [2004]

• Clinical Microbiology Reviews
  • Mycoplasmas and Ureaplasmas as Neonatal Pathogens [2005]
  • Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants [2004]

• Clinics
  • Pharmacokinetics of cephalosporins in the neonate: a review [2011]

• Clinics in Perinatology
  • The Use of Antiviral Drugs During the Neonatal Period [2012]
  • Antibiotic Use and Misuse in the Neonatal Intensive Care Unit [2012]
  • The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis [2010]

• Current Opinion in Infectious Diseases
  • Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future [2009]

• European Journal of Immunology
  • Safety and Efficacy of Neonatal Vaccination [2009]

• Infection and Immunity
  • Neonatal Innate Immunity to Infectious Agents [2006]

• Malaysian Family Physicians
  • Neonatal conjunctivitis - A review [2008]

• Neonatology
  • Biomarkers in neonatology: the next generation of tests [2012]
  • An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks [2012]
  • Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome? [2011]

• Pediatric Research
  • Developmental biology of the innate immune response: implications for neonatal and infant vaccine development [2009]

• Pediatrics
  • Molecular Assays in the Diagnosis of Neonatal Sepsis: A Systematic Review and Meta-analysis [2011]
  • Streptococcus pneumoniae Infections in the Neonate [2003]
  • Implementation of Evidence-Based Potentially Better Practices to Decrease Nosocomial Infections [2003]
  • Evaluation and Development of Potentially Better Practices to Prevent Neonatal Nosocomial Bacteremia [2003]

• PLoS Neglected Tropical Diseases
  • Congenital Chagas Disease: Recommendations for Diagnosis, Treatment and Control of Newborns, Siblings and Pregnant Women [2011]

• Tropical Medicine & International Health
  • Susceptibility of community-acquired pathogens to antibiotics in Africa and Asia in neonates – an alarmingly short review [2011]

{Related topics}

• Guidelines
  • Tuberculosis in pregnancy
  • Trichomoniasis in pregnancy
  • Toxoplasmosis
  • Tetanus in pregnancy and newborn
  • Sexually transmitted diseases in pregnancy
  • Rubella
  • Obstetrics, perinatology
  • Neonatology
  • Malaria in pregnancy
  • Infections in pregnancy
  • Herpes infections in pregnancy and newborn
  • Hepatitis in pregnancy and newborn
  • Hepatitis
  • HIV/AIDS in pregnancy and newborn
  • HIV/AIDS
  • Group B streptococcal infections
  • Gonorrhea in pregnancy and newborn
  • Genital infections, sexually transmitted diseases
  • Cytomegalovirus
  • Congenital syphilis
  • Chlamydia infection in pregnancy
  • Candidiasis in pregnancy and newborn
  • Bacterial vaginosis in pregnancy