Center of Medical Genetics of National Academy of Sciences of Armenia, Yerevan, Armenia
Prof. Tamara F. Sarkisian
Director of the Center of Medical Genetics of National Academy of Sciences
of Armenia
5/1 Zakiyan str, 375010,
Yerevan, Armenia
Tel:
(+374 1) 544365 (Office),
(+374 1) 527419 (Home)
Fax :
(+374 1) 544369
E-mail :mailto:tamsar@sci.am
Departments of the Center of Medical Genetics:
Medical Service and Counseling:
Gynecology
Internal Medicine
Andrology - Sexology
Pediatry
Family Medicine
Laboratory Service:
1. Molecular DNA-diagnostics
Familial mediterranean fever
Cystic fybrosis
Sexually transmitted disorders
2. Oncological investigations
BRCA1&2 mutations
Prevention of cervical cancer (detection of 6 types of HPV, PAP-smears, colposcopy)
Tumor markers
Estrogen/Progesterone receptors
3. Prenatal/postnatal cytogenetics
FISH
Karyotyping using differential staining
Chorionic villi sampling analysis
Amniotic fluid analysis
4. Prenatal screening of pregnant women
Serum PAPP-A/hCG
Serum AFP/hCG
5. Diagnosis and treatment of infertile couples (according to WHO recommendations)
Examination of human semen according to WHO recommendations
Microdeletions of Y chromosome
Gynecological examinations
Hormones
6. Biochemical and molecular markers
Main research interests :
Creation of Center of Medical Genetics of NAS of Armenia in 1999. Application
of methods of molecular genetics and cytogenetics for diagnostics of genetic
disorders. Genetic counseling, using prenatal diagnosis and risk calculations.
Genetic investigations of patients with chromosome syndromes, mental retardations.
DNA-diagnostics of Familial Mediterranean Fever and other hereditary disorders.
Publications
1.Cleaver J., Arutyunian R., Sarkisian T., Kaufmann W., Greene A., Coriell L. (1980) Similar defects in DNA repair and replication in the pigmented xerodermoid and the Xeroderma pigmentosum variants. Carcinogenesis 1:647-655.2.Arutyunian R., Sarkisian T.,Oganesian G.,Durnev A. (1993) Comparative investigation of anticlastogenic effects in cells cultures of healthy donors and patients with nettle-rash. Mutation Research 320:335-341.
3.Emerit I., Chernjavsky L., Arutyunian R., Oganesian N., Sarkisian T., Mejlumian H. (1994) Transferable clastogenic activity in plasma from persons exposed as salvage personnel at the Chernobyl reactor. Journal Cancer Res.Clin.Oncol. 120/4:558-561.
4. Emerit I., Arutyunian R., Oganesian N., Levy A., Chernjavsky L., Sarkisian T., Pogosian A., Asrian K. (1995) Radiation-induced clastogenic factors: anticlastogenic effect of Ginkgo biloba extract. Free Radical Biology & Medicine, 1 :1 - 7.
5.Emerit I.,Oganesian N., Sarkisian T., Arutyunian R., Pogosian A., Asrian K., Levy A., Cerniavski L. (1995) Clastogenic factors in the plasma of Chernobyl accident recovery workers (liquidators). Anticlastogenic effect of Ginkgo biloba extract. Radiation Research 144:198-205.
6. Emerit I. , Oganesian N., Sarkisian T., Arutyunian R., Pogosian A., Asrian K., Levy A., Cerniavski L. (1997) Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements. Mutation Research 377:239-246.
7. Sarkisian T., Emerit I. , Arutyunyan R., Cerniavski L., Levy A. (1997) Familial Mediterranean Fever: clastogenic plasma factors correlated with increased O2 - production by neutrophils. Human Genetics 101: 238-242.
8. Emerit I., Oganesian N., Sarkisian T., Arutyunian R., Pogosian A., Asrian K., Levy A., Cerniavski L. (1997) Antioxidant Treatment of Radiation Injuries. Antioxidants for Radiation Injuries 3(2):125-131.
9. Arutyunyan R., Sarkisian T. (1997) Anticlastogenesis in cells of patients from the groups of genetic risk. In: “Fundamental and Molecular Mechanisms of Mutagenesis”, sect. of Mutation Research, 379/1:1.
10. Emerit I., Sarkisian T. , Oganesian N., Arutyunyan R., Pogosian A., Asrian K., Levy A., Cerniavski L. (1997) Oxidative stress and low dose irradiation. In: Low doses of ionizing radiation: biological effects and regulatory control”, pp. 116-120.
11. Cazeneuve C., Sarkisian T., Goosans M., Ayrapetyan A., Amselem S. (1999) MEFV gene analysis in Armenian patients with FMF: diagnostic value, unfavorable renal prognosis of the M694V homozygous genotype, genetic and therapeutic implications. Amer. Journal of Medical Genetics 65:88-97.
12. Torosyan Y., Aksentijevich I., Sarkisian T., Astvatsatryan V., Ayvazyan., Centola M., Chae JJ., Kastner DL. (1999) A population-based survey reveals an extremely high FMF carriers frequency in Armenia, suggesting heterozygote advantage. In: “49th Annual Meeting of the American Society of Human Genetics”, California.
13. Torosyan Y., Aksentijevich I., Sarkisian T., Kastner D. et al. (1999) A population-based survey reveals an extremely high FMF carrier frequency in Armenia, suggesting heterozygote advantage. Amer. Journal of Medical Genetics 65: 4-2266.
14. Caseneuve C.,Sarkisian T.,Amselem S. et al. (2000) MEFV mutations in Armenian patients with FMF. In:” 2nd Conference of FMF”, Antalia.
15.Caseneuve C., Sarkisian T., Amselem S et al. (2000) Identification of MEFV- Independent Modifying Genetic Factors for FMF. Amer. Journal of Medical Genetics.
16. Arutyunyan R., Sarkisian T., et al. (2000) UV-C Irradiation-Induced DNA Damage in Leucocytes of Patients with Familial Mediterranean Fever. Central European Journal of Occupational and Environmental Medicine 6(1):11-17.
17. Bofetta P., Sarkisian T., Arutyunyan R. (2001) Chromosome aberrations in lymphocytes of persons exposed to an earthquake in Armenia. Scand J Work Environ Health 27(2): 120-124
18. Sarkisian T.F., Ajrapetyan H.S., Mndjoyan E.H., Oganesyan Z.R., Babikyan D.T. (2001). Molecular study of MEFV gene mutations in Armenian population. In: “31th Annual Meeting of EEMS”, Belgium.
19. Papazyan M., Sarkisian T., Babloyan A., Sanamyan A., Leumann E., Sarkissian A. (2002) Who is at risk to develop renal amyloidosis in FMF. Clin. and Exp.Rheumatology, 20:4, 88.
20. Sarkisian T., Ajrapetyan H., Hovanessyan Z., Beglaryan A., Astvatsatryan V. (2002) Patterns of FMF morbidity in modern Armenian population. Clin. and Exp.Rheumatology, 20:4, 88.
21. Ajrapetyan H., Hovannesyan Z., Shahsuvaryan G., Sarkisian T. (2002) The spectrum of MEFV mutations in Armenian population. Clin. and Exp.Rheumatology, 20:4, 88.
22. Cazeneuve C., Atayan K., Genevieve D., Ajrapetyan H., Sarkisian T., Amselem S. (2002) MEFV mutation spectrum in FMF patients from Karabakh. Clin. and Exp. Rheumatology, 20:4, 88.
23. Nasidze I., Sarkisian T., Kerimov A., Stoneking M. (2003) Testing hypothesis of language replacement in the Caucasus: evidence from the Y-chromosome. Hum.Genet, 112, 255-261.
24. Sarkissian A., Papazyan M., Leumann E., Sarkisian T., Sanamyan A. (2003) Late administration of colchicine in renal amyloidosis of FMF: does the genotype predict response? In: “Nephrology Dialisis Transplantation”, Oxford Univ.Press,624-625.
25. Sarkissian A., Papazyan M., Leumann E., Sarkisian T., Sanamyan A. , Babloyan A. (2003) Risk factors for renal amyloidosis in FMF.In: “Nephrology Dialisis Transplantation”, Oxford Univ.Press,624-625.
In total: 100 articles
Edited by Aldo Campana,