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type=3D"centerTitle"/></v:shape><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id=3D"_x0000_s1134595" typ= e=3D"#_x0000_m932868" style=3D'position:absolute;left:45.25pt;top:252pt;width:629.5pt;height:17= 4pt; mso-wrap-style:square;v-text-anchor:top' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1134594" class=3DCT style=3D'mso-line-spacing:"90 = 0 0"'><span style=3D'position:absolute;top:23.5%;left:.56%;width:99.43%;height:10.25%'= ><span lang=3DEN-GB style=3D'font-size:133%'><b>Future methods of fertility </b><= /span></span><span style=3D'position:absolute;top:33.0%;left:8.42%;width:83.33%;height:10.25%= '><span lang=3DEN-GB style=3D'font-size:133%'><b>regulation</b></span></span></div> <div v:shape=3D"_x0000_s1134595" class=3DCB> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:46.75%; left:7.3%;width:85.58%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:= 88%; text-shadow:auto;color:#000099'><b>Catherine d’Arcangues, Ph.D., M.D. = </b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:52.74%; left:2.8%;width:94.56%;height:5.25%'><span lang=3DEN-GB style=3D'font-size= :75%; text-shadow:auto'><b>Department of Reproductive Health and Research </= b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:58.0%;left:= 7.3%; width:85.58%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;text-= shadow: auto'><b>World Health Organization </b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:63.5%;left:= 7.3%; width:85.58%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;text-= shadow: auto;display:none'><b> </b></span></div> <div style=3D'mso-line-spacing:"80 20 0"'><span style=3D'position:absolute; top:68.75%;left:7.3%;width:85.58%;height:4.5%'><span style=3D'font-size:63= %; text-shadow:auto'><b><i>Training in Reproductive Health Research<br> </i></b></span></span><span style=3D'position:absolute;top:72.25%;left:7.= 3%; width:85.58%;height:4.5%'><span style=3D'font-size:63%;text-shadow:auto'><= b><i>Geneva 2006</i></b></span><span lang=3DEN-GB style=3D'font-size:63%;text-shadow:a= uto; mso-special-format:lastCR;display:none'><b><i> </i></b></span></span><= /div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master37_image002.png Content-Transfer-Encoding: base64 Content-Type: image/png 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rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1085.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D22.03.2006> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1110"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image003.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id= =3D"_x0000_s1136642" type=3D"#_x0000_m931844" style=3D'position:absolute;left:42.125pt;top:1in; width:636pt;height:5in' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1136642"> <div class=3DB1 style=3D'mso-margin-left-alt:567;mso-text-indent-alt:396'>= </div> <div class=3DB2 style=3D'mso-margin-left-alt:1417;mso-text-indent-alt:1129= '></div> <div class=3DB3 style=3D'mso-margin-left-alt:1770;mso-text-indent-alt:1530= '></div> <div class=3DB4 style=3D'mso-margin-left-alt:2123;mso-text-indent-alt:1883= '></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:14.5%;left:6.92%;width:91.19%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>1.<span style=3D'mso-tab-count:1;width:1.33%'> </spa= n>Improvement of existing methods </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3'><span style=3D'position:absolute;top:25.75%;left:6.92%;width:89.7%;height:6.75%'= ><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'text-shadow:auto'><b><span style=3D'mso-tab-count:1; width:5.47%'> </span></b></span><span lang=3DEN-GB style=3D'text-shadow:au= to; color:#000066;mso-color-index:1'><b>Efficacy, side-effects, duration of </= b></span></span><span style=3D'position:absolute;top:32.75%;left:11.79%;width:91.57%;height:6.75= %'><span lang=3DEN-GB style=3D'text-shadow:auto;color:#000066;mso-color-index:1'><b= >action, manufacturing process, cost </b></span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:44.25%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>2.<span style=3D'mso-tab-count:1;width:1.4%'> </span= >New approaches </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:55.5%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'text-shadow:auto'><b><span style=3D'mso-tab-count:1; width:5.67%'> </span></b></span><span lang=3DEN-GB style=3D'text-shadow:au= to; color:#000066;mso-color-index:1'><b>Mode of action </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:67.0%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>3.<span style=3D'mso-tab-count:1;width:1.4%'> </span= >New targets for contraception</b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image003.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAPklEQVQY07WNwQoAIAhDZ7L87T49GlgGXRvvMOZU4Kc6 QKDJh3ABhVGaKx9natoN1Xg3KTxvWj5CJix+89IEa7UBFlGieV0AAAAASUVORK5CYIJ= 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href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1088.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Intra-uterine devices"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1116"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" 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style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>IUD releasing a progesterone receptor </span></span><span style=3D'position:ab= solute; top:64.75%;left:9.73%;width:84.45%;height:6.75%'><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>modu= lator (CDB-2914) </span></span> <div style=3D'position:absolute;top:73.25%;left:5.99%;width:88.2%;height:6= .75%'><span style=3D'position:absolute;top:0%;left:4.24%;width:95.75%;height:100.0%'><= span style=3D'color:#CC3300;mso-color-index:4'><span class=3DBB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:37.03%;left:-4= .43%; width:1.99%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Copp= er IUD releasing indomethacin</span></span></div> </div> <v:shape id=3D"_x0000_s1142788" type=3D"#_x0000_t75" style=3D'position:abs= olute; left:509.875pt;top:42pt;width:154.25pt;height:3in'> 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style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Jade= lle</span><span lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:30.0%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.55%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>levonorgestrel, 2 rods, 5 years&= #13;</span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:39.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'position:absolute; top:0%;left:4.32%;width:95.67%;height:100.0%'><span style=3D'color:#CC3300; mso-color-index:4'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";color:#CC0000;font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:37.03%;left:-4= .52%; width:2.03%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Impl= anon</span><span lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:49.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.55%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>etonogestrel, 1 rod, 3 years = ;</span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:59.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'position:absolute; top:0%;left:4.32%;width:95.67%;height:100.0%'><span style=3D'color:#CC0000; mso-color-index:3'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"= *" style=3D'position:absolute;top:33.33%;left:-4.52%;width:2.03%;height:33.33= %'><![endif]></span></span><span lang=3DFR style=3D'color:#CC0000;mso-color-index:3'>Nestorone</span><span = lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:69.75%; left:7.67%;width:89.32%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.19%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>pure progestogen, 1 rod, 2 years= </span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image012.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl 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d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1090.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Injectables (1)"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style> .CB {color:#292929;} .CT {color:#CC0000;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1120"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master37.xml"> <p:shaperange href=3D"master37.xml#_x0000_s932865"/><![if !ppt]><p:shapera= nge href=3D"master37.xml#_x0000_s932866"/><p:shaperange href=3D"master37.xml#_x0000_s932870"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s932870" src=3D"master37_image013.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s932870" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>7= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master37.xml#_x0000_m932867"/><v:shape id= =3D"_x0000_s1146882" type=3D"#_x0000_m932867" style=3D'position:absolute;left:104pt;top:0;widt= h:501.5pt; height:78pt;mso-wrap-style:square;v-text-anchor:middle' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"centerTitle"/></v:shape><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id=3D"_x0000_s1146883" typ= e=3D"#_x0000_m932868" style=3D'position:absolute;left:47.375pt;top:72.75pt;width:625.5pt;height= :396pt; mso-wrap-style:square;v-text-anchor:top' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1146882" class=3DCT style=3D'mso-line-spacing:"90 = 0 0"; position:absolute;top:2.5%;left:15.35%;width:67.79%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>Injectables (1)</b></span></div> <div v:shape=3D"_x0000_s1146883" style=3D'tab-interval:.5868in;tab-stops:.= 3975in'> <div class=3DCB1 style=3D'mso-margin-left-alt:342;mso-text-indent-alt:342'= ></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:14.5%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= green'>Improved pharmacokinetic profile : </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:22.0%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Biodegradable microspheres</span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b>:<span style=3D'mso-spacerun:y= es'> </span> </b></span></span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:29.49%;left:7.49%;width:93.82%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b><span style=3D'mso-spacerun:ye= s'> </span></b></span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:au= to'>norethisterone, norgestimate, progesterone<span style=3D'mso-spacerun:yes'> </span></span= ><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto;display:none'><b> = ;</b></span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:37.0%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Controlled particle size distribution</span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b>: </b></span>= </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:44.5%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b><span style=3D'mso-spacerun:ye= s'> </span></b></span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:au= to'>DMPA, levonorgestrel butanoate </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:51.75%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto;display:none'> </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:59.24%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= green'>Decreased side-effects : </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:66.75%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Monolithic macrocrystals</span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b>: </b></span></span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229'><span style=3D'position:absolute;top:74.25%;left:7.49%;width:98.87%;height:6.0%'= ><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b><span style=3D'mso-spacerun:yes'> </span></b></span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'>progesterone, 17-beta- estradiol, testosterone </span></span><span style=3D'position:absolute;top:80.5%; left:11.61%;width:87.82%;height:6.0%'><span lang=3DEN-GB style=3D'font-siz= e:88%; text-shadow:auto'>combined for once-a-month administration</span></span></= div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master37_image013.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA 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rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1091.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Injectables (2)"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1122"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image014.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>8= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> 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xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1092.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Contraceptive vaginal rings= "> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style> .CB {color:#292929;} .CT {color:#CC0000;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" speed= =3D"255" flag=3D"1"/><o:shapelayout v:ext=3D"edit"> <o:idmap 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soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>9= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id= =3D"_x0000_s1149954" type=3D"#_x0000_m932868" style=3D'position:absolute;left:13.375pt;top:102= pt; width:382.75pt;height:408pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1149954" style=3D'tab-interval:.4166in;tab-stops:.= 3975in'> <div class=3DCB3 style=3D'mso-margin-left-alt:840;mso-text-indent-alt:840'= ></div> <div class=3DCB4 style=3D'mso-margin-left-alt:1104;mso-text-indent-alt:110= 4'></div> <div class=3DCB style=3D'text-align:left'><span style=3D'position:absolute; top:20.0%;left:4.68%;width:58.05%;height:7.75%'><span style=3D'font-size:1= 13%'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:32.25%;left:-3.22%;width:3.54%;height:35.48%'><![endif]></span></span>= <span lang=3DEN-GB style=3D'font-size:113%'><span style=3D'mso-spacerun:yes'> </= span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>Progestogen only <s= pan style=3D'mso-tab-count:3;width:16.62%'> </span><span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:a= bsolute; top:28.0%;left:2.8%;width:52.05%;height:6.75%'><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-tab-count:1; width:7.63%'> </span>(for continuous use) </span></span></div> <div class=3DCB style=3D'text-align:left;position:absolute;top:36.0%;left:= 2.8%; width:60.29%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:6.59%'> </span>- </span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC3300;mso-color-index:4'>Progering </span><= span lang=3DEN-GB style=3D'font-size:75%'>- Silesia (3 months) </span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 0 0"'><span style=3D'position:absolute;top:41.5%;left:2.8%;width:60.11%;height:6.75%'>= <span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span><span lang= =3DEN-GB style=3D'font-size:75%'>- nestorone - Pop.C. (12 <span style=3D'mso-tab-co= unt: 3;width:15.99%'> </span></span></span><span style=3D'position:absolute; top:48.5%;left:2.8%;width:51.31%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:7.74%'> </spa= n><span style=3D'mso-spacerun:yes'> </span>months) </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 0 0"'><span style=3D'position:absolute;top:54.0%;left:5.43%;width:55.8%;height:6.75%'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-4= .69%; top:-.34em;font-size:160%'>•</span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-GB style=3D'col= or:#000066; mso-color-index:1'>Estrogen-progestogen </span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'pos= ition: absolute;top:61.0%;left:2.8%;width:51.31%;height:6.75%'><span lang=3DEN-GB= ><span style=3D'mso-tab-count:1;width:7.74%'> </span> </span><span lang=3DEN-GB style=3D'font-size:75%'>(3 weeks in /1 week out) </span></span></div> <div class=3DCB style=3D'text-align:left;position:absolute;top:69.0%;left:= 2.8%; width:60.48%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> </span>- </span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC3300;mso-color-index:4'>Nuvaring</span><sp= an lang=3DEN-GB style=3D'font-size:75%'> - Organon (1 month) </span></div> <div class=3DCB style=3D'text-align:left'><span style=3D'position:absolute; top:75.5%;left:2.8%;width:54.3%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:7.31%'> </spa= n>- nestorone/EE - Pop.C. (12<br> </span></span><span style=3D'position:absolute;top:80.75%;left:2.8%;width= :51.31%; height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'ms= o-tab-count: 1;width:7.74%'> </span><span style=3D'mso-spacerun:yes'> </span>months)</= span></span></div> </div> <v:shape id=3D"_x0000_s1149956" type=3D"#_x0000_t75" style=3D'position:abs= olute; left:396.125pt;top:180pt;width:304pt;height:226.875pt' stroked=3D"t" strokecolor=3D"#66f" strokeweight=3D"3pt"> <v:stroke linestyle=3D"thinThin"/> <v:imagedata src=3D"slide1092_image017.png" o:title=3D"vag_ring_hands"/> </v:shape><p:shaperange href=3D"master37.xml#_x0000_m932867"/><v:shape id= =3D"_x0000_s1149957" type=3D"#_x0000_m932867" style=3D'position:absolute;left:54pt;top:10.25pt; width:612.125pt;height:115.75pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"centerTitle"/></v:shape> <div v:shape=3D"_x0000_s1149957" class=3DCT style=3D'position:absolute;top= :8.75%; left:6.36%;width:87.64%;height:8.5%'><span lang=3DFR style=3D'font-size:11= 1%; text-shadow:none;color:#CC0000;mso-color-index:3'><b>Contraceptive vaginal rings</b></span><span style=3D'font-size:111%;text-shadow:none;color:#CC00= 00; mso-color-index:3;mso-special-format:lastCR;display:none'><b> </b></sp= an></div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master37_image016.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAO0lEQVQY02NgoCVgByMmJDYzGDGABdmRVILEGxCyjAwM bDC9rKgqWcGIGWYmI5jBhmQjK6rt7KjakQAAbYkBGV9ZnDgAAAAASUVORK5CYIJ= ------=_NextPart_01C64DC0.ECC8CCC0 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<div class=3DB2 style=3D'mso-margin-left-alt:779;mso-text-indent-alt:635'>= </div> <div class=3DB3 style=3D'mso-margin-left-alt:1036;mso-text-indent-alt:892'= ></div> <div class=3DB style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:229; position:absolute;top:17.25%;left:2.8%;width:103.93%;height:6.0%'><span style=3D'position:absolute;top:0%;left:3.78%;width:96.21%;height:100.0%'><= span style=3D'font-size:88%;color:#CC0000;mso-color-index:3'><span style=3D'mso= -special-format: bullet;mso-bullet-image:"image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-3= .93%; width:1.49%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#CC0000;mso-color-index:3'>Patch releasing an estrogen and a progestogen</span><span lang=3DFR style=3D'font-size:88%; color:#000066;mso-color-index:1'>: </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:23.5%;left:1= 1.79%; width:101.12%;height:6.5%'><span style=3D'color:#000066;mso-color-index:1'= ><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .14%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'mso-hansi-= font-family: Arial;color:#000066;mso-color-index:1'>EVRA</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>:<span style=3D'mso-spacerun:yes= '> </span>norelgestromin 150 </span><span lang=3DFR style=3D'font-family:Symb= ol; color:#000066;mso-color-index:1;mso-char-type:symbol'>m</span><span lang= =3DFR style=3D'color:#000066;mso-color-index:1'>g + ethinyl estradiol </span></s= pan><span style=3D'position:absolute;top:29.24%;left:11.79%;width:87.45%;height:6.5%= '><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>20 </span><span lang= =3DFR style=3D'font-family:Symbol;color:#000066;mso-color-index:1;mso-char-type:= symbol'>m</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>g </span></span></= div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:36.5%;left:8.61%;width:90.44= %; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>levonorgestrel + ethinyl estradiol </span></span></= div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:43.0%;left:1= 1.79%; width:87.45%;height:6.5%'><span style=3D'color:#000066;mso-color-index:1'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>gestodene 50 </span><span lang=3DFR style=3D'font-famil= y:Symbol; color:#000066;mso-color-index:1;mso-char-type:symbol'>m</span><span lang= =3DFR style=3D'color:#000066;mso-color-index:1'>g + ethinyl estradiol 18 </span>= <span lang=3DFR style=3D'font-family:Symbol;color:#000066;mso-color-index:1;mso-= char-type: symbol'>m</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>= g<span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:= absolute; top:49.0%;left:11.79%;width:87.45%;height:6.0%'><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>(Angeliq - Schering) </span>= </span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:55.75%;left:8.61%;width:90.4= 4%; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1;visibility:h= idden'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000066;mso-c= olor-index: 1;display:none'> </span></span></div> <div class=3DB style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:229; position:absolute;top:62.75%;left:2.8%;width:96.44%;height:6.0%'><span style=3D'position:absolute;top:0%;left:4.07%;width:95.72%;height:100.0%'><= span style=3D'font-size:88%;color:#CC0000;mso-color-index:3'><span style=3D'mso= -special-format: bullet;mso-bullet-image:"image010\.png";font-size:150%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:0%;left:-4.25%; width:4.46%;height:91.66%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#CC0000;mso-color-index:3'>Patch releasing a progestogen</span><span lang=3DFR style=3D'font-size:88%;color:#000066;mso= -color-index: 1'>: </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:69.5%;left:1= 1.79%; width:91.01%;height:6.0%'><span style=3D'color:#000066;mso-color-index:1'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .49%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>nestorone (also being developed as gel and </span></spa= n><span style=3D'position:absolute;top:75.0%;left:11.79%;width:87.45%;height:6.0%'= ><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>spray) </span></sp= an></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:82.0%;left:8.61%;width:90.44= %; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>norgestimate</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image018.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY02NgoAFgByMIYAIjuCAzGEHE2ZG0gMQbELKM DAxsYAVAZayoKlnBiBlmJiOYwYZkNSuqM9hRtSMBAG89ARv/zqoCAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1094.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1094.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Natural methods"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1127"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image019.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1154050" type=3D"#_x0000_m931843" style=3D'position:absolute;left:45.375pt;top:36p= t; width:637.375pt;height:90pt' o:spt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21= 600r21600,l21600,xe" filled=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#006 [1]= "> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"f"/> <v:stroke joinstyle=3D"miter" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow color=3D"#969696 [2]"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1154051" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:50.625pt;top:138pt;width:288.125pt;height= :276pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1154050" class=3DT style=3D'position:absolute;top:= 10.75%; left:7.3%;width:86.7%;height:9.25%'><span lang=3DFR style=3D'font-size:122%= '><b>Natural methods</b></span></div> <div v:shape=3D"_x0000_s1154051" class=3DB><span style=3D'position:absolut= e; top:26.49%;left:11.79%;width:34.45%;height:6.0%'><span style=3D'font-size:= 88%; color:#000066;mso-color-index:1'><span class=3DBB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-1= 0.86%; width:4.34%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>Standard days </sp= an></span><span style=3D'position:absolute;top:32.75%;left:11.79%;width:37.64%;height:6.0%= '><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>method, = based on<span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:absolute;top:39.0%;left:11.79%;width:39.51%;height:6.0%'= ><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>abstinen= ce/protecti</span></span><span style=3D'position:absolute;top:45.25%;left:11.79%;width:40.63%;height:6.0%= '><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>on from = cycle day 8 </span></span><span style=3D'position:absolute;top:51.5%;left:11.79%; width:34.45%;height:6.0%'><span lang=3DFR style=3D'font-size:88%;color:#00= 0066; mso-color-index:1'>to cycle day 19. </span></span> <div style=3D'position:absolute;top:58.99%;left:8.05%;width:38.2%;height:6= .0%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1;mso-speci= al-format: lastCR;display:none'> </span></div> </div> <v:shape id=3D"_x0000_s1154052" type=3D"#_x0000_t75" alt=3D"" style=3D'pos= ition:absolute; left:565.375pt;top:246pt;width:16.625pt;height:0'> <v:imagedata src=3D"slide1094_image020.png" o:title=3D"leer155"/> </v:shape><v:shape id=3D"_x0000_s1154053" type=3D"#_x0000_t75" alt=3D"" st= yle=3D'position:absolute; left:565.375pt;top:246pt;width:16.625pt;height:0'> <v:imagedata src=3D"slide1094_image020.png" o:title=3D"leer155"/> </v:shape><v:shape id=3D"_x0000_s1154054" type=3D"#_x0000_t75" alt=3D"" st= yle=3D'position:absolute; left:370.75pt;top:180pt;width:281.75pt;height:100.75pt'> <v:imagedata src=3D"slide1094_image021.jpg" o:title=3D"10504_verhuetung"/> </v:shape><v:shape id=3D"_x0000_s1154055" type=3D"#_x0000_t75" alt=3D"" st= yle=3D'position:absolute; left:565.375pt;top:246pt;width:16.625pt;height:0'> <v:imagedata src=3D"slide1094_image020.png" o:title=3D"leer155"/> </v:shape><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt= =3D"202" path=3D"m,l,21600r21600,l21600,xe"> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s1154058" type=3D"#_x0000_t202" style= =3D'position:absolute; left:430.875pt;top:329.125pt;width:97.25pt;height:40.875pt' filled=3D"f" stroked=3D"f"> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s1154059" type=3D"#_x0000_t202" style=3D'p= osition:absolute; left:54.5pt;top:336pt;width:581.875pt;height:74.5pt' filled=3D"f" stroked= =3D"f"> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s1154058" class=3DO style=3D'text-align:center;mso-= line-spacing: "100 50 0"'><span style=3D'position:absolute;top:62.0%;left:60.86%;width:1= 1.61%; height:6.0%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-= size: 156%;text-shadow:auto;color:black;mso-special-format:lastCR;display:none'>= <b> </b></span></span></div> <div v:shape=3D"_x0000_s1154059"> <div class=3DO1 style=3D'mso-margin-left-alt:342;mso-text-indent-alt:342'>= </div> <div class=3DO style=3D'mso-line-spacing:"100 20 0";mso-margin-left-alt:22= 9; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:63.25%;left:12.54%;width:79.4%;height:6.0%'><span style=3D'font-size:1= 56%'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-4.95%;width:1.88%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:156%'>"Two days" method, based on cervical </span></span><span 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style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image044.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1168386" type=3D"#_x0000_m931843" style=3D'position:absolute;left:36.125pt;top:0;w= idth:652pt; height:90pt;mso-wrap-style:none;v-text-anchor:middle' o:spt=3D"1" o:userd= rawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked=3D"f" strokecolor= =3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1168387" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:29.375pt;top:108pt;width:648.125pt;height= :342pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1168386" class=3DT style=3D'position:absolute;top:= 4.75%; left:-4.86%;width:110.48%;height:7.75%'><span lang=3DEN-GB><b>Microbicides= with contraceptive action</b></span></div> <div v:shape=3D"_x0000_s1168387" class=3DB> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:20.5%;left:8.8%;width:97.0%;height:5.25%'><span style=3D'font-size:75%= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.86%;width:1.35%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products that create a </span><span lang= =3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%;color:#CC0000;mso-color= -index: 3'>protective physical </span><span lang=3DFR style=3D'font-size:75%;color= :#CC0000; mso-color-index:3'>barrier</span><span lang=3DFR style=3D'font-size:75%; color:yellow'> </span><span lang=3DFR style=3D'mso-hansi-font-family:Arial; font-size:75%'>in the </span></span><span style=3D'position:absolute;top:2= 5.25%; left:8.8%;width:97.37%;height:5.25%'><span lang=3DFR style=3D'font-size:75= %'>vagina: e.g. Sulfated and sulfonated polymers, such as </span></span><span style=3D'position:absolute;top:30.0%;left:8.8%;width:84.45%;height:5.25%'>= <span lang=3DFR style=3D'font-size:75%'>cellulose sulfate, polystyrene sulfonate= . </span></span></div> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:37.5%;left:8.8%;width:96.25%;height:5.25%'><span style=3D'font-size:75= %'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.89%;width:1.36%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products which increase vaginal defense mechanisms </span></span><span style=3D'position:absolute;top:42.25%;left:= 8.8%; width:101.31%;height:5.25%'><span lang=3DFR style=3D'font-size:75%'>by </s= pan><span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%;color:#CC0000; mso-color-index:3'>maintaining natural acidity</span><span lang=3DFR style=3D'font-size:75%'> (which immobilises sperm): </span></span><span style=3D'position:absolute;top:47.25%;left:8.8%;width:84.45%;height:5.25%'= ><span lang=3DFR style=3D'font-size:75%'>e.g. BufferGel and Acidform. </span>= </span></div> <div style=3D'mso-line-spacing:"90 50 0";position:absolute;top:54.5%;left:= 5.05%; width:99.81%;height:5.25%'><span style=3D'position:absolute;top:0%;left:3.= 75%; width:96.24%;height:100.0%'><span style=3D'font-size:75%;color:#CC0000; mso-color-index:3'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"= *" style=3D'position:absolute;top:33.33%;left:-3.89%;width:1.36%;height:33.33= %'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>Surfacta= nt </span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%'>products</sp= an><span lang=3DFR style=3D'font-size:75%'>: e.g. acylcarnitine analogs, C31G. = </span></span></div> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:62.0%;left:8.8%;width:95.69%;height:5.25%'><span style=3D'font-size:75= %'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.91%;width:1.36%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products which block attachment of HIV t= o target cells </span></span><span style=3D'position:absolute;top:66.75%;left:8.8%; width:94.38%;height:5.25%'><span lang=3DFR style=3D'font-size:75%'>and</sp= an><span lang=3DFR style=3D'font-size:75%;color:yellow'> </span><span lang=3DFR style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>sperm - zona pellu= cida fusion</span><span lang=3DFR style=3D'font-size:75%'>: e.g. naphthyl urea = </span></span><span style=3D'position:absolute;top:71.5%;left:8.8%;width:84.45%;height:5.25%'>= <span lang=3DFR style=3D'font-size:75%'>derivatives.</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image044.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY02NgoAFgZ2BghbGZwAgiCETMYAQRZ0fSAhJv QMgyMjCwgRUwgY1CVskKRswwMxnBDDZsVrMjIWwAAG31ARk222ZrAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1102.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1102.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Immunocontraceptives"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1143"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image045.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1170434" type=3D"#_x0000_m931843" style=3D'position:absolute;left:53.375pt;top:18p= t; width:613.5pt;height:66pt;mso-wrap-style:none;v-text-anchor:middle' o:spt= =3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" fillcol= or=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode= =3D"custom"> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt=3D"202" path=3D"m,l,21600r21600,l21600,xe= "> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s1170435" type=3D"#_x0000_t202" style= =3D'position:absolute; left:26.75pt;top:101.375pt;width:666.75pt;height:343.25pt;v-text-anchor:m= iddle' filled=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt"> <v:fill color2=3D"white [0]"/> <v:stroke dashstyle=3D"longDash"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s1170434" class=3DT style=3D'position:absolute;top:= 5.0%; left:8.42%;width:83.33%;height:9.25%'><span lang=3DEN-GB style=3D'font-siz= e:122%; color:#CC0000;mso-color-index:3'><b>Immunocontraceptives</b></span></div> <div v:shape=3D"_x0000_s1170435"> <div class=3DO1 style=3D'mso-margin-left-alt:680;mso-text-indent-alt:680'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:793;mso-text-indent-alt:793'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:906;mso-text-indent-alt:906'>= </div> <div class=3DO style=3D'position:absolute;top:19.75%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Most advanced immunocontraceptives are based on hCG :<span style=3D'mso-spacerun:yes'> </span> </span></div> <div class=3DO style=3D'position:absolute;top:24.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%;display:none'> </= span></div> <div class=3DO><span style=3D'position:absolute;top:28.5%;left:4.68%;width= :105.99%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Their goal is to gen= erate antibodies against hCG secreted by embryonic </span></span><span style=3D'position:absolute;top:33.0%;left:4.68%;width:106.74%;height:4.5%'= ><span lang=3DFR style=3D'font-size:111%'>trophoblastic cells, necessary for main= tainance of the corpus luteum and </span></span><span style=3D'position:absolute; top:37.5%;left:4.68%;width:90.82%;height:4.5%'><span lang=3DFR style=3D'fo= nt-size: 111%'>the continued production of progesterone: </span></span></div> <div class=3DO><span style=3D'position:absolute;top:42.0%;left:4.68%;width= :100.56%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-t= ab-count: 1;width:9.94%'> </span>hCG </span><span lang=3DFR style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:"Times New Ro= man"; mso-hansi-font-family:"Times New Roman";font-size:111%'>β</span><span lang=3DFR style=3D'font-size:111%'> Chain: whole or the 109-145 amino acid sequence of<span style=3D'mso-spacerun:yes'> </span></span></span>= <span style=3D'position:absolute;top:46.25%;left:4.68%;width:90.82%;height:4.5%'= ><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-tab-count:1;width:11= .0%'> </span>the C-terminal portion </span></span></div> <div class=3DO style=3D'position:absolute;top:50.75%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :7.64%'> </span>+ diphtheria toxoid as carrier </span></div> <div class=3DO style=3D'position:absolute;top:55.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :7.64%'> </span>+ muramyl dipeptide as adjuvant </span></div> <div class=3DO style=3D'position:absolute;top:59.75%;left:4.68%;width:99.6= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :6.96%'> </span>+ squalene/mannide monooleate (4:1) as emulsifying agent </span= ></div> <div class=3DO style=3D'position:absolute;top:64.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%;display:none'> </= span></div> <div class=3DO style=3D'position:absolute;top:68.5%;left:4.68%;width:90.82= %; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Other targets: - zona pellucida (permanent effect on ovaries) </span></div> <div class=3DO><span style=3D'position:absolute;top:73.0%;left:4.68%;width= :103.37%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-t= ab-count: 1;width:9.67%'> </span>- molecules on sperm surface, e.g. fertilin (PH-30), fertilisation </span></span><span style=3D'position:absolute;top:77.5%; left:4.68%;width:90.82%;height:4.5%'><span lang=3DFR style=3D'font-size:11= 1%'><span style=3D'mso-tab-count:1;width:11.0%'> </span>antigen (FA-1), sperm protein (SP-10), LDH-C4</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image045.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY02NgoAFgByMIYAIjuCAzGEHE2ZG0gMQbELKM 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href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1103.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Anti-progestins for contrac= eption"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1145"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image046.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1172482" type=3D"#_x0000_m931843" style=3D'position:absolute;left:30.125pt;top:0;w= idth:655.375pt; height:90pt' o:spt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600= ,xe" filled=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#006 [1]= "> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"f"/> <v:stroke joinstyle=3D"miter" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow color=3D"#969696 [2]"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1172483" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:34.625pt;top:108pt;width:645.375pt;height= :384pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1172482" class=3DT style=3D'position:absolute;top:= 4.5%; left:-3.37%;width:106.17%;height:8.5%'><span lang=3DFR style=3D'mso-hansi-= font-family: Arial;font-size:111%'><b>Anti-progestins for contraception</b></span></div> <div v:shape=3D"_x0000_s1172483"> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 21.0%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Sequential regimen= </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0";position:absolute;top= :29.0%; left:10.86%;width:82.77%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.61%;width:96.15%;height:100.0%'><span style=3D'font-size:86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.76%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone + Norethisterone </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0";position:absolute;top= :37.0%; left:10.86%;width:82.77%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.61%;width:96.38%;height:100.0%'><span style=3D'font-size:86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.75%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone + Medroxyprogesterone acetate </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0"'><span style=3D'posit= ion:absolute; top:45.0%;left:13.85%;width:95.13%;height:5.25%'><span style=3D'font-size:= 86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.14%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone (days 1-15) + nomegestrol acetate (days </span></span><span style=3D'posit= ion: absolute;top:50.25%;left:13.85%;width:79.58%;height:5.25%'><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>16-28) </span>= </span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 58.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Continuous regimen= : 0,1 to 10 mg/day </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 66.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Weekly use: 2,5 to= 50 mg doses </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 74.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Monthly use: 200 m= g 2 days after the LH peak </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 82.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Emergency contrace= ption: 10 mg</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image046.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY07VOQQ4AIAjCmvHtnl6xWfqAGCcEAfgAihsD cKAlsYuQyBQ5+nxXU5ayeXW62OOnRdGt9jqDNZ6wAHTCASRXi8keAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1104.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1104.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: METHODS FOR MALE CONTRACEPT= ION"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1147"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image047.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1174530" type=3D"#_x0000_m931843" style=3D'position:absolute;left:53.375pt;top:48p= t; width:613.375pt;height:90pt;mso-wrap-style:none;v-text-anchor:middle' o:s= pt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1174531" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:102.125pt;top:186pt;width:484pt;height:22= 1.625pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1174530" class=3DT><span style=3D'position:absolut= e; top:8.0%;left:8.42%;width:83.33%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>METHODS FOR<br> </b></span></span><span style=3D'position:absolute;top:17.75%;left:6.55%; width:86.89%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>= MALE CONTRACEPTION</b></span></span></div> <div v:shape=3D"_x0000_s1174531" class=3DB> <div style=3D'position:absolute;top:35.5%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm production </span></span></div> <div style=3D'position:absolute;top:43.0%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm transport </span></span></div> <div style=3D'position:absolute;top:50.5%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm deposition </span></span></div> <div style=3D'position:absolute;top:58.0%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Modify sperm function </span></span></div> <div style=3D'position:absolute;top:65.25%;left:15.16%;width:65.35%;height= :6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" 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></span></div> </div> <div v:shape=3D"_x0000_s1176596"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'mso-line-spacing:"90 0 0";position:absolute;top:49= .25%; left:39.88%;width:2.99%;height:4.0%'><span lang=3DEN-GB style=3D'color:bla= ck'><b>T</b></span></div> </div> <div v:shape=3D"_x0000_s1176597"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'mso-line-spacing:"90 0 0";position:absolute;top:49= .25%; left:53.93%;width:4.11%;height:4.0%'><span lang=3DEN-GB style=3D'color:bla= 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iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAPklEQVQY07WNwQoAIAhDZ7L87T49GlgGXRvvMOZU4IM6 wGKafAgXUBhlZeXjTE27oRrvJoXnTctHyITFb16actMBIWvwN5wAAAAASUVORK5CYIJ= ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1106.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1106.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Methods to supress sperm pr= oduction"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1151"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image049.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1178626" type=3D"#_x0000_m931843" style=3D'position:absolute;left:58.625pt;top:48p= t; width:613.5pt;height:66pt;mso-wrap-style:none;v-text-anchor:middle' o:spt= =3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1178627" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:60.125pt;top:2in;width:608.125pt;height:3= 06pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1178626" class=3DT style=3D'position:absolute;top:= 11.5%; left:-3.93%;width:109.55%;height:7.75%'><span lang=3DEN-GB><b>Methods to s= upress sperm production</b></span></div> <div v:shape=3D"_x0000_s1178627"> <div class=3DB style=3D'mso-line-spacing:"100 60 0";position:absolute;top:= 27.75%; left:9.36%;width:82.58%;height:6.0%'><span style=3D'position:absolute; top:0%;left:4.53%;width:95.46%;height:100.0%'><span style=3D'font-size:88%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-4= .75%; width:1.9%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Hormonal </spa= n></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0";position:absolute;top= :37.75%; left:14.41%;width:77.52%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.86%;width:96.13%;height:100.0%'><span style=3D'color:#000066; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>Testosterone esters= </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0"'><span style=3D'posit= ion:absolute; top:47.5%;left:17.41%;width:74.53%;height:6.0%'><span style=3D'color:#0000= 66; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>progestogen or GnRH analogue + </span></span><span style=3D'position:absolute;top:53.75%;left:= 17.41%; width:74.53%;height:6.0%'><span lang=3DEN-GB style=3D'color:#000066;mso-co= lor-index: 1'>testosterone </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";position:absolute;top:= 63.75%; left:9.36%;width:94.94%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.94%;width:96.05%;height:100.0%'><span style=3D'font-size:88%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .1%; width:1.64%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Immunological, bas= ed on antibodies against </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0";position:absolute;top= :73.75%; left:14.41%;width:77.52%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.86%;width:96.13%;height:100.0%'><span style=3D'color:#000066; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>GnRH, LH, FSH, their receptors</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image049.png Content-Transfer-Encoding: base64 Content-Type: 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rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1107.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Methods for male sterilizat= ion"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1153"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image050.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1180674" type=3D"#_x0000_m931843" style=3D'position:absolute;left:42.125pt;top:12p= t; width:642pt;height:54pt;mso-wrap-style:square;v-text-anchor:middle' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:inset= mode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"title"/></v:shape><v:rect id=3D"_x0000_s1180675" s= tyle=3D'position:absolute; left:50.5pt;top:66pt;width:429.5pt;height:2in;v-text-anchor:middle' fille= d=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#006 [1]" strokeweigh= t=3D"1pt"> <v:fill color2=3D"white [0]"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt"/> </v:rect><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id= =3D"_x0000_s1180676" type=3D"#_x0000_m931844" style=3D'position:absolute;left:66.125pt;top:222= pt; width:492pt;height:240pt;mso-wrap-style:square;v-text-anchor:top' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:inset= mode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1180674" class=3DT style=3D'position:absolute;top:= 3.25%; left:3.37%;width:94.38%;height:8.5%'><span lang=3DEN-GB style=3D'font-size= :111%'><b>Methods for male sterilization</b></span></div> <div v:shape=3D"_x0000_s1180675" class=3DO> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:14.0%;left:= 8.05%; width:57.86%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>No scalpel vasectomy </b></span></div> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:24.0%;left:= 8.05%; width:57.86%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>Fascial interposition </b></span></div> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:34.0%;left:= 8.05%; width:63.29%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>Percutaneous vas occlusion</b></span></div> </div> <div v:shape=3D"_x0000_s1180676" style=3D'tab-stops:2.625in 3.8125in 4.437= 5in'> <div class=3DB1 style=3D'mso-margin-left-alt:2028;mso-text-indent-alt:2016= '></div> <div class=3DB2 style=3D'mso-margin-left-alt:2124;mso-text-indent-alt:2100= '></div> <div class=3DB3 style=3D'mso-margin-left-alt:2196;mso-text-indent-alt:2196= '></div> <div class=3DB4 style=3D'mso-margin-left-alt:2268;mso-text-indent-alt:2280= '></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:42.0%;left:10.11%;width:66.47%;height:6.0%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:88%'><b>- </b></span><span lang=3DEN-GB style=3D'font-size:75%'><b> </b></span><span lang=3DEN-GB style=3D'font-si= ze:75%'>Permanent, with </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:48.25%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>scler= osing agents</span><span lang=3DEN-GB style=3D'font-size:75%'>: </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:53.5%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>e.g. methylcyanoacrylate, </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:58.99%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> = </span>polyurethane </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:64.25%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'>-<span style=3D'mso-spacerun:yes'> </span>Reversible, with </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:69.5%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>non-s= clerosing agents</span><span lang=3DEN-GB style=3D'font-size:75%'>: </span></di= v> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:75.0%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>e.g. silicone plugs </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:80.25%;left:10.11%;width:76.59%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>or</span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'> resi= ns</span><span lang=3DEN-GB style=3D'font-size:75%'>:<span style=3D'mso-spacerun:yes'> <= /span>e.g. maleic anhydride / styrene</span></div> </div> <v:shape id=3D"_x0000_s1180677" type=3D"#_x0000_t75" style=3D'position:abs= olute; 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Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1111.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Some of the more promising = leads"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if 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Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= 7</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1188866" type=3D"#_x0000_m931843" style=3D'position:absolute;left:36.125pt;top:36p= t; width:660pt;height:54pt;mso-wrap-style:none;v-text-anchor:middle' o:spt= =3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1188867" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:24.125pt;top:120pt;width:660pt;height:348= pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1188866" class=3DT style=3D'position:absolute;top:= 7.75%; left:-3.74%;width:109.36%;height:8.5%'><span lang=3DFR style=3D'font-size:= 111%'><b>Some of the more promising leads</b></span></div> <div v:shape=3D"_x0000_s1188867" class=3DB> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:23.25%;left:8.05%;width:102.05%;height:5.25%'><span style=3D'font-size= :75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .66%; width:1.28%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Lonidamine analogu= es: deplete immature germ cells from </span></span><span style=3D'position:abs= olute; top:28.5%;left:8.05%;width:86.14%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>seminiferous epithelium. </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:36.0%; left:4.3%;width:100.56%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.72%;width:96.27%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .86%; width:1.35%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of epid= idymal proteins: eppin and cystatin-11 </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:43.5%; left:4.3%;width:89.88%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.16%;width:95.83%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:28.57%;left:-4= .34%; width:1.52%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of testis-specific enzymes (GST, SAC) </span></span></div> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:50.75%;left:8.05%;width:97.56%;height:5.25%'><span style=3D'font-size:= 75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .83%; width:1.34%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of fusi= on of sperm with zona pellucida: GnRH </span></span><span style=3D'position:abso= lute; top:56.25%;left:8.05%;width:86.14%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>antagonists. <= /span></span></div> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:63.75%;left:8.05%;width:90.26%;height:5.25%'><span style=3D'font-size:= 75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:28.57%;left:-4= .14%; width:1.45%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Change in endometr= ial receptivity: LIF antagonists; </span></span><span style=3D'position:absolu= te; top:69.0%;left:8.05%;width:100.18%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>antibodies against= LIF, IL-11, or the IL-11 receptor; ebaf. </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:76.5%; left:4.3%;width:104.49%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.58%;width:96.41%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .71%; width:1.3%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Anti-angiogenic ag= ents (magainin analogues, fumagillin).</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: 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id=3D"_x0000_s1190916" type=3D"#_x0000_t202" style= =3D'position:absolute; left:80.5pt;top:367.25pt;width:559pt;height:93.5pt;mso-wrap-style:none; v-text-anchor:middle' filled=3D"f" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt"> <v:stroke dashstyle=3D"longDash"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s1190914" class=3DT><span style=3D'position:absolut= e; top:5.75%;left:-5.61%;width:111.42%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>Challenges for the development<br> </b></span></span><span style=3D'position:absolute;top:15.5%;left:.93%; width:98.12%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>= of new technologies</b></span></span></div> <div v:shape=3D"_x0000_s1190915" class=3DB> <div style=3D'position:absolute;top:31.0%;left:6.92%;width:91.76%;height:5= .25%'><span style=3D'position:absolute;top:0%;left:4.08%;width:95.91%;height:100.0%'><= span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .25%; width:1.48%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Cost and time (10-= 15 years, US$ 200-300 million) </span></span></div> <div style=3D'position:absolute;top:37.25%;left:6.92%;width:87.07%;height:= 5.25%'><span style=3D'position:absolute;top:0%;left:4.3%;width:95.69%;height:100.0%'><s= pan style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .49%; width:1.57%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Industry involvement </span></span></div> <span style=3D'position:absolute;top:43.75%;left:10.67%;width:94.56%;heigh= t: 5.25%'><span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position= :absolute; top:33.33%;left:-3.96%;width:1.38%;height:33.33%'><![endif]></span></span>= <span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Persp= ectives of users and potential users, of different </span></span><span style=3D'position:absolute;top:49.0%;left:10.67%;width:93.44%;height:5.25%= '><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>relig= ious and socio-cultural backgrounds, and of new </span></span><span style=3D'positi= on: absolute;top:54.5%;left:10.67%;width:83.33%;height:5.25%'><span lang=3DEN-= GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>generations of wom= en and men </span></span> <div style=3D'position:absolute;top:60.75%;left:6.92%;width:94.75%;height:= 5.25%'><span style=3D'position:absolute;top:0%;left:3.95%;width:96.04%;height:100.0%'><= span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .11%; width:1.44%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Access in resource= -poor settings (cost, technology)</span></span></div> </div> <div v:shape=3D"_x0000_s1190916" class=3DO> <div style=3D'text-align:center;position:absolute;top:69.0%;left:4.68%; width:91.01%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:133%;colo= r:#CC0000; mso-color-index:3'>For women to benefit from these new technologies, <= /span></div> <div style=3D'text-align:center;position:absolute;top:74.25%;left:6.36%; width:87.45%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:133%;colo= r:#CC0000; mso-color-index:3'>they need better access to education and income </s= pan></div> <div style=3D'text-align:center;position:absolute;top:79.5%;left:11.04%; 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lang=3DEN-GB style=3D'font-family:"Times New Roman";font-size:61%;mso-special-format:las= tCR'><i> </i></span></div> </div> <v:shapetype id=3D"_x0000_s11271" style=3D'position:absolute;left:297pt;top= :735.375pt; width:225.75pt;height:36.25pt;v-text-anchor:bottom' coordsize=3D"21600,216= 00" o:master=3D"" o:spt=3D"1" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" = fillcolor=3D"#0c9 [4]" stroked=3D"f" strokecolor=3D"black [1]"> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"t"/> <v:stroke joinstyle=3D"miter" o:forcedash=3D"t"/> <v:shadow color=3D"gray [2]"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" grouping=3D"t"/> <v:textbox inset=3D"2.55408mm,1.2771mm,2.55408mm,1.2771mm"/> <p:placeholder type=3D"slideNumber" position=3D"5" size=3D"quarter"/></v:s= hapetype> <div v:shape=3D"_x0000_s11271" style=3D'tab-interval:1.0069in'> <div class=3DO1 style=3D'mso-margin-left-alt:289;mso-text-indent-alt:289'><= /div> <div class=3DO2 style=3D'mso-margin-left-alt:580;mso-text-indent-alt:580'><= /div> <div class=3DO3 style=3D'mso-margin-left-alt:870;mso-text-indent-alt:870'><= /div> <div class=3DO4 style=3D'mso-margin-left-alt:1148;mso-text-indent-alt:1148'= ></div> <div class=3DO style=3D'text-align:right'><span lang=3DEN-GB style=3D'font-= family:"Times New Roman"; font-size:61%;mso-field-code:meta16'><i>‹#›</i></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";font-size:61%;mso-special-format:las= tCR'><i> </i></span></div> </div> <p:notes id=3D"1084" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1109"/> </o:shapelayout><v:shape id=3D"_x0000_s1135618" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt' filled=3D"f" stroked=3D"t" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke dashstyle=3D"solid" opacity=3D"1" filltype=3D"solid" linestyle= =3D"single" endcap=3D"flat" o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1135= 619" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt;mso-wrap-style:square;v-text-anchor:top' filled=3D"f" stroke= d=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.49597mm,1.2261mm,2.49597mm,1.2261mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1135619" class=3DN style=3D'mso-line-spacing:"87 3= 0 0"'><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New R= oman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1085" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1111"/> </o:shapelayout><v:shape id=3D"_x0000_s1137666" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1137= 667" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1137667" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1086" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1113"/> </o:shapelayout><v:shape id=3D"_x0000_s1139714" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1139= 715" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1139715" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1087" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1115"/> </o:shapelayout><v:shape id=3D"_x0000_s1141762" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1141= 763" type=3D"#_x0000_m11269" style=3D'position:absolute;left:43pt;top:369.25pt; width:444.5pt;height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1141763" class=3DN> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Gynefix</b></span><span lang=3DEN-GB style=3D'font-family:"Times= New Roman"; mso-ascii-font-family:"Times New Roman"'>: 330 mm2 (6 sleeves) or </span><= span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>mini-Gynefix</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'> 200 mm2 (4 sleeves). Aim is to </span><span lang=3DEN-GB style=3D'font-fam= ily: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>decrease expulsions, pain and bleeding.<span style=3D'mso-spacerun:yes'> </span>Bo= th have the same efficacy and are designed to </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>last 10 years.<span style=3D'mso-spacerun:yes'> </span>Less bleeding with mini-Gynefix.<span style=3D'mso-spacerun:yes'> </span>Difficulty: inserti= on technique. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Femilis</b></span><span lang=3DEN-GB style=3D'font-family:"Times= New Roman"; mso-ascii-font-family:"Times New Roman"'> and </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Femilis-Slim</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: release 20 </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-= font-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g/day LNG. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Fibroplant</b></span><span lang=3DEN-GB style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman"'> releases 14 </span><span lang=3D= EN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roman";mso-han= si-font-family: Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g/day LNG. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Not shown: </sp= an><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Gyneplant</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: 4 copper sleeves plus one fibre which releases 5 </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roman";mso-han= si-font-family: Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g/day LNG</span></div> </div> </p:notes><p:notes id=3D"1088" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1117"/> </o:shapelayout><v:shape id=3D"_x0000_s1143810" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1143= 811" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1143811" class=3DN> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman"'>Also under development: </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Swing</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>, which has a coil of copper (380 mm2) for </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>the vertical arm and horizontal arms that bend upward to reduce expulsions.= 3;</span> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Anti-progestin-= releasing IUD (CDB-2914) will provide bleed-free system. </span></div> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1089" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1119"/> </o:shapelayout><v:shape id=3D"_x0000_s1145858" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1145= 859" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1145859" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Ne= storone</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'> (ST1435): 19-nor progesterone derivative, orally inactive, pure </span><sp= an lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>progestogen, without any estrogenic or androgenic activity. 10 to 100 times </span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>more potent than progesterone. </span> <div><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font= -family: "Times New Roman";mso-hansi-font-family:Arial'><b>Elcometrine</b></span><s= pan lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: releases nestorone over 6 months, available in Brazil only. </span></= div> <span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-fami= ly:"Times New Roman"; mso-hansi-font-family:Arial'><b>Uniplant</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'> (=3D Surplant): releases nomegestrol acetate, one year duration of </span>= <span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>action.<span style=3D'mso-spacerun:yes'> </span>Developed by Theramex with South-to-So= uth</span></div> </p:notes><p:notes id=3D"1090" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1121"/> </o:shapelayout><v:shape id=3D"_x0000_s1147906" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.375pt;top:58.625pt;width:385.875pt;height:289.375pt' filled=3D"f" stroked=3D"t" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke dashstyle=3D"solid" opacity=3D"1" filltype=3D"solid" linestyle= =3D"single" endcap=3D"flat" o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1147= 907" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:325.875pt;mso-wrap-style:square;v-text-anchor:top' filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.49575mm,1.226mm,2.49575mm,1.226mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1147907" class=3DN style=3D'mso-line-spacing:"87 3= 0 0"'><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roma= n"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1091" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1172"/> </o:shapelayout><v:shape id=3D"_x0000_s1200130" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:73.25pt;top:59.75pt;width:382.875pt;height:287.125pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1200= 131" type=3D"#_x0000_m11269" style=3D'position:absolute;left:71pt;top:370.75pt; width:386.5pt;height:346.875pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape></p:notes><p:notes id=3D"1092" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1124"/> </o:shapelayout><v:shape id=3D"_x0000_s1150978" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1150= 979" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1150979" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Pr= ogering:</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"; mso-hansi-font-family:Arial'> releases 15 to 5 mg/day progesterone over 3 = to 4 months, </span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-= ascii-font-family: "Times New Roman";mso-hansi-font-family:Arial'>available in Chile and Peru since 1998. </span><span lang=3DFR style=3D'font-family:"Times New Rom= an"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Nu= varing</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: 3-keto-desogestrel 120 </span><span style=3D'font-family:Arial;mso-ascii-f= ont-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g + Ethinyl estradiol 15 </span><span style=3D'font-family:Arial;mso-ascii-f= ont-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g, approved by </span><span lang=3DFR style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>U.S.FDA in 2001, in France in Apr= il 2004. </span> <div><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font= -family: "Times New Roman";mso-hansi-font-family:Arial'><b>Nestorone/EE</b></span><= span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: 150 </span><span style=3D'font-family:Arial;mso-ascii-font-family:"Times N= ew Roman"; mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g + 15 </span><span style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'= >µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>g</span></div> </div> </p:notes><p:notes id=3D"1093" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1126"/> </o:shapelayout><v:shape id=3D"_x0000_s1153026" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1153= 027" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1153027" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>Evra: less effective in women weighing 90 kg or more. </span></div> </p:notes><p:notes id=3D"1094" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1128"/> </o:shapelayout><v:shape id=3D"_x0000_s1155074" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1155= 075" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1155075" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Standard days</b></span><span lang=3DEN-GB style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>: failure rate of 5% with perfect use, and of 12 % in actual </span><span lang=3DEN-GB style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>use.<span style=3D'mso-spacerun:y= es'> </span>Cycles must be regular, between 26 and 32 days. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Two days method</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: based on observation of the cervical mucus yesterday </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>and today.<span style=3D'mso-spacerun:yes'> </span>If mucus is present on one= of these days, contraceptive </span><span lang=3DEN-GB style=3D'font-family:"= Times New Roman"; mso-ascii-font-family:"Times New Roman"'>protection is needed.<span style=3D'mso-spacerun:yes'> </span>Simpler than sympto-thermal method, not dependant </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>on cycle length<span style=3D'mso-spacerun:yes'> </span>Under investigation. </span> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Both methods can be used to plan a pregnancy. </spa= n></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1095" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1130"/> </o:shapelayout><v:shape id=3D"_x0000_s1157122" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1157= 123" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1157123" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Essure</b></span><span lang=3DEN-GB style=3D'font-family:"Times = New Roman"; mso-ascii-font-family:"Times New Roman"'> (=3D STOP): under local anaesthe= sia, insertion lasts less than one hour.<span style=3D'mso-spacerun:yes'> </sp= an></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>Proper placement checked with hysteroscopy, X-ray or ultrasound.<span style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Contraception needed for 3 months following insertion. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Adiana:</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'> low frequency radiation to create lesions on= the fallopian tubes, </span><span lang=3DEN-GB style=3D'font-family:"Times New= Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'>follo= wed by application of porous plastic matrix on the lesion to encourage </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'>scar formation for the next 3 months.</span><= span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New R= oman"; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'><b> </b></span= ><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Ovabloc:</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'> injection of liquid silicone in fallopian tubes.<span style=3D'mso-spacerun:yes'> </span>Follow-up with X-</span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'>ray over one year. Shift of the silicone plugs observed in 10% cases over 1 </span><span lang=3DEN-GB style=3D'font-famil= y:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'>year.= </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New R= oman"; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'><b> </b></span= ><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Quinacrine</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: toxicological studies underway.<span style=3D'mso-spacerun:yes'> </span>Clinical studies tested various </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>regimens.</span></div> </p:notes><p:notes id=3D"1096" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1132"/> </o:shapelayout><v:shape id=3D"_x0000_s1159170" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1159= 171" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1159171" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Polyurethane or plastic condoms: longer shelf-life, can be used with oil-</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>based lubricant, more comfortable.<span style=3D'mso-spacerun:yes'> </span>Slip= page and breakage problems</span></div> </p:notes><p:notes id=3D"1097" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1134"/> </o:shapelayout><v:shape id=3D"_x0000_s1161218" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1161= 219" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1161219" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1098" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1136"/> </o:shapelayout><v:shape id=3D"_x0000_s1163266" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1163= 267" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1163267" class=3DN> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial'> </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman";mso-hansi-font-family:Arial'><b>Lea's shield</b></span><= span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>: silicone, one size, with ring to facilitate removal, et valve to </span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>avoid pressure/suction and allow menstrual flow.<span style=3D'mso-spacerun:yes'= > </span>Use: keep for 8 hours </span><span lang=3DEN-GB style=3D'font-famil= y:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>after intercourse, never more tha= n 48 hours.<span style=3D'mso-spacerun:yes'> </span>Approved by the U.S.FDA in= </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>2002. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>SILCS</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: silicone, development based on numerous acceptability studies with </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>users and providers.<span style=3D'mso-spacerun:yes'> </span>One size.<span style=3D'mso-spacerun:yes'> </span>Under testing. </span> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1099" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1138"/> </o:shapelayout><v:shape id=3D"_x0000_s1165314" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1165= 315" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1165315" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Ov</b></span><span lang=3DEN-GB style=3D'font-family:Arial;mso-a= scii-font-family: "Times New Roman";mso-hansi-font-family:Arial'><b>è</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>s</b></span><span lang=3DEN-GB style=3D'fo= nt-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>: produced in France by Veos, available since 1997.<span style=3D'mso-spacerun:yes'> </span>Three sizes.<span style=3D'mso-spacerun:yes'> </span>The </span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>dome is a membrane which sticks to the cervix like a film.<span style=3D'mso-spacerun:yes'> </span>Under </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>investigation. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>FemCap</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: Approved by U.S.FDA in 2003, available in many European </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>countries<span style=3D'mso-spacerun:yes'> </span>Three sizes.<span style=3D'mso-spaceru= n:yes'> </span>Designed to prevent displacement and to avoid </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>pressure on the urethra.</span></div> </p:notes><p:notes id=3D"1100" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1140"/> </o:shapelayout><v:shape id=3D"_x0000_s1167362" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1167= 363" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; 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height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1175555" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1105" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1150"/> </o:shapelayout><v:shape id=3D"_x0000_s1177602" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1177= 603" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1177603" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1106" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1152"/> </o:shapelayout><v:shape id=3D"_x0000_s1179650" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1179= 651" type=3D"#_x0000_m11269" style=3D'position:absolute;left:23.625pt;top:368p= t; width:474pt;height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1179651" class=3DN> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>T microspheres </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman"'>MENT (implant, transdermal gel, patch) and MENT acetate (implant) - MENT has the </span><span lang=3DEN-GB style=3D'font-family:"T= imes New Roman"; mso-ascii-font-family:"Times New Roman"'>advantage over T that it does not overstimulate the prostate </span> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>TU in tea seed oil </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>TU in soybean oil (to achieve higher concentration) = ;</span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>DMPA + testosterone pellets (too many pellet expulsions) </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>DMPA + TU in tea seed oil </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG rods + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG rods + T pellets </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG pills + TE </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Jadelle + T or TE </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Net-EN + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Jadelle + MENT </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Implanon + MENT </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Cyproterone acetate + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1107" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1154"/> </o:shapelayout><v:shape id=3D"_x0000_s1181698" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1181= 699" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1181699" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; 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height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1187843" class=3DN> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial'> </span></div> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1111" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1162"/> </o:shapelayout><v:shape id=3D"_x0000_s1189890" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1189= 891" type=3D"#_x0000_m11269" style=3D'position:absolute;left:17.875pt;top:368p= t; width:506.75pt;height:364pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1189891" class=3DN> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Lonidamine</= b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> is an anticancer drug with antispermatogenic capability, abandoned because= of kidney </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>damage.<span style=3D'mso-spacerun:yes'> </span>Analogues being investigated (e.g. AF-= 2364, AF-2785).<span style=3D'mso-spacerun:yes'> </span>One has specific action= on Sertoli </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>cells </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Epididymal proteins</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roma= n"; mso-ascii-font-family:"Times New Roman"'>:2 lead candidates: </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'><b>eppin</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> (epididymal protease inhibitor) and cystatin-11. Test </span><span lang=3D= EN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>undertaken to see if immunoneutralization of </span><span lang=3DEN-GB style=3D'font-= family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>cystatin-11<= /b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> leads to infertility, but vaccine approach </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>seen as controversial, thus research aims to develop inhibitors. </span></d= iv> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Testis-speci= fic enzymes</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman= "; mso-ascii-font-family:"Times New Roman"'>: </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>-<span style=3D'mso-spacerun:yes'> </span>isoforms of the detoxification enzyme glutathione S-transferase (GST) are present in the </span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>seminiferous tubule fluid and on the sperm surface.<span style=3D'mso-spacerun:yes'> </span>Inhibition of GST using glutathione analogues </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>leads to interference in sperm function, such as motility, acrosome reaction, and fertilising ability. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>-<span style=3D'mso-spacerun:yes'> </span>Human soluble adenylyl cyclase (SAC) a= ppears to be involved with the signal transduction events </span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>in the sperm during capacitation, hyperactivation, and the acrosome reaction.<span style=3D'mso-spacerun:yes'> </span>Testis-specific </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>expression of the novel enzyme could lead to development of sperm-specific antagonist= s of its </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-a= scii-font-family: "Times New Roman"'>activity. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Leukemia inhibi= ting factor (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'><b>LIF</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>) is essential for implantation. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Interleukin-11 = (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'><b>IL-11</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>) is essential for successful decidualization. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Pre-implantation factor (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'><b>PIF</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>), identified in 2-cell embryo, is earliest signal for recognition of </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>pregnancy.<span style=3D'mso-spacerun:yes'> </span>Inhibitory scrambled peptide under investigation for anti-implantation activity. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Regulation of meiosis by modulating the germ cell nuclear factor (</span><span lang=3DEN= -GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'><b>GCNF</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>), predominantly expressed </span><span lang=3DEN-GB style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman"'>in testis and ovary - under investigation. </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'><b>Ebaf</b></span><span lang=3DEN-GB style=3D'font-fami= ly:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'> (=3DLefty) is a marker of a non-receptive endometrium.</span></div> </div> </p:notes><p:notes id=3D"1112" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1164"/> </o:shapelayout><v:shape id=3D"_x0000_s1191938" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1191= 939" type=3D"#_x0000_m11269" 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PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii<GetSldList().mList.length; ii++) { if ( GetSldList().mList[ii].mSldHref =3D=3D href ) return ii+1 } return 1 } function GetHrefObj( sldIdx ){ return GetSldList().mList[sldIdx-1] } function IsFramesMode(){ return ( SCREEN_MODE =3D=3D "Frames" ) } function IsFullScrMode(){ return ( SCREEN_MODE =3D=3D "FullScreen" ) } function GoToNextSld() { ii=3DgCurSld + 1 if( GetHrefObj( ii-1 ).mOrigVis =3D=3D 0 ) { if( ii<=3DGetSldList().mList.length ) { obj=3DGetHrefObj(ii) obj.mVis=3D1 GoToSldNum(ii) return } } else { obj=3DGetHrefObj( ii ) while ( obj && ( obj.mOrigVis =3D=3D 0 ) ) obj=3DGetHrefObj(++ii) if( obj && obj.mOrigVis ) { GoToSldNum(ii) return } } if( gSldStack.length > 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('<html><body dir=3D' + dir + ' bgcolor=3Dblack onload=3Dparent= .SetupEndShow() onunload=3Dparent.Unload()><center><p><font face=3DTahoma c= olor=3Dwhite size=3D2><br><b>' + ENDSHOW_MESG + '</b></font></p></center></= body></html>') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii<arr.length;ii++) { this.mList[ii] =3D new hrefList( arr[ii].mSldHref, arr[ii].mOrigVis, arr[= ii].mAdvDelay, arr[ii].mAdvOnClk ); if( arr[ii].mOrigVis ) this.mList[ii].mSldIdx =3D idx++; } this.mNumVisSlds =3D idx-1; this.fEndShow =3D fEnd; } function GetSldList() { return gSldStack[gSldStack.length-1] } function GetCurSld() { return parent.GetSldList().mList[parent.gCurSld - 1]= } gSldStack =3D new Array(); gSldStack[0] =3D new SldList(gMainDoc,gCurSld,1) function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } /********************************************* Custom Shows implementation When ViewCustomShow() is called, we create a new array that is a subset of the slides in=20 the main doc. This list pushed on a stack so we can return after the end of the custom show. *********************************************/ function ViewCustomShow(idx,fEnd) { if( !IsFullScrMode() ) return; var sldList =3D new Array(); var custShow =3D custShowList[idx-1]; var jj =3D 0; for( ii=3D0;ii<custShow.length;ii++ ) { if( custShow[ii] <=3D gMainDoc.length ) sldList[jj++] =3D gMainDoc[custShow[ii]-1]; } if (sldList.length > 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Next",sPrev=3D"Previous",sEnd=3D"End Show",sFont=3D"Arial",sAr= row=3D"Arrow",sFreeform=3D"Freeform",sRect=3D"Rectangle",sOval=3D"Oval" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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Improvement of existing methods</li> <li> Efficacy, side-effects, duration of action, manufacturing process, = cost</li> <li>2. New approaches</li> <li> Mode of action</li> <li>3. New targets for contraception</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>3</font></div> </td> <td> <div id=3DPPTP3 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1086.htm');" id=3DPPTL3>1. Improvement of existing methods</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>4</font></div> </td> <td> <div id=3DPPTP4 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1087.htm');" id=3DPPTL4>Intra-uterine de= vices</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>5</font></div> </td> <td> <div id=3DPPTP5 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1088.htm');" id=3DPPTL5>Intra-uterine de= vices</a></font></div> <div id=3DPPTC5 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Also under development:</li> <br> <br> <li>Swing: copper-releasing with coil stem</li> <li>IUD releasing a progesterone receptor modulator (CDB-2914)</li> <li>Copper IUD releasing indomethacin</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>6</font></div> </td> <td> <div id=3DPPTP6 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1089.htm');" id=3DPPTL6>Contraceptive im= plants</a></font></div> <div id=3DPPTC6 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Jadelle:</li> <li> levonorgestrel, 2 rods, 5 years</li> <li>Implanon:</li> <li> etonogestrel, 1 rod, 3 years</li> <li>Nestorone:</li> <li> pure progestogen, 1 rod, 2 years</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>7</font></div> </td> <td> <div id=3DPPTP7 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1090.htm');" id=3DPPTL7>Injectables (1)<= /a></font></div> <div id=3DPPTC7 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Improved pharmacokinetic profile :</li> <li>Biodegradable microspheres:</li> <li><span style=3D'mso-spacerun:yes'> </span>norethisterone, norgestim= ate, progesterone</li> <li>Controlled particle size distribution:</li> <li><span style=3D'mso-spacerun:yes'> </span>DMPA, levonorgestrel buta= noate</li> <br> <br> <li>Decreased side-effects :</li> <li>Monolithic macrocrystals:</li> <li><span style=3D'mso-spacerun:yes'> </span>progesterone, 17-beta- estradiol, testosterone combined for once-a-month administration</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>8</font></div> </td> <td> <div id=3DPPTP8 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1091.htm');" id=3DPPTL8>Injectables (2)<= /a></font></div> <div id=3DPPTC8 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Safer delivery system :</li> <li>Provision of Cyclofem in non-reusable disposable syringes (Uniject, Soloshot)</li> <br> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>9</font></div> </td> <td> <div id=3DPPTP9 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1092.htm');" id=3DPPTL9>Contraceptive va= ginal rings</a></font></div> <div id=3DPPTC9 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li><span style=3D'mso-spacerun:yes'> </span>Progestogen only (for continuous use)</li> <li> - Progering - Silesia (3 months)</li> <li><span style=3D'mso-spacerun:yes'> </span>- nestorone - Pop.C. (12 <span style=3D'mso-spacerun:yes'> </span>months)</li> <li><span style=3D'mso-spacerun:yes'> </span>Estrogen-progestogen <span style=3D'mso-spacerun:yes'> </span> (3 weeks in /1 week out)= </li> <li><span style=3D'mso-spacerun:yes'> </span>- Nuvaring - Organon (1 = month)</li> <li> - nestorone/EE - Pop.C. (12<br> <span style=3D'mso-spacerun:yes'> </span>months)</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>10</font></div> </td> <td> <div id=3DPPTP10 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1093.htm');" id=3DPPTL10>Transdermal sys= tems</a></font></div> <div id=3DPPTC10 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Patch releasing an estrogen and a progestogen:</li> <ul> <li>EVRA:<span style=3D'mso-spacerun:yes'> </span>norelgestromin 150 <= font face=3DSymbol>m</font><font face=3DArial>g + ethinyl estradiol 20 <= /font><font face=3DSymbol>m</font><font face=3DArial>g</font></li> <li>levonorgestrel + ethinyl estradiol</li> <li>gestodene 50 <font face=3DSymbol>m</font><font face=3DArial>g + eth= inyl estradiol 18 </font><font face=3DSymbol>m</font><font face=3DArial>= g<span style=3D'mso-spacerun:yes'> </span>(Angeliq - Schering)</font></li> <br> <br> </ul> <li>Patch releasing a progestogen:</li> <ul> <li>nestorone (also being developed as gel and spray)</li> <li>norgestimate</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>11</font></div> </td> <td> <div id=3DPPTP11 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1094.htm');" id=3DPPTL11>Natural methods= </a></font></div> <div id=3DPPTC11 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Standard days method, based on<span style=3D'mso-spacerun:yes'> </span>abstinence/protection from cycle day 8 to cycle day 19.</li> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>12</font></div> </td> <td> <div id=3DPPTP12 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1095.htm');" id=3DPPTL12>Female steriliz= ation</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>13</font></div> </td> <td> <div id=3DPPTP13 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1096.htm');" id=3DPPTL13>Male condoms</a= ></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>14</font></div> </td> <td> <div id=3DPPTP14 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1097.htm');" id=3DPPTL14>Female condoms<= /a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>15</font></div> </td> <td> <div id=3DPPTP15 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1098.htm');" id=3DPPTL15>New diaphragms<= /a></font></div> <div id=3DPPTC15 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Lea's Shield®</li> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>16</font></div> </td> <td> <div id=3DPPTP16 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1099.htm');" id=3DPPTL16>New cervical ca= ps</a></font></div> <div id=3DPPTC16 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>FemCap™</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>17</font></div> </td> <td> <div id=3DPPTP17 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1100.htm');" id=3DPPTL17>2. <span style=3D'mso-spacerun:yes'> </span>New approaches</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>18</font></div> </td> <td> <div id=3DPPTP18 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1101.htm');" id=3DPPTL18>Microbicides wi= th contraceptive action</a></font></div> <div id=3DPPTC18 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Products that create a protective physical barrier in the vagina: e.= g. Sulfated and sulfonated polymers, such as cellulose sulfate, polysty= rene sulfonate.</li> <li>Products which increase vaginal defense mechanisms by maintaining natural acidity (which immobilises sperm): e.g. BufferGel and Acidfo= rm.</li> <li>Surfactant products: e.g. acylcarnitine analogs, C31G.</li> <li>Products which block attachment of HIV to target cells and sperm - z= ona pellucida fusion: e.g. naphthyl urea derivatives.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>19</font></div> </td> <td> <div id=3DPPTP19 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1102.htm');" id=3DPPTL19>Immunocontracep= tives</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>20</font></div> </td> <td> <div id=3DPPTP20 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1103.htm');" id=3DPPTL20>Anti-progestins= for contraception</a></font></div> <div id=3DPPTC20 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Sequential regimen</li> <ul> <li>Mifepristone + Norethisterone</li> <li>Mifepristone + Medroxyprogesterone acetate</li> <li>Mifepristone (days 1-15) + nomegestrol acetate (days 16-28)</li> </ul> <li>Continuous regimen: 0,1 to 10 mg/day</li> <li>Weekly use: 2,5 to 50 mg doses</li> <li>Monthly use: 200 mg 2 days after the LH peak</li> <li>Emergency contraception: 10 mg</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>21</font></div> </td> <td> <div id=3DPPTP21 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1104.htm');" id=3DPPTL21>METHODS FOR<br> MALE CONTRACEPTION</a></font></div> <div id=3DPPTC21 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Prevent sperm production</li> <li>Prevent sperm transport</li> <li>Prevent sperm deposition</li> <li>Modify sperm function</li> <li>Prevent fertilization</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>22</font></div> </td> <td> <div id=3DPPTP22 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1105.htm');" id=3DPPTL22>Hormonal contro= l of sperm production</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>23</font></div> </td> <td> <div id=3DPPTP23 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1106.htm');" id=3DPPTL23>Methods to supr= ess sperm production</a></font></div> <div id=3DPPTC23 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Hormonal</li> <ul> <li>Testosterone esters</li> <li>progestogen or GnRH analogue + testosterone</li> </ul> <li>Immunological, based on antibodies against</li> <ul> <li>GnRH, LH, FSH, their receptors</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>24</font></div> </td> <td> <div id=3DPPTP24 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1107.htm');" id=3DPPTL24>Methods for male sterilization</a></font></div> <div id=3DPPTC24 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>- <span style=3D'mso-spacerun:yes'> </span>Permanent, with</li> <li><span style=3D'mso-spacerun:yes'> </span>sclerosing agents:</li> <li><span style=3D'mso-spacerun:yes'> </span>e.g. methylcyanoacrylate,= </li> <li><span style=3D'mso-spacerun:yes'> </span>polyurethane</li> <li>-<span style=3D'mso-spacerun:yes'> </span>Reversible, with</li> <li><span style=3D'mso-spacerun:yes'> </span>non-sclerosing agents:</l= i> <li><span style=3D'mso-spacerun:yes'> </span>e.g. silicone plugs</li> <li><span style=3D'mso-spacerun:yes'> </span>or resins:<span style=3D'mso-spacerun:yes'> </span>e.g. maleic anhydride / styrene<= /li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>25</font></div> </td> <td> <div id=3DPPTP25 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1108.htm');" id=3DPPTL25>3.<span style=3D'mso-spacerun:yes'> </span> New targets</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>26</font></div> </td> <td> <div id=3DPPTP26 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1109.htm');" id=3DPPTL26>Possible target= s</a></font></div> <div id=3DPPTC26 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li> Gametogenesis</li> <li><span style=3D'mso-spacerun:yes'> </span> Sperm motility</li> <li><span style=3D'mso-spacerun:yes'> </span> Sperm capacitation</li> <li><span style=3D'mso-spacerun:yes'> </span> Acrosomal reaction</li> <li><span style=3D'mso-spacerun:yes'> </span> Follicular development</li> <li><span style=3D'mso-spacerun:yes'> </span> Implantation</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>27</font></div> </td> <td> <div id=3DPPTP27 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1110.htm');" id=3DPPTL27><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>28</font></div> </td> <td> <div id=3DPPTP28 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1111.htm');" id=3DPPTL28>Some of the more promising leads</a></font></div> <div id=3DPPTC28 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Lonidamine analogues: deplete immature germ cells from seminiferous epithelium.</li> <li>Inhibitors of epididymal proteins: eppin and cystatin-11</li> <li>Inhibitors of testis-specific enzymes (GST, SAC)</li> <li>Inhibitors of fusion of sperm with zona pellucida: GnRH antagonists.= </li> <li>Change in endometrial receptivity: LIF antagonists; antibodies again= st LIF, IL-11, or the IL-11 receptor; ebaf.</li> <li>Anti-angiogenic agents (magainin analogues, fumagillin).</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>29</font></div> </td> <td> <div id=3DPPTP29 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1112.htm');" id=3DPPTL29>Challenges for = the development<br> of new technologies</a></font></div> <div id=3DPPTC29 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Cost and time (10-15 years, US$ 200-300 million)</li> <li>Industry involvement</li> <li>Perspectives of users and potential users, of different religious and socio-cultural backgrounds, and of new generations of women and men<= /li> <li>Access in resource-poor settings (cost, technology)</li> </ul> </font></div> </td> </tr> </table> </div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/oledata.mso Content-Transfer-Encoding: base64 Content-Type: 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type=3D"centerTitle"/></v:shape><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id=3D"_x0000_s1134595" typ= e=3D"#_x0000_m932868" style=3D'position:absolute;left:45.25pt;top:252pt;width:629.5pt;height:17= 4pt; mso-wrap-style:square;v-text-anchor:top' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1134594" class=3DCT style=3D'mso-line-spacing:"90 = 0 0"'><span style=3D'position:absolute;top:23.5%;left:.56%;width:99.43%;height:10.25%'= ><span lang=3DEN-GB style=3D'font-size:133%'><b>Future methods of fertility </b><= /span></span><span style=3D'position:absolute;top:33.0%;left:8.42%;width:83.33%;height:10.25%= '><span lang=3DEN-GB style=3D'font-size:133%'><b>regulation</b></span></span></div> <div v:shape=3D"_x0000_s1134595" class=3DCB> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:46.75%; left:7.3%;width:85.58%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:= 88%; text-shadow:auto;color:#000099'><b>Catherine d’Arcangues, Ph.D., M.D. = </b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:52.74%; left:2.8%;width:94.56%;height:5.25%'><span lang=3DEN-GB style=3D'font-size= :75%; text-shadow:auto'><b>Department of Reproductive Health and Research </= b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:58.0%;left:= 7.3%; width:85.58%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;text-= shadow: auto'><b>World Health Organization </b></span></div> <div style=3D'mso-line-spacing:"80 20 0";position:absolute;top:63.5%;left:= 7.3%; width:85.58%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;text-= shadow: auto;display:none'><b> </b></span></div> <div style=3D'mso-line-spacing:"80 20 0"'><span style=3D'position:absolute; top:68.75%;left:7.3%;width:85.58%;height:4.5%'><span style=3D'font-size:63= %; text-shadow:auto'><b><i>Training in Reproductive Health Research<br> </i></b></span></span><span style=3D'position:absolute;top:72.25%;left:7.= 3%; width:85.58%;height:4.5%'><span style=3D'font-size:63%;text-shadow:auto'><= b><i>Geneva 2006</i></b></span><span lang=3DEN-GB style=3D'font-size:63%;text-shadow:a= uto; mso-special-format:lastCR;display:none'><b><i> </i></b></span></span><= /div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master37_image002.png Content-Transfer-Encoding: base64 Content-Type: image/png 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rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1085.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D22.03.2006> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1110"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image003.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id= =3D"_x0000_s1136642" type=3D"#_x0000_m931844" style=3D'position:absolute;left:42.125pt;top:1in; width:636pt;height:5in' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1136642"> <div class=3DB1 style=3D'mso-margin-left-alt:567;mso-text-indent-alt:396'>= </div> <div class=3DB2 style=3D'mso-margin-left-alt:1417;mso-text-indent-alt:1129= '></div> <div class=3DB3 style=3D'mso-margin-left-alt:1770;mso-text-indent-alt:1530= '></div> <div class=3DB4 style=3D'mso-margin-left-alt:2123;mso-text-indent-alt:1883= '></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:14.5%;left:6.92%;width:91.19%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>1.<span style=3D'mso-tab-count:1;width:1.33%'> </spa= n>Improvement of existing methods </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3'><span style=3D'position:absolute;top:25.75%;left:6.92%;width:89.7%;height:6.75%'= ><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'text-shadow:auto'><b><span style=3D'mso-tab-count:1; width:5.47%'> </span></b></span><span lang=3DEN-GB style=3D'text-shadow:au= to; color:#000066;mso-color-index:1'><b>Efficacy, side-effects, duration of </= b></span></span><span style=3D'position:absolute;top:32.75%;left:11.79%;width:91.57%;height:6.75= %'><span lang=3DEN-GB style=3D'text-shadow:auto;color:#000066;mso-color-index:1'><b= >action, manufacturing process, cost </b></span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:44.25%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>2.<span style=3D'mso-tab-count:1;width:1.4%'> </span= >New approaches </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:55.5%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'text-shadow:auto'><b><span style=3D'mso-tab-count:1; width:5.67%'> </span></b></span><span lang=3DEN-GB style=3D'text-shadow:au= to; color:#000066;mso-color-index:1'><b>Mode of action </b></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";mso-margin-left-alt:28= 3; position:absolute;top:67.0%;left:6.92%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;text-shadow:auto;color:#= CC3300; mso-color-index:4'><b>3.<span style=3D'mso-tab-count:1;width:1.4%'> </span= >New targets for contraception</b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image003.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAPklEQVQY07WNwQoAIAhDZ7L87T49GlgGXRvvMOZU4Kc6 QKDJh3ABhVGaKx9natoN1Xg3KTxvWj5CJix+89IEa7UBFlGieV0AAAAASUVORK5CYIJ= 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href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image004.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1138692" type=3D"#_x0000_m931843" style=3D'position:absolute;left:36pt;top:3in;wid= th:648.125pt; height:90pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke 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href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1088.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Intra-uterine devices"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1116"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" 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type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1142786" class=3DT style=3D'position:absolute;top:= 17.0%; left:5.99%;width:66.1%;height:7.75%'><span lang=3DFR>Intra-uterine devices= </span></div> <div v:shape=3D"_x0000_s1142787" class=3DB> <div style=3D'position:absolute;top:32.25%;left:5.99%;width:88.2%;height:6= .75%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-ind= ex:4'>Also under development: </span></div> <div style=3D'position:absolute;top:40.75%;left:5.99%;width:88.2%;height:6= .75%'><span style=3D'position:absolute;top:0%;left:4.24%;width:95.75%;height:100.0%'><= span style=3D'color:#CC3300;mso-color-index:4;visibility:hidden'><span class=3D= BB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .43%; width:1.99%;height:33.33%'><![endif]></span></span><span lang=3DFR 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style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>IUD releasing a progesterone receptor </span></span><span style=3D'position:ab= solute; top:64.75%;left:9.73%;width:84.45%;height:6.75%'><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>modu= lator (CDB-2914) </span></span> <div style=3D'position:absolute;top:73.25%;left:5.99%;width:88.2%;height:6= .75%'><span style=3D'position:absolute;top:0%;left:4.24%;width:95.75%;height:100.0%'><= span style=3D'color:#CC3300;mso-color-index:4'><span class=3DBB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:37.03%;left:-4= .43%; width:1.99%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Copp= er IUD releasing indomethacin</span></span></div> </div> <v:shape id=3D"_x0000_s1142788" type=3D"#_x0000_t75" style=3D'position:abs= olute; left:509.875pt;top:42pt;width:154.25pt;height:3in'> 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Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1089.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Contraceptive implants"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1118"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image012.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1144834" type=3D"#_x0000_m931843" style=3D'position:absolute;left:53.375pt;top:18p= t; width:613.375pt;height:90pt;mso-wrap-style:none;v-text-anchor:middle' o:s= pt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1144835" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:48.125pt;top:102pt;width:636pt;height:330= pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1144834" class=3DT style=3D'position:absolute;top:= 7.75%; left:8.42%;width:83.33%;height:8.5%'><span lang=3DFR style=3D'font-size:11= 1%; color:#CC0000;mso-color-index:3'><b>Contraceptive implants</b></span></div> <div v:shape=3D"_x0000_s1144835" class=3DB> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:20.0%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'position:absolute; top:0%;left:4.32%;width:95.67%;height:100.0%'><span style=3D'color:#CC3300; mso-color-index:4'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";color:#CC0000;font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .52%; width:2.03%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Jade= lle</span><span lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:30.0%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.55%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>levonorgestrel, 2 rods, 5 years&= #13;</span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:39.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'position:absolute; top:0%;left:4.32%;width:95.67%;height:100.0%'><span style=3D'color:#CC3300; mso-color-index:4'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";color:#CC0000;font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:37.03%;left:-4= .52%; width:2.03%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;color:#CC3300;mso-color-index:4'>Impl= anon</span><span lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:49.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.55%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>etonogestrel, 1 rod, 3 years = ;</span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:59.75%; left:7.67%;width:86.51%;height:6.75%'><span style=3D'position:absolute; top:0%;left:4.32%;width:95.67%;height:100.0%'><span style=3D'color:#CC0000; mso-color-index:3'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"= *" style=3D'position:absolute;top:33.33%;left:-4.52%;width:2.03%;height:33.33= %'><![endif]></span></span><span lang=3DFR style=3D'color:#CC0000;mso-color-index:3'>Nestorone</span><span = lang=3DFR>: </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:69.75%; left:7.67%;width:89.32%;height:6.75%'><span style=3D'mso-special-format:no= bullet; display:none;color:#CC0000;font-size:50%'>•</span><span lang=3DFR><span style=3D'mso-tab-count:2;width:11.19%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>pure progestogen, 1 rod, 2 years= </span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image012.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl 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d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1090.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Injectables (1)"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style> .CB {color:#292929;} .CT {color:#CC0000;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1120"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master37.xml"> <p:shaperange href=3D"master37.xml#_x0000_s932865"/><![if !ppt]><p:shapera= nge href=3D"master37.xml#_x0000_s932866"/><p:shaperange href=3D"master37.xml#_x0000_s932870"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s932870" src=3D"master37_image013.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s932870" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>7= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master37.xml#_x0000_m932867"/><v:shape id= =3D"_x0000_s1146882" type=3D"#_x0000_m932867" style=3D'position:absolute;left:104pt;top:0;widt= h:501.5pt; height:78pt;mso-wrap-style:square;v-text-anchor:middle' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"centerTitle"/></v:shape><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id=3D"_x0000_s1146883" typ= e=3D"#_x0000_m932868" style=3D'position:absolute;left:47.375pt;top:72.75pt;width:625.5pt;height= :396pt; mso-wrap-style:square;v-text-anchor:top' o:userdrawn=3D"f" filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:shadow on=3D"f" color=3D"gray"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt" o:singleclick=3D"t"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1146882" class=3DCT style=3D'mso-line-spacing:"90 = 0 0"; position:absolute;top:2.5%;left:15.35%;width:67.79%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>Injectables (1)</b></span></div> <div v:shape=3D"_x0000_s1146883" style=3D'tab-interval:.5868in;tab-stops:.= 3975in'> <div class=3DCB1 style=3D'mso-margin-left-alt:342;mso-text-indent-alt:342'= ></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:14.5%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= green'>Improved pharmacokinetic profile : </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:22.0%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Biodegradable microspheres</span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b>:<span style=3D'mso-spacerun:y= es'> </span> </b></span></span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:29.49%;left:7.49%;width:93.82%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b><span style=3D'mso-spacerun:ye= s'> </span></b></span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:au= to'>norethisterone, norgestimate, progesterone<span style=3D'mso-spacerun:yes'> </span></span= ><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto;display:none'><b> = ;</b></span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:37.0%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Controlled particle size distribution</span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b>: </b></span>= </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:44.5%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto'><b><span style=3D'mso-spacerun:ye= s'> </span></b></span><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:au= to'>DMPA, levonorgestrel butanoate </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:51.75%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:88%;text-shadow:auto;display:none'> </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:59.24%;left:7.49%;width:85.01%;height:6.0%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= green'>Decreased side-effects : </span></div> <div class=3DCB style=3D'text-align:left;mso-margin-left-alt:229;position:= absolute; top:66.75%;left:7.49%;width:85.01%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:4.84%;width:95.37%;height:100.0%'><span style=3D'font-size:88%; color:#CC3300;mso-color-index:4;text-shadow:auto'><span style=3D'mso-speci= al-format: bullet;mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if= !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-5= .08%; width:1.84%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:88%;text-shadow:auto;color:= #CC3300; mso-color-index:4'>Monolithic macrocrystals</span><span lang=3DEN-GB 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soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>9= </span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id= =3D"_x0000_s1149954" type=3D"#_x0000_m932868" style=3D'position:absolute;left:13.375pt;top:102= pt; width:382.75pt;height:408pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1149954" style=3D'tab-interval:.4166in;tab-stops:.= 3975in'> <div class=3DCB3 style=3D'mso-margin-left-alt:840;mso-text-indent-alt:840'= ></div> <div class=3DCB4 style=3D'mso-margin-left-alt:1104;mso-text-indent-alt:110= 4'></div> <div class=3DCB style=3D'text-align:left'><span style=3D'position:absolute; top:20.0%;left:4.68%;width:58.05%;height:7.75%'><span style=3D'font-size:1= 13%'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:32.25%;left:-3.22%;width:3.54%;height:35.48%'><![endif]></span></span>= <span lang=3DEN-GB style=3D'font-size:113%'><span style=3D'mso-spacerun:yes'> </= span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>Progestogen only <s= pan style=3D'mso-tab-count:3;width:16.62%'> </span><span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:a= bsolute; top:28.0%;left:2.8%;width:52.05%;height:6.75%'><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-tab-count:1; width:7.63%'> </span>(for continuous use) </span></span></div> <div class=3DCB style=3D'text-align:left;position:absolute;top:36.0%;left:= 2.8%; width:60.29%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:6.59%'> </span>- </span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC3300;mso-color-index:4'>Progering </span><= span lang=3DEN-GB style=3D'font-size:75%'>- Silesia (3 months) </span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 0 0"'><span style=3D'position:absolute;top:41.5%;left:2.8%;width:60.11%;height:6.75%'>= <span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span><span lang= =3DEN-GB style=3D'font-size:75%'>- nestorone - Pop.C. (12 <span style=3D'mso-tab-co= unt: 3;width:15.99%'> </span></span></span><span style=3D'position:absolute; top:48.5%;left:2.8%;width:51.31%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:7.74%'> </spa= n><span style=3D'mso-spacerun:yes'> </span>months) </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 0 0"'><span style=3D'position:absolute;top:54.0%;left:5.43%;width:55.8%;height:6.75%'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-4= .69%; top:-.34em;font-size:160%'>•</span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-GB style=3D'col= or:#000066; mso-color-index:1'>Estrogen-progestogen </span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'pos= ition: absolute;top:61.0%;left:2.8%;width:51.31%;height:6.75%'><span lang=3DEN-GB= ><span style=3D'mso-tab-count:1;width:7.74%'> </span> </span><span lang=3DEN-GB style=3D'font-size:75%'>(3 weeks in /1 week out) </span></span></div> <div class=3DCB style=3D'text-align:left;position:absolute;top:69.0%;left:= 2.8%; width:60.48%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> </span>- </span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC3300;mso-color-index:4'>Nuvaring</span><sp= an lang=3DEN-GB style=3D'font-size:75%'> - Organon (1 month) </span></div> <div class=3DCB style=3D'text-align:left'><span style=3D'position:absolute; top:75.5%;left:2.8%;width:54.3%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-tab-count:1;width:7.31%'> </spa= n>- nestorone/EE - Pop.C. 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style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image018.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1152002" type=3D"#_x0000_m931843" style=3D'position:absolute;left:48.125pt;top:12p= t; width:613.375pt;height:54pt;mso-wrap-style:none;v-text-anchor:middle' o:s= pt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1152003" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:12.375pt;top:90pt;width:707.75pt;height:3= 96pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1152002" class=3DT style=3D'position:absolute;top:= 3.25%; left:7.67%;width:83.33%;height:8.5%'><span lang=3DFR style=3D'font-size:11= 1%'><b>Transdermal systems</b></span></div> <div v:shape=3D"_x0000_s1152003"> <div class=3DB2 style=3D'mso-margin-left-alt:779;mso-text-indent-alt:635'>= </div> <div class=3DB3 style=3D'mso-margin-left-alt:1036;mso-text-indent-alt:892'= ></div> <div class=3DB style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:229; position:absolute;top:17.25%;left:2.8%;width:103.93%;height:6.0%'><span style=3D'position:absolute;top:0%;left:3.78%;width:96.21%;height:100.0%'><= span style=3D'font-size:88%;color:#CC0000;mso-color-index:3'><span style=3D'mso= -special-format: bullet;mso-bullet-image:"image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-3= .93%; width:1.49%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#CC0000;mso-color-index:3'>Patch releasing an estrogen and a progestogen</span><span lang=3DFR style=3D'font-size:88%; color:#000066;mso-color-index:1'>: </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:23.5%;left:1= 1.79%; width:101.12%;height:6.5%'><span style=3D'color:#000066;mso-color-index:1'= ><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .14%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'mso-hansi-= font-family: Arial;color:#000066;mso-color-index:1'>EVRA</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>:<span style=3D'mso-spacerun:yes= '> </span>norelgestromin 150 </span><span lang=3DFR style=3D'font-family:Symb= ol; color:#000066;mso-color-index:1;mso-char-type:symbol'>m</span><span lang= =3DFR style=3D'color:#000066;mso-color-index:1'>g + ethinyl estradiol </span></s= pan><span style=3D'position:absolute;top:29.24%;left:11.79%;width:87.45%;height:6.5%= '><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>20 </span><span lang= =3DFR style=3D'font-family:Symbol;color:#000066;mso-color-index:1;mso-char-type:= symbol'>m</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>g </span></span></= div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:36.5%;left:8.61%;width:90.44= %; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>levonorgestrel + ethinyl estradiol </span></span></= div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:43.0%;left:1= 1.79%; width:87.45%;height:6.5%'><span style=3D'color:#000066;mso-color-index:1'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>gestodene 50 </span><span lang=3DFR style=3D'font-famil= y:Symbol; color:#000066;mso-color-index:1;mso-char-type:symbol'>m</span><span lang= =3DFR style=3D'color:#000066;mso-color-index:1'>g + ethinyl estradiol 18 </span>= <span lang=3DFR style=3D'font-family:Symbol;color:#000066;mso-color-index:1;mso-= char-type: symbol'>m</span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>= g<span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:= absolute; top:49.0%;left:11.79%;width:87.45%;height:6.0%'><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>(Angeliq - Schering) </span>= </span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:55.75%;left:8.61%;width:90.4= 4%; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1;visibility:h= idden'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000066;mso-c= olor-index: 1;display:none'> </span></span></div> <div class=3DB style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:229; position:absolute;top:62.75%;left:2.8%;width:96.44%;height:6.0%'><span style=3D'position:absolute;top:0%;left:4.07%;width:95.72%;height:100.0%'><= span style=3D'font-size:88%;color:#CC0000;mso-color-index:3'><span style=3D'mso= -special-format: bullet;mso-bullet-image:"image010\.png";font-size:150%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:0%;left:-4.25%; width:4.46%;height:91.66%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#CC0000;mso-color-index:3'>Patch releasing a progestogen</span><span lang=3DFR style=3D'font-size:88%;color:#000066;mso= -color-index: 1'>: </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342'><span style=3D'position:absolute;top:69.5%;left:1= 1.79%; width:91.01%;height:6.0%'><span style=3D'color:#000066;mso-color-index:1'>= <span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .49%; top:.1em;font-size:90%'>–</span></span><span lang=3DFR style=3D'color:#000= 066; mso-color-index:1'>nestorone (also being developed as gel and </span></spa= n><span style=3D'position:absolute;top:75.0%;left:11.79%;width:87.45%;height:6.0%'= ><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>spray) </span></sp= an></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:52= 2; mso-text-indent-alt:342;position:absolute;top:82.0%;left:8.61%;width:90.44= %; height:6.0%'><span style=3D'position:absolute;top:0%;left:3.51%;width:96.6= 8%; height:100.0%'><span style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000;position:absolute;left:-3= .64%; 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style=3D'position:absolute;top:33.33%;left:-1= 0.86%; width:4.34%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>Standard days </sp= an></span><span style=3D'position:absolute;top:32.75%;left:11.79%;width:37.64%;height:6.0%= '><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>method, = based on<span style=3D'mso-spacerun:yes'> </span></span></span><span style=3D'position:absolute;top:39.0%;left:11.79%;width:39.51%;height:6.0%'= ><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>abstinen= ce/protecti</span></span><span style=3D'position:absolute;top:45.25%;left:11.79%;width:40.63%;height:6.0%= '><span lang=3DFR style=3D'font-size:88%;color:#000066;mso-color-index:1'>on from = cycle day 8 </span></span><span style=3D'position:absolute;top:51.5%;left:11.79%; width:34.45%;height:6.0%'><span lang=3DFR style=3D'font-size:88%;color:#00= 0066; mso-color-index:1'>to cycle day 19. 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New approaches"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1139"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image043.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1166340" type=3D"#_x0000_m931843" style=3D'position:absolute;left:36pt;top:222pt;w= idth:648.125pt; height:90pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape> <div v:shape=3D"_x0000_s1166340" class=3DT style=3D'position:absolute;top:= 44.75%; left:5.99%;width:88.2%;height:10.25%'><span lang=3DFR style=3D'mso-hansi-f= ont-family: Arial;font-size:133%;color:#CC0000;mso-color-index:3'><b>2.</b></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:133%;color:yellow= '><b><span style=3D'mso-tab-count:1;width:5.01%'> </span><span style=3D'mso-spacerun:= yes'> </span></b></span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;fon= t-size: 133%;color:#CC0000;mso-color-index:3'><b>New approaches</b></span><span style=3D'mso-hansi-font-family:Arial;font-size:133%;color:#CC0000;mso-colo= r-index: 3;mso-special-format:lastCR;display:none'><b> </b></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image043.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAQUlEQVQY07WN2Q0AIAxC8ais7egqRm0HkLwPQg+AD6pA Oz6LKYoidk53svL+pkkfqDWLmybK+Zlkbh01hWtkPHcabKQBF8fVwJQAAAAASUVORK5CYIJ= ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1101.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1101.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Microbicides with contraceptive action"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1141"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image044.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1168386" type=3D"#_x0000_m931843" style=3D'position:absolute;left:36.125pt;top:0;w= idth:652pt; height:90pt;mso-wrap-style:none;v-text-anchor:middle' o:spt=3D"1" o:userd= rawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked=3D"f" strokecolor= =3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1168387" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:29.375pt;top:108pt;width:648.125pt;height= :342pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1168386" class=3DT style=3D'position:absolute;top:= 4.75%; left:-4.86%;width:110.48%;height:7.75%'><span lang=3DEN-GB><b>Microbicides= with contraceptive action</b></span></div> <div v:shape=3D"_x0000_s1168387" class=3DB> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:20.5%;left:8.8%;width:97.0%;height:5.25%'><span style=3D'font-size:75%= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.86%;width:1.35%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products that create a </span><span lang= =3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%;color:#CC0000;mso-color= -index: 3'>protective physical </span><span lang=3DFR style=3D'font-size:75%;color= :#CC0000; mso-color-index:3'>barrier</span><span lang=3DFR style=3D'font-size:75%; color:yellow'> </span><span lang=3DFR style=3D'mso-hansi-font-family:Arial; font-size:75%'>in the </span></span><span style=3D'position:absolute;top:2= 5.25%; left:8.8%;width:97.37%;height:5.25%'><span lang=3DFR style=3D'font-size:75= %'>vagina: e.g. Sulfated and sulfonated polymers, such as </span></span><span style=3D'position:absolute;top:30.0%;left:8.8%;width:84.45%;height:5.25%'>= <span lang=3DFR style=3D'font-size:75%'>cellulose sulfate, polystyrene sulfonate= . </span></span></div> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:37.5%;left:8.8%;width:96.25%;height:5.25%'><span style=3D'font-size:75= %'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.89%;width:1.36%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products which increase vaginal defense mechanisms </span></span><span style=3D'position:absolute;top:42.25%;left:= 8.8%; width:101.31%;height:5.25%'><span lang=3DFR style=3D'font-size:75%'>by </s= pan><span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%;color:#CC0000; mso-color-index:3'>maintaining natural acidity</span><span lang=3DFR style=3D'font-size:75%'> (which immobilises sperm): </span></span><span style=3D'position:absolute;top:47.25%;left:8.8%;width:84.45%;height:5.25%'= ><span lang=3DFR style=3D'font-size:75%'>e.g. BufferGel and Acidform. </span>= </span></div> <div style=3D'mso-line-spacing:"90 50 0";position:absolute;top:54.5%;left:= 5.05%; width:99.81%;height:5.25%'><span style=3D'position:absolute;top:0%;left:3.= 75%; width:96.24%;height:100.0%'><span style=3D'font-size:75%;color:#CC0000; mso-color-index:3'><span style=3D'mso-special-format:bullet;mso-bullet-ima= ge: "image010\.png";font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"= *" style=3D'position:absolute;top:33.33%;left:-3.89%;width:1.36%;height:33.33= %'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>Surfacta= nt </span><span lang=3DFR style=3D'mso-hansi-font-family:Arial;font-size:75%'>products</sp= an><span lang=3DFR style=3D'font-size:75%'>: e.g. acylcarnitine analogs, C31G. = </span></span></div> <div style=3D'mso-line-spacing:"90 50 0"'><span style=3D'position:absolute; top:62.0%;left:8.8%;width:95.69%;height:5.25%'><span style=3D'font-size:75= %'><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-3.91%;width:1.36%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'font-size:75%'>Products which block attachment of HIV t= o target cells </span></span><span style=3D'position:absolute;top:66.75%;left:8.8%; width:94.38%;height:5.25%'><span lang=3DFR style=3D'font-size:75%'>and</sp= an><span lang=3DFR style=3D'font-size:75%;color:yellow'> </span><span lang=3DFR style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>sperm - zona pellu= cida fusion</span><span lang=3DFR style=3D'font-size:75%'>: e.g. naphthyl urea = </span></span><span style=3D'position:absolute;top:71.5%;left:8.8%;width:84.45%;height:5.25%'>= <span lang=3DFR style=3D'font-size:75%'>derivatives.</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image044.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY02NgoAFgZ2BghbGZwAgiCETMYAQRZ0fSAhJv QMgyMjCwgRUwgY1CVskKRswwMxnBDDZsVrMjIWwAAG31ARk222ZrAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1102.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1102.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Immunocontraceptives"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1143"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image045.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1170434" type=3D"#_x0000_m931843" style=3D'position:absolute;left:53.375pt;top:18p= t; width:613.5pt;height:66pt;mso-wrap-style:none;v-text-anchor:middle' o:spt= =3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" fillcol= or=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode= =3D"custom"> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt=3D"202" path=3D"m,l,21600r21600,l21600,xe= "> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s1170435" type=3D"#_x0000_t202" style= =3D'position:absolute; left:26.75pt;top:101.375pt;width:666.75pt;height:343.25pt;v-text-anchor:m= iddle' filled=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt"> <v:fill color2=3D"white [0]"/> <v:stroke dashstyle=3D"longDash"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s1170434" class=3DT style=3D'position:absolute;top:= 5.0%; left:8.42%;width:83.33%;height:9.25%'><span lang=3DEN-GB style=3D'font-siz= e:122%; color:#CC0000;mso-color-index:3'><b>Immunocontraceptives</b></span></div> <div v:shape=3D"_x0000_s1170435"> <div class=3DO1 style=3D'mso-margin-left-alt:680;mso-text-indent-alt:680'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:793;mso-text-indent-alt:793'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:906;mso-text-indent-alt:906'>= </div> <div class=3DO style=3D'position:absolute;top:19.75%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Most advanced immunocontraceptives are based on hCG :<span style=3D'mso-spacerun:yes'> </span> </span></div> <div class=3DO style=3D'position:absolute;top:24.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%;display:none'> </= span></div> <div class=3DO><span style=3D'position:absolute;top:28.5%;left:4.68%;width= :105.99%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Their goal is to gen= erate antibodies against hCG secreted by embryonic </span></span><span style=3D'position:absolute;top:33.0%;left:4.68%;width:106.74%;height:4.5%'= ><span lang=3DFR style=3D'font-size:111%'>trophoblastic cells, necessary for main= tainance of the corpus luteum and </span></span><span style=3D'position:absolute; top:37.5%;left:4.68%;width:90.82%;height:4.5%'><span lang=3DFR style=3D'fo= nt-size: 111%'>the continued production of progesterone: </span></span></div> <div class=3DO><span style=3D'position:absolute;top:42.0%;left:4.68%;width= :100.56%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-t= ab-count: 1;width:9.94%'> </span>hCG </span><span lang=3DFR style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:"Times New Ro= man"; mso-hansi-font-family:"Times New Roman";font-size:111%'>β</span><span lang=3DFR style=3D'font-size:111%'> Chain: whole or the 109-145 amino acid sequence of<span style=3D'mso-spacerun:yes'> </span></span></span>= <span style=3D'position:absolute;top:46.25%;left:4.68%;width:90.82%;height:4.5%'= ><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-tab-count:1;width:11= .0%'> </span>the C-terminal portion </span></span></div> <div class=3DO style=3D'position:absolute;top:50.75%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :7.64%'> </span>+ diphtheria toxoid as carrier </span></div> <div class=3DO style=3D'position:absolute;top:55.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :7.64%'> </span>+ muramyl dipeptide as adjuvant </span></div> <div class=3DO style=3D'position:absolute;top:59.75%;left:4.68%;width:99.6= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width= :6.96%'> </span>+ squalene/mannide monooleate (4:1) as emulsifying agent </span= ></div> <div class=3DO style=3D'position:absolute;top:64.25%;left:4.68%;width:90.8= 2%; height:4.5%'><span lang=3DFR style=3D'font-size:111%;display:none'> </= span></div> <div class=3DO style=3D'position:absolute;top:68.5%;left:4.68%;width:90.82= %; height:4.5%'><span lang=3DFR style=3D'font-size:111%'>Other targets: - zona pellucida (permanent effect on ovaries) </span></div> <div class=3DO><span style=3D'position:absolute;top:73.0%;left:4.68%;width= :103.37%; height:4.5%'><span lang=3DFR style=3D'font-size:111%'><span style=3D'mso-t= ab-count: 1;width:9.67%'> </span>- molecules on sperm surface, e.g. fertilin (PH-30), fertilisation </span></span><span style=3D'position:absolute;top:77.5%; left:4.68%;width:90.82%;height:4.5%'><span lang=3DFR style=3D'font-size:11= 1%'><span style=3D'mso-tab-count:1;width:11.0%'> </span>antigen (FA-1), sperm protein (SP-10), LDH-C4</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image045.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY02NgoAFgByMIYAIjuCAzGEHE2ZG0gMQbELKM 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href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1103.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Anti-progestins for contrac= eption"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1145"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image046.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1172482" type=3D"#_x0000_m931843" style=3D'position:absolute;left:30.125pt;top:0;w= idth:655.375pt; height:90pt' o:spt=3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600= ,xe" filled=3D"f" fillcolor=3D"#c30 [4]" stroked=3D"f" strokecolor=3D"#006 [1]= "> <v:fill color2=3D"white [0]" o:detectmouseclick=3D"f"/> <v:stroke joinstyle=3D"miter" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow color=3D"#969696 [2]"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1172483" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:34.625pt;top:108pt;width:645.375pt;height= :384pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1172482" class=3DT style=3D'position:absolute;top:= 4.5%; left:-3.37%;width:106.17%;height:8.5%'><span lang=3DFR style=3D'mso-hansi-= font-family: Arial;font-size:111%'><b>Anti-progestins for contraception</b></span></div> <div v:shape=3D"_x0000_s1172483"> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 21.0%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Sequential regimen= </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0";position:absolute;top= :29.0%; left:10.86%;width:82.77%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.61%;width:96.15%;height:100.0%'><span style=3D'font-size:86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.76%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone + Norethisterone </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0";position:absolute;top= :37.0%; left:10.86%;width:82.77%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.61%;width:96.38%;height:100.0%'><span style=3D'font-size:86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.75%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone + Medroxyprogesterone acetate </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 50 0"'><span style=3D'posit= ion:absolute; top:45.0%;left:13.85%;width:95.13%;height:5.25%'><span style=3D'font-size:= 86%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; color:#CC0000;position:absolute;left:-3.14%;top:.1em;font-size:90%'>–</spa= n></span><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>Mifepris= tone (days 1-15) + nomegestrol acetate (days </span></span><span style=3D'posit= ion: absolute;top:50.25%;left:13.85%;width:79.58%;height:5.25%'><span lang=3DFR style=3D'font-size:86%;color:#000066;mso-color-index:1'>16-28) </span>= </span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 58.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Continuous regimen= : 0,1 to 10 mg/day </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 66.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Weekly use: 2,5 to= 50 mg doses </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 74.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Monthly use: 200 m= g 2 days after the LH peak </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 82.25%; left:5.8%;width:87.82%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.26%;width:95.73%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .45%; width:1.55%;height:33.33%'><![endif]></span></span><span lang=3DFR style=3D'font-size:75%;color:#000066;mso-color-index:1'>Emergency contrace= ption: 10 mg</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image046.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY07VOQQ4AIAjCmvHtnl6xWfqAGCcEAfgAihsD cKAlsYuQyBQ5+nxXU5ayeXW62OOnRdGt9jqDNZ6wAHTCASRXi8keAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1104.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html 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<v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1174530" class=3DT><span style=3D'position:absolut= e; top:8.0%;left:8.42%;width:83.33%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>METHODS FOR<br> </b></span></span><span style=3D'position:absolute;top:17.75%;left:6.55%; width:86.89%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>= MALE CONTRACEPTION</b></span></span></div> <div v:shape=3D"_x0000_s1174531" class=3DB> <div style=3D'position:absolute;top:35.5%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm production </span></span></div> <div style=3D'position:absolute;top:43.0%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm transport </span></span></div> <div style=3D'position:absolute;top:50.5%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent sperm deposition </span></span></div> <div style=3D'position:absolute;top:58.0%;left:15.16%;width:65.35%;height:= 6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Modify sperm function </span></span></div> <div style=3D'position:absolute;top:65.25%;left:15.16%;width:65.35%;height= :6.0%'><span style=3D'position:absolute;top:0%;left:5.73%;width:94.26%;height:100.0%'><= span style=3D'font-size:88%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-6= .07%; width:2.43%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Prevent fertilizat= ion</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image047.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAPklEQVQY02NgoA1gApNsDAysMDY7GDGDEUQBO5J6kHgD QpYRrJcdrIwVVSUrGDHDzGSEWcQAE2FFYsMRNgAAbP0BGIQwBtUAAAAASUVORK5CYIJ= ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/slide1105.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html 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strokecolor=3D"#006 [1]" strokeweight=3D"1pt"> <v:fill color2=3D"white [0]"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt"/> </v:rect> <div v:shape=3D"_x0000_s1176582"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"90 0 0";positi= on:absolute; top:81.75%;left:35.58%;width:29.02%;height:4.5%'><span lang=3DEN-GB style=3D'mso-bidi-font-family:Arial;font-size:111%;text-shadow:auto;color:= #CC0000'>SPERMATOZOIDS</span></div> </div> <div v:shape=3D"_x0000_s1176584"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"90 0 0";positi= on:absolute; top:68.0%;left:44.75%;width:10.48%;height:3.5%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:89%;text-shadow:auto;color:= #000066'><b>TESTES</b></span></div> </div> <div v:shape=3D"_x0000_s1176587"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"90 0 0";positi= on:absolute; top:25.5%;left:45.31%;width:9.73%;height:3.5%'><span lang=3DEN-GB style=3D'mso-hansi-font-family:Arial;font-size:89%;color:#000066'><b>BRAIN= </b></span></div> </div> <div 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tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape> <div v:shape=3D"_x0000_s1176595"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"90 0 0";positi= on:absolute; top:34.0%;left:58.05%;width:14.41%;height:3.5%'><span lang=3DEN-GB style=3D'font-size:89%;color:#000066'><b>PITUITARY</b></span><span lang=3D= EN-GB style=3D'color:#000066;mso-special-format:lastCR;display:none'><b> </b= ></span></div> </div> <div v:shape=3D"_x0000_s1176596"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'mso-line-spacing:"90 0 0";position:absolute;top:49= .25%; left:39.88%;width:2.99%;height:4.0%'><span lang=3DEN-GB style=3D'color:bla= ck'><b>T</b></span></div> </div> <div v:shape=3D"_x0000_s1176597"> <div class=3DO1 style=3D'mso-margin-left-alt:500;mso-text-indent-alt:292'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:580'></div> <div class=3DO3 style=3D'mso-margin-left-alt:902;mso-text-indent-alt:902'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1140'></div> <div class=3DO style=3D'mso-line-spacing:"90 0 0";position:absolute;top:49= .25%; left:53.93%;width:4.11%;height:4.0%'><span lang=3DEN-GB style=3D'color:bla= 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rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1106.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Methods to supress sperm pr= oduction"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1151"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image049.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>1= 0</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1178626" type=3D"#_x0000_m931843" style=3D'position:absolute;left:58.625pt;top:48p= t; width:613.5pt;height:66pt;mso-wrap-style:none;v-text-anchor:middle' o:spt= =3D"1" o:userdrawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked= =3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1178627" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:60.125pt;top:2in;width:608.125pt;height:3= 06pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1178626" class=3DT style=3D'position:absolute;top:= 11.5%; left:-3.93%;width:109.55%;height:7.75%'><span lang=3DEN-GB><b>Methods to s= upress sperm production</b></span></div> <div v:shape=3D"_x0000_s1178627"> <div class=3DB style=3D'mso-line-spacing:"100 60 0";position:absolute;top:= 27.75%; left:9.36%;width:82.58%;height:6.0%'><span style=3D'position:absolute; top:0%;left:4.53%;width:95.46%;height:100.0%'><span style=3D'font-size:88%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:29.16%;left:-4= .75%; width:1.9%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Hormonal </spa= n></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0";position:absolute;top= :37.75%; left:14.41%;width:77.52%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.86%;width:96.13%;height:100.0%'><span style=3D'color:#000066; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>Testosterone esters= </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0"'><span style=3D'posit= ion:absolute; top:47.5%;left:17.41%;width:74.53%;height:6.0%'><span style=3D'color:#0000= 66; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>progestogen or GnRH analogue + </span></span><span style=3D'position:absolute;top:53.75%;left:= 17.41%; width:74.53%;height:6.0%'><span lang=3DEN-GB style=3D'color:#000066;mso-co= lor-index: 1'>testosterone </span></span></div> <div class=3DB style=3D'mso-line-spacing:"100 60 0";position:absolute;top:= 63.75%; left:9.36%;width:94.94%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.94%;width:96.05%;height:100.0%'><span style=3D'font-size:88%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .1%; width:1.64%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:88%;color:#000066;mso-color-index:1'>Immunological, bas= ed on antibodies against </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 60 0";position:absolute;top= :73.75%; left:14.41%;width:77.52%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.86%;width:96.13%;height:100.0%'><span style=3D'color:#000066; mso-color-index:1'><span style=3D'mso-special-format:bullet;color:#CC0000; position:absolute;left:-4.02%;top:.1em;font-size:90%'>–</span></span><span lang=3DEN-GB style=3D'color:#000066;mso-color-index:1'>GnRH, LH, FSH, their receptors</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image049.png Content-Transfer-Encoding: base64 Content-Type: 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rel=3DMain-File href=3D"../Future_Methods_Darcangues_2= 006.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>Future methods of fertility regulation - Catherine d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1107.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Methods for male sterilizat= ion"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1153"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; 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position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1180674" class=3DT style=3D'position:absolute;top:= 3.25%; left:3.37%;width:94.38%;height:8.5%'><span lang=3DEN-GB style=3D'font-size= :111%'><b>Methods for male sterilization</b></span></div> <div v:shape=3D"_x0000_s1180675" class=3DO> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:14.0%;left:= 8.05%; width:57.86%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>No scalpel vasectomy </b></span></div> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:24.0%;left:= 8.05%; width:57.86%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>Fascial interposition </b></span></div> <div style=3D'mso-line-spacing:"160 0 0";position:absolute;top:34.0%;left:= 8.05%; width:63.29%;height:6.0%'><span lang=3DEN-GB style=3D'font-size:156%;color= :green'><b>Percutaneous vas occlusion</b></span></div> </div> <div v:shape=3D"_x0000_s1180676" style=3D'tab-stops:2.625in 3.8125in 4.437= 5in'> <div class=3DB1 style=3D'mso-margin-left-alt:2028;mso-text-indent-alt:2016= '></div> <div class=3DB2 style=3D'mso-margin-left-alt:2124;mso-text-indent-alt:2100= '></div> <div class=3DB3 style=3D'mso-margin-left-alt:2196;mso-text-indent-alt:2196= '></div> <div class=3DB4 style=3D'mso-margin-left-alt:2268;mso-text-indent-alt:2280= '></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:42.0%;left:10.11%;width:66.47%;height:6.0%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:88%'><b>- </b></span><span lang=3DEN-GB style=3D'font-size:75%'><b> </b></span><span lang=3DEN-GB style=3D'font-si= ze:75%'>Permanent, with </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:48.25%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>scler= osing agents</span><span lang=3DEN-GB style=3D'font-size:75%'>: </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:53.5%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>e.g. methylcyanoacrylate, </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:58.99%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> = </span>polyurethane </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:64.25%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'>-<span style=3D'mso-spacerun:yes'> </span>Reversible, with </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:69.5%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'>non-s= clerosing agents</span><span lang=3DEN-GB style=3D'font-size:75%'>: </span></di= v> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:75.0%;left:10.11%;width:66.47%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>e.g. silicone plugs </span></div> <div class=3DB style=3D'mso-line-spacing:"100 0 0";mso-margin-left-alt:194= 4; position:absolute;top:80.25%;left:10.11%;width:76.59%;height:5.25%'><span style=3D'mso-special-format:nobullet;display:none;color:#CC0000;font-size:= 50%'>•</span><span lang=3DEN-GB style=3D'font-size:75%'><span style=3D'mso-spacerun:yes'> <= /span>or</span><span lang=3DEN-GB style=3D'font-size:75%;color:#CC0000;mso-color-index:3'> resi= ns</span><span lang=3DEN-GB style=3D'font-size:75%'>:<span style=3D'mso-spacerun:yes'> <= /span>e.g. maleic anhydride / styrene</span></div> </div> <v:shape id=3D"_x0000_s1180677" type=3D"#_x0000_t75" style=3D'position:abs= olute; 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d’Arcangues</titl= e> <![if IE]> <base href=3D"file:///C:\2C09C636\Future_Methods_Darcangues_2006_files\slide1109.= htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"22.03.2006: Possible targets"> <link rel=3DStylesheet href=3D"master36_stylesheet.css"> <![if !ppt]> <style> .CB {color:#292929;} .CT {color:#CC0000;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><p:slidetransition advancetime=3D"0" speed= =3D"255" flag=3D"1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1157"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master37.xml"> <p:shaperange href=3D"master37.xml#_x0000_s932865"/><![if !ppt]><p:shapera= nge href=3D"master37.xml#_x0000_s932866"/><p:shaperange href=3D"master37.xml#_x0000_s932870"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s932870" src=3D"master37_image053.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s932870" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= 6</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master37.xml#_x0000_m932868"/><v:shape id= =3D"_x0000_s1184770" type=3D"#_x0000_m932868" style=3D'position:absolute;left:165.375pt;top:16= 2pt; width:442.75pt;height:270pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape><p:shaperange href=3D"master37.xml#_x0000_m932867"/><v:shape id=3D"_x0000_s1184772" typ= e=3D"#_x0000_m932867" style=3D'position:absolute;left:54pt;top:48pt;width:612.125pt;height:115.= 75pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"centerTitle"/></v:shape> <div v:shape=3D"_x0000_s1184770" class=3DCB> <div style=3D'text-align:left;position:absolute;top:31.0%;left:23.97%; width:59.55%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 51%; width:97.48%;height:100.0%'><span style=3D'mso-special-format:bullet;mso-b= ullet-image: "image010\.png";color:#CC0000;font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:37.03%;left:-2= .58%; width:2.9%;height:33.33%'><![endif]></span><span lang=3DEN-GB><span style=3D'mso-tab-count:1;width:14.59%'> </span></span><span lang=3DFR style=3D'color:#000066;mso-color-index:1'>Gametogenesis<span style=3D'mso-spacerun:yes'> </span> </span></span></div> <div style=3D'text-align:left;position:absolute;top:39.5%;left:23.97%; width:59.55%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 51%; width:97.48%;height:100.0%'><span style=3D'color:#000066;mso-color-index:1= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:37.03%;left:-2.58%;width:2.9%;height:33.33%'><![endif]></span></span><= span lang=3DFR style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width:12= .47%'> </span>Sperm motility </span></span></div> <div style=3D'text-align:left;position:absolute;top:48.0%;left:23.97%; width:59.55%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 51%; width:97.48%;height:100.0%'><span style=3D'color:#000066;mso-color-index:1= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:37.03%;left:-2.58%;width:2.9%;height:33.33%'><![endif]></span></span><= span lang=3DFR style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width:12= .47%'> </span>Sperm capacitation </span></span></div> <div style=3D'text-align:left;position:absolute;top:56.5%;left:23.97%; width:59.55%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 51%; width:97.48%;height:100.0%'><span style=3D'color:#000066;mso-color-index:1= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:37.03%;left:-2.58%;width:2.9%;height:33.33%'><![endif]></span></span><= span lang=3DFR style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width:12= .47%'> </span>Acrosomal reaction </span></span></div> <div style=3D'text-align:left;position:absolute;top:65.25%;left:23.97%; width:65.16%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 29%; width:97.7%;height:100.0%'><span style=3D'color:#000066;mso-color-index:1'= ><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-2.35%;width:2.64%;height:33.33%'><![endif]></span></span>= <span lang=3DFR style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width:11= .36%'> </span>Follicular development </span></span></div> <div style=3D'text-align:left;position:absolute;top:73.75%;left:23.97%; width:59.55%;height:6.75%'><span style=3D'position:absolute;top:0%;left:2.= 51%; width:97.48%;height:100.0%'><span style=3D'color:#000066;mso-color-index:1= '><span style=3D'mso-special-format:bullet;mso-bullet-image:"image010\.png";color:= #CC0000; font-size:50%'><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'posi= tion:absolute; top:33.33%;left:-2.58%;width:2.9%;height:33.33%'><![endif]></span></span><= span lang=3DFR style=3D'color:#000066;mso-color-index:1'><span style=3D'mso-spacerun:yes'> </span><span style=3D'mso-tab-count:1;width:12= .47%'> </span>Implantation</span></span></div> </div> <div v:shape=3D"_x0000_s1184772" class=3DCT 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o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1188866" class=3DT style=3D'position:absolute;top:= 7.75%; left:-3.74%;width:109.36%;height:8.5%'><span lang=3DFR style=3D'font-size:= 111%'><b>Some of the more promising leads</b></span></div> <div v:shape=3D"_x0000_s1188867" class=3DB> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:23.25%;left:8.05%;width:102.05%;height:5.25%'><span style=3D'font-size= :75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .66%; width:1.28%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Lonidamine analogu= es: deplete immature germ cells from </span></span><span style=3D'position:abs= olute; top:28.5%;left:8.05%;width:86.14%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>seminiferous epithelium. </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:36.0%; left:4.3%;width:100.56%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.72%;width:96.27%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .86%; width:1.35%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of epid= idymal proteins: eppin and cystatin-11 </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:43.5%; left:4.3%;width:89.88%;height:5.25%'><span style=3D'position:absolute; top:0%;left:4.16%;width:95.83%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:28.57%;left:-4= .34%; width:1.52%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of testis-specific enzymes (GST, SAC) </span></span></div> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:50.75%;left:8.05%;width:97.56%;height:5.25%'><span style=3D'font-size:= 75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .83%; width:1.34%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Inhibitors of fusi= on of sperm with zona pellucida: GnRH </span></span><span style=3D'position:abso= lute; top:56.25%;left:8.05%;width:86.14%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>antagonists. <= /span></span></div> <div style=3D'mso-line-spacing:"100 40 0"'><span style=3D'position:absolut= e; top:63.75%;left:8.05%;width:90.26%;height:5.25%'><span style=3D'font-size:= 75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:28.57%;left:-4= .14%; width:1.45%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Change in endometr= ial receptivity: LIF antagonists; </span></span><span style=3D'position:absolu= te; top:69.0%;left:8.05%;width:100.18%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>antibodies against= LIF, IL-11, or the IL-11 receptor; ebaf. </span></span></div> <div style=3D'mso-line-spacing:"100 40 0";position:absolute;top:76.5%; left:4.3%;width:104.49%;height:5.25%'><span style=3D'position:absolute; top:0%;left:3.58%;width:96.41%;height:100.0%'><span style=3D'font-size:75%; color:#000066;mso-color-index:1'><span style=3D'mso-special-format:bullet; mso-bullet-image:"image010\.png";color:#CC0000;font-size:50%'><![if !ppt]>= <img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-3= .71%; width:1.3%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Anti-angiogenic ag= ents (magainin analogues, fumagillin).</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: 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onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:white;clip:rect(0%= , 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000066,#969696,#cc0000,#cc3300,#ff9966,#fbdf53,#663300" masterhref=3D"master36.xml"> <p:shaperange href=3D"master36.xml#_x0000_s931841"/><![if !ppt]><p:shapera= nge href=3D"master36.xml#_x0000_s931842"/><p:shaperange href=3D"master36.xml#_x0000_s931845"/><![if !ppt]><img border=3D0 v:shapes=3D"_x0000_s931845" src=3D"master36_image060.png" alt=3D"Text Box: 05_STAG_DRep_Feb/‹#›" style=3D'position:absolute;top:78.5= %; left:.37%;width:2.8%;height:21.0%'><![endif]> <div v:shape=3D"_x0000_s931845" class=3DO style=3D'mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:88.0%;left:-5.05%;width:13.67%;height:1.5%;visibil= ity: hidden'><span style=3D'mso-bidi-font-family:Arial;font-size:33%'>05_STAG_D= Rep_Feb/</span><span style=3D'mso-bidi-font-family:Arial;font-size:33%;mso-field-code:meta16'>2= 7</span><span style=3D'font-family:Arial;mso-bidi-font-family:Arial;font-size:33%;mso-sp= ecial-format: lastCR;display:none'> </span></div> <![endif]><p:shaperange href=3D"master36.xml#_x0000_m931843"/><v:shape id= =3D"_x0000_s1190914" type=3D"#_x0000_m931843" style=3D'position:absolute;left:0;top:18pt;width= :720.125pt; height:126pt;mso-wrap-style:none;v-text-anchor:middle' o:spt=3D"1" o:user= drawn=3D"f" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" stroked=3D"f" strokecolor= =3D"#c00 [3]" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke dashstyle=3D"longDash" joinstyle=3D"miter" imagealignshape=3D"t" o:forcedash=3D"f"/> <v:imagedata preservegray=3D"f" grayscale=3D"f" bilevel=3D"f"/> <v:shadow on=3D"f" color=3D"#969696 [2]" obscured=3D"f"/> <o:extrusion v:ext=3D"view" on=3D"f" metal=3D"f" lightface=3D"t" lockrotationcenter=3D"t" autorotationcenter=3D"f" type=3D"parallel" ligh= tharsh=3D"t" lightharsh2=3D"f"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"f" grouping=3D"t"/> <v:textbox style=3D'mso-rotate-with-shape:f;mso-fit-shape-to-text:f; mso-fit-text-to-shape:f'/> <o:callout v:ext=3D"edit" minusx=3D"f" minusy=3D"f" dropauto=3D"f" length= specified=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master36.xml#_x0000_m931844"/><v:shape id=3D"_x0000_s1190915" typ= e=3D"#_x0000_m931844" style=3D'position:absolute;left:42.125pt;top:162pt;width:640.625pt;height= :222pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><v:shapetype id=3D= "_x0000_t202" coordsize=3D"21600,21600" o:spt=3D"202" path=3D"m,l,21600r21600,l21600,xe= "> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s1190916" type=3D"#_x0000_t202" style= =3D'position:absolute; left:80.5pt;top:367.25pt;width:559pt;height:93.5pt;mso-wrap-style:none; v-text-anchor:middle' filled=3D"f" stroked=3D"f" strokecolor=3D"#c00 [3]" strokeweight=3D"1pt"> <v:stroke dashstyle=3D"longDash"/> <v:shadow color=3D"#969696 [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s1190914" class=3DT><span style=3D'position:absolut= e; top:5.75%;left:-5.61%;width:111.42%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>Challenges for the development<br> </b></span></span><span style=3D'position:absolute;top:15.5%;left:.93%; width:98.12%;height:9.25%'><span lang=3DEN-GB style=3D'font-size:122%'><b>= of new technologies</b></span></span></div> <div v:shape=3D"_x0000_s1190915" class=3DB> <div style=3D'position:absolute;top:31.0%;left:6.92%;width:91.76%;height:5= .25%'><span style=3D'position:absolute;top:0%;left:4.08%;width:95.91%;height:100.0%'><= span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .25%; width:1.48%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Cost and time (10-= 15 years, US$ 200-300 million) </span></span></div> <div style=3D'position:absolute;top:37.25%;left:6.92%;width:87.07%;height:= 5.25%'><span style=3D'position:absolute;top:0%;left:4.3%;width:95.69%;height:100.0%'><s= pan style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .49%; width:1.57%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Industry involvement </span></span></div> <span style=3D'position:absolute;top:43.75%;left:10.67%;width:94.56%;heigh= t: 5.25%'><span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position= :absolute; top:33.33%;left:-3.96%;width:1.38%;height:33.33%'><![endif]></span></span>= <span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Persp= ectives of users and potential users, of different </span></span><span style=3D'position:absolute;top:49.0%;left:10.67%;width:93.44%;height:5.25%= '><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>relig= ious and socio-cultural backgrounds, and of new </span></span><span style=3D'positi= on: absolute;top:54.5%;left:10.67%;width:83.33%;height:5.25%'><span lang=3DEN-= GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>generations of wom= en and men </span></span> <div style=3D'position:absolute;top:60.75%;left:6.92%;width:94.75%;height:= 5.25%'><span style=3D'position:absolute;top:0%;left:3.95%;width:96.04%;height:100.0%'><= span style=3D'font-size:75%;color:#000066;mso-color-index:1'><span class=3DBB><= ![if !ppt]><img src=3Dimage010.png alt=3D"*" style=3D'position:absolute;top:33.33%;left:-4= .11%; width:1.44%;height:33.33%'><![endif]></span></span><span lang=3DEN-GB style=3D'font-size:75%;color:#000066;mso-color-index:1'>Access in resource= -poor settings (cost, technology)</span></span></div> </div> <div v:shape=3D"_x0000_s1190916" class=3DO> <div style=3D'text-align:center;position:absolute;top:69.0%;left:4.68%; width:91.01%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:133%;colo= r:#CC0000; mso-color-index:3'>For women to benefit from these new technologies, <= /span></div> <div style=3D'text-align:center;position:absolute;top:74.25%;left:6.36%; width:87.45%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:133%;colo= r:#CC0000; mso-color-index:3'>they need better access to education and income </s= pan></div> <div style=3D'text-align:center;position:absolute;top:79.5%;left:11.04%; width:78.08%;height:5.25%'><span lang=3DEN-GB style=3D'font-size:133%;colo= r:#CC0000; mso-color-index:3'>and to have greater decision-making power.</span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master36_image060.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAA8AAABUAQMAAABnUf89AAAAAXNSR0ICQMB9xQAAAAZQTFRFAAAA AABmAbZ9ogAAAAF0Uk5TAEDm2GYAAAAJcEhZcwAACDYAAAg0Ab6QHjwAAAAZdEVYdFNvZnR3YXJl AE1pY3Jvc29mdCBPZmZpY2V/7TVxAAAAP0lEQVQY07VOQQ4AIAjCmvHtnl6xWfqAGCcEAfgAihsD cKAlsYuQyBQ5+nxXU5ayeXW62OOnRdGt9jqDNZ6wAHTCASRXi8keAAAAAElFTkSuQmCC ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/master01.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" 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style=3D'mso-margin-left-alt:580;mso-text-indent-alt:580'><= /div> <div class=3DO3 style=3D'mso-margin-left-alt:870;mso-text-indent-alt:870'><= /div> <div class=3DO4 style=3D'mso-margin-left-alt:1148;mso-text-indent-alt:1148'= ></div> <div class=3DO style=3D'text-align:right'><span lang=3DEN-GB style=3D'font-= family:"Times New Roman"; font-size:61%;mso-field-code:meta16'><i>‹#›</i></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";font-size:61%;mso-special-format:las= tCR'><i> </i></span></div> </div> <p:notes id=3D"1084" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1109"/> </o:shapelayout><v:shape id=3D"_x0000_s1135618" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt' filled=3D"f" stroked=3D"t" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke dashstyle=3D"solid" opacity=3D"1" filltype=3D"solid" linestyle= 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mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1085" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1111"/> </o:shapelayout><v:shape id=3D"_x0000_s1137666" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1137= 667" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1137667" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1086" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1113"/> </o:shapelayout><v:shape id=3D"_x0000_s1139714" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1139= 715" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1139715" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1087" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1115"/> </o:shapelayout><v:shape id=3D"_x0000_s1141762" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1141= 763" type=3D"#_x0000_m11269" style=3D'position:absolute;left:43pt;top:369.25pt; width:444.5pt;height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1141763" class=3DN> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Gynefix</b></span><span lang=3DEN-GB style=3D'font-family:"Times= New Roman"; mso-ascii-font-family:"Times New Roman"'>: 330 mm2 (6 sleeves) or </span><= span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>mini-Gynefix</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'> 200 mm2 (4 sleeves). Aim is to </span><span lang=3DEN-GB style=3D'font-fam= ily: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>decrease expulsions, pain and bleeding.<span style=3D'mso-spacerun:yes'> </span>Bo= th have the same efficacy and are designed to </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>last 10 years.<span style=3D'mso-spacerun:yes'> </span>Less bleeding with mini-Gynefix.<span style=3D'mso-spacerun:yes'> </span>Difficulty: inserti= on technique. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Femilis</b></span><span lang=3DEN-GB style=3D'font-family:"Times= New Roman"; mso-ascii-font-family:"Times New Roman"'> and </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Femilis-Slim</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: release 20 </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-= font-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g/day LNG. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Fibroplant</b></span><span lang=3DEN-GB style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman"'> releases 14 </span><span lang=3D= EN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roman";mso-han= si-font-family: Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g/day LNG. </span></div> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Not shown: </sp= an><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Gyneplant</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: 4 copper sleeves plus one fibre which releases 5 </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roman";mso-han= si-font-family: Arial'>µ</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g/day LNG</span></div> </div> </p:notes><p:notes id=3D"1088" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1117"/> </o:shapelayout><v:shape id=3D"_x0000_s1143810" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1143= 811" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1143811" class=3DN> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman"'>Also under development: </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Swing</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>, which has a coil of copper (380 mm2) for </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>the vertical arm and horizontal arms that bend upward to reduce expulsions.= 3;</span> <div style=3D'mso-line-spacing:"100 60 0"'><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Anti-progestin-= releasing IUD (CDB-2914) will provide bleed-free system. </span></div> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1089" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1119"/> </o:shapelayout><v:shape id=3D"_x0000_s1145858" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1145= 859" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1145859" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Ne= storone</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'> (ST1435): 19-nor progesterone derivative, orally inactive, pure </span><sp= an lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>progestogen, without any estrogenic or androgenic activity. 10 to 100 times </span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>more potent than progesterone. </span> <div><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font= -family: "Times New Roman";mso-hansi-font-family:Arial'><b>Elcometrine</b></span><s= pan lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: releases nestorone over 6 months, available in Brazil only. </span></= div> <span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-fami= ly:"Times New Roman"; mso-hansi-font-family:Arial'><b>Uniplant</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'> (=3D Surplant): releases nomegestrol acetate, one year duration of </span>= <span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>action.<span style=3D'mso-spacerun:yes'> </span>Developed by Theramex with South-to-So= uth</span></div> </p:notes><p:notes id=3D"1090" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1121"/> </o:shapelayout><v:shape id=3D"_x0000_s1147906" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.375pt;top:58.625pt;width:385.875pt;height:289.375pt' filled=3D"f" stroked=3D"t" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke dashstyle=3D"solid" opacity=3D"1" filltype=3D"solid" linestyle= =3D"single" endcap=3D"flat" o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1147= 907" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:325.875pt;mso-wrap-style:square;v-text-anchor:top' filled=3D"f" stroked=3D"f" strokeweight=3D"1pt" o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <v:shadow on=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.49575mm,1.226mm,2.49575mm,1.226mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1147907" class=3DN style=3D'mso-line-spacing:"87 3= 0 0"'><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Times New Roma= n"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1091" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1172"/> </o:shapelayout><v:shape id=3D"_x0000_s1200130" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:73.25pt;top:59.75pt;width:382.875pt;height:287.125pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1200= 131" type=3D"#_x0000_m11269" style=3D'position:absolute;left:71pt;top:370.75pt; width:386.5pt;height:346.875pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape></p:notes><p:notes id=3D"1092" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1124"/> </o:shapelayout><v:shape id=3D"_x0000_s1150978" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1150= 979" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1150979" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Pr= ogering:</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"; mso-hansi-font-family:Arial'> releases 15 to 5 mg/day progesterone over 3 = to 4 months, </span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-= ascii-font-family: "Times New Roman";mso-hansi-font-family:Arial'>available in Chile and Peru since 1998. </span><span lang=3DFR style=3D'font-family:"Times New Rom= an"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'><b>Nu= varing</b></span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: 3-keto-desogestrel 120 </span><span style=3D'font-family:Arial;mso-ascii-f= ont-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g + Ethinyl estradiol 15 </span><span style=3D'font-family:Arial;mso-ascii-f= ont-family: "Times New Roman";mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>g, approved by </span><span lang=3DFR style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>U.S.FDA in 2001, in France in Apr= il 2004. </span> <div><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font= -family: "Times New Roman";mso-hansi-font-family:Arial'><b>Nestorone/EE</b></span><= span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>: 150 </span><span style=3D'font-family:Arial;mso-ascii-font-family:"Times N= ew Roman"; mso-hansi-font-family:Arial'>µ</span><span lang=3DFR style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>g + 15 </span><span style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'= >µ</span><span lang=3DFR style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Ti= mes New Roman"'>g</span></div> </div> </p:notes><p:notes id=3D"1093" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1126"/> </o:shapelayout><v:shape id=3D"_x0000_s1153026" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1153= 027" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1153027" class=3DN><span lang=3DFR style=3D'font-f= amily:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>Evra: less effective in women weighing 90 kg or more. </span></div> </p:notes><p:notes id=3D"1094" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1128"/> </o:shapelayout><v:shape id=3D"_x0000_s1155074" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1155= 075" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1155075" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Standard days</b></span><span lang=3DEN-GB style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>: failure rate of 5% with perfect use, and of 12 % in actual </span><span lang=3DEN-GB style=3D'font-family:= "Times New Roman"; mso-ascii-font-family:"Times New Roman"'>use.<span style=3D'mso-spacerun:y= es'> </span>Cycles must be regular, between 26 and 32 days. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Two days method</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: based on observation of the cervical mucus yesterday </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>and today.<span style=3D'mso-spacerun:yes'> </span>If mucus is present on one= of these days, contraceptive </span><span lang=3DEN-GB style=3D'font-family:"= Times New Roman"; mso-ascii-font-family:"Times New Roman"'>protection is needed.<span style=3D'mso-spacerun:yes'> </span>Simpler than sympto-thermal method, not dependant </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>on cycle length<span style=3D'mso-spacerun:yes'> </span>Under investigation. </span> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Both methods can be used to plan a pregnancy. </spa= n></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1095" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1130"/> </o:shapelayout><v:shape id=3D"_x0000_s1157122" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1157= 123" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1157123" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Essure</b></span><span lang=3DEN-GB style=3D'font-family:"Times = New Roman"; mso-ascii-font-family:"Times New Roman"'> (=3D STOP): under local anaesthe= sia, insertion lasts less than one hour.<span style=3D'mso-spacerun:yes'> </sp= an></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>Proper placement checked with hysteroscopy, X-ray or ultrasound.<span style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Contraception needed for 3 months following insertion. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'><b>Adiana:</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'> low frequency radiation to create lesions on= the fallopian tubes, </span><span lang=3DEN-GB style=3D'font-family:"Times New= Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'>follo= wed by application of porous plastic matrix on the lesion to encourage </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'>scar formation for the next 3 months.</span><= span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New R= oman"; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'><b> </b></span= ><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Ovabloc:</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-hansi-font-family:Arial'> injection of liquid silicone in fallopian tubes.<span style=3D'mso-spacerun:yes'> </span>Follow-up with X-</span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'>ray over one year. Shift of the silicone plugs observed in 10% cases over 1 </span><span lang=3DEN-GB style=3D'font-famil= y:"Times New Roman"; mso-ascii-font-family:"Times New Roman";mso-hansi-font-family:Arial'>year.= </span><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"Times New R= oman"; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'><b> </b></span= ><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>Quinacrine</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: toxicological studies underway.<span style=3D'mso-spacerun:yes'> </span>Clinical studies tested various </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>regimens.</span></div> </p:notes><p:notes id=3D"1096" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1132"/> </o:shapelayout><v:shape id=3D"_x0000_s1159170" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1159= 171" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1159171" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Polyurethane or plastic condoms: longer shelf-life, can be used with oil-</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>based lubricant, more comfortable.<span style=3D'mso-spacerun:yes'> </span>Slip= page and breakage problems</span></div> </p:notes><p:notes id=3D"1097" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1134"/> </o:shapelayout><v:shape id=3D"_x0000_s1161218" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1161= 219" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1161219" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1098" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1136"/> </o:shapelayout><v:shape id=3D"_x0000_s1163266" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1163= 267" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1163267" class=3DN> <div><span lang=3DFR style=3D'font-family:Arial;mso-ascii-font-family:"Tim= es New Roman"; mso-bidi-font-family:Arial'> </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman";mso-hansi-font-family:Arial'><b>Lea's shield</b></span><= span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>: silicone, one size, with ring to facilitate removal, et valve to </span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>avoid pressure/suction and allow menstrual flow.<span style=3D'mso-spacerun:yes'= > </span>Use: keep for 8 hours </span><span lang=3DEN-GB style=3D'font-famil= y:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>after intercourse, never more tha= n 48 hours.<span style=3D'mso-spacerun:yes'> </span>Approved by the U.S.FDA in= </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>2002. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>SILCS</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: silicone, development based on numerous acceptability studies with </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>users and providers.<span style=3D'mso-spacerun:yes'> </span>One size.<span style=3D'mso-spacerun:yes'> </span>Under testing. </span> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1099" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1138"/> </o:shapelayout><v:shape id=3D"_x0000_s1165314" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1165= 315" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1165315" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: "Times New Roman";mso-ascii-font-family:"Times New Roman";mso-hansi-font-f= amily: Arial'><b>Ov</b></span><span lang=3DEN-GB style=3D'font-family:Arial;mso-a= scii-font-family: "Times New Roman";mso-hansi-font-family:Arial'><b>è</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>s</b></span><span lang=3DEN-GB style=3D'fo= nt-family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>: produced in France by Veos, available since 1997.<span style=3D'mso-spacerun:yes'> </span>Three sizes.<span style=3D'mso-spacerun:yes'> </span>The </span><s= pan lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>dome is a membrane which sticks to the cervix like a film.<span style=3D'mso-spacerun:yes'> </span>Under </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>investigation. </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-hansi-font-family:Arial'><b>FemCap</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>: Approved by U.S.FDA in 2003, available in many European </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>countries<span style=3D'mso-spacerun:yes'> </span>Three sizes.<span style=3D'mso-spaceru= n:yes'> </span>Designed to prevent displacement and to avoid </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>pressure on the urethra.</span></div> </p:notes><p:notes id=3D"1100" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1140"/> </o:shapelayout><v:shape id=3D"_x0000_s1167362" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1167= 363" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1167363" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1101" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1142"/> </o:shapelayout><v:shape id=3D"_x0000_s1169410" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1169= 411" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1169411" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1102" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1144"/> </o:shapelayout><v:shape id=3D"_x0000_s1171458" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1171= 459" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1171459" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1103" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1146"/> </o:shapelayout><v:shape id=3D"_x0000_s1173506" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1173= 507" type=3D"#_x0000_m11269" style=3D'position:absolute;left:21.625pt;top:368p= t; width:463.5pt;height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1173507" class=3DN><span lang=3DFR style=3D'font-f= amily:Arial; mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial;mso-spe= cial-format: lastCR'> </span></div> </p:notes><p:notes id=3D"1104" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1148"/> </o:shapelayout><v:shape id=3D"_x0000_s1175554" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1175= 555" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1175555" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1105" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1150"/> </o:shapelayout><v:shape id=3D"_x0000_s1177602" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1177= 603" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1177603" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"1106" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1152"/> </o:shapelayout><v:shape id=3D"_x0000_s1179650" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1179= 651" type=3D"#_x0000_m11269" style=3D'position:absolute;left:23.625pt;top:368p= t; width:474pt;height:326pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1179651" class=3DN> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>T microspheres </span></div> <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-f= amily: "Times New Roman"'>MENT (implant, transdermal gel, patch) and MENT acetate (implant) - MENT has the </span><span lang=3DEN-GB style=3D'font-family:"T= imes New Roman"; mso-ascii-font-family:"Times New Roman"'>advantage over T that it does not overstimulate the prostate </span> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>TU in tea seed oil </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>TU in soybean oil (to achieve higher concentration) = ;</span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>DMPA + testosterone pellets (too many pellet expulsions) </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>DMPA + TU in tea seed oil </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG rods + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG rods + T pellets </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>LNG pills + TE </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Jadelle + T or TE </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Net-EN + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Jadelle + MENT </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Implanon + MENT </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'>Cyproterone acetate + TU </span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial'> </span></div> <div><span lang=3DEN-GB style=3D'font-family:Arial;mso-ascii-font-family:"= Times New Roman"; mso-bidi-font-family:Arial;mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"1107" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1154"/> </o:shapelayout><v:shape id=3D"_x0000_s1181698" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1181= 699" type=3D"#_x0000_m11269" style=3D'position:absolute;left:70pt;top:368pt;wi= dth:384.625pt; height:326pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1181699" class=3DN><span lang=3DEN-GB style=3D'fon= t-family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial; 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width:506.75pt;height:364pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1189891" class=3DN> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Lonidamine</= b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> is an anticancer drug with antispermatogenic capability, abandoned because= of kidney </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>damage.<span style=3D'mso-spacerun:yes'> </span>Analogues being investigated (e.g. AF-= 2364, AF-2785).<span style=3D'mso-spacerun:yes'> </span>One has specific action= on Sertoli </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'>cells </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Epididymal proteins</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roma= n"; mso-ascii-font-family:"Times New Roman"'>:2 lead candidates: </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'><b>eppin</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> (epididymal protease inhibitor) and cystatin-11. Test </span><span lang=3D= EN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>undertaken to see if immunoneutralization of </span><span lang=3DEN-GB style=3D'font-= family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>cystatin-11<= /b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'> leads to infertility, but vaccine approach </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>seen as controversial, thus research aims to develop inhibitors. </span></d= iv> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'><b>Testis-speci= fic enzymes</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman= "; mso-ascii-font-family:"Times New Roman"'>: </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>-<span style=3D'mso-spacerun:yes'> </span>isoforms of the detoxification enzyme glutathione S-transferase (GST) are present in the </span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>seminiferous tubule fluid and on the sperm surface.<span style=3D'mso-spacerun:yes'> </span>Inhibition of GST using glutathione analogues </span><span lang=3DE= N-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>leads to interference in sperm function, such as motility, acrosome reaction, and fertilising ability. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>-<span style=3D'mso-spacerun:yes'> </span>Human soluble adenylyl cyclase (SAC) a= ppears to be involved with the signal transduction events </span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>in the sperm during capacitation, hyperactivation, and the acrosome reaction.<span style=3D'mso-spacerun:yes'> </span>Testis-specific </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>expression of the novel enzyme could lead to development of sperm-specific antagonist= s of its </span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-a= scii-font-family: "Times New Roman"'>activity. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: Arial;mso-ascii-font-family:"Times New Roman";mso-bidi-font-family:Arial'>= </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Leukemia inhibi= ting factor (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'><b>LIF</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>) is essential for implantation. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Interleukin-11 = (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'><b>IL-11</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>) is essential for successful decidualization. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Pre-implantation factor (</span><span lang=3DEN-GB style=3D'font-family:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'><b>PIF</b></span><span lang=3DEN-= GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'>), identified in 2-cell embryo, is earliest signal for recognition of </span>= <span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>pregnancy.<span style=3D'mso-spacerun:yes'> </span>Inhibitory scrambled peptide under investigation for anti-implantation activity. </span></div> <div style=3D'mso-line-spacing:"100 0 0"'><span lang=3DEN-GB style=3D'font= -family: "Times New Roman";mso-ascii-font-family:"Times New Roman"'>Regulation of meiosis by modulating the germ cell nuclear factor (</span><span lang=3DEN= -GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"'><b>GCNF</b></span><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"'>), predominantly expressed </span><span lang=3DEN-GB style=3D'font-family:"Ti= mes New Roman"; mso-ascii-font-family:"Times New Roman"'>in testis and ovary - under investigation. </span></div> <div><span lang=3DEN-GB style=3D'font-family:"Times New Roman";mso-ascii-f= ont-family: "Times New Roman"'><b>Ebaf</b></span><span lang=3DEN-GB style=3D'font-fami= ly:"Times New Roman"; mso-ascii-font-family:"Times New Roman"'> (=3DLefty) is a marker of a non-receptive endometrium.</span></div> </div> </p:notes><p:notes id=3D"1112" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1164"/> </o:shapelayout><v:shape id=3D"_x0000_s1191938" type=3D"#_x0000_m11268" st= yle=3D'position:absolute; left:69.5pt;top:58.625pt;width:385.75pt;height:289.25pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1191= 939" type=3D"#_x0000_m11269" 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FullScrInit(); =09 MakeSldVis(); ChkAutoAdv() if( runAnimations ) { if( document.all("NSPlay") ) document.all("NSPlay").autoStart =3D false; if( sld.filters && sld.filters.revealtrans ) setTimeout( "document.body.start()", sld.filters.revealtrans.duration * = 1000 ); else document.body.start(); } } function MakeSldVis()=20 { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans )=09 { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply()=09 } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis()=20 { if( !IsNts() ) return false=20 SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) {=20 nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.filter !=3D ""; } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii<collSeq.length;ii++) { if( collSeq[ii].getAttribute( "p:nodeType" ) =3D=3D "mainSeq" ) { g_animMainSequence =3D collSeq[ii]; break; } } } =09 if( g_animItemsToHide && document.body.playAnimations !=3D false ) { for(jj =3D 0; jj < g_animItemsToHide.length; jj++) { if( hideObj =3D GetObj(g_animItemsToHide[jj]) ) hideObj.runtimeStyle.visibility=3D"hidden"; } } if( g_animInteractiveItems ){ for(jj =3D 0; jj < g_animInteractiveItems.length; jj++) { if( triggerObj =3D GetObj(g_animInteractiveItems[jj]) ) triggerObj.runtimeStyle.cursor=3D"hand"; } } =09 if( gUseSldTimings && ''+g_animSlideTime !=3D 'undefined' ) { adjustedTime =3D document.body.calculateAutoAdvanceTimes( g_animSlideTim= e, g_animEffectTimings ); if( IsWin("PPTSld") && adjustedTime !=3D g_animSlideTime ) { var sld =3D GetCurSld(); sld.mAdvDelay =3D adjustedTime * 1000; } } } return g_animUseRuntime; } gSldJump =3D 0, gSldJumpTrack =3D 0, gSldJumpIdx =3D ""; function _KPH() {=20 if( IsNts() ) return; if( !parent.IsFramesMode() && event.keyCode =3D=3D 27 && !HideMenu() ) parent.window.close( self ); else if( event.keyCode =3D=3D 32 ) { if( window.name =3D=3D "PPTSld" ) parent.PPTSld.DocumentOnClick(); else parent.GoToNextSld(); } CatchNumKeys( parent, event ); } function CatchNumKeys( win, event ) { if( win.IsFullScrMode() && (48<=3Devent.keyCode) && (event.keyCode<=3D57) = ) { gSldJump =3D 1; gSldJumpIdx +=3D (event.keyCode-48).toString(); } if( win.IsFullScrMode() && gSldJump && event.keyCode =3D=3D 13 ) { var numSlds =3D parent.GetSldList().mList.length if ( gSldJumpIdx > numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } var g_HLinkArray =3D new Array(); =20 function IMapAreaObj( areaObj, coords ) { this.areaObj =3D areaObj; this.coords =3D coords; } function InitHLinkArray() { var appVer =3D navigator.appVersion; var msie =3D appVer.indexOf ( "MSIE " ) var ver =3D 0; if ( msie >=3D 0 ) ver =3D parseInt ( appVer.substring( msie+5 ) ); linkNum =3D 0; for (i=3D0; i<document.all.tags("AREA").length; i++) { areaObj =3D document.all.tags("AREA").item(i); if( ( areaObj.id !=3D "pptxscale" ) || ( ver > 4 ) ) g_HLinkArray[linkNum++] =3D new IMapAreaObj( areaObj, ParseCoords( ar= eaObj.coords ) ); } } function ScaleHyperlinks( factor ) { =20 for ( ii=3D0; ii< g_HLinkArray.length; ii++) { coordsStr=3D""; imaObj =3D g_HLinkArray[ii]; for ( jj=3D0; jj < imaObj.coords.length-1; jj++ ) coordsStr +=3D (imaObj.coords[jj]*factor) + ","; coordsStr +=3D (imaObj.coords[jj]*factor); imaObj.areaObj.coords =3D coordsStr; } } function ParseCoords( coordsStr ) { var numArray =3D new Array(); var i =3D curPos =3D commaPos =3D 0; while ( ( commaPos =3D coordsStr.indexOf(",", curPos) ) !=3D -1 ) {=20 numArray[i++] =3D parseInt( coordsStr.substr( curPos, commaPos ) ); curPos =3D commaPos + 1; } numArray[i] =3D parseInt( coordsStr.substr( curPos ) ); return numArray; } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && !parent.IsFramesMode() ) || (event && (event.keyCode=3D=3D32) ) ) parent.GoToNextSld(); } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"End of slide show, click to exit.", SCREEN_MODE=3D"Fram= es", gIsEndShow=3D0, NUM_VIS_SLDS=3D29, SCRIPT_HREF=3D"script.js", FULLSCR_= HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide1084.htm",1,-1,1),new hrefList(= "slide1085.htm",1,-1,1),new hrefList("slide1086.htm",1,-1,1),new hrefList("= slide1087.htm",1,-1,1),new hrefList("slide1088.htm",1,-1,1),new hrefList("s= lide1089.htm",1,-1,1),new hrefList("slide1090.htm",1,-1,1),new hrefList("sl= ide1091.htm",1,-1,1),new hrefList("slide1092.htm",1,-1,1),new hrefList("sli= de1093.htm",1,-1,1),new hrefList("slide1094.htm",1,-1,1),new hrefList("slid= e1095.htm",1,-1,1),new hrefList("slide1096.htm",1,-1,1),new hrefList("slide= 1097.htm",1,-1,1),new hrefList("slide1098.htm",1,-1,1),new hrefList("slide1= 099.htm",1,-1,1),new hrefList("slide1100.htm",1,-1,1),new hrefList("slide11= 01.htm",1,-1,1),new hrefList("slide1102.htm",1,-1,1),new hrefList("slide110= 3.htm",1,-1,1),new hrefList("slide1104.htm",1,-1,1),new hrefList("slide1105= .htm",1,-1,1),new hrefList("slide1106.htm",1,-1,1),new hrefList("slide1107.= htm",1,-1,1),new hrefList("slide1108.htm",1,-1,1),new hrefList("slide1109.h= tm",1,-1,1),new hrefList("slide1110.htm",1,-1,1),new hrefList("slide1111.ht= m",1,-1,1),new hrefList("slide1112.htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii<GetSldList().mList.length; ii++) { if ( GetSldList().mList[ii].mSldHref =3D=3D href ) return ii+1 } return 1 } function GetHrefObj( sldIdx ){ return GetSldList().mList[sldIdx-1] } function IsFramesMode(){ return ( SCREEN_MODE =3D=3D "Frames" ) } function IsFullScrMode(){ return ( SCREEN_MODE =3D=3D "FullScreen" ) } function GoToNextSld() { ii=3DgCurSld + 1 if( GetHrefObj( ii-1 ).mOrigVis =3D=3D 0 ) { if( ii<=3DGetSldList().mList.length ) { obj=3DGetHrefObj(ii) obj.mVis=3D1 GoToSldNum(ii) return } } else { obj=3DGetHrefObj( ii ) while ( obj && ( obj.mOrigVis =3D=3D 0 ) ) obj=3DGetHrefObj(++ii) if( obj && obj.mOrigVis ) { GoToSldNum(ii) return } } if( gSldStack.length > 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('<html><body dir=3D' + dir + ' bgcolor=3Dblack onload=3Dparent= .SetupEndShow() onunload=3Dparent.Unload()><center><p><font face=3DTahoma c= olor=3Dwhite size=3D2><br><b>' + ENDSHOW_MESG + '</b></font></p></center></= body></html>') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii<arr.length;ii++) { this.mList[ii] =3D new hrefList( arr[ii].mSldHref, arr[ii].mOrigVis, arr[= ii].mAdvDelay, arr[ii].mAdvOnClk ); if( arr[ii].mOrigVis ) this.mList[ii].mSldIdx =3D idx++; } this.mNumVisSlds =3D idx-1; this.fEndShow =3D fEnd; } function GetSldList() { return gSldStack[gSldStack.length-1] } function GetCurSld() { return parent.GetSldList().mList[parent.gCurSld - 1]= } gSldStack =3D new Array(); gSldStack[0] =3D new SldList(gMainDoc,gCurSld,1) function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } /********************************************* Custom Shows implementation When ViewCustomShow() is called, we create a new array that is a subset of the slides in=20 the main doc. This list pushed on a stack so we can return after the end of the custom show. *********************************************/ function ViewCustomShow(idx,fEnd) { if( !IsFullScrMode() ) return; var sldList =3D new Array(); var custShow =3D custShowList[idx-1]; var jj =3D 0; for( ii=3D0;ii<custShow.length;ii++ ) { if( custShow[ii] <=3D gMainDoc.length ) sldList[jj++] =3D gMainDoc[custShow[ii]-1]; } if (sldList.length > 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Next",sPrev=3D"Previous",sEnd=3D"End Show",sFont=3D"Arial",sAr= row=3D"Arrow",sFreeform=3D"Freeform",sRect=3D"Rectangle",sOval=3D"Oval" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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left:-90px'></div> </div> </td> </table> </div> <div id=3DOtlNavObj onload=3D"Load()" onmouseover=3D"BtnOnOver()" onmousedown=3D"BtnOnDown()" onmouseout=3D"BtnOnOut()" onmouseup=3D"BtnOnUp(= )" onkeypress=3D"ExecBtn()" style=3D'display:none;visibility:hidden'> <table style=3D'position:relative;width:70px' align=3Dleft cellpadding=3D0 = cellspacing=3D0> <td nowrap><div title=3D"Show/Hide Outline" id=3D"nb_otl" onfocus=3D"BtnOnOver()" onblur=3D"BtnOnOut()" TABIND= EX=3D11 style=3D'position:absolute;top:0%;left:0%;width:100%;height:100%;cursor:de= fault'> <div id=3D"nb_otlElem" align=3Dcenter style=3D'position:relative;padding:3= px;font-family:Arial; color:buttontext;font-size:9pt'>Outline</div></div> </td> </table> <table style=3D'position:relative' align=3Dcenter cellpadding=3D0 cellspaci= ng=3D0> <td> <div style=3D'position:absolute;left:-18px;width:24px;height:20px;border-s= tyle: solid;border-width:1px;border-color:threedface' onfocus=3D"BtnOnOver()" on= blur=3D"BtnOnOut()" TABINDEX=3D12 id=3D"nb_otlTxtBorder"> <div style=3D'position:absolute;clip:rect(0px, 22px, 18px, 0px)'><img src=3Dbuttons.gif id=3D"nb_otlTxt" title=3D"Expand/Collapse Outline" style=3D'position:relative;left:-157px'></div> </div> </td> </table> </div> <div id=3DOtlObj style=3D'display:none;visibility:hidden;'> <table width=3D"100%" style=3D'font-family:Arial;font-size:9pt'> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>1</font></div> </td> <td width=3D"100%"> <div id=3DPPTP1 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1084.htm');" id=3DPPTL1>Future methods of fertility regulation</a></font></div> <div id=3DPPTC1 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Catherine d’Arcangues, Ph.D., M.D.</li> <li>Department of Reproductive Health and Research</li> <li>World Health Organization</li> <br> <br> <li>Training in Reproductive Health Research<br> Geneva 2006</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>2</font></div> </td> <td> <div id=3DPPTP2 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1085.htm');" id=3DPPTL2>"1"</a= ></font></div> <div id=3DPPTC2 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>1. Improvement of existing methods</li> <li> Efficacy, side-effects, duration of action, manufacturing process, = cost</li> <li>2. New approaches</li> <li> Mode of action</li> <li>3. New targets for contraception</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>3</font></div> </td> <td> <div id=3DPPTP3 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1086.htm');" id=3DPPTL3>1. Improvement of existing methods</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>4</font></div> </td> <td> <div id=3DPPTP4 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1087.htm');" id=3DPPTL4>Intra-uterine de= vices</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>5</font></div> </td> <td> <div id=3DPPTP5 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1088.htm');" id=3DPPTL5>Intra-uterine de= vices</a></font></div> <div id=3DPPTC5 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Also under development:</li> <br> <br> <li>Swing: copper-releasing with coil stem</li> <li>IUD releasing a progesterone receptor modulator (CDB-2914)</li> <li>Copper IUD releasing indomethacin</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>6</font></div> </td> <td> <div id=3DPPTP6 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1089.htm');" id=3DPPTL6>Contraceptive im= plants</a></font></div> <div id=3DPPTC6 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Jadelle:</li> <li> levonorgestrel, 2 rods, 5 years</li> <li>Implanon:</li> <li> etonogestrel, 1 rod, 3 years</li> <li>Nestorone:</li> <li> pure progestogen, 1 rod, 2 years</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>7</font></div> </td> <td> <div id=3DPPTP7 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1090.htm');" id=3DPPTL7>Injectables (1)<= /a></font></div> <div id=3DPPTC7 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Improved pharmacokinetic profile :</li> <li>Biodegradable microspheres:</li> <li><span style=3D'mso-spacerun:yes'> </span>norethisterone, norgestim= ate, progesterone</li> <li>Controlled particle size distribution:</li> <li><span style=3D'mso-spacerun:yes'> </span>DMPA, levonorgestrel buta= noate</li> <br> <br> <li>Decreased side-effects :</li> <li>Monolithic macrocrystals:</li> <li><span style=3D'mso-spacerun:yes'> </span>progesterone, 17-beta- estradiol, testosterone combined for once-a-month administration</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>8</font></div> </td> <td> <div id=3DPPTP8 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1091.htm');" id=3DPPTL8>Injectables (2)<= /a></font></div> <div id=3DPPTC8 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Safer delivery system :</li> <li>Provision of Cyclofem in non-reusable disposable syringes (Uniject, Soloshot)</li> <br> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>9</font></div> </td> <td> <div id=3DPPTP9 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1092.htm');" id=3DPPTL9>Contraceptive va= ginal rings</a></font></div> <div id=3DPPTC9 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li><span style=3D'mso-spacerun:yes'> </span>Progestogen only (for continuous use)</li> <li> - Progering - Silesia (3 months)</li> <li><span style=3D'mso-spacerun:yes'> </span>- nestorone - Pop.C. (12 <span style=3D'mso-spacerun:yes'> </span>months)</li> <li><span style=3D'mso-spacerun:yes'> </span>Estrogen-progestogen <span style=3D'mso-spacerun:yes'> </span> (3 weeks in /1 week out)= </li> <li><span style=3D'mso-spacerun:yes'> </span>- Nuvaring - Organon (1 = month)</li> <li> - nestorone/EE - Pop.C. (12<br> <span style=3D'mso-spacerun:yes'> </span>months)</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>10</font></div> </td> <td> <div id=3DPPTP10 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1093.htm');" id=3DPPTL10>Transdermal sys= tems</a></font></div> <div id=3DPPTC10 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Patch releasing an estrogen and a progestogen:</li> <ul> <li>EVRA:<span style=3D'mso-spacerun:yes'> </span>norelgestromin 150 <= font face=3DSymbol>m</font><font face=3DArial>g + ethinyl estradiol 20 <= /font><font face=3DSymbol>m</font><font face=3DArial>g</font></li> <li>levonorgestrel + ethinyl estradiol</li> <li>gestodene 50 <font face=3DSymbol>m</font><font face=3DArial>g + eth= inyl estradiol 18 </font><font face=3DSymbol>m</font><font face=3DArial>= g<span style=3D'mso-spacerun:yes'> </span>(Angeliq - Schering)</font></li> <br> <br> </ul> <li>Patch releasing a progestogen:</li> <ul> <li>nestorone (also being developed as gel and spray)</li> <li>norgestimate</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>11</font></div> </td> <td> <div id=3DPPTP11 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1094.htm');" id=3DPPTL11>Natural methods= </a></font></div> <div id=3DPPTC11 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Standard days method, based on<span style=3D'mso-spacerun:yes'> </span>abstinence/protection from cycle day 8 to cycle day 19.</li> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>12</font></div> </td> <td> <div id=3DPPTP12 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1095.htm');" id=3DPPTL12>Female steriliz= ation</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>13</font></div> </td> <td> <div id=3DPPTP13 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1096.htm');" id=3DPPTL13>Male condoms</a= ></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>14</font></div> </td> <td> <div id=3DPPTP14 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1097.htm');" id=3DPPTL14>Female condoms<= /a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>15</font></div> </td> <td> <div id=3DPPTP15 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1098.htm');" id=3DPPTL15>New diaphragms<= /a></font></div> <div id=3DPPTC15 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Lea's Shield®</li> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>16</font></div> </td> <td> <div id=3DPPTP16 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1099.htm');" id=3DPPTL16>New cervical ca= ps</a></font></div> <div id=3DPPTC16 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>FemCap™</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>17</font></div> </td> <td> <div id=3DPPTP17 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1100.htm');" id=3DPPTL17>2. <span style=3D'mso-spacerun:yes'> </span>New approaches</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>18</font></div> </td> <td> <div id=3DPPTP18 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1101.htm');" id=3DPPTL18>Microbicides wi= th contraceptive action</a></font></div> <div id=3DPPTC18 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Products that create a protective physical barrier in the vagina: e.= g. Sulfated and sulfonated polymers, such as cellulose sulfate, polysty= rene sulfonate.</li> <li>Products which increase vaginal defense mechanisms by maintaining natural acidity (which immobilises sperm): e.g. BufferGel and Acidfo= rm.</li> <li>Surfactant products: e.g. acylcarnitine analogs, C31G.</li> <li>Products which block attachment of HIV to target cells and sperm - z= ona pellucida fusion: e.g. naphthyl urea derivatives.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>19</font></div> </td> <td> <div id=3DPPTP19 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1102.htm');" id=3DPPTL19>Immunocontracep= tives</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>20</font></div> </td> <td> <div id=3DPPTP20 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1103.htm');" id=3DPPTL20>Anti-progestins= for contraception</a></font></div> <div id=3DPPTC20 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Sequential regimen</li> <ul> <li>Mifepristone + Norethisterone</li> <li>Mifepristone + Medroxyprogesterone acetate</li> <li>Mifepristone (days 1-15) + nomegestrol acetate (days 16-28)</li> </ul> <li>Continuous regimen: 0,1 to 10 mg/day</li> <li>Weekly use: 2,5 to 50 mg doses</li> <li>Monthly use: 200 mg 2 days after the LH peak</li> <li>Emergency contraception: 10 mg</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>21</font></div> </td> <td> <div id=3DPPTP21 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1104.htm');" id=3DPPTL21>METHODS FOR<br> MALE CONTRACEPTION</a></font></div> <div id=3DPPTC21 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Prevent sperm production</li> <li>Prevent sperm transport</li> <li>Prevent sperm deposition</li> <li>Modify sperm function</li> <li>Prevent fertilization</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>22</font></div> </td> <td> <div id=3DPPTP22 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1105.htm');" id=3DPPTL22>Hormonal contro= l of sperm production</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>23</font></div> </td> <td> <div id=3DPPTP23 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1106.htm');" id=3DPPTL23>Methods to supr= ess sperm production</a></font></div> <div id=3DPPTC23 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Hormonal</li> <ul> <li>Testosterone esters</li> <li>progestogen or GnRH analogue + testosterone</li> </ul> <li>Immunological, based on antibodies against</li> <ul> <li>GnRH, LH, FSH, their receptors</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>24</font></div> </td> <td> <div id=3DPPTP24 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1107.htm');" id=3DPPTL24>Methods for male sterilization</a></font></div> <div id=3DPPTC24 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>- <span style=3D'mso-spacerun:yes'> </span>Permanent, with</li> <li><span style=3D'mso-spacerun:yes'> </span>sclerosing agents:</li> <li><span style=3D'mso-spacerun:yes'> </span>e.g. methylcyanoacrylate,= </li> <li><span style=3D'mso-spacerun:yes'> </span>polyurethane</li> <li>-<span style=3D'mso-spacerun:yes'> </span>Reversible, with</li> <li><span style=3D'mso-spacerun:yes'> </span>non-sclerosing agents:</l= i> <li><span style=3D'mso-spacerun:yes'> </span>e.g. silicone plugs</li> <li><span style=3D'mso-spacerun:yes'> </span>or resins:<span style=3D'mso-spacerun:yes'> </span>e.g. maleic anhydride / styrene<= /li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>25</font></div> </td> <td> <div id=3DPPTP25 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1108.htm');" id=3DPPTL25>3.<span style=3D'mso-spacerun:yes'> </span> New targets</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>26</font></div> </td> <td> <div id=3DPPTP26 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1109.htm');" id=3DPPTL26>Possible target= s</a></font></div> <div id=3DPPTC26 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li> Gametogenesis</li> <li><span style=3D'mso-spacerun:yes'> </span> Sperm motility</li> <li><span style=3D'mso-spacerun:yes'> </span> Sperm capacitation</li> <li><span style=3D'mso-spacerun:yes'> </span> Acrosomal reaction</li> <li><span style=3D'mso-spacerun:yes'> </span> Follicular development</li> <li><span style=3D'mso-spacerun:yes'> </span> Implantation</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>27</font></div> </td> <td> <div id=3DPPTP27 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1110.htm');" id=3DPPTL27><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>28</font></div> </td> <td> <div id=3DPPTP28 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1111.htm');" id=3DPPTL28>Some of the more promising leads</a></font></div> <div id=3DPPTC28 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Lonidamine analogues: deplete immature germ cells from seminiferous epithelium.</li> <li>Inhibitors of epididymal proteins: eppin and cystatin-11</li> <li>Inhibitors of testis-specific enzymes (GST, SAC)</li> <li>Inhibitors of fusion of sperm with zona pellucida: GnRH antagonists.= </li> <li>Change in endometrial receptivity: LIF antagonists; antibodies again= st LIF, IL-11, or the IL-11 receptor; ebaf.</li> <li>Anti-angiogenic agents (magainin analogues, fumagillin).</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>29</font></div> </td> <td> <div id=3DPPTP29 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide1112.htm');" id=3DPPTL29>Challenges for = the development<br> of new technologies</a></font></div> <div id=3DPPTC29 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Cost and time (10-15 years, US$ 200-300 million)</li> <li>Industry involvement</li> <li>Perspectives of users and potential users, of different religious and socio-cultural backgrounds, and of new generations of women and men<= /li> <li>Access in resource-poor settings (cost, technology)</li> </ul> </font></div> </td> </tr> </table> </div> </body> </html> ------=_NextPart_01C64DC0.ECC8CCC0 Content-Location: file:///C:/2C09C636/Future_Methods_Darcangues_2006_files/oledata.mso Content-Transfer-Encoding: base64 Content-Type: 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