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content=3D"11.03.2006: Mother-to-child transmission (MTCT) of HIV Isabelle= de Vincenzi Training Course in Reproductive Health / Sexual Health Resea= rch Geneva 2006"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"132"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide 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filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s135170" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:22.85%'><span style=3D'font-size:95%'>M= other-to-child transmission (MTCT) of HIV</span><span style=3D'font-size:90%'><br> </span></span><span style=3D'position:absolute;top:19.28%;left:5.64%; width:88.34%;height:21.42%'><span style=3D'font-size:90%'><br> </span></span><span style=3D'position:absolute;top:37.14%;left:5.64%; width:88.34%;height:21.42%'><span style=3D'font-size:90%'>Isabelle de Vinc= enzi <br> </span></span><span style=3D'position:absolute;top:55.71%;left:5.64%; width:88.34%;height:21.42%'><span style=3D'font-size:90%'><br> </span></span><span style=3D'position:absolute;top:75.0%;left:4.73%;width= :90.34%; height:13.57%'><span style=3D'font-size:57%'>Training Course in Reproducti= ve Health / Sexual Health Research<br> </span></span><span style=3D'position:absolute;top:86.42%;left:5.64%; 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style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:rect id=3D"_x0000_s29698" style=3D'position:absolute;left:37.= 75pt; 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color=3D"black"/> <v:textbox inset=3D"0,0,0,0"/> </v:rect><![if !ppt]> <div style=3D'position:absolute;top:27.04%;left:4.68%;width:99.81%;height:= 56.33%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s25603" class=3DB> <div style=3D'position:absolute;top:3.0%;left:0%;width:91.18%;height:11.0%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :117%; color:yellow;mso-color-index:3'>Mechanisms of action:</span><span lang=3DFR style=3D'display:none'> </span></div> <div style=3D'position:absolute;top:19.5%;left:0%;width:91.18%;height:9.5%= '><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'color:yellow;mso-color-index:3;font-weight:normal'><span class=3D= BB style=3D'position:absolute;left:-4.05%;top:.43em'>l</span></span><span lan= g=3DFR style=3D'color:yellow;mso-color-index:3'>Maternal component:</span><span lang=3DFR> </span></span></div> <span style=3D'position:absolute;top:34.5%;left:0%;width:100.0%;height:9.5= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR><span style=3D'mso-spacerun:yes'>    </span>Reduce viral load in mother ’s = blood, genital fluids (and </span></span><span style=3D'position:absolute;top:46.= 5%; left:3.56%;width:90.99%;height:9.5%'><span lang=3DFR>milk) during pregnanc= y, delivery (and breastfeeding) </span></span> <div style=3D'position:absolute;top:61.5%;left:0%;width:91.18%;height:9.5%= '><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'color:yellow;mso-color-index:3;font-weight:normal'><span class=3D= BB style=3D'position:absolute;left:-4.05%;top:.43em'>l</span></span><span lan= g=3DFR style=3D'color:yellow;mso-color-index:3'>Infant regimen:</span><span lang= =3DFR> </span></span></div> <span style=3D'position:absolute;top:76.5%;left:0%;width:91.18%;height:9.5= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR><span style=3D'mso-spacerun:yes'>    </span>Act as post-exposure prophylaxis (vi= ral particles<span style=3D'mso-spacerun:yes'>    </span></span></span><span style=3D'position:absolute;top:89.0%;left:3.56%;width:87.8%;height:9.5%'><= span lang=3DFR>eventually transmitted during birth are eliminated)</span></span= ></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s25604" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><![if !ppt]> <div 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[1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30730" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:25.625pt;top:387.25pt;width:63.875pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30731" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:185.875pt;top:157.125pt;width:283.375pt;height:25pt' fillcolor=3D"si= lver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30732" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:185pt;top:203.5pt;width:166pt;height:25pt' fillcolor=3D"white [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30733" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:208.375pt;top:289.625pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30723" class=3DO style=3D'text-align:center;positi= on:absolute; top:22.81%;left:29.77%;width:16.29%;height:5.35%'><span lang=3DFR><b>Anten= atal</b></span></div> <div v:shape=3D"_x0000_s30724" class=3DO style=3D'text-align:center;positi= on:absolute; top:23.09%;left:54.68%;width:20.03%;height:5.35%'><span lang=3DFR><b>Intra= partum</b></span><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></d= iv> <div v:shape=3D"_x0000_s30725" class=3DO style=3D'text-align:center;positi= on:absolute; top:22.81%;left:75.09%;width:18.16%;height:5.35%'><span lang=3DFR><b>Postn= atal</b></span><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></d= iv> <div v:shape=3D"_x0000_s30726" class=3DO style=3D'position:absolute;top:30= .42%; left:3.74%;width:15.54%;height:5.35%'><span lang=3DFR style=3D'color:yello= w; mso-color-index:3'><b>ZDV long</b></span></div> <div v:shape=3D"_x0000_s30727" class=3DO style=3D'position:absolute;top:39= .43%; left:3.55%;width:16.85%;height:5.35%'><span lang=3DFR style=3D'color:yello= w; mso-color-index:3'><b>ZDV short</b></span></div> <div v:shape=3D"_x0000_s30728" class=3DO style=3D'position:absolute;top:56= .9%; left:3.74%;width:21.91%;height:5.35%'><span lang=3DFR style=3D'color:yello= w; mso-color-index:3'><b>ZDV+3TC (1)</b></span></div> <div v:shape=3D"_x0000_s30729" class=3DO style=3D'position:absolute;top:66= .76%; left:3.74%;width:21.91%;height:5.35%'><span lang=3DFR style=3D'color:yello= w; mso-color-index:3'><b>ZDV+3TC (2)</b></span></div> <div v:shape=3D"_x0000_s30730" class=3DO style=3D'position:absolute;top:74= .36%; left:4.11%;width:7.67%;height:5.35%'><span lang=3DFR style=3D'color:yellow; mso-color-index:3'><b>NVP</b></span></div> <div v:shape=3D"_x0000_s30731" class=3DO><span style=3D'position:absolute; top:30.7%;left:24.53%;width:34.08%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30732" class=3DO><span style=3D'position:absolute; top:39.43%;left:24.34%;width:19.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30733" class=3DO><span style=3D'position:absolute; top:55.77%;left:27.15%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30734" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:187.125pt;top:295.875pt;width:166pt;height:25pt' fillcolor=3D"white = [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30735" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:200.125pt;top:337.375pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30734" class=3DO><span style=3D'position:absolute; top:56.9%;left:24.53%;width:19.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30735" class=3DO><span style=3D'position:absolute; top:65.07%;left:26.21%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30736" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:186.125pt;top:346.5pt;width:281.625pt;height:25pt' fillcolor=3D"whit= e [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30737" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:190.625pt;top:379.625pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30736" class=3DO><span style=3D'position:absolute; top:66.76%;left:24.53%;width:33.7%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30737" class=3DO><span style=3D'position:absolute; top:72.95%;left:24.9%;width:.18%;height:5.35%'><span lang=3DFR style=3D'ms= o-special-format: lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30738" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:185.875pt;top:388.375pt;width:283.125pt;height:25pt' fillcolor=3D"wh= ite [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30739" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:448.375pt;top:382.375pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30740" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:495.25pt;top:391.625pt;width:44.5pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30741" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:426.5pt;top:179.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30738" class=3DO><span style=3D'position:absolute; top:74.64%;left:24.53%;width:33.89%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30739" class=3DO><span style=3D'position:absolute; top:73.52%;left:57.49%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s30740" class=3DO><span style=3D'position:absolute; top:75.21%;left:63.48%;width:3.74%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30741" class=3DO><span style=3D'position:absolute; top:34.92%;left:54.68%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30742" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:494pt;top:156.875pt;width:46pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30743" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:403.375pt;top:231pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30744" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:410.125pt;top:277.375pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30745" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:602.375pt;top:175.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30742" class=3DO><span style=3D'position:absolute; top:30.7%;left:63.29%;width:3.93%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30743" class=3DO><span style=3D'position:absolute; top:44.78%;left:51.87%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s30744" class=3DO><span style=3D'position:absolute; top:53.52%;left:52.62%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s30745" class=3DO><span style=3D'position:absolute; top:34.08%;left:76.96%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30746" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:559.375pt;top:156.875pt;width:212.875pt;height:25pt' fillcolor=3D"si= lver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30747" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:579.25pt;top:224.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30746" class=3DO style=3D'text-align:center;positi= on:absolute; top:30.7%;left:71.53%;width:25.09%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;color:#000306'>Infant</span><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></div> <div v:shape=3D"_x0000_s30747" class=3DO><span style=3D'position:absolute; top:43.38%;left:73.97%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30748" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:560.625pt;top:204.25pt;width:212.875pt;height:25pt' strokecolor=3D"y= ellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30749" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:558.75pt;top:379.625pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30750" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:565.625pt;top:280.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30748" class=3DO><span style=3D'position:absolute; top:39.71%;left:71.72%;width:25.09%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30749" class=3DO><span style=3D'position:absolute; top:72.95%;left:71.53%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s30750" class=3DO><span style=3D'position:absolute; top:54.08%;left:72.28%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30751" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:559.125pt;top:295.25pt;width:99.875pt;height:25pt' fillcolor=3D"silv= er" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30752" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:669.25pt;top:285.5pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30753" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:562.875pt;top:329.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30751" class=3DO style=3D'text-align:center;positi= on:absolute; top:56.9%;left:70.59%;width:12.73%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;color:#000306'>Infant+Mother</span><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></div> <div v:shape=3D"_x0000_s30752" class=3DO><span style=3D'position:absolute; top:55.21%;left:85.39%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s30753" class=3DO><span style=3D'position:absolute; top:63.38%;left:71.91%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30754" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:557.875pt;top:347.125pt;width:99.875pt;height:25pt' fillcolor=3D"sil= ver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30755" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:661pt;top:329.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30754" class=3DO style=3D'position:absolute;top:66= .76%; left:71.34%;width:12.73%;height:3.09%'><span lang=3DFR style=3D'font-size:= 58%; color:#000306'>Infant+Mother</span></div> <div v:shape=3D"_x0000_s30755" class=3DO><span style=3D'position:absolute; top:63.38%;left:84.45%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30756" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:655.25pt;top:346.75pt;width:117.5pt;height:25pt' fillcolor=3D"white = [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30757" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:671.875pt;top:280.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30756" class=3DO><span style=3D'position:absolute; top:66.76%;left:83.7%;width:13.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30757" class=3DO><span style=3D'position:absolute; top:54.08%;left:85.76%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30758" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:656pt;top:295.5pt;width:117.5pt;height:25pt' fillcolor=3D"white [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30759" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:328.375pt;top:235.125pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30758" class=3DO><span style=3D'position:absolute; top:56.9%;left:83.89%;width:13.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30759" class=3DO><span style=3D'position:absolute; top:45.63%;left:42.32%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30760" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:351.5pt;top:203.25pt;width:116.125pt;height:25pt' fillcolor=3D"silve= r" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30760" class=3DO><span style=3D'position:absolute; top:39.43%;left:45.31%;width:12.92%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <v:shape id=3D"_x0000_s30761" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:352.75pt;top:296.375pt;width:116.125pt;height:25pt' fillcolor=3D"sil= ver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30762" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:159.75pt;top:494.875pt;width:59pt;height:31.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30763" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:323.625pt;top:494pt;width:59pt;height:31.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30764" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:423.875pt;top:480.875pt;width:87.75pt;height:48pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]" strokewe= ight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D",0,,0"/> </v:shape><v:shape id=3D"_x0000_s30765" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:503.625pt;top:497.375pt;width:84.375pt;height:31.25pt;mso-wrap-style= :none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30766" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:554.375pt;top:475.75pt;width:55.5pt;height:31.25pt;mso-wrap-style:no= ne; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30767" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:617.875pt;top:480.75pt;width:76.25pt;height:21.625pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30768" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:699.125pt;top:475.125pt;width:92.875pt;height:31.25pt;mso-wrap-style= :none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30761" class=3DO><span style=3D'position:absolute; top:57.18%;left:45.5%;width:12.92%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30762" class=3DO style=3D'position:absolute;top:94= .64%; left:21.16%;width:6.92%;height:4.5%'><span lang=3DFR style=3D'font-size:83= %'>14wk</span></div> <div v:shape=3D"_x0000_s30763" class=3DO style=3D'position:absolute;top:94= .64%; left:41.76%;width:6.92%;height:4.5%'><span lang=3DFR style=3D'font-size:83= %'>36wk</span></div> <div v:shape=3D"_x0000_s30764" class=3DO><span style=3D'position:absolute; top:91.26%;left:54.49%;width:10.48%;height:4.5%'><span lang=3DFR style=3D'font-size:83%'>Onset of </span></span><span style=3D'position:abs= olute; top:96.05%;left:54.49%;width:9.36%;height:4.5%'><span lang=3DFR style=3D'font-size:83%'>labour</span></span></div> <div v:shape=3D"_x0000_s30765" class=3DO style=3D'position:absolute;top:95= .21%; left:64.41%;width:10.86%;height:4.5%'><span lang=3DFR style=3D'font-size:8= 3%'>Delivery</span></div> <div v:shape=3D"_x0000_s30766" class=3DO style=3D'position:absolute;top:90= .98%; left:70.97%;width:6.36%;height:4.5%'><span lang=3DFR style=3D'font-size:83= %'>Birth</span></div> <div v:shape=3D"_x0000_s30767" class=3DO style=3D'mso-line-spacing:"60 0 0= "; position:absolute;top:90.7%;left:78.83%;width:9.55%;height:4.5%'><span lang=3DFR style=3D'font-size:83%'>1wk PP</span></div> <div v:shape=3D"_x0000_s30768" class=3DO style=3D'position:absolute;top:90= .98%; left:89.13%;width:11.98%;height:4.5%'><span lang=3DFR style=3D'font-size:8= 3%'>4-6wk PP</span></div> <v:shapetype id=3D"_x0000_t68" coordsize=3D"21600,21600" o:spt=3D"68" adj= =3D"5400,5400" path=3D"m0@0l@1@0@1,21600@2,21600@2@0,21600@0,10800,xe"> <v:stroke joinstyle=3D"miter"/> <v:formulas> <v:f eqn=3D"val #0"/> <v:f eqn=3D"val #1"/> <v:f eqn=3D"sum 21600 0 #1"/> <v:f eqn=3D"prod #0 #1 10800"/> <v:f eqn=3D"sum #0 0 @3"/> </v:formulas> <v:path o:connecttype=3D"custom" o:connectlocs=3D"10800,0;0,@0;10800,2160= 0;21600,@0" o:connectangles=3D"270,180,90,0" textboxrect=3D"@1,@4,@2,21600"/> <v:handles> <v:h position=3D"#1,#0" xrange=3D"0,10800" yrange=3D"0,21600"/> </v:handles> </v:shapetype><v:shape id=3D"_x0000_s30769" type=3D"#_x0000_t68" style=3D'= position:absolute; left:559.125pt;top:460.25pt;width:8.5pt;height:15.375pt;mso-wrap-style:no= ne; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30770" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:652.875pt;top:461.375pt;width:8.5pt;height:15.375pt;mso-wrap-style:n= one; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30771" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:766.25pt;top:462.75pt;width:8.5pt;height:15.375pt;mso-wrap-style:non= e; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30772" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:180.625pt;top:458pt;width:12.25pt;height:35.875pt;mso-wrap-style:non= e; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30773" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:534pt;top:460.5pt;width:12.25pt;height:35.875pt;mso-wrap-style:none; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30774" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:349.875pt;top:456.25pt;width:7.125pt;height:29.75pt;mso-wrap-style:n= one; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30775" type=3D"#_x0000_t68" style=3D'posi= tion:absolute; left:488pt;top:458.875pt;width:10.75pt;height:20.875pt;mso-wrap-style:non= e; v-text-anchor:middle' fillcolor=3D"yellow [4]" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:shape><v:shape id=3D"_x0000_s30776" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:494pt;top:204.875pt;width:46pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30776" class=3DO><span style=3D'position:absolute; top:39.71%;left:63.29%;width:3.93%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <v:shape id=3D"_x0000_s30777" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:495pt;top:295.5pt;width:46pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30778" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:494pt;top:347.875pt;width:46pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30780" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:590pt;top:348.25pt;width:14.5pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30777" class=3DO><span style=3D'position:absolute; top:56.9%;left:63.48%;width:3.93%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30778" class=3DO><span style=3D'position:absolute; top:66.76%;left:63.29%;width:3.93%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30780" class=3DO><span style=3D'position:absolute; top:67.04%;left:75.46%;width:.18%;height:5.35%'><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <v:shape id=3D"_x0000_s30781" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:653.625pt;top:392.75pt;width:117.5pt;height:25pt' fillcolor=3D"white= [1]" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30782" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:554.875pt;top:393pt;width:99.875pt;height:25pt' fillcolor=3D"silver" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30783" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:22.25pt;top:428.75pt;width:140.25pt;height:36pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30781" class=3DO><span style=3D'position:absolute; top:75.49%;left:83.52%;width:13.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <div v:shape=3D"_x0000_s30782" class=3DO style=3D'text-align:center;positi= on:absolute; top:75.49%;left:70.97%;width:10.86%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;color:#000306'>Infant</span></div> <div v:shape=3D"_x0000_s30783" class=3DO style=3D'position:absolute;top:82= .25%; left:3.74%;width:19.28%;height:5.35%'><span lang=3DFR style=3D'color:yello= w; mso-color-index:3'><b>ZDV + NVP</b></span></div> <v:shape id=3D"_x0000_s30784" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:185.75pt;top:429.125pt;width:166pt;height:25pt' fillcolor=3D"white [= 1]" strokecolor=3D"yellow [3]" 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class=3DO><span style=3D'position:absolute; top:48.16%;left:83.7%;width:13.1%;height:3.09%'><span lang=3DFR style=3D'font-size:58%;mso-special-format:lastCR;display:none'> </span= ></span></div> <v:shape id=3D"_x0000_s30795" type=3D"#_x0000_t202" style=3D'position:abso= lute; left:556.375pt;top:249.5pt;width:162.75pt;height:25pt' fillcolor=3D"silve= r" strokecolor=3D"yellow [3]" strokeweight=3D"1pt"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s30796" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:267.625pt;top:484.375pt;width:59pt;height:31.25pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s30795" class=3DO style=3D'text-align:center;positi= on:absolute; 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<![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0026.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0026= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Ivory Coast Short-Course ZDV Trials: Combined Analys= is Through 24 Months Witkor S. XIII AIDS Conf, July 2000, Durban S Africa = (TuOrB354)"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"45"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s46082" type=3D"#_x0000_m1026" style=3D'position:absolute;left:58.625pt;top:23.5p= t; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0027= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D11.03.2006> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0048= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: ANRS Abidjan - 6 wks Tx rat= es"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"90"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s92162" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:4.68%;width:91.01%;height:1= 4.92%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s92162" class=3DT style=3D'position:absolute;top:16= .98%; left:0%;width:99.79%;height:62.26%'><span lang=3DFR>ANRS Abidjan - 6 wks Tx rates</span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s92163" type=3D"#_x0000_m1028" style=3D'position:absolute;left:39.125pt;top:204.2= 5pt; width:719.375pt;height:210.25pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:38.59%;left:4.86%;width:97.94%;height:= 40.28%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s92163" class=3DB> <div style=3D'mso-line-spacing:"165 30 0";position:absolute;top:9.09%; left:0%;width:100.0%;height:13.98%'><span style=3D'position:absolute;top:0= %; left:3.63%;width:96.55%;height:100.0%'><span style=3D'font-size:108%;font-= weight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.76%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span lang=3DFR style=3D'font-size:108%'>DITRAME <span style=3D'mso-tab-count:1; width:8.46%'> </span>(ZDV 36wks-delivery)<span style=3D'mso-tab-count:2; width:13.1%'> </span>12.8% </span></span></div> <div style=3D'mso-line-spacing:"165 30 0";position:absolute;top:37.76%; left:0%;width:100.0%;height:13.98%'><span style=3D'position:absolute;top:0= %; left:3.63%;width:96.55%;height:100.0%'><span style=3D'font-size:108%;font-= weight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.76%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span lang=3DFR style=3D'font-size:108%'>DITRAME+<span style=3D'mso-tab-count:1; width:7.4%'> </span>(ZDV + HIVNET012)<span style=3D'mso-tab-count:2;width:= 16.32%'> </span><span style=3D'mso-spacerun:yes'>  </span>6.2% </span></span></= div> <div style=3D'mso-line-spacing:"165 30 0";position:absolute;top:66.43%; left:0%;width:100.0%;height:13.98%'><span style=3D'position:absolute;top:0= %; left:3.63%;width:96.55%;height:100.0%'><span style=3D'font-size:108%;font-= weight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.76%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span lang=3DFR style=3D'font-size:108%'>DITRAME++<span style=3D'mso-tab-count:1; width:5.39%'> </span>(Combivir + HIVNET012)<span style=3D'mso-tab-count:1; width:8.21%'> </span><span style=3D'mso-spacerun:yes'>  </span>4.8%</span>= </span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0040.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0040= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Thailand Perinatal Prevention (1) Short-Course AZT T= rial Results "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"72"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s73730" type=3D"#_x0000_m1026" style=3D'position:absolute;left:62.75pt;top:17.875= pt; 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left:326.375pt;top:134.375pt;width:31pt;height:28.625pt;mso-wrap-style:no= ne; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s73754" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:399pt;top:134.375pt;width:92pt;height:28.625pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s73743" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:32.95%;left:71.72%;width:23.= 78%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>Most Effective </b></span></div> <div class=3DO style=3D'position:absolute;top:38.3%;left:71.72%;width:26.2= 1%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>(Tx<span style=3D'mso-spacerun:yes'>  </span>4% [vs SS])</b></span></div> </div> <div v:shape=3D"_x0000_s73744" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:69.85%;left:71.72%;width:25.= 65%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>Least Eff= ective </b></span></div> <div class=3DO style=3D'position:absolute;top:74.92%;left:71.72%;width:21.= 34%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>(Tx 11%)&= #13;</b></span></div> <div class=3DO style=3D'position:absolute;top:80.28%;left:71.72%;width:21.= 34%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%;mso-special-f= ormat: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73745" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:45.35%;left:71.72%;width:20.= 97%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>Intermedi= ate </b></span></div> <div class=3DO style=3D'position:absolute;top:50.42%;left:71.72%;width:17.= 41%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>(Tx<span style=3D'mso-spacerun:yes'>  </span>5%) </b></span></div> <div class=3DO style=3D'position:absolute;top:55.77%;left:71.72%;width:17.= 41%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%;mso-special-f= ormat: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73746" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:57.46%;left:71.72%;width:20.= 97%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>Intermedi= ate </b></span></div> <div class=3DO style=3D'position:absolute;top:62.81%;left:71.72%;width:17.= 41%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%'><b>(Tx<span style=3D'mso-spacerun:yes'>  </span>9%) </b></span></div> <div class=3DO style=3D'position:absolute;top:67.88%;left:71.72%;width:17.= 41%; height:5.07%'><span style=3D'font-family:Arial;font-size:96%;mso-special-f= ormat: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73748" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:34.08%;lef= t:4.11%; width:7.86%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'>= <b>Long- </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:38.3%;left= :4.49%; width:6.92%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'>= <b>Long </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:42.25%;lef= t:4.68%; width:6.55%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%; mso-special-format:lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73749" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:39.71%;lef= t:.93%; width:11.79%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'= ><b>Long- </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:43.94%;lef= t:.93%; width:11.79%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'= ><b>Short </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:47.88%;lef= t:.93%; width:11.79%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%; mso-special-format:lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73750" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:58.59%;left:5.05%;width:8.23= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Short-= 3;</b></span></div> <div class=3DO style=3D'position:absolute;top:62.81%;left:5.05%;width:6.92= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Long = </b></span></div> <div class=3DO style=3D'position:absolute;top:66.76%;left:5.05%;width:6.92= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%;mso-special-f= ormat: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73751" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:69.57%;left:5.05%;width:8.23= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Short-= 3;</b></span></div> <div class=3DO style=3D'position:absolute;top:73.8%;left:5.05%;width:7.3%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Short = ;</b></span></div> <div class=3DO style=3D'position:absolute;top:78.02%;left:5.05%;width:6.92= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%;mso-special-f= ormat: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s73752" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:26.47%;lef= t:24.71%; width:3.93%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'>= <b><u>AP</u></b></span></div> </div> <div v:shape=3D"_x0000_s73753" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:26.47%;lef= t:41.94%; width:2.8%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><= b><u>IP</u></b></span></div> </div> <div v:shape=3D"_x0000_s73754" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:26.47%;lef= t:50.18%; width:11.98%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'= ><b><u>PP Infant</u></b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0050.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; 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//--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"93"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s95234" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:67.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:.56%;width:99.25%;height:13= .23%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s95234" class=3DT style=3D'position:absolute;top:14= .89%; left:0%;width:100.0%;height:63.82%'><span style=3D'font-size:90%'><span style=3D'mso-spacerun:yes'> </span>Perinatal HIV Prevention Trial – Thaila= nd (2) </span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s95235" type=3D"#_x0000_m1028" style=3D'position:absolute;left:37.75pt;top:121.12= 5pt; width:719.375pt;height:357.75pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:22.81%;left:4.68%;width:105.99%;height= :68.16%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s95235" class=3DB> <div style=3D'position:absolute;top:2.06%;left:0%;width:85.86%;height:7.85= %'><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;l= eft:-4.05%; top:.43em'>l</span></span><span lang=3DEN-GB>All women received ZDV from 28weeks </span></span></div> <div style=3D'position:absolute;top:14.46%;left:0%;width:85.86%;height:7.8= 5%'><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;l= eft:-4.05%; top:.43em'>l</span></span><span lang=3DEN-GB>All new-borns received 1 week ZDV </span></span></div> <span style=3D'position:absolute;top:26.85%;left:0%;width:90.45%;height:7.= 85%'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DEN-GB style=3D'color:= yellow; mso-color-index:3'>Randomisation in 3 arms according to SD-NVP given to </= span></span><span style=3D'position:absolute;top:37.19%;left:3.35%;width:82.68%;height:7.85%= '><span lang=3DEN-GB style=3D'color:yellow;mso-color-index:3'>mother and child, mo= ther only, no NVP:</span><span style=3D'color:yellow;mso-color-index:3;display:= none'> </span></span> <div style=3D'position:absolute;top:49.58%;left:0%;width:87.8%;height:7.85= %'><span style=3D'position:absolute;top:0%;left:3.82%;width:96.37%;height:100.0%'><= span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;l= eft:-3.96%; top:.43em'>l</span></span>Nevirapine-Nevirapine arm - Tx rate 2.0% (1.2 to 3.4) </span></div> <div style=3D'position:absolute;top:61.98%;left:0%;width:85.86%;height:7.8= 5%'><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;l= eft:-4.05%; top:.43em'>l</span></span>Nevirapine-Placebo arm – Tx rate 2.8% (1.8 to 4.4) </span></div> <span style=3D'position:absolute;top:74.38%;left:3.35%;width:96.81%;height= :7.85%'><span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;l= eft:-3.46%; top:.43em'>l</span></span><span style=3D'mso-spacerun:yes'> </span>Placebo-Placebo arm – Tx rate 6.3% (4.2= to 9.5), stopped at </span><span style=3D'position:absolute;top:84.29%;left:3= .35%; width:82.68%;height:7.85%'>interim analysis</span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0038.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0038= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: ARV Use and HIV Transmission (WITS, USA)"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><p:slidetransition advancetime=3D"0" speed= =3D"1" effect=3D"zoom" direction=3D"in" flag=3D"1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"69"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden;filter:revealtrans(Duration=3D2, Transition=3D0)'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s70658" type=3D"#_x0000_m1026" style=3D'position:absolute;left:118.75pt;top:23.5p= t; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0034= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D11.03.2006> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0049= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Infant PEP - Women who have not received an ante-par= tum regimen"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"92"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s94210" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:4.78%;left:-3.37%;width:107.11%;height= :17.18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s94210" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:54.09%'><span lang=3DFR>Infant PEP - Wo= men who have not received </span></span><span style=3D'position:absolute;top:4= 5.9%; left:7.51%;width:84.79%;height:54.09%'><span lang=3DFR>an ante-partum regi= men</span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s94211" type=3D"#_x0000_m1028" style=3D'position:absolute;left:36.375pt;top:147.8= 75pt; width:719.375pt;height:361.75pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:27.88%;left:4.68%;width:107.67%;height= :69.01%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s94211" class=3DB> <div style=3D'mso-line-spacing:"145 30 0"'><span style=3D'position:absolut= e; top:4.08%;left:3.13%;width:85.39%;height:8.97%'><span style=3D'font-size:1= 17%; font-weight:normal'><span style=3D'mso-special-format:bullet;color:#FC0128; position:absolute;left:-3.66%;top:.43em;font-family:"Monotype Sorts"; font-size:68%'>l</span></span><span lang=3DFR style=3D'font-size:117%'>Wad= e (NY city)<span style=3D'mso-tab-count:1;width:8.89%'> </span>:<span style=3D'mso-tab-count:1;width:8.59%'> </span>6 weeks ZDV started<span style=3D'mso-spacerun:yes'>                               </span></span></= span><span style=3D'position:absolute;top:17.55%;left:3.13%;width:81.39%;height:8.97%= '><span lang=3DFR style=3D'font-size:117%'><span style=3D'mso-tab-count:5;width:47= .97%'> </span>within 48h of birth </span></span></div> <div style=3D'mso-line-spacing:"145 30 0";position:absolute;top:33.46%; left:0%;width:100.0%;height:8.97%'><span style=3D'position:absolute;top:0%; left:3.13%;width:96.69%;height:100.0%'><span style=3D'font-size:117%;font-= weight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.23%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span lang=3DFR style=3D'font-size:117%'>Gray (SA)<span style=3D'mso-tab-count:2; width:15.97%'> </span>: <span style=3D'mso-tab-count:1;width:6.65%'> </spa= n>1 week ZDV or 1 dose NVP </span></span></div> <div style=3D'mso-line-spacing:"145 30 0";position:absolute;top:49.79%; left:0%;width:84.52%;height:8.97%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DFR style=3D'font-size:117%'><span style=3D'mso-tab-count:6;width:49= .94%'> </span>(equivalent) </span></div> <div style=3D'mso-line-spacing:"145 30 0"'><span style=3D'position:absolut= e; top:66.12%;left:3.13%;width:95.13%;height:8.97%'><span style=3D'font-size:= 117%; font-weight:normal'><span style=3D'mso-special-format:bullet;color:#FC0128; position:absolute;left:-3.29%;top:.43em;font-family:"Monotype Sorts"; font-size:68%'>l</span></span><span lang=3DFR style=3D'font-size:117%'>Tah= a-Taha (Malawi): <span style=3D'mso-tab-count:1;width:7.04%'> </span>1 week ZDV += 1 dose NVP </span></span><span style=3D'position:absolute;top:79.18%;left:3.= 13%; width:90.6%;height:8.97%'><span lang=3DFR style=3D'font-size:117%'><span style=3D'mso-tab-count:5;width:43.09%'> </span>(better than NVP alone)</sp= an></span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0051.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0051= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Studies of Resistance in PMTCT trials using NVP"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style> .CB {color:white;} .CT {color:#FAFD00;} </style> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"94"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s96258" type=3D"#_x0000_m1026" style=3D'position:absolute;left:59.375pt;top:164pt; width:673.25pt;height:113.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"centerTitle"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:30.98%;left:3.18%;width:93.82%;height:= 21.97%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s96258" class=3DCT><span style=3D'position:absolute; top:8.97%;left:0%;width:100.0%;height:42.3%'>Studies of Resistance in PMTCT trials </span><span style=3D'position:absolute;top:44.87%;left:4.59%;width= :90.81%; height:42.3%'>using NVP</span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s96259" type=3D"#_x0000_m1028" style=3D'position:absolute;left:118.75pt;top:299pt; width:554.5pt;height:134.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"subTitle" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:56.61%;left:14.98%;width:70.22%;height= :25.91%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s96259" class=3DCB> <div style=3D'position:absolute;top:5.43%;left:0%;width:100.0%;height:20.6= 5%'>PACTG 316, HIVNET 012, </div> <div style=3D'position:absolute;top:38.04%;left:0%;width:100.0%;height:20.= 65%'>SAINT, HIVNET 023, and Peri-3</div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0052.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0052= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: PACTG 316 Schema, Results : SD NVP Did Not Improve E= fficacy of Longer or More Complex ARV Regimens Dorenbaum A et al. JAMA 200= 2;288:189-98 [LMofenson slide] "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"95"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s97282" type=3D"#_x0000_m1026" style=3D'position:absolute;left:26.375pt;top:14.62= 5pt; width:732.625pt;height:85pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:2.81%;left:-5.24%;width:109.92%;height= :16.61%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s97282" class=3DT style=3D'mso-line-spacing:"90 0 0= "'><span style=3D'position:absolute;top:3.38%;left:0%;width:100.0%;height:33.89%'><= span style=3D'font-size:60%'>PACTG 316 Schema, Results : SD NVP Did Not Improve Efficacy of Longer </span></span><span style=3D'position:absolute;top:33.8= 9%; left:7.83%;width:84.32%;height:33.89%'><span style=3D'font-size:60%'>or Mo= re Complex ARV Regimens<br> </span></span><span style=3D'position:absolute;top:64.4%;left:7.83%;width= :84.32%; height:28.81%'><span style=3D'font-size:50%;color:white;mso-color-index:1'= ><b><i>Dorenbaum A et al.<span style=3D'mso-spacerun:yes'>  </span>JAMA 2002;288:189-98<span style=3D'mso-spacerun:yes'>  </span></i></b></span><span style=3D'font-siz= e:45%; 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left:594pt;top:243.625pt;width:191.375pt;height:243.125pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]" strokewe= ight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s97291" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:23.5pt;top:275.625pt;width:143.625pt;height:161.75pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s97283" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:28.73%;lef= t:2.05%; width:29.02%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>Women receiving </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:34.08%;lef= t:4.49%; width:24.15%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>ARV during </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:39.15%;lef= t:4.49%; width:24.15%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>Pregnancy </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:44.5%;left= :4.49%; width:24.15%;height:4.5%'><span style=3D'font-family:Arial;font-size:83%'>= <b>(NNRTI naïve)</b></span></div> </div> <div v:shape=3D"_x0000_s97284" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:28.73%;lef= t:32.39%; width:15.16%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>Continue </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:34.08%;lef= t:33.7%; width:12.73%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>ARV</b></span></div> </div> <div v:shape=3D"_x0000_s97285" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:28.73%;lef= t:52.62%; width:18.91%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>6 Wks AZT </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:34.08%;lef= t:53.74%; width:16.66%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>Perinatal </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:39.43%;lef= t:52.05%; width:19.85%;height:5.07%'><span style=3D'font-family:Arial;font-size:96%'= ><b>Prophylaxis</b></span></div> </div> <div v:shape=3D"_x0000_s97286" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:47.6%;left= :30.14%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>200 mg </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:53.23%;lef= t:28.65%; width:22.47%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>dose of NVP </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:59.15%;lef= t:30.14%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:64.78%;lef= t:30.14%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:70.42%;lef= t:30.14%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>vs </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:76.05%;lef= t:30.14%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:81.69%;lef= t:28.08%; width:23.59%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>NVP Placebo</b></span></div> </div> <div v:shape=3D"_x0000_s97287" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:47.6%;left= :54.11%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>2 mg/kg </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:53.23%;lef= t:52.62%; width:22.47%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>dose of NVP </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:59.15%;lef= t:54.11%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>@ 48-72 hr </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:64.78%;lef= t:54.11%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:70.42%;lef= t:54.11%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>vs </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:76.05%;lef= t:54.11%; width:19.66%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:81.69%;lef= t:52.05%; width:23.59%;height:5.63%'><span style=3D'font-family:Arial;font-size:104%= '><b>NVP Placebo </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:87.6%;left= :54.11%; width:19.66%;height:7.6%'><span style=3D'font-family:Arial;font-size:146%; mso-special-format:lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s97288" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:25.07%;lef= t:73.03%; width:26.77%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%; color:#FFBF3C'><b>Transmission </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:31.26%;lef= t:75.28%; width:22.28%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%; color:#FFBF3C'><b><u>Rates</u></b></span></div> </div> <div v:shape=3D"_x0000_s97289" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:20.0%;left:13.85%;width:78.4= 6%; height:7.6%'><span style=3D'font-family:Arial;font-size:113%;color:#CC0000= '><b><u>Pregnancy</u></b></span><span style=3D'font-family:Arial;font-size:113%;color:#CC0000'><b><span style=3D'mso-spacerun:yes'>      </span></b></span><span style=3D'font-fam= ily: Arial;font-size:113%;color:#CC0000'><b><u>Labor</u></b></span><span style=3D'font-family:Arial;font-size:113%;color:#CC0000'><b><span style=3D'mso-spacerun:yes'>        </span></b></span><span style=3D'font-f= amily: Arial;font-size:113%;color:#CC0000'><b><u>Newborn</u></b></span><span style=3D'font-family:Arial;font-size:146%;color:#CC0000'><b><span style=3D'mso-spacerun:yes'>  </span><span style=3D'mso-tab-count:1;width:6= .37%'> </span></b></span></div> </div> <div v:shape=3D"_x0000_s97290" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:47.32%;lef= t:75.84%; width:22.65%;height:7.6%'><span style=3D'font-family:Arial;font-size:146%; color:#FFBF3C'><b>1.4% </b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 0 10";posi= tion: absolute;top:54.92%;left:75.65%;width:23.03%;height:4.78%'><span style=3D'font-family:Arial;font-size:92%;color:#FFBF3C'><b>(95% CI, 1-3%)&= #13;</b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 0 10";posi= tion: absolute;top:60.84%;left:75.84%;width:22.47%;height:7.6%'><span style=3D'font-family:Arial;font-size:146%;color:#FFBF3C;display:none'><b>&= #13;</b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 0 10";posi= tion: absolute;top:69.57%;left:75.84%;width:22.47%;height:7.6%'><span style=3D'font-family:Arial;font-size:146%;color:#FFBF3C;display:none'><b>&= #13;</b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 0 10";posi= tion: absolute;top:78.3%;left:75.84%;width:22.65%;height:7.6%'><span style=3D'font-family:Arial;font-size:146%;color:#FFBF3C'><b>1.6% </b><= /span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:86.76%;lef= t:75.65%; width:23.03%;height:4.78%'><span style=3D'font-family:Arial;font-size:92%; color:#FFBF3C'><b>(95% CI, 1-3%)</b></span></div> </div> <div v:shape=3D"_x0000_s97291" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:845'= ></div> <div class=3DO4 style=3D'mso-margin-left-alt:1408;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:53.2= 3%; left:3.93%;width:18.91%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>Randomize, </b></span></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:58.3= %; left:3.93%;width:20.22%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>stratified by: </b></span></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:63.0= 9%; left:3.93%;width:17.6%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>1) AP ARV </b></span></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:68.1= 6%; left:3.93%;width:18.16%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>(no, mono, </b></span></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:73.2= 3%; left:3.93%;width:16.85%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>combo) </b></span></div> <div class=3DO style=3D'mso-margin-left-alt:282;position:absolute;top:78.0= 2%; left:3.93%;width:20.22%;height:4.78%'><span style=3D'font-family:Arial; font-size:92%'><b>2) Entry CD4</b></span></div> </div> <v:line id=3D"_x0000_s97293" style=3D'position:absolute;flip:y' from=3D"17= 0.125pt,299pt" to=3D"217.125pt,363.5pt" strokecolor=3D"#03c" strokeweight=3D"2pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= =3D"block" endarrowwidth=3D"wide" endarrowlength=3D"long"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s97294" style=3D'position:absolute' from=3D"= 170.125pt,375.25pt" to=3D"237.625pt,422.25pt" strokecolor=3D"#114ffb [5]" strokeweight=3D"2pt= "> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= =3D"block" endarrowwidth=3D"wide" endarrowlength=3D"long"/> <v:shadow color=3D"white [2]"/> </v:line></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0054.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0054= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Incidence of NVP Resistance at 6 Weeks PP in Subst= udy of Women Receiving ARV in PACTG 316 Cunningham C et al. J Infect Dis = 2002;186:181-8 [L Mofenson slide]"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"98"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s100354" type=3D"#_x0000_m1026" style=3D'position:absolute;left:6.625pt;top:17.625= pt; width:772.125pt;height:87.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.38%;left:.74%;width:97.75%;height:17= .18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s100354" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:37.7%'><span style=3D'font-size:69%'><b= ><i>Incidence</i></b></span><span style=3D'font-size:69%'> of NVP Resistance at 6 Weeks PP <br> </span></span><span style=3D'position:absolute;top:32.78%;left:0%;width:1= 00.0%; height:37.7%'><span style=3D'font-size:69%'>in<span style=3D'mso-spacerun:= yes'>  </span>Substudy of Women Receiving ARV in<span style=3D'mso-spacerun:yes'>  </span>PACTG 316</span><span style=3D'font-size:90%'><br> </span></span><span style=3D'position:absolute;top:65.57%;left:0%;width:1= 00.0%; height:27.86%'><span style=3D'font-size:50%;color:white;mso-color-index:1'= ><b><i>Cunningham C et al.<span style=3D'mso-spacerun:yes'>  </span>J Infect Dis 2002;186:18= 1-8 </i></b></span><span style=3D'font-size:40%;color:white;mso-color-index:1'><b><i>[L Mofenson sl= ide]</i></b></span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s100355" type=3D"#_x0000_m1028" style=3D'position:absolute;left:59.625pt;top:139.6= 25pt; width:712.875pt;height:363.625pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:26.47%;left:7.49%;width:102.24%;height= :69.57%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s100355"> <div class=3DB style=3D'mso-line-spacing:"90 30 0"'><span style=3D'positio= n:absolute; top:0%;left:3.29%;width:96.15%;height:6.47%'><span style=3D'font-size:83%; font-weight:normal'><span style=3D'mso-special-format:bullet;color:#FC0128; position:absolute;left:-3.42%;top:.43em;font-family:"Monotype Sorts"; font-size:68%'>l</span></span><span style=3D'font-size:83%'>16/217 women w= ho did not have NVP resistance at delivery had NVP </span></span><span style=3D'position:absolute;top:5.66%;left:3.29%;width:84.79%;height:6.47%'= ><span style=3D'font-size:83%'>resistant virus detected at 6 weeks pp: </spa= n></span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0";position:absolute;top:= 13.36%; left:4.39%;width:83.69%;height:8.9%'><span style=3D'position:absolute; top:0%;left:3.5%;width:96.71%;height:100.0%'><span style=3D'font-weight:no= rmal'><span style=3D'mso-special-format:bullet;position:absolute;left:-3.61%;top:.15em= '>–</span></span>14/95 <span style=3D'color:yellow;mso-color-index:3'>(</span><span style=3D'font= -size: 117%;font-weight:normal;color:yellow;mso-color-index:3'>15%)</span> in NVP arm </span></div> <div class=3DB1 style=3D'mso-line-spacing:"90 20 0"'><span style=3D'positi= on:absolute; top:23.48%;left:7.32%;width:92.67%;height:8.9%'><span style=3D'font-weight= :normal'><span style=3D'mso-special-format:bullet;position:absolute;left:-3.16%;top:.15em= '>–</span></span>2/122 <span style=3D'font-size:117%;font-weight:normal;color:yellow;mso-color-in= dex: 3'>(2%)</span> in placebo arm (neither had received active </span><span style=3D'position:absolute;top:31.57%;left:7.32%;width:80.95%;height:7.69%= '>drug or open-label NNRTI) </span></div> <div class=3DB style=3D'mso-line-spacing:"90 30 0";position:absolute;top:4= 0.89%; left:0%;width:95.78%;height:6.47%'><span style=3D'position:absolute;top:0%; left:3.44%;width:96.55%;height:100.0%'><span style=3D'font-size:83%;font-w= eight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.56%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span style=3D'font-size:83%;font-weight:normal'>K103N </span><span style=3D'fon= t-size: 83%'>most common (alone in 7 and in combination in 3 women). </span></= span></div> <div class=3DB style=3D'mso-line-spacing:"90 30 0"'><span style=3D'positio= n:absolute; top:48.58%;left:3.29%;width:96.7%;height:6.47%'><span style=3D'font-size:8= 3%; font-weight:normal'><span style=3D'mso-special-format:bullet;color:#FC0128; position:absolute;left:-3.4%;top:.43em;font-family:"Monotype Sorts"; font-size:68%'>l</span></span><span style=3D'font-size:83%'>All women with= K103N mutation had mixture of mutant and wild-type </span></span><span style=3D'position:absolute;top:54.65%;left:3.29%;width:84.79%;height:6.47%= '><span style=3D'font-size:83%'>virus. </span></span></div> <div class=3DB style=3D'mso-line-spacing:"90 30 0"'><span style=3D'positio= n:absolute; top:62.34%;left:3.29%;width:95.6%;height:6.47%'><span style=3D'font-size:8= 3%; font-weight:normal'><span style=3D'mso-special-format:bullet;color:#FC0128; position:absolute;left:-3.44%;top:.43em;font-family:"Monotype Sorts"; font-size:68%'>l</span></span><span style=3D'font-size:83%'>Not related to= pre pregnancy or antenatal ARV’s; or to delivery CD4, </span></span><span style=3D'position:absolute;top:68.42%;left:3.29%;width:84.79%;height:6.47%= '><span style=3D'font-size:83%'>viral load, or other ARV resistance </span></span>= </div> </div> <![if !ppt]></div> <![endif]><v:line id=3D"_x0000_s100356" style=3D'position:absolute' from= =3D"19.75pt,111.375pt" to=3D"765.625pt,111.375pt" strokecolor=3D"white [1]"> <v:shadow color=3D"white [2]"/> </v:line></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0055.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; 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//--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"99"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:rect id=3D"_x0000_s101378" style=3D'position:absolute;left:59= .375pt; top:328.375pt;width:679.875pt;height:129pt;mso-wrap-style:none; v-text-anchor:middle' fillcolor=3D"#33f" stroked=3D"f" strokecolor=3D"whi= te [1]"> <v:shadow color=3D"white [2]"/> <v:textbox inset=3D"2.48286mm,1.2414mm,2.48286mm,1.2414mm"/> </v:rect> <div v:shape=3D"_x0000_s101378" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:68.73%;lef= t:8.42%; width:84.26%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:white'><b>Efficacy, simplicity and low cost make this </b></spa= n></div> <div class=3DO style=3D'text-align:center;position:absolute;top:74.92%;lef= t:.18%; width:100.56%;height:5.91%'><span style=3D'font-family:Times;font-size:113= %; color:white'><b>regimen currently deliverable in resource-limited settings= </b></span><span style=3D'font-family:Times;font-size:129%;color:white;mso-special-format:l= astCR; display:none'><b> </b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 01379" type=3D"#_x0000_m1026" style=3D'position:absolute;left:72.625pt;top:20.25= pt; width:673.25pt;height:88pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.66%;left:2.62%;width:98.31%;height:1= 7.46%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s101379" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:51.61%'><span style=3D'font-family:Time= s; font-size:90%;color:#8CF4EA;mso-color-index:7'><span style=3D'mso-tab-coun= t: 1;width:9.24%'> </span></span><span style=3D'font-family:Times;font-weight= :normal; color:#8CF4EA;mso-color-index:7'><span style=3D'mso-spacerun:yes'> </span>= HIVNET 012: Resistance Studies </span></span><span style=3D'position:absolute; top:45.16%;left:6.66%;width:86.66%;height:51.61%'><span style=3D'font-fami= ly: Times;font-weight:normal;color:#8CF4EA;mso-color-index:7'>in NVP arm –</sp= an><span style=3D'font-family:Times;font-size:60%;font-weight:normal;color:#8CF4EA; mso-color-index:7'> Sue Eshleman</span><span style=3D'font-family:Times; font-weight:normal;color:#8CF4EA;mso-color-index:7;mso-special-format:last= CR; display:none'> </span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s101380" type=3D"#_x0000_m1028" style=3D'position:absolute;left:76pt;top:140.625pt; width:673.25pt;height:174.5pt' stroked=3D"f" strokecolor=3D"#6cf"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke filltype=3D"solid" o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:26.19%;left:8.98%;width:86.51%;height:= 34.08%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s101380" class=3DB> <div style=3D'text-align:center;mso-line-spacing:"80 30 0";position:absolu= te; top:0%;left:.64%;width:98.48%;height:13.22%'><span style=3D'mso-special-fo= rmat: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-family:Times;font-size:83%;font-weight:no= rmal'>Women: 200 mg NVP at onset of labor </span></div> <div style=3D'text-align:center;mso-line-spacing:"80 30 0";position:absolu= te; top:14.87%;left:.64%;width:98.48%;height:13.22%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-family:Times;font-size:83%;font-weight:no= rmal'>Infants: 2 mg/kg NVP within 72 hrs of birth </span></div> <div style=3D'text-align:center;mso-line-spacing:"80 30 0";position:absolu= te; top:30.57%;left:.64%;width:98.48%;height:18.18%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-family:Times;font-size:83%;font-weight:no= rmal; color:yellow;mso-color-index:3'>Overall transmission rate 6-8 wks=3D </spa= n><span style=3D'font-family:Times;font-size:117%;color:yellow;mso-color-index:3'>= 11.8% </span></div> <div style=3D'text-align:center;mso-line-spacing:"80 30 0";position:absolu= te; top:51.23%;left:.64%;width:98.48%;height:18.18%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-family:Times;font-size:83%;font-weight:no= rmal; color:yellow;mso-color-index:3'>Overall transmission rate 18 months =3D </= span><span style=3D'font-family:Times;font-size:117%;font-weight:normal;color:yellow; mso-color-index:3'>15.9% </span></div> <div style=3D'text-align:center;mso-line-spacing:"80 30 0";position:absolu= te; top:71.9%;left:0%;width:100.0%;height:18.18%'><span style=3D'mso-special-f= ormat: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-family:Times;font-size:117%;font-weight:n= ormal; color:yellow;mso-color-index:3'>SD NVP Relative Efficacy 42% compared to Z= DV</span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0056.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0056= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: NVPR in women 6-8 weeks aft= er NVP"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; 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top:61.12%;left:56.74%;width:35.95%;height:3.66%'><span style=3D'font-fami= ly: Times;font-size:80%;color:#8CF4EA;mso-color-index:7'>Final (all available samples)</span></div> </div> <div v:shape=3D"_x0000_s102404"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:61.12%;left:30.89%;width:24.15%;height:3.94%'><span style=3D'font-fami= ly: Times;font-size:90%;color:#8CF4EA;mso-color-index:7'>70/279 (25%)</span></= div> </div> <div v:shape=3D"_x0000_s102405"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'mso-margin-left-alt:0;position:absolute;top:51.2= 6%; left:8.42%;width:20.97%;height:3.94%'><span style=3D'font-family:Times; font-size:90%;color:#8CF4EA;mso-color-index:7'>HIVNET 012</span></div> </div> <div v:shape=3D"_x0000_s102406"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:47.32%;left:56.74%;width:35.95%;height:3.66%'><span style=3D'font-fami= ly: Times;font-size:80%;color:#8CF4EA;mso-color-index:7'>AIDS (2000) 15:1951</= span></div> </div> <div v:shape=3D"_x0000_s102407"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:41.4%;left:30.89%;width:24.15%;height:3.94%'><span style=3D'font-famil= y: Times;font-size:90%;color:#8CF4EA;mso-color-index:7'>21/111 (19%)* </s= pan></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:47.6%;left:30.89%;width:24.15%;height:3.66%'><span style=3D'font-famil= y: Times;font-size:80%;color:#8CF4EA;mso-color-index:7'>41/48 (T) </span>= </div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:53.23%;left:30.89%;width:24.15%;height:3.66%'><span style=3D'font-fami= ly: Times;font-size:80%;color:#8CF4EA;mso-color-index:7'>70 (NT)</span><span style=3D'font-family:Times;font-size:90%;color:#8CF4EA;mso-color-index:7; mso-special-format:lastCR;display:none'> </span></div> </div> <div v:shape=3D"_x0000_s102408"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:34.08%;left:56.74%;width:35.95%;height:3.66%'><span style=3D'font-fami= ly: Times;font-size:80%;color:#8CF4EA;mso-color-index:7'>AIDS (2000) 14:F111</= span></div> </div> <div v:shape=3D"_x0000_s102409"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'text-align:center;mso-margin-left-alt:0;position= :absolute; top:33.8%;left:30.89%;width:24.15%;height:3.94%'><span style=3D'font-famil= y: Times;font-size:90%;color:#8CF4EA;mso-color-index:7'>3/15 (20%)</span></di= v> </div> <div v:shape=3D"_x0000_s102410"> <div class=3DTbl1 style=3D'mso-margin-left-alt:288'></div> <div class=3DTbl2 style=3D'mso-margin-left-alt:576'></div> <div class=3DTbl3 style=3D'mso-margin-left-alt:864'></div> <div class=3DTbl4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DTbl style=3D'mso-margin-left-alt:0;position:absolute;top:33.8= %; left:8.42%;width:20.97%;height:3.94%'><span style=3D'font-family:Times; font-size:90%;color:#8CF4EA;mso-color-index:7'>HIVNET 006`</span></div> </div> <div v:shape=3D"_x0000_s102420" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center'><span style=3D'position:absolut= e; top:81.12%;left:5.99%;width:88.2%;height:5.07%'><span style=3D'font-family= :Times; font-size:83%;color:#91FFFF'><b>*</b></span><span style=3D'font-family:Tim= es; font-size:96%;color:#CF0E30;mso-color-index:6'><b>NVPR mutations faded from detection by 12-24 months in </b></span></span><span style=3D'position:abs= olute; top:86.19%;left:12.54%;width:75.09%;height:5.07%'><span style=3D'font-fami= ly: Times;font-size:96%;color:#CF0E30;mso-color-index:6'><b>all evaluable wome= n</b></span><span style=3D'font-family:Times;font-size:113%;color:#CF0E30;mso-color-index:6; mso-special-format:lastCR;display:none'><b> </b></span></span></div> </div> <div v:shape=3D"_x0000_s102421" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-line-spacing:"100 50 0";position:absolute;top:= 71.83%; left:16.47%;width:83.52%;height:5.63%'><span style=3D'font-family:Tahoma; font-size:96%;color:#8CF4EA;mso-color-index:7'>Applied Biosystems ViroSeq HIV-1 Genotyping System</span></div> </div> <div v:shape=3D"_x0000_s102422" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:90.42%;left:7.67%;width:100.= 18%; height:4.78%'><span style=3D'font-family:Tahoma;font-size:83%'>Modeling da= ta indicates NVP levels could be >10 ng/mL (IC50=3D10 ng/mL) </span><= /div> <div class=3DO style=3D'position:absolute;top:94.92%;left:7.67%;width:83.5= 2%; height:4.78%'><span style=3D'font-family:Tahoma;font-size:83%'>to 28 days = post partum in some women who received SD NVP</span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 02423" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:4.49%;width:91.19%;height:1= 4.92%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s102423" class=3DT style=3D'position:absolute;top:1= 6.98%; left:0%;width:100.0%;height:62.26%'><span style=3D'text-shadow:none;color:= #8CF4EA; mso-color-index:7'>NVPR in women 6-8 weeks after NVP</span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0059.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0059= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Shift in Specific NNRTI-related Drug Resistance Muta= tions in 65 Ugandan Women in HIVNET 012 Eshleman et al. 2004 in press"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"105"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s107522" type=3D"#_x0000_m1026" style=3D'position:absolute;left:25.25pt;top:22pt;w= idth:745.875pt; height:88pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.94%;left:-4.11%;width:108.8%;height:= 17.18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s107522" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:37.7%'><span style=3D'mso-hansi-font-fa= mily: Arial;font-size:69%'>Shift in Specific NNRTI-related Drug Resistance Mutat= ions in 65 </span></span><span style=3D'position:absolute;top:32.78%;left:6.71%; width:86.74%;height:37.7%'><span style=3D'mso-hansi-font-family:Arial; font-size:69%'>Ugandan Women in HIVNET 012<br> </span></span><span style=3D'position:absolute;top:63.93%;left:6.71%; width:86.74%;height:32.78%'><span style=3D'mso-hansi-font-family:Arial; font-size:60%;color:white;mso-color-index:1'><b><i>Eshleman et al.<span style=3D'mso-spacerun:yes'>  </span>2004 in press</i></b></span><span style=3D'mso-hansi-font-family:Arial;font-size:60%;color:white;mso-color-i= ndex: 1;mso-special-format:lastCR;display:none'> </span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s107523" type=3D"#_x0000_m1028" style=3D'position:absolute;left:11pt;top:105.125pt; 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top:84.5%;left:2.05%;width:72.84%;height:4.5%'><span style=3D'font-family:= Arial; font-size:83%'><b>% with NNRTI </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:89.01%;left:2.05%;width:87.26%;height:5.07%'><span style=3D'font-famil= y: Arial;font-size:83%'><b><span style=3D'mso-spacerun:yes'>      </span>Muta= tions:</b></span><span style=3D'font-family:Arial;font-size:96%'><b><span style=3D'mso-spacerun:y= es'>  </span>14/65 (22%)<span style=3D'mso-spacerun:yes'>                         </span>18/65 (28%)<span style=3D'mso-spacerun:yes'>   </span></b></span><s= pan style=3D'font-size:96%;mso-special-format:lastCR;display:none'> </span= ></div> </div> <div v:shape=3D"_x0000_s107525" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:21.69%;left:3.37%;width:26.21%;height:4.5%'><span style=3D'font-family= :Arial; font-size:83%'><b>Mutation at codon</b></span></div> </div> <v:shape id=3D"_x0000_s107527" type=3D"#_x0000_t202" style=3D'position:abs= olute; left:132pt;top:152.5pt;width:266.125pt;height:35.875pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' fillcolor=3D"#00468c [0]" strokecolor=3D"whit= e [1]"> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s107527" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:29.85%;left:17.6%;width:33.14%;height:5.07%'><span style=3D'font-famil= y: Arial;font-size:96%;color:#9900CC'><b>HIV Subtypes A & D</b></span></d= iv> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0059_image009.emz Content-Transfer-Encoding: base64 Content-Type: image/x-emz H4sIAAAAAAACC+1bf2hd1R3/nnvfM0nTNPGtq3lUXVr8EdZ2PJuZKgimSxoNGkmiVls2bYcJC2Za axpcCNljFGFJadwYzJq++HSMIgyyPxyT4Yxg/tAhUwZbhEGCPwYTRTu7rXPs7e37vfd7br7vvHvf u/f1JWHghW/u9/y435+fc+6557woABhB2oPUiDRqA7yjwLs2PQZw6haAlgO93QAKPt4L8GML4DIw rhgSPtuBz543296LQfoFG1AA7EZqQUJxuxR2vhL5JiSr6dU/k9ojTNT3m0h93HdnRww2s7irO+o8 /hqUoflUh+XIijml9K07Omq8tlgHeDzJxiKgK9B7920DUNvZE0ffapGesMrdAZphVVaS+Xw+D1uZ b0BKMI/dYQdSLdLO1b55v7pNHAt96T5Sh9TdLOoH8H5MUYYA/koV4nrZ8tid++E4DMNRJ+eVXvUc Py1X56wF/pP/ipNduB7ezX3/oacTcGwWUn9/JgGtyF+FDQ+NOS5BHFxbSdYVSNSH7m+fScCH98ZT tx86C/dgHfn3g1viKeKpjq6/ZcArEw67fp5waOuzkKI4jtb/I/bTuxpTXShrF7Xj/fzTCbbejc1P sNyGfU597tan9nYepPuTvY2pD7y+ro3bUa4ua/uv5dgrwWPe0+tZr3NOafjLGuecMH17BTlvMXIO cBbGL/4uleScJ0XOX+orzjnVyZxT2cw5jfdNJQjKtMt+YXJuVTH/fnOC7Os39om/mse/vuZw7j2v /n9kx5ieQdkfKwKPW2+zznQ6DTLmtuBRV1rLp35B8y4NaEriBFJWue+2eeXicAK5GawdtbPqqD2v qKzlY3u6VejVuqD7VIHMTqQZKJQ5gaNyBltINpV1/xnuTzZkuT/1ob6jNlHWsecqjsNFpDp6/9nu 89chXSnio7zZLF8Qo+38DplguxIiJ+3cNsPx0GVtk3z2PlXYv8fo32P0B6P/Z1DY/zPDthcMe2aN /rNG/wGjf6fRv1Pgo0aMNxB8GNxKDFwbgIEweJZy/NYLdFWCW4lXjd8gzKw1Vtcl3lC43gqKdzeP jy3emu4bfXr+0mMnVmLsUJsc80XzEd+ljdqutLA3HSKvK0j70IgLIh8ryK1At7qALRcwtlTWNsS1 vYYNccNmiUtv/hV6zxF8latf6z2H3DmsXXGI+NV5MCbmwbiIibZnwccebcOCiMmCYYP2vdvz3fX7 N0jalm6OY62XzwN9fjlWRo7LzY+tIt/XCyw511DhO0diQvpG/ZKC1741o9K36BtHrca3Wc2rZrWM dW8hZRWVzTjCm/nAvMYC8krPSDwts/5CPC0D6SadKxHyCmcWAvNKbUnBSxu078v6Gfb7ArZoW8Lm 1arm2G0rHrt+eaV+ScFr3/pR6WGkQRHffoxpvxpWg+owUlb1++Q1P1TBeB2CAjwNK1d/IZ6GHd39 Dh9hvPaWGK+9Yrz2FtqgfR/2fHf93o2kbQmbV7uK43WoN9x4pX5JwWvfplDpCNKciO8UxnNKjas5 NYKUVVM+eX3zTPTxSs9IPI0rV38hnsYd3VMOHz6vZx4PHq/UlhS8tEH7Pu757vo9iKRtCZvX2CWM 19Dz0kIwfqktKXiZY1rDLIlYv4axXcLc6vxSOayf5JGqEn7NNUUQfs31hfZtACdJmmIGrVXfBqx5 NWCdwLohpKyicpR1RCzEOiKJ+k6wfq03iXqSqHfAIeLXdh2RFL6fAO276/duJG1L+HVEYV4v5X1j riPsiOuIacudc+dEfKcxntPWsJqzDiNl1bQVbR1hh1hHUD5pjp8uwtOwo3va4dd2HTEgfB/2fHf9 HkTStoRfR1RxvLaFHK8B64hF9Ok0zUUivosYz0Uro5as00hZtWhFW0fEQqwjKJ8Z5eovxFPG0b3o 8Gu7jpgWvmc8312/55C0LeHXEdUbr+Y6wo64jshZ7ru0SXyn5zCeOWtcNdkjSFmVs6KtI+wQ6wjK J727c0V4Gnd05xx+bdcRi8L3cc931+8la8SzJfw6onrjVb9gy37PpcXaIb2K2XbbxWyPyGu7Pa/a 7YzqsU8jZRWVi+a9fPTxSs9IPNEYaS/CU8bRTTpzUebhCtZNOWvV94znu+t3E5K2xS+vQXbJ/SKJ 80r3NuWenN8+p943NJ/T7WNcDtr3HONy0D7nGJeD9jXHuBy0jznGZYmHe/BONIj0HMp+DO+/VTom /95PpNuo7k7jnCbPVx/nsYHlaZk9LHPQR2ZPCJk3Cpn3M9HeLsncYsjUbVYZmTegpQ0+cmdZ7q+h WO5sKLk3+srtYrlHfOR2hZC7V9hb6dlPTYX7pGH2oq9zTtkA7qazK+W/HynPD+PizPik7ZJ3fthU jfPDTZOk+9nNOzqS8EvlnLZtr5vU57nNf0zASls8Re1XoIF3LiWcMz5qf3Hnv/775CeQ+lajOnf8 o4Tzrkhhf+JfQf6Nm+sm78fyzw7GU7vvOAu/QDr9kXt++xTeqUxeP/z7+tSpB846svV1Ep/7/AG3 ni6S9yrW7Xu0PvUK5+C4IysBL2I9yW3KbIOWtzdPkj36GT1fTfwpAc+P1qeo3+sfuva9hPrM88M4 4zHLv7t4jsYe0oPG+NnDdVtK4PE7yN+FX0DfhW/j+D4OLXDMuT8Oj8Ij+Pdy/l3Hl/newGcENUa5 gcuNBq6V8c7cSFybe/7mvB6Ecz3fHrWL53v5PqDyr0T7J6qwncqyXcuT8qmdcnuMYon8y7x/9o6R W912WYnc0ny0DzPahWPve5jLBs7b5eyjnNtOIj1iuTLftYr16ba6EvqOOLHaAzehzvsQRYPwMGp1 ddTyvYZ/r9Fg0HrkP+g8eiN0WsZ5tN9+VhS7rIDz7SC7/snP99v0ntsYnWHXbWH2n+Q+U9D52S6W Q3220Zjj3w0ErQO3Md/MY2SE97NpjqNvlq8Z739qa2V7So3JO5wVSxvOu66tjYK2Cr1QhTNpy4hT FOyGwchG2VKVfTZjv8v8bpd7XOUw9YRy8/bDCjD1FGPqfR9M/Sgkpg5hVG5C6mT71gtTxv77hmLq Um3RmIqXwFS8zJ6BuddmYlDur5XD1KeMKaqMiqlay839IasYU9QWBlMHnXmqHfb7YOpLa4ipWMDc vhGYulRbou5D+e2/lDsvlHt75TBF5x2Ut7EKMDXJmPqDD6YmQ2LqNozKzYiq/eKbYj0w9cW7z3j3 5SHcuy9ffp5aZkx9WgGmLjKmaJ/QxNRFK8p66gY44LOeSnzx7ov0XRIr8S3S6jMnmjbW8beslmv+ D4JpT5T/Xyj1LO0jf50xTP/v8dUOgGs8X9O38m5+WvL6/KCJn7HE/3hsYSwBtxP/P7XoR+7sMgAA ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0060.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0060= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: HIVNET 012: NVPR in infants 6-8 weeks after SD NVP = "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"106"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:rect id=3D"_x0000_s108546" style=3D'position:absolute;left:36= .25pt; top:152pt;width:732.625pt;height:230.125pt' filled=3D"f" fillcolor=3D"yel= low [4]" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.45697mm,1.2069mm,= 2.45697mm,1.2069mm"/> </v:rect><v:rect id=3D"_x0000_s108547" style=3D'position:absolute;left:486= .25pt; top:482pt;width:280.25pt;height:30.5pt;mso-wrap-style:none;v-text-anchor:= top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white = [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:rect> <div v:shape=3D"_x0000_s108546" style=3D'tab-interval:.9774in'> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:29.85%;lef= t:5.43%; width:90.82%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#CF0E30;mso-color-index:6;display:none'><b> </b></span></div> <div class=3DO style=3D'position:absolute;top:36.05%;left:5.43%;width:94.1= 9%; height:7.6%'><span style=3D'position:absolute;top:0%;left:2.18%;width:97.8= 1%; height:100.0%'><span style=3D'font-family:Times;font-size:129%'><span style=3D'mso-special-format:bullet;color:#CF0E30;mso-color-index:6;positio= n: absolute;left:-2.23%;top:-.22em;font-size:150%'>•</span></span><span style=3D'font-family:Times;font-size:129%'><b>NVPR was detected in 11/24 (= </b></span><span style=3D'font-family:Times;font-size:146%'><b>46%)</b></span><span style=3D'font-family:Times;font-size:129%'><b> of infants </b></span><= /span></div> <div class=3DO style=3D'position:absolute;top:43.94%;left:5.43%;width:90.8= 2%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.26%;width:97.= 73%; height:100.0%'><span style=3D'font-family:Times;font-size:129%'><span style=3D'mso-special-format:bullet;color:#CF0E30;mso-color-index:6;positio= n: absolute;left:-2.32%;top:-.3em;font-size:150%'>•</span></span><span style=3D'font-family:Times;font-size:129%'><b>Majority Y181C </b></spa= n></span></div> <div class=3DO style=3D'position:absolute;top:50.98%;left:5.43%;width:90.8= 2%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.26%;width:97.= 73%; height:100.0%'><span style=3D'font-family:Times;font-size:129%'><span style=3D'mso-special-format:bullet;color:#CF0E30;mso-color-index:6;positio= n: absolute;left:-2.32%;top:-.3em;font-size:150%'>•</span></span><span style=3D'font-family:Times;font-size:129%'><b>NVPR mutations faded from detection </b></span></span></div> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282; position:absolute;top:58.02%;left:9.92%;width:86.51%;height:6.76%'><span style=3D'position:absolute;top:0%;left:2.38%;width:97.61%;height:100.0%'><= span style=3D'font-family:Times;font-size:129%'><span style=3D'mso-special-form= at:bullet; color:#8CF4EA;mso-color-index:7;position:absolute;left:-2.43%;top:-.3em; font-size:150%'>•</span></span><span style=3D'font-family:Times;font-size:= 129%'><b>by 14-16 weeks in half of the infants and </b></span></span></div> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282; position:absolute;top:65.07%;left:9.92%;width:86.51%;height:6.76%'><span style=3D'position:absolute;top:0%;left:2.38%;width:97.61%;height:100.0%'><= span style=3D'font-family:Times;font-size:129%'><span style=3D'mso-special-form= at:bullet; color:#8CF4EA;mso-color-index:7;position:absolute;left:-2.43%;top:-.3em; font-size:150%'>•</span></span><span style=3D'font-family:Times;font-size:= 129%'><b>by 12 months in all evaluable infants</b></span></span></div> </div> <div v:shape=3D"_x0000_s108547" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:92.39%;left:62.35%;width:41.= 38%; height:4.5%'><span style=3D'font-family:Times;font-size:83%;color:#CF0E30; mso-color-index:6'><b>Eshleman, AIDS (2000) 15:1951</b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 08548" type=3D"#_x0000_m1026" style=3D'position:absolute;left:54.25pt;top:18.125= pt; width:723.75pt;height:77pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.09%;left:.56%;width:104.3%;height:15= .21%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s108548" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:50.0%'><span style=3D'font-size:81%; font-weight:normal;color:yellow;mso-color-index:3'>HIVNET 012:<span style=3D'mso-spacerun:yes'>  </span>NVPR in infants 6-8 weeks after SD NVP= </span><span style=3D'font-size:81%;font-weight:normal;color:#CF0E30;mso-color-index:6'= > </span><span style=3D'font-size:90%;font-weight:normal;color:#CF0E30;mso-color-index:6'= ><br> </span></span><span style=3D'position:absolute;top:42.59%;left:6.1%;width= :87.79%; height:55.55%'><span style=3D'font-size:90%;font-weight:normal;color:#CF0E= 30; mso-color-index:6;mso-special-format:lastCR;display:none'> </span></sp= an></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0061.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0061= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: HIVNET 012: Comparison of NVPR mutations in women v= s. infants"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style> .CT {color:#FAFD00;} </style> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"108"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:rect id=3D"_x0000_s110594" style=3D'position:absolute;left:54= .875pt; top:255.75pt;width:686.5pt;height:222.875pt;mso-wrap-style:none; v-text-anchor:middle' filled=3D"f" fillcolor=3D"yellow [4]" strokecolor= =3D"#36f" strokeweight=3D"4.5pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> </v:rect><v:group id=3D"_x0000_s110596" style=3D'position:absolute;left:12= 5.875pt; top:278.125pt;width:509.125pt;height:171.5pt' coordorigin=3D"928,960" coordsize=3D"3703,1829"> <v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt=3D"202" p= ath=3D"m,l,21600r21600,l21600,xe"> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s110597" type=3D"#_x0000_t202" style= =3D'position:absolute; left:3760;top:960;width:871;height:1801;mso-wrap-style:none;v-text-ancho= r:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white= [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm= ,2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s110598" type=3D"#_x0000_t202" style=3D'p= osition:absolute; left:2390;top:960;width:883;height:1829;mso-wrap-style:none;v-text-ancho= r:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white= [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm= ,2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s110599" type=3D"#_x0000_t202" style=3D'p= osition:absolute; left:928;top:960;width:700;height:1829;mso-wrap-style:none;v-text-anchor= :top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white= [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm= ,2.48286mm,1.2414mm"/> </v:shape></v:group> <div v:shape=3D"_x0000_s110597" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:53.8%;left= :65.91%; width:13.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%= '><b>Infants </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:60.0%;left= :65.91%; width:13.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%= '><b>n=3D11 </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:65.91%;lef= t:65.91%; width:13.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:72.11%;lef= t:65.54%; width:14.23%;height:5.91%'><span style=3D'font-family:Times;font-size:113%= '><b>2 (18%) </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:78.3%;left= :64.6%; width:16.29%;height:5.91%'><span style=3D'font-family:Times;font-size:113%= '><b>10 (91%)</b></span></div> </div> <div v:shape=3D"_x0000_s110598" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:53.8%;left= :42.13%; width:13.85%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>Women </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:60.0%;left= :42.32%; width:13.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>n=3D70 </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:65.91%;lef= t:42.32%; width:13.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7;display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:72.11%;lef= t:40.82%; width:16.29%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>59 (84%) </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:78.3%;left= :40.82%; width:16.29%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>26 (37%)</b></span></div> </div> <div v:shape=3D"_x0000_s110599" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:53.8%;left= :16.85%; width:10.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:white;display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:60.0%;left= :16.85%; width:10.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:white;display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:65.91%;lef= t:16.85%; width:10.48%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#66CCFF;display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:72.11%;lef= t:15.91%; width:12.35%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>K103N </b></span></div> <div class=3DO style=3D'text-align:center;position:absolute;top:78.3%;left= :15.91%; width:12.17%;height:5.91%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>Y181C</b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 10600" type=3D"#_x0000_m1026" style=3D'position:absolute;left:59.375pt;top:12.75= pt; width:673.25pt;height:113.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"centerTitle"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:2.53%;left:-.56%;width:101.12%;height:= 21.97%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s110600" class=3DCT><span style=3D'position:absolut= e; top:11.53%;left:0%;width:100.0%;height:38.46%'><span style=3D'font-size:90= %; text-shadow:none;color:#8CF4EA;mso-color-index:7'>HIVNET 012: Comparison of NVPR mutations<br> </span></span><span style=3D'position:absolute;top:43.58%;left:7.96%; width:84.25%;height:38.46%'><span style=3D'font-size:90%;text-shadow:none; color:#8CF4EA;mso-color-index:7'><span style=3D'mso-spacerun:yes'> </span>= in women vs. infants</span></span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0062.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0062= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: HIVNET 012: NVPR in late-infected infants"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"109"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:rect id=3D"_x0000_s111619" style=3D'position:absolute;left:53= .75pt; top:163.5pt;width:684.25pt;height:344.625pt' filled=3D"f" fillcolor=3D"ye= llow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:rect><v:rect id=3D"_x0000_s111620" style=3D'position:absolute;left:511= .75pt; top:482.625pt;width:280.25pt;height:30.625pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:rect> <div v:shape=3D"_x0000_s111619" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:32.11%;left:7.67%;width:98.3= 1%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.09%;width:97.= 9%; height:100.0%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.14%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:129%;color:#8CF4EA;mso-color-index:7'= ><b>12 were diagnosed with HIV-1 after age 6-8 wks<span style=3D'mso-spacerun:yes= '>  </span> </b></span></span></div> <div class=3DO style=3D'position:absolute;top:39.15%;left:7.67%;width:84.8= 3%; height:6.76%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>  </span>(median 10= mo, range 77-550 days) </b></span></div> <div class=3DO style=3D'position:absolute;top:46.19%;left:7.67%;width:93.6= 3%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.2%;width:97.6= %; height:100.0%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.25%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:129%;color:#8CF4EA;mso-color-index:7'= ><b>Samples were available from 9 infants 2-9 mo </b></span></span></div> <div class=3DO style=3D'position:absolute;top:53.23%;left:7.67%;width:84.8= 3%; height:6.76%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>  </span>after diagnosis </b></span></div> <div class=3DO style=3D'position:absolute;top:60.28%;left:7.67%;width:84.8= 3%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.42%;width:97.= 57%; height:100.0%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.48%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:129%;color:#8CF4EA;mso-color-index:7'= ><b>8/9<span style=3D'mso-spacerun:yes'>  </span>lacked NVPR mutations, including 2<span style=3D'mso-spacerun:yes'>  </span> </b></span></span></div> <div class=3DO style=3D'position:absolute;top:67.32%;left:7.67%;width:99.4= 3%; height:6.76%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>   </span>whose mot= hers had NVPR mutations at 6-8 wks </b></span></div> <div class=3DO style=3D'position:absolute;top:74.36%;left:7.67%;width:90.2= 6%; height:6.76%'><span style=3D'position:absolute;top:0%;left:2.28%;width:97.= 71%; height:100.0%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.33%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:129%;color:#8CF4EA;mso-color-index:7'= ><b>1 infant diagnosed at 12 mo had K103N and </b></span></span></div> <div class=3DO style=3D'position:absolute;top:81.4%;left:7.67%;width:91.57= %; height:6.76%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>  </span>Y181C at 1= 5 and 18 mo. The mother had the </b></span></div> <div class=3DO style=3D'position:absolute;top:88.45%;left:7.67%;width:84.8= 3%; height:6.76%'><span style=3D'font-family:Times;font-size:129%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>   </span>same muta= tions at 6 wks pp</b></span></div> </div> <div v:shape=3D"_x0000_s111620" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:92.39%;left:65.54%;width:41.= 38%; height:4.5%'><span style=3D'font-family:Times;font-size:83%;color:#8CF4EA; mso-color-index:7'><b>Eshleman, AIDS (2000) 15:1951</b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 11621" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:-1.87%;width:104.11%;height= :14.92%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s111621" class=3DT style=3D'position:absolute;top:1= 6.98%; left:0%;width:100.0%;height:62.26%'><span style=3D'text-shadow:none;color:= #8CF4EA; mso-color-index:7'>HIVNET 012: NVPR in late-infected infants</span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0063.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0063= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Summary: HIVNET 012 Resistance Data "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><p:slidetransition advancetime=3D"0" flag=3D= "1"/><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"111"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt= =3D"202" path=3D"m,l,21600r21600,l21600,xe"> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s113666" type=3D"#_x0000_t202" style= =3D'position:absolute; left:43.75pt;top:126.5pt;width:715pt;height:372.75pt' filled=3D"f" fillco= lor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s113666" style=3D'tab-interval:.9774in'> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:25.07%;lef= t:-.18%; width:101.87%;height:7.6%'><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b>NVPR emerges by 6 wks in </b></span><s= pan style=3D'font-family:Times;font-size:146%;color:#CF0E30;mso-color-index:6'= ><b>25%</b></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b> women & </b></span><span style=3D'font-family:Times;font-size:146%; color:#CF0E30;mso-color-index:6'><b>46%</b></span><span style=3D'font-fami= ly: Times;font-size:113%;color:#8CF4EA;mso-color-index:7'><b> infants </b>= </span></div> <div class=3DO style=3D'position:absolute;top:32.95%;left:6.36%;width:88.7= 6%; height:5.91%'><span style=3D'position:absolute;top:0%;left:2.1%;width:97.8= 9%; height:100.0%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.15%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b>NVPR is more common in women with </b></span></span></div> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282; position:absolute;top:39.15%;left:10.86%;width:84.26%;height:5.91%'><span style=3D'position:absolute;top:0%;left:1.77%;width:98.0%;height:100.0%'><s= pan style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><span style=3D'mso-special-format:bullet;position:absolute;left:-1.81%;font-fami= ly: Wingdings'>§</span></span><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b><span style=3D'mso-spacerun:yes'> </span>high baseline VL<span style=3D'mso-spacerun:yes'>  </span> </b></span></span></div> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282; position:absolute;top:45.35%;left:10.86%;width:84.26%;height:5.91%'><span style=3D'position:absolute;top:0%;left:1.77%;width:98.0%;height:100.0%'><s= pan style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><span style=3D'mso-special-format:bullet;position:absolute;left:-1.81%;font-fami= ly: Wingdings'>§</span></span><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b><span style=3D'mso-spacerun:yes'> </sp= an>low baseline CD4 cell count </b></span></span></div> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282; position:absolute;top:51.26%;left:10.86%;width:84.26%;height:5.91%'><span style=3D'position:absolute;top:0%;left:1.77%;width:98.0%;height:100.0%'><s= pan style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><span style=3D'mso-special-format:bullet;position:absolute;left:-1.81%;font-fami= ly: Wingdings'>§</span></span><span style=3D'font-family:Times;font-size:113%; color:#8CF4EA;mso-color-index:7'><b><span style=3D'mso-spacerun:yes'> </span>subtype D infection </b></span></sp= an></div> <div class=3DO style=3D'position:absolute;top:57.46%;left:6.36%;width:90.8= 2%; height:5.91%'><span style=3D'position:absolute;top:0%;left:2.06%;width:98.= 14%; height:100.0%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.1%;top:-.3em;font-size:150%'>•= </span></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b>NVPR is </b></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4E= A; mso-color-index:7'><b><u>not</u></b></span><span style=3D'font-family:Time= s; font-size:113%;color:#8CF4EA;mso-color-index:7'><b> associated with increa= sed MTCT, and </b></span></span></div> <div class=3DO style=3D'position:absolute;top:63.66%;left:6.36%;width:103.= 18%; height:5.91%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>  </span>transmissi= on of NVPR virus by breast-feeding uncommon </b></span></div> <div class=3DO style=3D'position:absolute;top:69.85%;left:6.36%;width:91.0= 1%; height:5.91%'><span style=3D'position:absolute;top:0%;left:2.05%;width:98.= 14%; height:100.0%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-2.09%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b>Different mutations are found in women vs. infants </b></span></span></div> <div class=3DO style=3D'position:absolute;top:75.77%;left:6.36%;width:101.= 87%; height:5.91%'><span style=3D'position:absolute;top:0%;left:1.83%;width:98.= 16%; height:100.0%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-1.87%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b>Different mutations<span style=3D'mso-spacerun:yes'>  </span>found in women 7d vs. 6w post-NVP </b></span></span></div> <div class=3DO style=3D'position:absolute;top:81.97%;left:6.36%;width:102.= 05%; height:5.91%'><span style=3D'position:absolute;top:0%;left:1.83%;width:98.= 16%; height:100.0%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4= EA; mso-color-index:7'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-1.86%;top:-.3em;font-size:150%'>= •</span></span><span style=3D'font-family:Times;font-size:113%;color:#8CF4EA;mso-color-index:7'= ><b>Complex patterns of mutations are found in some women </b></span></span></div> <div class=3DO style=3D'position:absolute;top:88.16%;left:6.36%;width:88.7= 6%; height:5.91%'><span style=3D'font-family:Times;font-size:113%;color:#8CF4E= A; mso-color-index:7'><b><span style=3D'mso-spacerun:yes'>   </span>as early = as 7d after NVP exposure</b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 13667" type=3D"#_x0000_m1026" style=3D'position:absolute;left:97.625pt;top:17.25= pt; width:673.75pt;height:112.5pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.38%;left:12.17%;width:85.58%;height:= 21.69%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s113667" class=3DT><span style=3D'position:absolute; top:11.68%;left:0%;width:100.0%;height:38.96%'><span style=3D'font-size:90= %; font-weight:normal;color:#8CF4EA;mso-color-index:7'>Summary: HIVNET 012 Resistance Data<br> </span></span><span style=3D'position:absolute;top:45.45%;left:.21%;width= :99.56%; height:38.96%'><span style=3D'font-size:90%;font-weight:normal;color:#8CF4= EA; mso-color-index:7;mso-special-format:lastCR;display:none'> </span></sp= an></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s113668" type=3D"#_x0000_m1028" style=3D'position:absolute;left:37.75pt;top:121.12= 5pt; width:719.375pt;height:318pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:22.81%;left:4.68%;width:91.19%;height:= 60.84%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s113668" class=3DB> <div style=3D'position:absolute;top:2.31%;left:0%;width:99.79%;height:8.79= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span> </div> <div style=3D'position:absolute;top:16.2%;left:0%;width:99.79%;height:8.79= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'mso-tab-count:1; 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mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-fami= ly: Arial;font-size:113%;color:#0033CC'><b>ZDV 300mg bid </b></span></div> <div class=3DO style=3D'mso-line-spacing:"75 50 0";mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:72.39%;left:1.68%;width:29.96%;height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:"Arial Unicode MS";mso-bi= di-font-family: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC;mso-special= -format: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s115716" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 50 0";mso-= char-wrap: 1;mso-kinsoku-overflow:1;position:absolute;top:40.28%;left:4.86%;width:26.= 59%; height:6.76%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:129%; color:#CF0E30;mso-color-index:6'><b>Antepartum</b></span></div> </div> <v:shape id=3D"_x0000_s115717" type=3D"#_x0000_t202" style=3D'position:abs= olute; left:257.375pt;top:269.75pt;width:211.25pt;height:182.375pt;rotation:360' fillcolor=3D"#ff9" strokecolor=3D"white [1]"> <v:fill rotate=3D"t"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48256mm,1.24125mm= ,2.48256mm,1.24125mm"/> </v:shape><v:shape id=3D"_x0000_s115718" type=3D"#_x0000_t202" style=3D'po= sition:absolute; left:486.25pt;top:203.875pt;width:241.125pt;height:44.625pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48256mm,1.24125mm= ,2.48256mm,1.24125mm"/> </v:shape><v:shape id=3D"_x0000_s115719" type=3D"#_x0000_t202" style=3D'po= sition:absolute; left:481.75pt;top:269.75pt;width:310.25pt;height:175.25pt' fillcolor=3D"#= ff9" strokecolor=3D"white [1]"> <v:fill rotate=3D"t"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48256mm,1.24125mm= ,2.48256mm,1.24125mm"/> </v:shape><v:shape id=3D"_x0000_s115720" type=3D"#_x0000_t202" style=3D'po= sition:absolute; left:275pt;top:204.875pt;width:211.625pt;height:44.625pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48256mm,1.24125mm= ,2.48256mm,1.24125mm"/> </v:shape> <div v:shape=3D"_x0000_s115717" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:51.54%;left:33.52%;width:24.9%;height:3.94%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:75%;color:white;mso-color-inde= x: 2;display:none'><b> </b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"80 20 0";mso-c= har-wrap: 1;mso-kinsoku-overflow:1'><span style=3D'position:absolute;top:55.77%; left:32.39%;width:27.15%;height:5.91%'><span style=3D'font-family:Arial; mso-ascii-font-family:Arial;mso-bidi-font-family:Arial;mso-hansi-font-fami= ly: Arial;font-size:113%;color:#0033CC'><b>ZDV 300mg<span style=3D'mso-spacerun:yes'>  </span>q </b></span></span><span style=3D'pos= ition: absolute;top:60.56%;left:33.52%;width:24.9%;height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC'><b>3hrs &#= 13;</b></span></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"80 20 0";mso-c= har-wrap: 1;mso-kinsoku-overflow:1;position:absolute;top:66.76%;left:33.52%;width:24= .9%; height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:113%; color:#0033CC'><b>+ </b></span></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"80 20 0";mso-c= har-wrap: 1;mso-kinsoku-overflow:1;position:absolute;top:72.95%;left:33.52%;width:24= .9%; height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:113%; color:#0033CC'><b>NVP 200mg </b></span></div> <div class=3DO style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1;position:absolute;top:78.87%;left:33.52%;width:24.9%;height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC;mso-special= -format: lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s115718" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;mso-line-spacing:"100 50 0";mso-= char-wrap: 1;mso-kinsoku-overflow:1;position:absolute;top:39.71%;left:62.35%;width:28= .83%; height:6.76%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:129%; color:#CF0E30;mso-color-index:6'><b>Postpartum</b></span></div> </div> <div v:shape=3D"_x0000_s115719" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-line-spacing:"100 50 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1;position:absolute;top:52.11%;left:61.79%;width:37.45%;height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC'><b>Infant only </b></span></div> <div class=3DO style=3D'mso-line-spacing:"90 25 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:59.43%;left:61.79%;width:43.07%; height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:113%; color:#0033CC'><b>NVP 2 mg/kg po at 48-</b></span></span><span style=3D'position:absolute;top:64.78%;left:61.79%;width:37.45%;height:5.91= %'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC'><b>72 hrs + </b></span></span></div> <div class=3DO style=3D'mso-line-spacing:"90 25 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:71.83%;left:61.79%;width:43.82%; height:5.91%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial; mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:113%; color:#0033CC'><b>ZDV 2mg/kg po 4x/day </b></span></span><span style=3D'position:absolute;top:77.46%;left:61.79%;width:37.45%;height:5.91= %'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:113%;color:#0033CC'><b>x 4wks = </b></span></span></div> </div> <div v:shape=3D"_x0000_s115720" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-line-spacing:"100 50 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1;position:absolute;top:40.0%;left:35.58%;width:26.21%;height:6.76%'><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: Arial;mso-hansi-font-family:Arial;font-size:129%;color:#CF0E30;mso-color-i= ndex: 6'><b>Intrapartum</b></span></div> </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s1= 15724" type=3D"#_x0000_m1026" style=3D'position:absolute;left:59.375pt;top:5.875= pt; width:673.25pt;height:113.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"centerTitle"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:1.12%;left:7.49%;width:85.39%;height:2= 1.97%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s115724" class=3DCT><span style=3D'position:absolut= e; top:7.69%;left:0%;width:99.78%;height:33.33%'><span style=3D'font-size:76%; text-shadow:none;color:#8CF4EA;mso-color-index:7'>Thailand: Peri-3 Study<b= r> </span></span><span style=3D'position:absolute;top:34.61%;left:0%;width:9= 9.78%; height:33.33%'><span style=3D'font-size:76%;text-shadow:none;color:#8CF4EA; mso-color-index:7'>Collaboration Thai MOH and CDC <br> </span></span><span style=3D'position:absolute;top:62.82%;left:0%;width:9= 9.78%; height:24.35%'><span style=3D'font-size:57%;color:#8CF4EA;mso-color-index:= 7'>Phase II, Open label</span></span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0065.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0065= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Peri-3 Results and Conclus= ions "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"115"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s117762" type=3D"#_x0000_m1026" style=3D'position:absolute;left:0;top:14.625pt;wid= th:11in; height:88pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:2.81%;left:0%;width:100.37%;height:17.= 18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s117762" class=3DT style=3D'position:absolute;top:2= 1.31%; left:0%;width:99.81%;height:52.45%'><span style=3D'font-family:Arial;mso-a= scii-font-family: Arial;mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-weight:n= ormal; color:#8CF4EA;mso-color-index:7'><span style=3D'mso-tab-count:1;width:9.07= %'> </span>Peri-3 Results and Conclusions </span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s117763" type=3D"#_x0000_m1028" style=3D'position:absolute;left:66pt;top:134.875pt; width:673.25pt;height:363.5pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:25.07%;left:8.42%;width:100.37%;height= :69.85%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s117763" class=3DB> <div style=3D'mso-line-spacing:"80 30 0"'><span style=3D'position:absolute; top:0%;left:3.54%;width:93.84%;height:7.66%'><span style=3D'font-weight:no= rmal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:absolute;left:-3= .77%; top:-.3em;font-family:"Monotype Sorts";font-size:150%'>l</span></span><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>Short cou= rse ZDV starting at 34 weeks plus the 2-dose </span></span><span style=3D'posi= tion: absolute;top:6.04%;left:3.35%;width:91.23%;height:7.66%'><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>intrapart= um/neonatal NVP regimen was safe and well </span></span><span style=3D'position:absolu= te; top:12.5%;left:3.35%;width:81.52%;height:7.66%'><span style=3D'mso-bidi-fo= nt-family: Arial;mso-hansi-font-family:Arial'>tolerated </span></span></div> <div style=3D'mso-line-spacing:"80 30 0"'><span style=3D'position:absolute; top:20.96%;left:3.54%;width:93.09%;height:7.66%'><span style=3D'font-weigh= t: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.8%;top:-.3em;font-family:"Monotype Sorts";font-size:150%'>l</span>= </span><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>Transmiss= ion rate was 4.6%; about half that seen with </span></span><span style=3D'posi= tion: absolute;top:27.01%;left:3.35%;width:81.52%;height:7.66%'><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>short cou= rse ZDV alone </span></span></div> <div style=3D'mso-line-spacing:"80 30 0"'><span style=3D'position:absolute; top:35.88%;left:3.54%;width:91.6%;height:7.66%'><span style=3D'font-weight= :normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:absolute;left:-3= .86%; top:-.3em;font-family:"Monotype Sorts";font-size:150%'>l</span></span><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>The combi= ned ZDV+ SD NVP regimen appeared more </span></span><span style=3D'position:ab= solute; top:41.93%;left:3.35%;width:91.79%;height:7.66%'><span style=3D'mso-bidi-f= ont-family: Arial;mso-hansi-font-family:Arial'>effective in reducing<span style=3D'mso-spacerun:yes'>  </span>perinatal HIV transmission than </span= ></span><span style=3D'position:absolute;top:48.38%;left:3.35%;width:81.52%;height:7.66%= '><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>short cou= rse ZDV alone<span style=3D'mso-spacerun:yes'>  </span> </span></span></di= v> <div style=3D'mso-line-spacing:"80 30 0"'><span style=3D'position:absolute; top:56.85%;left:3.54%;width:91.79%;height:8.87%'><span style=3D'color:yell= ow; mso-color-index:3;font-weight:normal'><span style=3D'mso-special-format:bu= llet; color:#FC0128;position:absolute;left:-3.86%;top:-.2em;font-family:"Monotyp= e Sorts"; font-size:150%'>l</span></span><span style=3D'mso-bidi-font-family:Arial; mso-hansi-font-family:Arial;color:yellow;mso-color-index:3'>Maternal resistance at 6 wks was 20% (</span><span style=3D'mso-bidi-font-family:Ar= ial; mso-hansi-font-family:Arial;font-size:117%;font-weight:normal;color:yellow; mso-color-index:3'>18%</span><span style=3D'mso-bidi-font-family:Arial; mso-hansi-font-family:Arial;color:yellow;mso-color-index:3'> NVP and </spa= n></span><span style=3D'position:absolute;top:64.51%;left:3.35%;width:81.52%;height:8.87%= '><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;color:yell= ow; mso-color-index:3'>2% ZDV); Infant NVP resistance was </span><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial;font-size:= 117%; font-weight:normal;color:yellow;mso-color-index:3'>20% </span></span><= /div> <div style=3D'mso-line-spacing:"80 30 0"'><span style=3D'position:absolute; top:74.19%;left:3.54%;width:92.53%;height:7.66%'><span style=3D'font-weigh= t: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.83%;top:-.3em;font-family:"Monotype Sorts";font-size:150%'>l</span= ></span><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>The clini= cal significance of transient detection of NVP </span></span><span style=3D'position:absolute;top:80.24%;left:3.35%;width:96.64%;height:7.66%= '><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>mutation following exposure to SD NVP is unknown and </span></span><span style=3D'position:absolute;top:86.69%;left:3.35%;width:81.52%;height:7.66%= '><span style=3D'mso-bidi-font-family:Arial;mso-hansi-font-family:Arial'>needs to = be evaluated</span></span></div> </div> <![if !ppt]></div> <![endif]><v:line id=3D"_x0000_s117764" style=3D'position:absolute' from= =3D"46.25pt,99.625pt" to=3D"739.25pt,99.625pt" strokecolor=3D"#f30" strokeweight=3D"2.25pt"> <v:shadow color=3D"white [2]"/> </v:line></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0066.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0066= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Efficacy of NVP-based HAART in NVP-exposed and unexp= osed women"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"117"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s119810" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:5.63%;left:-2.43%;width:105.43%;height= :15.77%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s119810" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:53.57%'><span lang=3DEN-GB style=3D'fon= t-size: 90%'>Efficacy of NVP-based HAART in NVP-exposed </span></span><span style=3D'position:absolute;top:44.64%;left:6.74%;width:86.14%;height:53.57= %'><span lang=3DEN-GB style=3D'font-size:90%'>and unexposed women</span><span style=3D'font-size:90%;mso-special-format:lastCR;display:none'> </span= ></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s119811" type=3D"#_x0000_m1028" style=3D'position:absolute;left:37.75pt;top:121.12= 5pt; width:719.375pt;height:387.5pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:22.81%;left:4.68%;width:100.56%;height= :73.8%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s119811" class=3DB> <div style=3D'position:absolute;top:1.9%;left:0%;width:90.5%;height:6.1%'>= <span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'font-size:83%;color:yellow;mso-color-index:3;font-weight:normal'>= <span class=3DBB style=3D'position:absolute;left:-4.05%;top:.43em'>l</span></spa= n><span style=3D'font-size:83%;color:yellow;mso-color-index:3'>After 6 months of H= AART: </span></span></div> <div style=3D'position:absolute;top:11.45%;left:0%;width:90.5%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'><span style=3D'mso-tab-count:1;width:3.74%'> </span>- 68% of the 50 women with at least one mutation, </span></div> <div style=3D'position:absolute;top:20.99%;left:0%;width:90.5%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'><span style=3D'mso-tab-count:1;width:3.74%'> </span>- 80% of the 92 exposed women without mutation and </span></div> <div style=3D'position:absolute;top:30.53%;left:0%;width:90.5%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'><span style=3D'mso-tab-count:1;width:3.74%'> </span>- 85% of the 27 non exposed = women had a viral load <400 </span></div> <div style=3D'position:absolute;top:40.07%;left:0%;width:90.5%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'>(p f= or trend =3D 0.057) </span></div> <div style=3D'position:absolute;top:49.61%;left:0%;width:90.5%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'>(vir= al load <50: 38%, 50%, 74%; p for trend =3D 0.0034). </span></div> <div style=3D'position:absolute;top:59.16%;left:0%;width:90.5%;height:6.1%= '><span style=3D'position:absolute;top:0%;left:3.9%;width:96.29%;height:100.0%'><s= pan style=3D'font-size:83%;font-weight:normal'><span class=3DBB style=3D'posit= ion:absolute; left:-4.05%;top:.43em'>l</span></span><span style=3D'font-size:83%'>NVP-ex= posed women who </span><span style=3D'font-size:83%;color:yellow;mso-color-index= :3'>started therapy > 6 mths PP</span><span style=3D'font-size:83%'>: </span></= span></div> <div style=3D'position:absolute;top:68.7%;left:0%;width:100.0%;height:6.1%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span style=3D'font-size:83%'><span style=3D'mso-tab-count:1;width:3.38%'> </span>91% without mutation and 77%= with mutation had a viral load <400, </span></div> <span style=3D'position:absolute;top:78.24%;left:3.53%;width:96.46%;height= :6.1%'><span style=3D'font-size:83%;color:yellow;mso-color-index:3;font-weight:normal'>= <span class=3DBB style=3D'position:absolute;left:-3.66%;top:.43em'>l</span></spa= n><span style=3D'font-size:83%;color:yellow;mso-color-index:3'>Therapy started <= ;6 months PP</span><span style=3D'font-size:83%'>: 69% without mutation and 5= 8% with </span></span><span style=3D'position:absolute;top:85.87%;left:3.53%; width:87.15%;height:6.1%'><span style=3D'font-size:83%'>mutation had a vir= al load <400.</span></span></div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0071.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0071= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Treatment Options Preservation Study (TOPS) McIntyr= e et al (Bangkok, abstract LbOrB09)"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"129"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s132098" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:3.74%;width:92.88%;height:1= 4.92%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s132098" class=3DT><span style=3D'position:absolute; top:5.66%;left:0%;width:100.0%;height:50.94%'><span style=3D'font-size:81%= '>Treatment Options Preservation Study (TOPS) <br> </span></span><span style=3D'position:absolute;top:50.94%;left:1.0%;width= :97.78%; height:39.62%'><span style=3D'font-size:62%'>McIntyre et al (Bangkok, abst= ract LbOrB09)</span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s132099" type=3D"#_x0000_m1028" style=3D'position:absolute;left:14.875pt;top:121.1= 25pt; width:761pt;height:406.625pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:22.81%;left:-6.17%;width:118.72%;heigh= t: 77.46%;filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s132099"> <div class=3DB style=3D'text-align:center'><span style=3D'position:absolut= e; top:1.81%;left:0%;width:94.47%;height:6.18%'><span style=3D'mso-special-fo= rmat: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:92%'>Supplementing NVP SD for the mo= ther and infant with either a 4 or a 7-</span></span><span style=3D'position:ab= solute; top:9.81%;left:2.2%;width:92.9%;height:6.18%'><span style=3D'font-size:92%= '>day course of ZDV + 3TC (given as Combivir®) for the mother and the </span></s= pan><span style=3D'position:absolute;top:17.81%;left:9.62%;width:78.23%;height:6.18%= '><span style=3D'font-size:92%'>baby </span></span></div> <div class=3DB style=3D'position:absolute;top:28.0%;left:6.78%;width:86.11= %; height:6.18%'><span style=3D'position:absolute;top:0%;left:3.29%;width:96.= 7%; height:100.0%'><span style=3D'font-size:92%;font-weight:normal'><span clas= s=3DBB style=3D'position:absolute;left:-3.4%;top:.43em'>l</span></span><span style=3D'font-size:92%'>5-fold reduction in NVP resistance after 6 wks of follow-up PP. </span></span></div> <div class=3DB><span style=3D'position:absolute;top:37.81%;left:9.62%;widt= h:90.37%; height:6.18%'><span style=3D'font-size:92%;font-weight:normal'><span class= =3DBB style=3D'position:absolute;left:-3.14%;top:.43em'>l</span></span><span style=3D'font-size:92%'><span style=3D'mso-spacerun:yes'> </span>At interim analysis, 6 wks resistance data available for 61 mothers; </span></span><s= pan style=3D'position:absolute;top:46.18%;left:9.62%;width:78.23%;height:6.18%= '><span style=3D'font-size:92%'>Resistance was detected in : </span></span></d= iv> <div class=3DB1 style=3D'position:absolute;top:54.18%;left:10.56%;width:77= .28%; height:6.18%'><span style=3D'position:absolute;top:0%;left:3.06%;width:96.= 93%; height:100.0%'><span style=3D'font-size:92%;font-weight:normal'><span clas= s=3DB1B style=3D'position:absolute;left:-3.15%'>–</span></span><span style=3D'font= -size: 92%'>53.3% of group 1 mothers (NVP only), </span></span></div> <div class=3DB1 style=3D'position:absolute;top:61.81%;left:10.56%;width:77= .28%; height:6.18%'><span style=3D'position:absolute;top:0%;left:3.06%;width:96.= 93%; height:100.0%'><span style=3D'font-size:92%;font-weight:normal'><span clas= s=3DB1B style=3D'position:absolute;left:-3.15%'>–</span></span><span style=3D'font= -size: 92%'>5.0% in group 2 (NVP + 4 days Combivir) and </span></span></div> <div class=3DB1 style=3D'position:absolute;top:69.45%;left:10.56%;width:77= .28%; height:6.18%'><span style=3D'position:absolute;top:0%;left:3.06%;width:96.= 93%; height:100.0%'><span style=3D'font-size:92%;font-weight:normal'><span clas= s=3DB1B style=3D'position:absolute;left:-3.15%'>–</span></span><span style=3D'font= -size: 92%'>13.6% in group 3 (NVP + 7 days Combivir), </span></span></div> <div class=3DB1><span style=3D'position:absolute;top:77.45%;left:10.56%; width:89.43%;height:6.18%'><span style=3D'mso-special-format:nobullet; display:none'>–</span><span style=3D'font-size:92%'>(9.3% of those receivi= ng NVP single-dose + Combivir® irrespective </span></span><span style=3D'position= :absolute; top:83.63%;left:12.93%;width:74.92%;height:6.18%'><span style=3D'font-size= :92%'>of the duration) (p=3D0.001)</span></span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0035.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0035= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: PACTG 316: Resistance Mutations Present at Delivery= in 70 Women with RNA >3,000 Sullivan J. XIII AIDS Conf, July 2000, Du= rban S Africa (LbOr014) "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"63"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s64514" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"c= ustom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.48286mm,1.2414mm,2.48286mm,1.2414mm" o:singleclick=3D"t"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:1.49%;width:97.37%;height:1= 7.46%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s64514" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:37.09%'><span style=3D'font-size:69%; font-weight:normal'>PACTG 316:<span style=3D'mso-spacerun:yes'>  </span>Resistance Mutations Present at Delivery in 70 </span></span><span style=3D'position:absolute;top:32.25%;left:4.23%;width:91.53%;height:37.09= %'><span style=3D'font-size:69%;font-weight:normal'>Women with RNA >3,000<br> </span></span><span style=3D'position:absolute;top:62.9%;left:4.23%;width= :91.53%; height:37.09%'><span style=3D'font-size:69%;font-weight:normal'><span style=3D'mso-spacerun:yes'> </span></span><span style=3D'font-size:45%;fon= t-weight: normal;color:white;mso-color-index:1'><i>Sullivan J.<span style=3D'mso-spacerun:yes'>  </span>XIII AIDS Conf, July 2000, Durban S Af= rica (LbOr014)</i></span><span style=3D'font-size:69%;font-weight:normal'> </sp= an></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s64515" type=3D"#_x0000_m1028" style=3D'position:absolute;left:47pt;top:164.25pt;= width:673pt; height:316.625pt' o:spt=3D"75" o:bwpure=3D"blackTextAndLines" o:bwnormal= =3D"blackTextAndLines" o:preferrelative=3D"t" path=3D"m@4@5l@4@11@9@11@9@5xe" filled=3D"f" strok= ed=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke joinstyle=3D"miter" o:forcedash=3D"f"/> <v:imagedata src=3D"slide0035_image010.emz" o:title=3D""/> <v:formulas> <v:f eqn=3D"if lineDrawn pixelLineWidth 0"/> <v:f eqn=3D"sum @0 1 0"/> <v:f eqn=3D"sum 0 0 @1"/> <v:f eqn=3D"prod @2 1 2"/> <v:f eqn=3D"prod @3 21600 pixelWidth"/> <v:f eqn=3D"prod @3 21600 pixelHeight"/> <v:f eqn=3D"sum @0 0 1"/> <v:f eqn=3D"prod @6 1 2"/> <v:f eqn=3D"prod @7 21600 pixelWidth"/> <v:f eqn=3D"sum @8 21600 0"/> <v:f eqn=3D"prod @7 21600 pixelHeight"/> <v:f eqn=3D"sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok=3D"f" gradientshapeok=3D"t" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" aspectratio=3D"t"/> <p:placeholder type=3D"graph" position=3D"1"/></v:shape><o:OLEObject Type= =3D"Embed" ProgID=3D"MSGraph.Chart.8" ShapeID=3D"_x0000_s64515" DrawAspect=3D"Conten= t" ObjectID=3D"32"> <p:oleclientdata subtype=3D"graph" menuname=3D"Chart" clipboardname=3D"Microsoft Graph 2000 Chart" followcolorscheme=3D"fullSc= heme"/></o:OLEObject> <v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,21600" o:spt=3D"202" pa= th=3D"m,l,21600r21600,l21600,xe"> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s64516" type=3D"#_x0000_t202" style=3D= 'position:absolute; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0067= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: ANRS 075: Open-Label ZDV/3TC Prophylaxis and ARV Dru= g Resistance at 6 wks PP (N=3D132) Mandelbrot et al. JAMA 2001;285:2083-9= 3 [adapted L Mofenson slide]"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"118"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s120834" type=3D"#_x0000_m1026" style=3D'position:absolute;left:59.375pt;top:17.62= 5pt; width:673.25pt;height:87.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:3.38%;left:7.49%;width:85.39%;height:1= 7.18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s120834" class=3DT><span style=3D'position:absolute; top:1.63%;left:0%;width:99.78%;height:37.7%'><span style=3D'font-size:69%'= >ANRS 075: Open-Label ZDV/3TC Prophylaxis<br> </span></span><span style=3D'position:absolute;top:34.42%;left:0%;width:9= 9.78%; height:37.7%'><span style=3D'font-size:69%'>and ARV Drug Resistance at 6 w= ks PP (N=3D132)</span><span style=3D'font-size:69%;color:#006600'> <br> </span></span><span style=3D'position:absolute;top:67.21%;left:0%;width:9= 9.78%; height:26.22%'><span style=3D'font-size:45%;color:white;mso-color-index:1'= ><b><i>Mandelbrot et al.<span style=3D'mso-spacerun:yes'>  </span>JAMA 2001;285:2083-93 [ada= pted L Mofenson slide]</i></b></span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s120835" type=3D"#_x0000_m1028" style=3D'position:absolute;left:47.5pt;top:126.25p= t; width:706.125pt;height:369.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:23.94%;left:5.99%;width:96.81%;height:= 70.42%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s120835"> <div class=3DB1 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= .39%; left:4.64%;width:87.62%;height:7.6%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#8CF4EA;mso-color-index:7'>–</span><b><u>3TC Resistance (M184V)</u></b>: </div> <div class=3DB2 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 8.39%; left:9.47%;width:82.78%;height:8.8%'><span style=3D'position:absolute; top:0%;left:2.8%;width:97.19%;height:100.0%'><span style=3D'font-size:117%= '><span style=3D'mso-special-format:bullet;color:#CF0E30;mso-color-index:6;positio= n: absolute;left:-2.88%'>•</span></span><span style=3D'font-size:117%'>Mother= s: 39% (mutant 58%; mixed, 42%) </span></span></div> <div class=3DB3 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 17.2%; left:14.11%;width:86.07%;height:8.8%'><span style=3D'position:absolute; top:0%;left:2.69%;width:97.3%;height:100.0%'><span style=3D'font-size:140%= '><span style=3D'mso-special-format:bullet;color:#CF0E30;mso-color-index:6;positio= n: absolute;left:-2.77%'>–</span></span><span style=3D'font-size:140%'>Only 1= (2%) had resistance prior to 3TC dosing </span></span></div> <div class=3DB3 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 26.4%; left:14.11%;width:78.14%;height:8.8%'><span style=3D'position:absolute; top:0%;left:2.97%;width:97.02%;height:100.0%'><span style=3D'font-size:140= %; visibility:hidden'><span style=3D'mso-special-format:bullet;color:#CF0E30; mso-color-index:6;position:absolute;left:-3.06%'>–</span></span><span style=3D'font-size:140%;display:none'> </span></span></div> <div class=3DB style=3D'mso-line-spacing:"90 0 0";position:absolute;top:34= .8%; left:0%;width:92.26%;height:8.8%'><span style=3D'position:absolute;top:0%; left:3.77%;width:96.22%;height:100.0%'><span style=3D'font-size:117%;font-= weight: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.92%;font-family:"Monotype Sorts"'>l</span></span><span style=3D'font-size:117%'>Risk factors for maternal 3TC resistance:<span style=3D'mso-spacerun:yes'>  </span> </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 43.2%; left:4.64%;width:87.62%;height:7.6%'><span style=3D'position:absolute; top:0%;left:3.31%;width:96.68%;height:100.0%'><span style=3D'font-weight:n= ormal'><span style=3D'mso-special-format:bullet;position:absolute;left:-3.42%'>–</span>= </span>CD4 lower </span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 51.19%; left:4.64%;width:87.62%;height:7.6%'><span style=3D'position:absolute; top:0%;left:3.31%;width:96.68%;height:100.0%'><span style=3D'font-weight:n= ormal'><span style=3D'mso-special-format:bullet;position:absolute;left:-3.42%'>–</span>= </span>HIV RNA higher </span></div> <div class=3DB1 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 58.8%; left:4.64%;width:87.62%;height:7.6%'><span style=3D'position:absolute; top:0%;left:3.31%;width:96.68%;height:100.0%'><span style=3D'font-weight:n= ormal'><span style=3D'mso-special-format:bullet;position:absolute;left:-3.42%'>–</span>= </span>Longer duration 3TC: </span></div> <div class=3DB2 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 66.79%; left:9.47%;width:82.78%;height:8.0%'><span style=3D'position:absolute; top:0%;left:2.8%;width:97.19%;height:100.0%'><span style=3D'font-size:108%; color:yellow;mso-color-index:3'><span style=3D'mso-special-format:bullet; position:absolute;left:-2.88%'>•</span></span><span style=3D'font-size:108= %; color:yellow;mso-color-index:3'>0%<span style=3D'mso-spacerun:yes'>  </span>(0/12) if <1 month 3TC </span></span></div> <div class=3DB2 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 75.19%; left:9.47%;width:82.78%;height:8.0%'><span style=3D'position:absolute; top:0%;left:2.8%;width:97.19%;height:100.0%'><span style=3D'font-size:108%; color:yellow;mso-color-index:3'><span style=3D'mso-special-format:bullet; position:absolute;left:-2.88%'>•</span></span><span style=3D'font-size:108= %; color:yellow;mso-color-index:3'>20% (14/70) if 1-2 months 3TC </span><= /span></div> <div class=3DB2 style=3D'mso-line-spacing:"100 0 0";position:absolute;top:= 83.6%; left:9.47%;width:82.78%;height:8.0%'><span style=3D'position:absolute; top:0%;left:2.8%;width:97.19%;height:100.0%'><span style=3D'font-size:108%; color:yellow;mso-color-index:3'><span style=3D'mso-special-format:bullet; position:absolute;left:-2.88%'>•</span></span><span style=3D'font-size:108= %; color:yellow;mso-color-index:3'>50% (37/74) if >2 months 3TC </span><sp= an style=3D'font-size:83%;color:yellow;mso-color-index:3;mso-special-format:l= astCR; display:none'> </span></span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0068.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0068= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: PETRA: ZDV or 3TC Antiretroviral Resistance Giuliano= M et al. AIDS 2003;17:1570-3 [adapted from L Mofenson slide]"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"119"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s121858" type=3D"#_x0000_m1026" style=3D'position:absolute;left:39.625pt;top:5.875= pt; width:712.75pt;height:88pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:1.12%;left:4.49%;width:91.19%;height:1= 7.18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s121858" class=3DT style=3D'mso-line-spacing:"80 0 = 0"'><span style=3D'position:absolute;top:3.27%;left:0%;width:100.0%;height:44.26%'><= span style=3D'font-size:81%;color:#8CF4EA;mso-color-index:7'>PETRA: ZDV or 3TC Antiretroviral Resistance</span><span style=3D'font-size:69%;color:#8CF4EA; mso-color-index:7'><br> </span></span><span style=3D'position:absolute;top:37.7%;left:.61%;width:= 98.76%; height:54.09%'><span style=3D'font-size:50%;color:white;mso-color-index:1'= ><b><i>Giuliano M et al.<span style=3D'mso-spacerun:yes'>  </span>AIDS 2003;17:1570-3</i><= /b></span> <span style=3D'font-size:40%'><b><i>[adapted from L Mofenson slide]</i></b= ></span><span style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s121859" type=3D"#_x0000_m1028" style=3D'position:absolute;left:63.75pt;top:135.37= 5pt; width:673.25pt;height:353.5pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:25.63%;left:8.05%;width:100.56%;height= :74.08%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s121859"> <div class=3DB><span style=3D'position:absolute;top:1.9%;left:3.35%;width:= 89.57%; height:7.22%'><span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;left:-3.74%;top:.43em'>l</span></span>Virus fro= m 50 women each in arm A and B at 1 week </span><span style=3D'position:absolut= e; top:11.02%;left:3.35%;width:81.37%;height:7.22%'>postpartum was genotyped. </span></div> <div class=3DB><span style=3D'position:absolute;top:23.19%;left:3.35%;widt= h:96.46%; height:8.36%'><span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;left:-3.47%;top:.65em'>l</span></span>Arm A:<sp= an style=3D'mso-spacerun:yes'>  </span>6/50 <span style=3D'font-size:117%;fon= t-weight: normal'>(12%)</span> had M184V (3TC) and 1/50 <span style=3D'font-size:117= %; font-weight:normal'>(2%)</span> had </span><span style=3D'position:absolut= e; top:33.84%;left:3.35%;width:81.37%;height:7.22%'>M41L (ZDV) mutation<span style=3D'mso-spacerun:yes'>  </span> </span></div> <div class=3DB style=3D'position:absolute;top:45.24%;left:0%;width:87.52%; height:7.22%'><span style=3D'position:absolute;top:0%;left:3.82%;width:96.= 17%; height:100.0%'><span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;left:-3.98%;top:.43em'>l</span></span>Transmiss= ion unrelated to presence of mutation: </span></div> <div class=3DB1 style=3D'position:absolute;top:54.37%;left:4.46%;width:80.= 26%; height:7.22%'><span style=3D'position:absolute;top:0%;left:3.48%;width:96.= 28%; height:100.0%'><span style=3D'font-weight:normal'><span class=3DB1B style=3D'position:absolute;left:-3.61%'>–</span></span>1/11 (9%) if M184V&= #13;</span></div> <div class=3DB1 style=3D'position:absolute;top:63.11%;left:4.46%;width:80.= 26%; height:7.22%'><span style=3D'position:absolute;top:0%;left:3.48%;width:96.= 28%; height:100.0%'><span style=3D'font-weight:normal'><span class=3DB1B style=3D'position:absolute;left:-3.61%'>–</span></span>5/39 (13%) if no M1= 84V (NS) </span></div> <div class=3DB style=3D'position:absolute;top:74.9%;left:0%;width:84.72%; height:8.36%'><span style=3D'position:absolute;top:0%;left:3.95%;width:96.= 04%; height:100.0%'><span style=3D'font-weight:normal'><span class=3DBB style=3D'position:absolute;left:-4.11%;top:.65em'>l</span></span>Arm B: 0/= 50 <span style=3D'font-size:117%;font-weight:normal'>(0%)</span> women had NRTI mutations. </span></div> <div class=3DB1 style=3D'position:absolute;top:85.17%;left:4.46%;width:80.= 26%; height:7.22%'><span style=3D'mso-special-format:nobullet;display:none'>–</= span> </div> <div class=3DB1 style=3D'position:absolute;top:93.91%;left:4.46%;width:80.= 26%; 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charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base 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class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:42.81%;left:23.4%;width:9.17%;height:3.94%'><span lang=3DEN-GB style=3D'font-size:75%'>14 wks</span><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span></div> <div v:shape=3D"_x0000_s31756" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:38.02%;left:30.89%;width:10.29%;height:3.94%'><span lang=3DEN-GB style=3D'font-size:75%'>6 months</span><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span></div> <div v:shape=3D"_x0000_s31757" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:34.08%;left:44.0%;width:12.54%;height:3.94%'><span lang=3DEN-GB style=3D'font-size:75%'>12 months</span><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span></div> <div v:shape=3D"_x0000_s31758" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:35.49%;left:80.71%;width:11.61%;height:3.94%'><span lang=3DEN-GB style=3D'font-size:75%'>24 months</span><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span></div> <div v:shape=3D"_x0000_s31759" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:76.61%;left:80.71%;width:14.23%;height:5.35%'><span lang=3DEN-GB>Child age</span></div> <v:line id=3D"_x0000_s31760" style=3D'position:absolute;mso-wrap-style:non= e; v-text-anchor:middle' from=3D"628.5pt,435pt" to=3D"633pt,435pt" strokecol= or=3D"white [1]" strokeweight=3D"1pt"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s31761" style=3D'position:absolute;flip:y; mso-wrap-style:none;v-text-anchor:middle' from=3D"151.5pt,184.5pt" to=3D"= 151.5pt,198pt" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:shape id=3D"_x0000_s31762" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:1in;top:483pt;width:213pt;height:24pt' filled=3D"f" fillcolor=3D"yel= low [4]" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s31762" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:92.39%;left:9.92%;width:28.65%;height:3.09%'><span lang=3DEN-GB style=3D'font-size:58%'>Source: Nduati et al. JAMA 2000</span= ><span lang=3DEN-GB style=3D'mso-special-format:lastCR;display:none'> </span>= </div> <p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s3= 1763" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:5.63%;left:4.68%;width:91.19%;height:1= 5.77%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s31763" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:53.57%'><span lang=3DEN-GB style=3D'fon= t-size: 90%'>Balancing the risks of breastfeeding and </span></span><span style=3D'position:absolute;top:44.64%;left:0%;width:99.58%;height:53.57%'>= <span lang=3DEN-GB style=3D'font-size:90%'>formula feeding</span><span style=3D'= 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style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:31.54%;left:3.18%;width:27.5= 2%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Botswana (Harvard)</b></span></div> </div> <div v:shape=3D"_x0000_s75786" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:48.16%;left:3.18%;width:45.1= 3%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Ethiopia/= India/Uganda</b></span></div> </div> <div v:shape=3D"_x0000_s75787" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:59.43%;left:3.18%;width:30.1= 4%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Thai (CDC= )</b></span></div> </div> <div v:shape=3D"_x0000_s75788" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:72.67%;left:3.18%;width:29.2= 1%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>DITRAME+1= </b></span></div> </div> <div v:shape=3D"_x0000_s75789" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:18.3%;left:32.02%;width:3.93= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b><u>AP</u>= </b></span><span style=3D'font-family:Arial;font-size:75%;mso-special-format:lastCR;display= :none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s75790" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:18.3%;left:54.3%;width:12.73= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b><u>PP inf= ant </u></b></span><span style=3D'font-family:Arial;font-size:75%;mso-special-format:lastCR;display= :none'><b> </b></span></div> </div> <v:line id=3D"_x0000_s75792" style=3D'position:absolute;mso-wrap-style:non= e; v-text-anchor:middle' from=3D"475.25pt,156.125pt" to=3D"475.25pt,167.875p= t" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s75793" style=3D'position:absolute;mso-wrap-= style:none; v-text-anchor:middle' from=3D"528pt,156.125pt" to=3D"528pt,167.875pt" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:shape id=3D"_x0000_s75794" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:25pt;top:217.625pt;width:14pt;height:28.625pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75795" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:17.625pt;top:220.625pt;width:165pt;height:28.625pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s75794" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO><span style=3D'position:absolute;top:42.25%;left:4.11%;widt= h:.18%; height:3.94%'><span lang=3DFR style=3D'font-family:Arial;font-size:75%;mso= -special-format: lastCR;display:none'><b> </b></span></span></div> </div> <div v:shape=3D"_x0000_s75795" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:42.81%;left:3.18%;width:19.2= 8%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>HPTN 046<= /b></span></div> </div> <v:line id=3D"_x0000_s75796" style=3D'position:absolute;mso-wrap-style:non= e; v-text-anchor:middle' from=3D"228.75pt,156.125pt" to=3D"228.75pt,167.875p= t" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:shape id=3D"_x0000_s75797" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:646.75pt;top:320.375pt;width:123.875pt;height:58.625pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75798" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:234.625pt;top:121pt;width:48pt;height:50.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75799" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:363pt;top:126.875pt;width:35pt;height:45.375pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75800" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:402.625pt;top:121pt;width:38pt;height:50.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s75797" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:61.69%;left:82.58%;width:14.04%;height:4.5%'><span style=3D'font-famil= y: Arial;font-size:83%;display:none'><b> </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:66.19%;left:82.58%;width:14.04%;height:5.07%'><span style=3D'font-size= :96%; mso-special-format:lastCR;display:none'> </span></div> </div> <div v:shape=3D"_x0000_s75798" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:23.94%;left:30.52%;width:4.4= 9%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>34 <= /b></span></div> <div class=3DO style=3D'position:absolute;top:27.88%;left:30.52%;width:5.4= 3%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>wks</b></= span></div> </div> <div v:shape=3D"_x0000_s75799" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:24.78%;left:46.62%;width:2.8%;height:3.09%'><span style=3D'font-family= :Arial; font-size:58%;display:none'><b> </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:28.16%;left:46.62%;width:3.37%;height:3.94%'><span style=3D'font-famil= y: Arial;font-size:75%'><b>3d</b></span></div> </div> <div v:shape=3D"_x0000_s75800" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:23.94%;left:51.68%;width:3.1= 8%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>1 </= b></span></div> <div class=3DO style=3D'position:absolute;top:27.88%;left:51.68%;width:3.7= 4%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>wk</b></s= pan></div> </div> <v:line id=3D"_x0000_s75801" style=3D'position:absolute;mso-wrap-style:non= e; v-text-anchor:middle' from=3D"363pt,156.125pt" to=3D"363pt,167.875pt" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s75802" style=3D'position:absolute;mso-wrap-= style:none; v-text-anchor:middle' from=3D"402.625pt,156.125pt" to=3D"402.625pt,167.87= 5pt" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:shape id=3D"_x0000_s75803" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:620.375pt;top:121pt;width:41pt;height:50.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s75803" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:23.94%;left:79.21%;width:3.5= 5%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b><span style=3D'mso-spacerun:yes'> </span>6 </b></span></div> <div class=3DO style=3D'position:absolute;top:27.88%;left:79.21%;width:4.3= %; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>mo</b></s= pan></div> </div> <v:line id=3D"_x0000_s75804" style=3D'position:absolute;mso-wrap-style:non= e; v-text-anchor:middle' from=3D"620.375pt,156.125pt" to=3D"620.375pt,167.87= 5pt" strokecolor=3D"white [1]"> <v:stroke endarrow=3D"block"/> <v:shadow color=3D"white [2]"/> </v:line><v:shape id=3D"_x0000_s75805" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:17.625pt;top:191.375pt;width:1in;height:28.625pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75806" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:668.75pt;top:173.75pt;width:106.75pt;height:21.375pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75807" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:636.5pt;top:203pt;width:155.5pt;height:49pt' filled=3D"f" fillcolor= =3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75808" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:686.375pt;top:126.875pt;width:78.375pt;height:40.5pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75809" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:636.875pt;top:232.375pt;width:138.625pt;height:21.375pt; mso-wrap-style:none;v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D= "yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75810" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:646.75pt;top:261.75pt;width:171.625pt;height:21.375pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75811" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:674.625pt;top:326.25pt;width:89pt;height:21.375pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75812" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:639.5pt;top:384.875pt;width:119.125pt;height:35.75pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75813" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:17.625pt;top:337.875pt;width:150.125pt;height:56.25pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75814" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:674.625pt;top:355.5pt;width:89pt;height:21.375pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75815" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:17.625pt;top:431.75pt;width:197pt;height:71.875pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75816" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:528pt;top:437.625pt;width:269.5pt;height:78.875pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75817" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:17.625pt;top:279.25pt;width:197pt;height:28.625pt;mso-wrap-style:non= e; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75818" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:642.5pt;top:279.25pt;width:152.375pt;height:50.125pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75820" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:17.125pt;top:408.25pt;width:73pt;height:28.625pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape><v:shape id=3D"_x0000_s75821" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:602.875pt;top:408.25pt;width:146.875pt;height:21.375pt;mso-wrap-styl= e:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:shape> <div v:shape=3D"_x0000_s75805" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:37.18%;left:3.18%;width:8.98%;height:3.94%'><span style=3D'font-family= :Arial; font-size:75%'><b>SIMBA</b></span></div> </div> <div v:shape=3D"_x0000_s75806" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:33.8%;left:85.39%;width:12.17%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>AZT +- NVPx1</b></span></div> </div> <div v:shape=3D"_x0000_s75807" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:39.15%;left:81.27%;width:19.66%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%'><b>AZT/DDI + NVP </b></span><span style=3D'font-famil= y: Arial;font-size:50%'><b><i>vs</i></b></span><span style=3D'font-family:Ari= al; font-size:50%'><b> 3TC </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:42.25%;left:81.27%;width:17.97%;height:5.07%'><span style=3D'font-size= :96%; mso-special-format:lastCR;display:none'> </span></div> </div> <div v:shape=3D"_x0000_s75808" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:24.78%;left:87.64%;width:9.92%;height:3.09%'><span style=3D'font-famil= y: Arial;font-size:58%'><b>PP infant </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:28.16%;left:87.64%;width:8.42%;height:3.09%'><span style=3D'font-famil= y: Arial;font-size:58%'><b><u>regimen</u></b></span></div> </div> <div v:shape=3D"_x0000_s75809" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:44.78%;left:81.27%;width:19.1%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVP (daily) </b></span><span style=3D'font-family:= Arial; font-size:50%'><b><i>vs</i></b></span><span style=3D'font-family:Arial; font-size:50%'><b><span style=3D'mso-spacerun:yes'>  </span>NVPx1</b></spa= n></div> </div> <div v:shape=3D"_x0000_s75810" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:50.42%;left:82.58%;width:20.03%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%'><b>NVP(daily) </b></span><span style=3D'font-family:A= rial; font-size:50%'><b><i>vs</i></b></span><span style=3D'font-family:Arial; font-size:50%'><b> NVPx1</b></span></div> </div> <div v:shape=3D"_x0000_s75811" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:62.53%;left:86.14%;width:11.61%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%'><b>AZT + NVPx1</b></span></div> </div> <div v:shape=3D"_x0000_s75812" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:73.8%;left:81.64%;width:16.1%;height:2.81%'><span style=3D'font-family= :Arial; font-size:50%'><b>AZT + NVPx1/AZT </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:76.61%;left:81.64%;width:13.48%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%;mso-special-format:lastCR;display:none'><b> </b></= span></div> </div> <div v:shape=3D"_x0000_s75813" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'position:absolute;top:64.78%;left:3.18%;width:18.7= 2%; height:3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Thai (Harvard) </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:69.01%;left:3.18%;width:17.41%;height:5.07%'><span style=3D'font-size:= 96%; mso-special-format:lastCR;display:none'> </span></div> </div> <div v:shape=3D"_x0000_s75814" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:68.16%;left:86.14%;width:11.61%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%'><b>AZT + NVPx1</b></span></div> </div> <div v:shape=3D"_x0000_s75815" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:82.81%;left:3.18%;width:27.9%;height:3.94%'><span style=3D'font-family= :Arial; font-size:75%'><b>Zambia (Harvard)/SA/ </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:86.76%;left:3.18%;width:26.21%;height:3.94%'><span style=3D'font-famil= y: Arial;font-size:75%'><b>HIVNET 024/Uganda </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:90.98%;left:3.18%;width:23.22%;height:3.94%'><span style=3D'font-famil= y: Arial;font-size:75%;mso-special-format:lastCR;display:none'><b> </b></= span></div> </div> <div v:shape=3D"_x0000_s75816" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:83.66%;left:67.6%;width:32.39%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVPx1 +-AZT </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:86.47%;left:67.6%;width:32.39%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVPx1+EBF abrupt </b></span><span style=3D'font-fa= mily: Arial;font-size:50%'><b><i>vs</i></b></span><span style=3D'font-family:Ari= al; font-size:50%'><b> routine wean; </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:89.29%;left:67.6%;width:32.39%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVPx1+EBF </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:91.83%;left:67.6%;width:38.95%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVPx1 + AP/IP<span style=3D'mso-spacerun:yes'>  </span>antiobiotics vs no antibiotics </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:94.64%;left:67.6%;width:32.39%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>NVPx1 vs NVPx1 + HIVIG </b></span></div> </div> <div v:shape=3D"_x0000_s75817" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:53.8%;left:3.18%;width:27.9%;height:3.94%'><span style=3D'font-family:= Arial; font-size:75%'><b>PEPI (Brazil, US?)/SA</b></span><span style=3D'font-size= :96%; mso-special-format:lastCR;display:none'> </span></div> </div> <div v:shape=3D"_x0000_s75818" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:53.8%;left:82.02%;width:17.6%;height:2.81%'><span style=3D'font-family= :Arial; font-size:50%'><b>AZT </b></span><span style=3D'font-family:Arial;font-siz= e: 50%'><b><i>vs</i></b></span><span style=3D'font-family:Arial;font-size:50%= '><b><span style=3D'mso-spacerun:yes'>  </span>NPV; </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:56.33%;left:82.02%;width:21.16%;height:2.81%'><span style=3D'font-fami= ly: Arial;font-size:50%'><b>AZT vs AZT + NVPx3 </b></span><span style=3D'font-= family: Arial;font-size:50%'><b><i>vs</i></b></span><span style=3D'font-family:Ari= al; font-size:50%'><b> </b></span></div> <div class=3DO style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:59.15%;left:82.02%;width:17.6%;height:2.81%'><span style=3D'font-famil= y: Arial;font-size:50%'><b>AZT + 3TC/NFV 2wk</b></span></div> </div> <div v:shape=3D"_x0000_s75820" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:78.3%;left= :2.24%; width:9.17%;height:3.94%'><span style=3D'font-family:Arial;font-size:75%'>= <b>Malawi</b></span></div> </div> <div v:shape=3D"_x0000_s75821" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:78.3%;left= :75.28%; width:20.41%;height:2.81%'><span style=3D'font-family:Arial;font-size:50%'= ><b>NVPx1 vs NVPx1 + AZT</b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0041_image016.emz Content-Transfer-Encoding: base64 Content-Type: image/x-emz H4sIAAAAAAACC+1aTWwbRRj9Zu0QJ4SotopaAgK7qBBZCJmjc+AvLcVSiiJTQQ8IOREXJFDrcABV SLW4OarghrrAgWOlciB3LiAkhAgHzKk3JDiABUq59Wbem51Zf2ucsDG1KhvGetnvm915+83Mm9md 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xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0046= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: SIMBA: Stopping Infection from Mother-to-child from = Breastfeeding in Africa – Infant Prophylaxis Vyankandondera J et al. IAS M= eeting, Paris France 2003"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"87"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s89090" type=3D"#_x0000_m1026" style=3D'position:absolute;left:13.25pt;top:11.75p= t; width:765.5pt;height:85pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:-.28%;left:-6.36%;width:112.73%;height= :20.56%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s89090" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:100.0%;height:39.72%'><span style=3D'font-size:86%'>S= IMBA: Stopping Infection from Mother-to-child from </span></span><span style=3D'position:absolute;top:34.24%;left:7.14%;width:85.88%;height:39.72= %'><span style=3D'font-size:86%'>Breastfeeding in Africa – Infant Prophylaxis<br> </span></span><span style=3D'position:absolute;top:67.12%;left:5.81%; width:88.7%;height:32.87%'><span style=3D'font-size:71%;color:white;mso-co= lor-index: 1'><b><i>Vyankandondera J et al.<span style=3D'mso-spacerun:yes'>  </span>= IAS Meeting, Paris France 2003</i></b></span><span style=3D'font-size:86%; color:white;mso-color-index:1;mso-special-format:lastCR;display:none'> = ;</span></span></div> <![if !ppt]></div> <![endif]><v:line id=3D"_x0000_s89091" style=3D'position:absolute' from=3D= "23.5pt,99.625pt" to=3D"774.375pt,99.625pt" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" 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width:184.75pt;height:64.5pt;mso-wrap-style:none;v-text-anchor:middle' fillcolor=3D"#03c" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> </v:rect><v:rect id=3D"_x0000_s89098" style=3D'position:absolute;left:323.= 375pt; top:375.25pt;width:191.375pt;height:64.5pt;mso-wrap-style:none; v-text-anchor:middle' fillcolor=3D"#69f" strokecolor=3D"white [1]"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> </v:rect> <div v:shape=3D"_x0000_s89092" class=3DO style=3D'text-align:center;positi= on:absolute; top:85.07%;left:41.76%;width:50.74%;height:6.19%'><span style=3D'font-fami= ly: Arial;font-size:117%;color:#00468C;mso-color-index:0'><b>Infant: NVP x 6 months</b></span></div> <div v:shape=3D"_x0000_s89093" class=3DO style=3D'text-align:center;positi= on:absolute; top:56.61%;left:41.01%;width:50.74%;height:6.19%'><span style=3D'font-fami= ly: Arial;font-size:117%'><b>Infant: 3TC x 6 months</b></span></div> <div v:shape=3D"_x0000_s89094" class=3DO> <div style=3D'text-align:center;position:absolute;top:42.53%;left:39.51%; width:25.46%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%= '><b>Mother: AZT </b></span></div> <div style=3D'text-align:center;position:absolute;top:48.73%;left:40.63%; width:23.22%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%= '><b>+ ddI x 1 wk</b></span></div> </div> <div v:shape=3D"_x0000_s89095" class=3DO style=3D'text-align:center'><span style=3D'position:absolute;top:43.38%;left:3.18%;width:24.71%;height:5.35%= '><span style=3D'font-family:Arial;color:#00468C;mso-color-index:0'><b>AZT +ddI st= art </b></span></span><span style=3D'position:absolute;top:48.73%;left:5.05%;width:20.78%;height:5.35%= '><span style=3D'font-family:Arial;color:#00468C;mso-color-index:0'><b>36 wks</b><= /span><span style=3D'color:#00468C;mso-color-index:0;mso-special-format:lastCR;display= :none'> </span></span></div> <div v:shape=3D"_x0000_s89096" class=3DO> <div style=3D'text-align:center;position:absolute;top:72.11%;left:28.46%; width:11.61%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>AZT </b></span></div> <div style=3D'text-align:center;position:absolute;top:77.46%;left:28.46%; width:11.61%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>+ddI</b></span></div> </div> <div v:shape=3D"_x0000_s89097" class=3DO> <div style=3D'text-align:center;position:absolute;top:65.91%;left:5.05%; width:21.53%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%; color:#00468C;mso-color-index:0'><b><span style=3D'mso-spacerun:yes'> </span> </b></span></div> <div style=3D'text-align:center;position:absolute;top:72.11%;left:5.05%; width:21.53%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>AZT +ddI </b></span></div> <div style=3D'text-align:center;position:absolute;top:77.46%;left:5.05%; width:21.53%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>start 36 wks</b></span><span style=3D'color:#00468C; mso-color-index:0;display:none'> </span></div> <div style=3D'text-align:center;position:absolute;top:83.09%;left:5.05%; width:21.53%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%; color:#00468C;mso-color-index:0;mso-special-format:lastCR;display:none'><b= > </b></span></div> </div> <div v:shape=3D"_x0000_s89098" class=3DO> <div style=3D'text-align:center;position:absolute;top:71.54%;left:40.26%; width:25.46%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%= '><b>Mother: AZT </b></span></div> <div style=3D'text-align:center;position:absolute;top:77.46%;left:41.38%; width:23.22%;height:5.91%'><span style=3D'font-family:Arial;font-size:113%= '><b>+ ddI x 1 wk</b></span></div> </div> <v:rect id=3D"_x0000_s89099" style=3D'position:absolute;left:211.25pt;top:= 222.875pt; width:105.5pt;height:64.5pt;mso-wrap-style:none;v-text-anchor:middle' fillcolor=3D"#06f" strokecolor=3D"white [1]"> <v:shadow color=3D"white [2]"/> </v:rect><v:shape id=3D"_x0000_s89100" type=3D"#_x0000_t202" style=3D'posi= tion:absolute; left:33pt;top:187.625pt;width:99.75pt;height:35.25pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s89101" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:33pt;top:346pt;width:99.75pt;height:35.125pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s89102" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:29.375pt;top:118.5pt;width:738.5pt;height:79.25pt' filled=3D"f" fillcolor=3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s89103" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:314pt;top:482pt;width:431.75pt;height:28.125pt;mso-wrap-style:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s89104" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:310.25pt;top:334.25pt;width:431.75pt;height:58.75pt;mso-wrap-style:n= one; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s89099" class=3DO> <div style=3D'text-align:center;position:absolute;top:43.09%;left:27.71%; width:11.61%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>AZT </b></span></div> <div style=3D'text-align:center;position:absolute;top:48.73%;left:27.71%; width:11.61%;height:5.35%'><span style=3D'font-family:Arial;color:#00468C; mso-color-index:0'><b>+ddI</b></span></div> </div> <div v:shape=3D"_x0000_s89100" class=3DO style=3D'position:absolute;top:36= .61%; left:5.05%;width:11.79%;height:5.35%'><span style=3D'font-family:Arial'><b= >Arm 1:</b></span></div> <div v:shape=3D"_x0000_s89101" class=3DO style=3D'position:absolute;top:66= .47%; left:5.05%;width:11.79%;height:5.35%'><span style=3D'font-family:Arial'><b= >Arm 2:</b></span></div> <div v:shape=3D"_x0000_s89102" class=3DO> <div style=3D'text-align:center;position:absolute;top:23.38%;left:4.68%; width:91.57%;height:4.5%'><span style=3D'font-family:Arial;font-size:83%'>= <b>All women get AZT+ddI “PETRA Arm A”-like 3-part regimen </b></span></div> <div style=3D'text-align:center;position:absolute;top:27.88%;left:4.68%; width:91.57%;height:4.5%'><span style=3D'font-family:Arial;font-size:83%'>= <b>Counseling exclusive breastfeeding for 3-6 months </b></span></div> <div style=3D'text-align:center;position:absolute;top:32.39%;left:4.68%; width:91.57%;height:4.5%'><span style=3D'font-family:Arial;font-size:83%'>= <b>Breastfeeding infants randomized to NVP vs 3TC</b></span><span style=3D'font-family:Aria= l; mso-special-format:lastCR;display:none'><b> </b></span></div> </div> <div v:shape=3D"_x0000_s89103" class=3DO style=3D'position:absolute;top:92= .39%; left:40.63%;width:57.49%;height:3.94%'><span style=3D'font-family:Arial; font-size:75%'><b>Birth-14 days, 2 mg/kg q d; then 2 mg/kg bid</b></span><= /div> <div v:shape=3D"_x0000_s89104" class=3DO> <div style=3D'position:absolute;top:64.22%;left:40.07%;width:57.49%;height= :3.94%'><span style=3D'font-family:Arial;font-size:75%'><b>Birth-14 days, 2 mg/kg bid; t= hen 4 mg/kg bid </b></span></div> <div style=3D'position:absolute;top:68.45%;left:40.07%;width:47.94%;height= :5.63%'><span style=3D'font-size:108%;mso-special-format:lastCR;display:none'> </spa= n></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0047.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0047= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: SIMBA: MTCT In Utero, Intrapartum/Early Postpartum = & Postnatal (Breast Milk) through 6 Mos "> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if 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href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s91138" type=3D"#_x0000_m1026" style=3D'position:absolute;left:26.375pt;top:23.5p= t; width:739.25pt;height:87.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:1.97%;left:-5.43%;width:111.04%;height= :21.4%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s91138" class=3DT><span style=3D'position:absolute; top:0%;left:7.92%;width:84.14%;height:38.15%'><span style=3D'font-size:86%= 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strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91169" style=3D'position:absolute' from=3D= "192,1264" to=3D"192,1542" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91170" style=3D'position:absolute' from=3D= "5616,1264" to=3D"5616,1542" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91171" style=3D'position:absolute' from=3D= "192,1542" to=3D"192,1820" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91172" style=3D'position:absolute' from=3D= "5616,1542" to=3D"5616,1820" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91173" style=3D'position:absolute' from=3D= "192,1820" to=3D"192,2098" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91174" style=3D'position:absolute' from=3D= "5616,1820" to=3D"5616,2098" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91175" style=3D'position:absolute' from=3D= "192,2098" to=3D"192,2411" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91176" style=3D'position:absolute' from=3D= "5616,2098" to=3D"5616,2411" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91177" style=3D'position:absolute' from=3D= "192,2411" to=3D"192,2689" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91178" style=3D'position:absolute' from=3D= "5616,2411" to=3D"5616,2689" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91179" style=3D'position:absolute' from=3D= "192,1264" to=3D"5616,1264" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91180" style=3D'position:absolute' from=3D= "4800,788" to=3D"4800,2689" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke dashstyle=3D"3 1" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91181" style=3D'position:absolute' from=3D= "5616,2689" to=3D"5616,3168" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D= "2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91182" style=3D'position:absolute' from=3D= "192,2689" to=3D"192,3168" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"= 2.25pt"> <v:stroke endcap=3D"square" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s91183" style=3D'position:absolute' from=3D= "192,2689" to=3D"5616,2689" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:stroke imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line></v:group><v:shapetype id=3D"_x0000_t202" coordsize=3D"21600,216= 00" o:spt=3D"202" path=3D"m,l,21600r21600,l21600,xe"> <v:stroke joinstyle=3D"miter"/> <v:path gradientshapeok=3D"t" o:connecttype=3D"rect"/> </v:shapetype><v:shape id=3D"_x0000_s91184" type=3D"#_x0000_t202" style=3D= 'position:absolute; left:176.875pt;top:372.625pt;width:15.875pt;height:35.125pt;mso-wrap-styl= e:none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape><v:shape id=3D"_x0000_s91185" type=3D"#_x0000_t202" style=3D'pos= ition:absolute; left:224.5pt;top:430.75pt;width:346.5pt;height:33.625pt;mso-wrap-style:no= ne; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"#00468c [0]"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s91140"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:67.32%;left:6.74%;width:92.5%;height:3.66%'><span style=3D'mso-special= -format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:80%'>(No statistically significant difference between arms) </span></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:72.95= %; left:6.74%;width:92.5%;height:3.66%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:80%;color:#006600;mso-special-format:lastCR;display:non= e'> </span></div> </div> <div v:shape=3D"_x0000_s91141"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:60.84%;left:71.72%;width:13.29%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>1 (0.5%)</span></div> </div> <div v:shape=3D"_x0000_s91142"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:53.8%;left:71.72%;width:13.29%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>1 (0.5%)</span></div> </div> <div v:shape=3D"_x0000_s91143"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:47.32%;left:71.72%;width:13.29%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>11 (6%)</span></div> </div> <div v:shape=3D"_x0000_s91144"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:40.84%;left:71.72%;width:13.29%;height:3.94= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :90%; mso-special-format:lastCR;display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s91145"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:34.36%;left:71.72%;width:13.29%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>13 (7%)</span></div> </div> <div v:shape=3D"_x0000_s91146"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:23.38%;left:71.72%;width:13.29%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>NVP arm </span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:29.29%;left:71.72%;width:13.29%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:70%'>N=3D198</span></div> </div> <div v:shape=3D"_x0000_s91147"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:60.84%;left:86.7%;width:12.54%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>3 (1%)</span></div> </div> <div v:shape=3D"_x0000_s91148"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:53.8%;left:86.7%;width:12.54%;height:3.94%'><span style=3D'mso-special= -format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>3 (1%)</span></div> </div> <div v:shape=3D"_x0000_s91149"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:47.32%;left:86.7%;width:12.54%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>24 (6%)</span></div> </div> <div v:shape=3D"_x0000_s91150"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:40.84%;left:86.7%;width:12.54%;height:3.94%= '><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :90%; mso-special-format:lastCR;display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s91151"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:34.36%;left:86.7%;width:12.54%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>30 (8%)</span></div> </div> <div v:shape=3D"_x0000_s91152"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:23.38%;left:86.7%;width:12.54%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>Total </span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:29.29%;left:86.7%;width:12.54%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:70%'>N=3D397</span></div> </div> <div v:shape=3D"_x0000_s91153"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:47.32%;left:55.99%;width:14.23%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>13 (7%)</span></div> </div> <div v:shape=3D"_x0000_s91154"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:47.32= %; left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:90%'><span style=3D'mso-spacerun:yes'>  </span>Birth</s= pan></div> </div> <div v:shape=3D"_x0000_s91155"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:60.84%;left:55.99%;width:14.23%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>2 (1%)</span></div> </div> <div v:shape=3D"_x0000_s91156"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:60.84= %; left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:90%'><span style=3D'mso-spacerun:yes'>  </span>Late pos= tnatal (4 wks-6 mos)</span><span style=3D'font-size:90%;color:#006600'>*</span></= div> </div> <div v:shape=3D"_x0000_s91157"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:53.8%;left:55.99%;width:14.23%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>2 (1%)</span></div> </div> <div v:shape=3D"_x0000_s91158"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:53.8%; left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:90%'><span style=3D'mso-spacerun:yes'>  </span>IP/Early postnatal (<4 wks)</span></div> </div> <div v:shape=3D"_x0000_s91159"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:40.84%;left:55.99%;width:14.23%;height:3.94= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :90%; mso-special-format:lastCR;display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s91160"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:40.84= %; left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:90%'><b><i>First positive HIV test:</i></b></span><span style=3D'font-size:90%;color:#006600;mso-special-format:lastCR;display:non= e'><b><i> </i></b></span></div> </div> <div v:shape=3D"_x0000_s91161"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:34.36%;left:55.99%;width:14.23%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>17 (9%)</span></div> </div> <div v:shape=3D"_x0000_s91162"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:34.36= %; left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'font-size:90%'>Overall HIV Infection - 6 Mos</span></div> </div> <div v:shape=3D"_x0000_s91163"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:23.38%;left:55.99%;width:14.23%;height:3.94%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:90%'>3TC arm </span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:29.29%;left:55.99%;width:14.23%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span style=3D'font-size:70%'>N=3D199</span></div> </div> <div v:shape=3D"_x0000_s91164"> <div class=3DHB1 style=3D'mso-margin-left-alt:288'></div> <div class=3DHB2 style=3D'mso-margin-left-alt:576'></div> <div class=3DHB3 style=3D'mso-margin-left-alt:864'></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1152'></div> <div class=3DHB style=3D'mso-margin-left-alt:0'><span style=3D'position:ab= solute; top:23.38%;left:6.74%;width:47.56%;height:3.94%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DFR style=3D'font-size:90%;mso-special-format:las= tCR; display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s91184" class=3DO><span style=3D'position:absolute; top:71.54%;left:23.22%;width:.18%;height:5.35%'><span lang=3DFR style=3D'mso-special-format:lastCR;display:none'> </span></span></div> <div v:shape=3D"_x0000_s91185" class=3DO style=3D'text-align:center;positi= on:absolute; top:82.53%;left:25.09%;width:50.56%;height:4.78%'><span style=3D'font-fami= ly: Arial;font-size:92%'><b>Median duration BF 3.3-3.5 mos</b></span><span style=3D'font-family:Arial;font-size:92%;mso-special-format:lastCR;display= :none'><b><i> </i></b></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0044.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File 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style=3D'font-family:Arial;font-size:60%;mso-ansi-language:FR'>New HIV infections and cumulative MTCT transmission </span></span><span style=3D'position:absolute;top:27.86%;left:4.15%;width:91.87%;height:32.78= %'><span lang=3DEN-US style=3D'font-family:Arial;font-size:60%;mso-ansi-language:FR= '>rates by age and treatment group < 500 CD4</span><span lang=3DFR style=3D'fon= t-family: Arial;font-size:60%;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> <![if !ppt]></div> <![endif]><v:group id=3D"_x0000_s79875" style=3D'position:absolute;left:29= .375pt; top:129pt;width:709.875pt;height:302.5pt' coordorigin=3D"336,1014" coords= ize=3D"5808,2476"> <v:rect id=3D"_x0000_s79876" style=3D'position:absolute;left:5455;top:101= 4; width:689;height:438;v-text-anchor:middle-center' filled=3D"f" fillcolor= =3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]" alignshape=3D"f" o:detectmouseclick=3D"t"= /> 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startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79922" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"4608,1014" to=3D"4608,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79923" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"2880,1014" to=3D"2880,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79924" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"5455,1014" to=3D"5455,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79925" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,1729" to=3D"6144,1729" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79926" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2005" to=3D"6144,2005" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79927" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2282" to=3D"6144,2282" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79928" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2558" to=3D"6144,2558" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79929" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2869" to=3D"6144,2869" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s79930" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,3179" to=3D"6144,3179" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line></v:group><v:rect id=3D"_x0000_s79931" style=3D'position:absolut= e; left:107.5pt;top:457.375pt;width:548.375pt;height:35.25pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:rect> <div v:shape=3D"_x0000_s79876" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:28.45%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>95% CI</span></div> </div> <div v:shape=3D"_x0000_s79877" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>% </span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.7%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>Efficacy</span></div> </div> <div v:shape=3D"_x0000_s79878" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><u>Placebo</u></span><span lang=3DEN-US style=3D'fon= t-size: 70%;font-weight:normal;mso-ansi-language:FR'> (N =3D 55 / 136)</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R; display:none'><u> </u></span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.7%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>HIV Transm. Rate (No.)</span></div> </div> <div v:shape=3D"_x0000_s79879" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:16.66%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><u>ZDV</u></span><span lang=3DEN-US style=3D'font-si= ze:70%; font-weight:normal;mso-ansi-language:FR'> (N =3D 50 / 137)</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R; display:none'><u> </u></span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.7%;left:16.66%;width:26.02%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>HIV Transm. Rate</span></div> </div> <div v:shape=3D"_x0000_s79880" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:28.45= %; left:8.42%;width:7.67%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>Age</span></div> </div> <div v:shape=3D"_x0000_s79881" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:76.9%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-30 - 29</span></div> </div> <div v:shape=3D"_x0000_s79882" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:76.9%;left:70.03%;width:12.54%;height:3.66%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><span style=3D'mso-spacerun:yes'>   </span>4%</span>= <span lang=3DEN-US style=3D'font-size:80%;font-weight:normal;mso-ansi-language:F= R'>*</span></div> </div> <div v:shape=3D"_x0000_s79883" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:76.9%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>41.3</span></div> </div> <div v:shape=3D"_x0000_s79884" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:76.9%; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>39.6</span></div> </div> <div v:shape=3D"_x0000_s79885" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:76.9%; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>24 mos.</span></div> </div> <div v:shape=3D"_x0000_s79886" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:69.85%;left:83.14%;width:10.11%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s79887" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:69.85%;left:70.03%;width:12.54%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s79888" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:69.85%;left:43.25%;width:26.02%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s79889" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0'><span style=3D'position:ab= solute; top:69.85%;left:29.58%;width:13.1%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DFR style=3D'font-size:70%;font-weight:normal;mso= -ansi-language: FR;mso-special-format:lastCR;display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s79890" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:69.85= %; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>18 mos.</span></div> </div> <div v:shape=3D"_x0000_s79891" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:62.53%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-39 - 26</span></div> </div> <div v:shape=3D"_x0000_s79892" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:62.53%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><span style=3D'mso-spacerun:yes'>  </span>-1%</span>= </div> </div> <div v:shape=3D"_x0000_s79893" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:62.53%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>38.0</span></div> </div> <div v:shape=3D"_x0000_s79894" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:62.53= %; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>38.5</span></div> </div> <div v:shape=3D"_x0000_s79895" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:62.53= %; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>12 mos.</span></div> </div> <div v:shape=3D"_x0000_s79896" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:55.77%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-19 - 42</span></div> </div> <div v:shape=3D"_x0000_s79897" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:55.77%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>17%</span></div> </div> <div v:shape=3D"_x0000_s79898" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:55.77%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>35.3</span></div> </div> <div v:shape=3D"_x0000_s79899" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:55.77= %; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>29.3</span></div> </div> <div v:shape=3D"_x0000_s79900" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:55.77= %; left:7.3%;width:8.8%;height:3.09%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>6 mos.</span></div> </div> <div v:shape=3D"_x0000_s79901" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:49.29%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-17 - 45</span></div> </div> <div v:shape=3D"_x0000_s79902" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:49.29%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>20%</span></div> </div> <div v:shape=3D"_x0000_s79903" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:49.29%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>34.3</span></div> </div> <div v:shape=3D"_x0000_s79904" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:49.29= %; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>27.5</span></div> </div> <div v:shape=3D"_x0000_s79905" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:49.29= %; left:7.3%;width:8.8%;height:3.09%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>3 mos.</span></div> </div> <div v:shape=3D"_x0000_s79906" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.09%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-18 - 46</span></div> </div> <div v:shape=3D"_x0000_s79907" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.09%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>20%</span></div> </div> <div v:shape=3D"_x0000_s79908" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.09%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>32.0</span></div> </div> <div v:shape=3D"_x0000_s79909" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:43.09= %; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>25.6</span></div> </div> <div v:shape=3D"_x0000_s79910" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:43.09= %; left:6.74%;width:9.36%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>6 weeks</span></div> </div> <div v:shape=3D"_x0000_s79911" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.61%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>-27 - 53</span></div> </div> <div v:shape=3D"_x0000_s79912" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.61%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>23%</span></div> </div> <div v:shape=3D"_x0000_s79913" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.61%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'> 26.1</span></div> </div> <div v:shape=3D"_x0000_s79914" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:36.61= %; left:27.9%;width:14.79%;height:3.09%'><span style=3D'mso-special-format:no= bullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>20.1</span></div> </div> <div v:shape=3D"_x0000_s79915" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:36.61= %; left:6.74%;width:9.36%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>2 weeks</span></div> </div> <div v:shape=3D"_x0000_s79931" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:87.6%;left= :8.61%; width:79.4%;height:5.07%'><span lang=3DEN-US style=3D'font-family:Arial; font-size:96%;mso-ansi-language:FR'>* risk difference at 24 months =3D 2.4% (-9.9 - 14.8%)</span><span lang=3DFR style=3D'font-family:Arial;font-size:= 96%; mso-ansi-language:FR;mso-special-format:lastCR;display:none'> </span><= /div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0045.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator 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style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s80898" type=3D"#_x0000_m1026" style=3D'position:absolute;left:29.375pt;top:29.37= 5pt; width:733.25pt;height:87.875pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.48286mm,1.2414mm,2.48286mm,1.2414mm" o:singleclick=3D"t"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:5.63%;left:.56%;width:99.06%;height:17= .18%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s80898" class=3DT><span style=3D'position:absolute; top:1.63%;left:0%;width:100.0%;height:32.78%'><span lang=3DEN-US style=3D'font-family:Arial;font-size:60%;mso-ansi-language:FR'>New HIV infections and cumulative MTCT transmission </span></span><span style=3D'position:absolute;top:27.86%;left:4.15%;width:91.87%;height:32.78= %'><span lang=3DEN-US style=3D'font-family:Arial;font-size:60%;mso-ansi-language:FR= '>rates by age and treatment group > 500 CD4</span><span lang=3DFR style=3D'fon= t-family: Arial;font-size:60%;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> <![if !ppt]></div> <![endif]><v:group id=3D"_x0000_s80899" style=3D'position:absolute;left:29= .375pt; top:129pt;width:709.875pt;height:310.75pt' coordorigin=3D"336,1014" coordsize=3D"5808,2476"> <v:rect id=3D"_x0000_s80900" style=3D'position:absolute;left:5455;top:101= 4; width:689;height:438;v-text-anchor:middle-center' filled=3D"f" fillcolor= =3D"yellow [4]" stroked=3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]" alignshape=3D"f" 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from=3D"1152,1014" to=3D"1152,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80946" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"4608,1014" to=3D"4608,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80947" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"2880,1014" to=3D"2880,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80948" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"5455,1014" to=3D"5455,3490" strokecolor=3D"white [1]" strokeweig= ht=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80949" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,1729" to=3D"6144,1729" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80950" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2005" to=3D"6144,2005" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80951" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2282" to=3D"6144,2282" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80952" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2558" to=3D"6144,2558" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80953" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,2869" to=3D"6144,2869" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line><v:line id=3D"_x0000_s80954" style=3D'position:absolute;v-text-a= nchor:middle-center' from=3D"336,3179" to=3D"6144,3179" strokecolor=3D"white [1]" strokeweigh= t=3D"1pt"> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarrow= width=3D"narrow" endarrowlength=3D"short" imagealignshape=3D"f"/> <v:shadow color=3D"white [2]"/> </v:line></v:group><v:rect id=3D"_x0000_s80955" style=3D'position:absolut= e; left:114.875pt;top:457.375pt;width:553.5pt;height:35.25pt;mso-wrap-style:= none; v-text-anchor:top-baseline' filled=3D"f" fillcolor=3D"yellow [4]" stroked= =3D"f" strokecolor=3D"white [1]" strokeweight=3D"1pt"> <v:fill color2=3D"#00468c [0]"/> <v:stroke startarrowwidth=3D"narrow" startarrowlength=3D"short" endarroww= idth=3D"narrow" endarrowlength=3D"short"/> <v:shadow color=3D"white [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.48286mm,1.2414mm,= 2.48286mm,1.2414mm"/> </v:rect> <div v:shape=3D"_x0000_s80900" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:28.45%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>95% CI</span></div> </div> <div v:shape=3D"_x0000_s80901" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>% </span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.98%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>Efficacy</span></div> </div> <div v:shape=3D"_x0000_s80902" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><u>Placebo</u></span><span lang=3DEN-US style=3D'fon= t-size: 70%;font-weight:normal;mso-ansi-language:FR'> (N =3D 38 / 179)</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R; display:none'><u> </u></span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.98%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>HIV Transm. Rate (No.)</span></div> </div> <div v:shape=3D"_x0000_s80903" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:25.91%;left:16.66%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><u>ZDV</u></span><span lang=3DEN-US style=3D'font-si= ze:70%; font-weight:normal;mso-ansi-language:FR'> (N =3D 16 / 177)</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R; display:none'><u> </u></span></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:30.98%;left:16.66%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>HIV Transm. Rate</span></div> </div> <div v:shape=3D"_x0000_s80904" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:28.45= %; left:8.42%;width:7.67%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>Age</span></div> </div> <div v:shape=3D"_x0000_s80905" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:78.3%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>28 - 76</span></div> </div> <div v:shape=3D"_x0000_s80906" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:78.3%;left:70.03%;width:12.54%;height:3.66%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><span style=3D'mso-spacerun:yes'>   </span>59%</span= ><span lang=3DEN-US style=3D'font-size:80%;font-weight:normal;mso-ansi-language:F= R'>*</span></div> </div> <div v:shape=3D"_x0000_s80907" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:78.3%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>22.0</span></div> </div> <div v:shape=3D"_x0000_s80908" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:78.3%; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>9.1</span></div> </div> <div v:shape=3D"_x0000_s80909" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:78.3%; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>24 mos.</span></div> </div> <div v:shape=3D"_x0000_s80910" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:70.98%;left:83.14%;width:10.11%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s80911" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:70.98%;left:70.03%;width:12.54%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s80912" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0'><span style=3D'position:absolute;top:70.98%;left:43.25%;width:26.02%;height:3.09= %'><span style=3D'mso-special-format:nobullet;display:none;color:#FC0128;font-famil= y: "Monotype Sorts";font-size:68%'>l</span><span lang=3DFR style=3D'font-size= :70%; font-weight:normal;mso-ansi-language:FR;mso-special-format:lastCR;display: none'> </span></span></div> </div> <div v:shape=3D"_x0000_s80913" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0'><span style=3D'position:ab= solute; top:70.98%;left:29.58%;width:13.1%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DFR style=3D'font-size:70%;font-weight:normal;mso= -ansi-language: FR;mso-special-format:lastCR;display:none'> </span></span></div> </div> <div v:shape=3D"_x0000_s80914" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:70.98= %; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>18 mos.</span></div> </div> <div v:shape=3D"_x0000_s80915" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:63.66%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>24 - 75</span></div> </div> <div v:shape=3D"_x0000_s80916" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:63.66%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'><span style=3D'mso-spacerun:yes'>  </span>56%</span>= </div> </div> <div v:shape=3D"_x0000_s80917" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:63.66%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>20.9</span></div> </div> <div v:shape=3D"_x0000_s80918" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:63.66= %; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>9.1</span></div> </div> <div v:shape=3D"_x0000_s80919" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:63.66= %; left:6.92%;width:9.17%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>12 mos.</span></div> </div> <div v:shape=3D"_x0000_s80920" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:56.61%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>18 - 74</span></div> </div> <div v:shape=3D"_x0000_s80921" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:56.61%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>54%</span></div> </div> <div v:shape=3D"_x0000_s80922" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:56.61%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>19.2</span></div> </div> <div v:shape=3D"_x0000_s80923" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:56.61= %; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>8.8</span></div> </div> <div v:shape=3D"_x0000_s80924" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:56.61= %; left:7.3%;width:8.8%;height:3.09%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>6 mos.</span></div> </div> <div v:shape=3D"_x0000_s80925" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:50.14%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>23 - 76</span></div> </div> <div v:shape=3D"_x0000_s80926" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:50.14%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>57%</span></div> </div> <div v:shape=3D"_x0000_s80927" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:50.14%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: = 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>19.3</span></div> </div> <div v:shape=3D"_x0000_s80928" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:50.14= %; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>8.4</span></div> </div> <div v:shape=3D"_x0000_s80929" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:50.14= %; left:7.3%;width:8.8%;height:3.09%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>3 mos.</span></div> </div> <div v:shape=3D"_x0000_s80930" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.66%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>27 - 78</span></div> </div> <div v:shape=3D"_x0000_s80931" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.66%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>60%</span></div> </div> <div v:shape=3D"_x0000_s80932" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:43.66%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-speci= al-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>19.3</span></div> </div> <div v:shape=3D"_x0000_s80933" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:43.66= %; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>7.7</span></div> </div> <div v:shape=3D"_x0000_s80934" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:43.66= %; left:6.74%;width:9.36%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>6 weeks</span></div> </div> <div v:shape=3D"_x0000_s80935" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.9%;left:83.14%;width:10.11%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>12 - 81</span></div> </div> <div v:shape=3D"_x0000_s80936" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.9%;left:70.03%;width:12.54%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'>59%</span></div> </div> <div v:shape=3D"_x0000_s80937" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'text-align:center;mso-margin-left-alt:0;position:= absolute; top:36.9%;left:43.25%;width:26.02%;height:3.09%'><span style=3D'mso-specia= l-format: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal; mso-ansi-language:FR'> 14.7</span></div> </div> <div v:shape=3D"_x0000_s80938" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:36.9%; left:28.46%;width:14.41%;height:3.09%'><span style=3D'mso-special-format:n= obullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>6.0</span></div> </div> <div v:shape=3D"_x0000_s80939" style=3D'tab-interval:.9774in'> <div class=3DHB1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'= ></div> <div class=3DHB2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'= ></div> <div class=3DHB3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'= ></div> <div class=3DHB4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:112= 6'></div> <div class=3DHB style=3D'mso-margin-left-alt:0;position:absolute;top:36.9%; left:6.74%;width:9.36%;height:3.09%'><span style=3D'mso-special-format:nob= ullet; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-US style=3D'font-size:70%;font-weight:normal;mso-ansi-language:F= R'>2 weeks</span></div> </div> <div v:shape=3D"_x0000_s80955" style=3D'tab-interval:.9774in'> <div class=3DO1 style=3D'mso-margin-left-alt:282;mso-text-indent-alt:282'>= </div> <div class=3DO2 style=3D'mso-margin-left-alt:563;mso-text-indent-alt:563'>= </div> <div class=3DO3 style=3D'mso-margin-left-alt:845;mso-text-indent-alt:845'>= </div> <div class=3DO4 style=3D'mso-margin-left-alt:1126;mso-text-indent-alt:1126= '></div> <div class=3DO style=3D'text-align:center;position:absolute;top:87.6%;left= :9.55%; width:80.14%;height:5.07%'><span lang=3DEN-US style=3D'font-family:Arial; font-size:96%;mso-ansi-language:FR'>* risk difference at 24 months =3D 12.= 7% (5.1 - 20.3%)</span><span lang=3DFR style=3D'font-family:Arial;font-size:9= 6%; mso-ansi-language:FR;mso-special-format:lastCR;display:none'> </span><= /div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0072.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0072= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Is PMTCT solved ?"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"130"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s133122" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.75pt;top:33pt;w= idth:718.25pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:6.19%;left:4.68%;width:91.01%;height:1= 4.92%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s133122" class=3DT style=3D'position:absolute;top:1= 6.98%; left:0%;width:99.79%;height:62.26%'><span lang=3DEN-GB>Is PMTCT solved ?</= span><span style=3D'mso-special-format:lastCR;display:none'> </span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s133123" type=3D"#_x0000_m1028" style=3D'position:absolute;left:17.875pt;top:148.3= 75pt; width:739.25pt;height:352.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:28.16%;left:2.24%;width:109.92%;height= :70.98%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s133123" class=3DB> <div style=3D'mso-line-spacing:"115 30 0";position:absolute;top:1.19%; left:0%;width:91.99%;height:7.53%'><span style=3D'mso-special-format:nobul= let; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'>   </span></span><span lang= =3DEN-GB style=3D'color:yellow;mso-color-index:3'> HAART during late pregnancy to a= ll HIV-infected women </span></div> <div style=3D'mso-line-spacing:"115 30 0";position:absolute;top:12.3%; left:0%;width:85.0%;height:7.53%'><span style=3D'mso-special-format:nobull= et; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span lang=3DEN-GB style=3D'color:yellow;mso-color-index:3'><span style=3D'mso-spacerun:yes'>             </span> </span></div> <div style=3D'mso-line-spacing:"115 30 0"'><span style=3D'position:absolut= e; top:23.41%;left:3.06%;width:92.5%;height:7.53%'><span style=3D'font-weight= :normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:absolute;left:-3= .31%; top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span></span><span lang=3DEN-GB>Which HAART regimen for asymptomatic women with high </span><= /span><span style=3D'position:absolute;top:32.53%;left:3.06%;width:81.94%;height:7.53%= '><span lang=3DEN-GB>CD4? </span></span></div> <div style=3D'mso-line-spacing:"115 30 0"'><span style=3D'position:absolut= e; top:43.65%;left:0%;width:95.05%;height:7.53%'><span style=3D'mso-special-f= ormat: nobullet;display:none;color:#FC0128;font-family:"Monotype Sorts";font-size: 68%'>l</span><span lang=3DEN-GB><span style=3D'mso-spacerun:yes'>    </span>(toxicity/adherence/cost/interaction with food&drinks/cold </sp= an></span><span style=3D'position:absolute;top:52.38%;left:3.06%;width:81.94%;height:7.53%= '><span lang=3DEN-GB>chain…) </span></span></div> <div style=3D'mso-line-spacing:"115 30 0"'><span style=3D'position:absolut= e; top:63.49%;left:3.06%;width:81.94%;height:7.53%'><span style=3D'font-weigh= t: normal'><span style=3D'mso-special-format:bullet;color:#FC0128;position:ab= solute; left:-3.74%;top:.43em;font-family:"Monotype Sorts";font-size:68%'>l</span>= </span><span lang=3DEN-GB>Risk of viral rebound during breast-feeding versus </span></s= pan><span style=3D'position:absolute;top:72.22%;left:3.06%;width:96.93%;height:7.53%= '><span lang=3DEN-GB>feasibility/risk/cost of replacement feeding up to 6 months P= P </span></span><span style=3D'position:absolute;top:81.34%;left:3.06%;width:81.94%;height:7.53%= '><span lang=3DEN-GB>versus risk of transmission </span></span></div> <div style=3D'mso-line-spacing:"115 30 0";position:absolute;top:92.46%; left:0%;width:85.0%;height:7.53%'><span style=3D'mso-special-format:nobull= et; display:none;color:#FC0128;font-family:"Monotype Sorts";font-size:68%'>l</= span><span style=3D'mso-special-format:lastCR;display:none'> </span></div> </div> <![if !ppt]></div> <![endif]></p:slide></div> </body> </html> ------=_NextPart_01C644B3.AAE5CEE0 Content-Location: file:///C:/5809C636/MTCT_HIV_de_Vincenzi_2006_files/slide0073.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dwindows-125= 2"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../MTCT_HIV_de_Vincenzi_2006.h= tm"> <link rel=3DPreview href=3Dpreview.wmf> <link rel=3DOLE-Object-Data href=3Doledata.mso> <!--[if !mso]> <style> v\:* {behavior:url(#default#VML);} o\:* {behavior:url(#default#VML);} p\:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} v\:textbox {display:none;} </style> <![endif]--> <title>Mother-to-child transmission (MTCT) of HIV - Isabelle de Vincenzi</t= itle> <![if IE]> <base href=3D"file:///C:\5809C636\MTCT_HIV_de_Vincenzi_2006_files\slide0073= .htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"11.03.2006: Challenge (1) Low Program Coverage* (1)"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint> <!--.sld {left:0px !important; width:6.0in !important; height:3.99in !important; font-size:107% !important;} --> </style> <script src=3Dscript.js></script><script><!-- if( !IsNts() ) Redirect( "PPTSld" ); //--></script><!--[if vml]><script>g_vml =3D 1; </script><![endif]--><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"131"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:355px;font-size:16px;background-color:#00468C;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"792,527" colors=3D"#00468c,#ffffff,#ffffff,#ffff00,#ffff00,#114ffb,#cf0e30,#8cf4ea" masterhref=3D"master03.xml"> <p:shaperange href=3D"master03.xml#_x0000_s1025"/><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1027"/><p:shaperange href=3D"master03.xml#_x0000_s1029"/> <div v:shape=3D"_x0000_s1030" class=3DO> <div style=3D'position:absolute;top:87.6%;left:4.49%;width:.93%;height:4.5= %'><span style=3D'font-family:"Arial Narrow";font-size:83%'><b><span style=3D'mso-spacerun:yes'> </span></b></span></div> </div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D= "_x0000_s134146" type=3D"#_x0000_m1026" style=3D'position:absolute;left:37.875pt;top:33pt;= width:718.125pt; height:77.125pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><![if !ppt]> <div style=3D'position:absolute;top:5.63%;left:4.86%;width:91.01%;height:1= 5.77%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s134146" class=3DT><span style=3D'position:absolute; top:0%;left:0%;width:99.79%;height:53.57%'><span style=3D'font-size:90%'>C= hallenge (1)<br> </span></span><span style=3D'position:absolute;top:44.64%;left:0%;width:9= 9.79%; height:53.57%'><span style=3D'font-size:90%;color:#FF9900'>Low </span><span style=3D'font-size:81%;color:#FF9900'>Program Coverage* (1)</span><span lang=3DEN-GB style=3D'font-size:81%;color:#FF9900;mso-special-format:lastC= R; display:none'> </span></span></div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s134147" type=3D"#_x0000_m1028" style=3D'position:absolute;left:37.875pt;top:121.1= 25pt; width:352.875pt;height:318pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1" size=3D"half"/></v:shape><![i= f !ppt]> <div style=3D'position:absolute;top:22.81%;left:4.86%;width:44.94%;height:= 69.85%; filter:DropShadow(Color=3D#000000, OffX=3D1, OffY=3D1)'><![endif]> <div v:shape=3D"_x0000_s134147"> <div class=3DHB style=3D'position:absolute;top:1.61%;left:0%;width:99.58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:7.53%;width:92.= 46%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span clas= s=3DHBB style=3D'position:absolute;left:-8.14%;top:.43em'>l</span></span><span style=3D'font-size:90%'>Few good efforts: </span></span></div> <div class=3DHB style=3D'position:absolute;top:10.88%;left:0%;width:99.58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:7.53%;width:92.= 46%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span clas= s=3DHBB style=3D'position:absolute;left:-8.14%;top:.43em'>l</span></span><span style=3D'font-size:90%'>CEE/CIS: </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:18.14%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Belarus: 87% </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:25.0%;left:10.0%;width:89.= 58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Ukraine: 49% </span></span></div> <div class=3DHB style=3D'position:absolute;top:33.87%;left:0%;width:99.58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:7.53%;width:92.= 46%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span clas= s=3DHBB style=3D'position:absolute;left:-8.14%;top:.43em'>l</span></span><span style=3D'font-size:90%'>LAC: </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:41.12%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Uruguay: 97% </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:48.38%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Belize: 70% </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:55.24%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Brazil: 33% </span></span></div> <div class=3DHB style=3D'position:absolute;top:64.11%;left:0%;width:99.58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:7.53%;width:92.= 46%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span clas= s=3DHBB style=3D'position:absolute;left:-8.14%;top:.43em'>l</span></span><span style=3D'font-size:90%'>SSA </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:71.37%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Mauritius: 100% </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:78.62%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%'>Botswana: 34% </span></span></div> <div class=3DHB1 style=3D'position:absolute;top:85.48%;left:10.0%;width:89= .58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:6.97%;width:92.= 55%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal;visibility:= hidden'><span class=3DHB1B style=3D'position:absolute;left:-7.53%'>–</span></span><span style=3D'font-size:90%;display:none'> </span></span></div> <div class=3DHB style=3D'position:absolute;top:94.35%;left:0%;width:99.58%; height:5.64%'><span style=3D'position:absolute;top:0%;left:7.53%;width:92.= 46%; height:100.0%'><span style=3D'font-size:90%;font-weight:normal;visibility:= hidden'><span class=3DHBB style=3D'position:absolute;left:-8.14%'>l</span></span><span lang=3DEN-GB style=3D'font-size:90%;mso-special-format:lastCR;display:none= '> </span></span></div> </div> <![if !ppt]></div> <![endif]><p:shaperange href=3D"master03.xml#_x0000_m1028"/><v:shape id=3D= "_x0000_s134148" type=3D"#_x0000_m1028" style=3D'position:absolute;left:288.25pt;top:119.6= 25pt; 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grouping=3D"t"/> <v:textbox inset=3D"2.51356mm,3.5pt,2.51356mm,3.5pt"/> <p:placeholder type=3D"body" position=3D"3" size=3D"quarter"/></v:shapetyp= e> <div v:shape=3D"_x0000_m2050" class=3DN> <div>Click to edit Master notes styles </div> <div><span style=3D'mso-special-format:lastCR'> </span></div> </div> <v:shapetype id=3D"_x0000_m2051" style=3D'position:absolute;left:51.75pt;to= p:66.625pt; width:434.25pt;height:289.375pt;v-text-anchor:middle' coordsize=3D"21600,2= 1600" o:master=3D"" o:spt=3D"1" path=3D"m,l,21600r21600,l21600,xe" filled=3D"f" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke joinstyle=3D"miter"/> <v:shadow obscured=3D"t"/> <v:path gradientshapeok=3D"t" fillok=3D"f" o:connecttype=3D"rect"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage" position=3D"2"/></v:shapetype><v:rect i= d=3D"_x0000_s2052" style=3D'position:absolute;left:501.75pt;top:759.5pt;width:31.125pt;height= :26.25pt; mso-wrap-style:none;v-text-anchor:middle' filled=3D"f" fillcolor=3D"#618ff= d [4]" stroked=3D"f" strokecolor=3D"black [1]" strokeweight=3D"1pt"> <v:fill color2=3D"white [0]"/> <v:shadow color=3D"#919191 [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t' inset=3D"2.51356mm,3.5pt,2.51= 356mm,3.5pt"/> </v:rect> <div v:shape=3D"_x0000_s2052" class=3DO style=3D'text-align:right'><span style=3D'font-family:Arial;font-size:58%;text-shadow:auto;mso-field-code:me= ta16'><i>‹#›</i></span><span style=3D'font-family:Arial;font-size:58%;text-shadow:auto;mso-special-forma= t: lastCR'><i> </i></span></div> <p:notes id=3D"26" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"46"/> </o:shapelayout><v:shape id=3D"_x0000_s47106" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s4710= 7" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s47107" class=3DN>Factors associated with breast mi= lk postnatal transmission risk included: <div>Mean antenatal viral load (adjusted OR 3.3 per 1 log increase) </= div> <div>Mean antenatal CD4 count (adjusted OR 1.6 per 100 cell decrease) = </div> Short-course ZDV did not affect postnatal breast milk transmission risk (a= djusted OR 1.1) <div style=3D'mso-line-spacing:"40 30 0"'> </div> Thus, more advanced maternal HIV disease associated with increased risk of postnatal transmission. <div style=3D'mso-line-spacing:"30 30 0"'> </div> While short-course ZDV efficacy was retained at 24 months demonstrating significant lasting benefit even in breastfeeding population, the risk of postnatal transmission was ~9% and further interventions to decrease breast milk transmission needed.</div> </p:notes><p:notes id=3D"27" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"48"/> </o:shapelayout><v:shape id=3D"_x0000_s49154" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s4915= 5" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s49155" class=3DN> <div><b>Gray<span style=3D'mso-spacerun:yes'>  </span>G.<span style=3D'mso-spacerun:yes'>  </span>Abstract LbOr05.<span style=3D'mso-spacerun:yes'>  </span>PETRA Trial.</b> </div> <div>18 month efficacy results of PETRA, evaluating 3 ZDV/3TC regimens:= 3;</div> <div>- Arm A - AP 36 wks/IP oral/PP 1 wk baby and mother </div> <div>- Arm B - IP oral/PP 1 week baby and mother </div> <div>- Arm C - IP oral </div> <div>- Placebo </div> <div style=3D'mso-line-spacing:"0 30 0"'> </div> Enrolled 1457 women in 2 sites S. Africa, 1 site Tanzania and Uganda; some significant differences between sites.<span style=3D'mso-spacerun:yes'>  </span>At entry, overall median CD4 count 450; 33% cesarean section rate (= half elective, primarily S. Africa); 69% breastfeeding (S. Africa 41%, mean duration 6 wks, range 3-12 wks; East Africa 99%, mean duration 24 wks, ran= ge 12-48 wks); infant mortality East Africa 7.0-7.5% vs 1.7-2.5% in S. Africa. <div style=3D'mso-line-spacing:"0 30 0"'> </div> Data presented for HIV infection and death (not transmission alone and not= by site).<span style=3D'mso-spacerun:yes'>  </span>While significant efficacy= in Arms A (RR 0.48, 95% CI 0.3-0.7)) and B (RR 0.66, 95% CI 0.5-0.9%) at age 6 wks, no longer significant at 18 months (Arm A, RR 0.78, 95% CI 0.6-1.0; A= rm B, RR 0.92, 95% CI, 0.7-1.2). <div style=3D'mso-line-spacing:"0 30 0"'> </div> Risk factors for transmission differed at 6 wks (elective C/S, maternal CD= 4) and 18 mos (maternal CD4, breastfeeding); 2-fold increase risk transmission with breastfeeding.</div> </p:notes><p:notes id=3D"29" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"52"/> </o:shapelayout><v:shape id=3D"_x0000_s53250" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s5325= 1" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s53251" class=3DN>When evaluate 12 month efficacy b= y HIV infection or death (similar to PETRA analysis), NVP efficacy is still observed.<span style=3D'mso-spacerun:yes'>  </span> <div> </div> At 6-8 wks, absolute difference NVP vs ZDV is 9.1% and at 12 months is 9.3%.<span style=3D'mso-spacerun:yes'>  </span> <div> </div> Survival curves for uninfected infants similar between NVP vs ZDV arms at = 18 months (~93% survival) and for infected infants (~62% survival). <div> </div> Transmission associated with higher maternal viral load (RR 2.1 per 1 log increase); NVP had more reduction in HIV RNA at day 7 postpartum than ZDV women (-1.03 log vs -0,.17 log, p<0.001); by 6 wks postpartum, similar increase in both NVP and ZDV arms (+0.18 log NVP vs<span style=3D'mso-spacerun:yes'>  </span>+0.11 log, p=3D0.12). </div> </p:notes><p:notes id=3D"28" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"50"/> </o:shapelayout><v:shape id=3D"_x0000_s51202" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s5120= 3" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s51203" class=3DN> <div><b>Owen M.<span style=3D'mso-spacerun:yes'>  </span>Abstract LbOr01.<= span style=3D'mso-spacerun:yes'>  </span>HIVNET 012</b> </div> 12 month efficacy analysis of HIVNET 012 (single dose IP/PP infant NVP vs IP/PP infant x1 wk ZDV).<span style=3D'mso-spacerun:yes'>  </span>Data ava= ilable on 96% infants at 12 months.<span style=3D'mso-spacerun:yes'>  </span>Almo= st all infants breastfed, with encouragement to wean at age 6 months, with rates similar both groups; after age 6 months, women in ZDV compared to NVP arm = more likely to stop breastfeeding. <div style=3D'mso-line-spacing:"10 30 0"'> </div> Efficacy of NVP in reducing transmission retained at age 12 months.<span style=3D'mso-spacerun:yes'>  </span>Absolute reduction transmission NVP vs= ZDV was 8.2% at 6-8 wks and 8.4% at 12 months.<span style=3D'mso-spacerun:yes'= >  </span> <div style=3D'mso-line-spacing:"0 30 0"'> </div> 12 month efficacy remains even when control for breastfeeding.<span style=3D'mso-spacerun:yes'>  </span>Cox proportional hazard: univariate, N= VP vs ZDV 0.58 (95% CI, 0.4-0.8%); controlling for breastfeeding in time-depende= nt model, NVP vs ZDV 0.58 (95% CI 0.4-0.9). <div style=3D'mso-line-spacing:"0 30 0"'> </div> No significant difference in any serious adverse events between groups for mothers or infants including rash, anemia, liver function (minor adverse events more common in infant ZDV arm during first 6 wks). <div><span style=3D'mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"32" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"58"/> </o:shapelayout><v:shape id=3D"_x0000_s59394" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s5939= 5" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s59395" class=3DN>Similar findings were seen for HIV infection or death, with no difference between arms.<span style=3D'mso-spacerun:yes'>  </span>Infant mortality was similar in both a= rms, with 10 deaths in NVP vs 17 in ZDV group.<span style=3D'mso-spacerun:yes'>  </span>Maternal CD4 count was associated with risk of infant death.</div> </p:notes><p:notes id=3D"34" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"62"/> </o:shapelayout><v:shape id=3D"_x0000_s63490" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s6349= 1" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s63491" class=3DN>Maternal antenatal antiretroviral treatment was associated with risk of perinatal transmission.<span style=3D'mso-spacerun:yes'>  </span>Transmission was highest, 21% in women= without therapy and also ZDV monotherapy when administered for maternal HIV disease (prior to 4/94); these rates were not significantly different.<span style=3D'mso-spacerun:yes'>  </span>Transmission was significantly lower w= ith 076 ZDV monotherapy (8%), non-HAART multi-antiretroviral (4%), and lowest = with HAART (1%). In univariate analysis, significant factors associated with transmission was maternal delivery RNA, low maternal CD4 count,<span style=3D'mso-spacerun:yes'>  </span>type of antiretroviral therapy, matern= al AIDS-defining illness, duration of membrane rupture, elective cesarean delivery, maternal antenatal hard drug use, gestational age of infant, low infant birthweight. In multivariate analysis, independent risk factors= for transmission were higher antenatal delivery RNA, increasing complexity of<= span style=3D'mso-spacerun:yes'>  </span>maternal antiretroviral therapy, durat= ion of membrane rupture over 4 hours, infant birthweight <2500 grams, and elec= tive cesarean delivery (the latter borderline significance).</div> </p:notes><p:notes id=3D"52" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"96"/> </o:shapelayout><v:shape id=3D"_x0000_s98306" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s9830= 7" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.7= 5pt; width:394.375pt;height:356.75pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.55797mm,1.279mm,2.55797mm,1.279mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape></p:notes><p:notes= id=3D"60" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"107"/> </o:shapelayout><v:shape id=3D"_x0000_s109570" type=3D"#_x0000_m2051" styl= e=3D'position:absolute; left:44.25pt;top:59.625pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1095= 71" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.7= 5pt; width:394.375pt;height:356.625pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.58419mm,1.2921mm,2.58419mm,1.2921mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s109571" class=3DN>In HIVNET 012, 36 infants were H= IV-1 infected by 14-16 weeks of age despite NVP prophylaxis. <div>Our analysis included 31 of the 36 mothers. </div> These women had high viral loads compared to the majority of women in HIVN= ET 012 whose infants were not infected. Therefore, this group of women may ha= ve been more likely develop NVP resistance after NVP administration. We a= lso analyzed 16 of the HIV-1 infected infants. 12 of those infants had evidenc= e of HIV-1 infection at the time of birth. <div><span style=3D'mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"62" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"110"/> </o:shapelayout><v:shape id=3D"_x0000_s112642" type=3D"#_x0000_m2051" styl= e=3D'position:absolute; left:45.75pt;top:59.625pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1126= 43" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.7= 5pt; width:394.375pt;height:356.625pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.58419mm,1.2921mm,2.58419mm,1.2921mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s112643" class=3DN>To date, we have analyzed samples obtained 14 weeks after delivery from 2 of the 7 infants with NVP resistan= ce mutations detected at 6 weeks of age. In one infant, NVP resistance mutations were absent in the 14 week follow-up sample. <div>In the other infant, the Y181C mutation was still detected at 14 weeks. </div> We are in the process of analyzing additional follow-up samples from infan= ts with NVP resistance mutations.</div> </p:notes><p:notes id=3D"63" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"112"/> </o:shapelayout><v:shape id=3D"_x0000_s114690" type=3D"#_x0000_m2051" styl= e=3D'position:absolute; left:44.25pt;top:59.625pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1146= 91" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.7= 5pt; width:394.375pt;height:356.625pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.58419mm,1.2921mm,2.58419mm,1.2921mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape></p:notes><p:notes= id=3D"64" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"114"/> </o:shapelayout><v:shape id=3D"_x0000_s116738" type=3D"#_x0000_m2051" styl= e=3D'position:absolute; left:46.75pt;top:59.375pt;width:444pt;height:296pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1167= 39" type=3D"#_x0000_m2050" style=3D'position:absolute;left:70.75pt;top:375.12= 5pt; width:395.5pt;height:361.5pt;mso-wrap-style:square;v-text-anchor:top' o:insetmode=3D"custom"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate:0;direction:LTR; mso-rotate-with-shape:f;mso-fit-shape-to-text:f;mso-fit-text-to-shape:f' inset=3D"2.51586mm,1.2579mm,2.51586mm,1.2579mm" o:singleclick=3D"t"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s116739" class=3DN><span style=3D'font-family:Arial; mso-ascii-font-family:Arial;mso-bidi-font-family:"Times New Roman"'>Women received zidovudine from thirty-four weeks gestation.<span style=3D'mso-spacerun:yes'>  </span></span><span style=3D'font-family:Aria= l; mso-ascii-font-family:Arial;mso-bidi-font-family:"Times New Roman"'>Nevira= pine was added at intrapartum and infants were given Nevirapine </span><span style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-bidi-font-famil= y: "Times New Roman"'>at forty-eight to seventy-two hours and zidovudine for = four weeks after </span><span style=3D'font-family:Arial;mso-ascii-font-family:= Arial; mso-bidi-font-family:"Times New Roman"'>birth.</span><span style=3D'font-f= amily: "Times New Roman";mso-ascii-font-family:Arial;mso-bidi-font-family:"Times = New Roman"; mso-special-format:lastCR'><i> </i></span></div> </p:notes><p:notes id=3D"65" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"116"/> </o:shapelayout><v:shape id=3D"_x0000_s118786" type=3D"#_x0000_m2051" styl= e=3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s1187= 87" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.7= 5pt; width:394.375pt;height:356.75pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s118787" class=3DN>Our study demonstrated that shor= t course ZDV starting at 34 weeks gestation given in combination with a dose of NVP= to women at labor and to their infants shortly after birth was safe and well tolerated.<span style=3D'mso-spacerun:yes'>  </span>The transmission rate = was 4.6% and lower than seen in our previous study.<span style=3D'mso-spacerun:yes'>  </span> Given the safety profile, transmi= ssion rates, and the efficacy results from a recently completed Phase III trial conducted in Thailand that will be presented at the late breaker session, a combination short course ZDV and NVP regimen will now be used in Thailand = and may be useful in other countries. Future studies are needed to evaluate whether the development of a new NVP mutation following a single dose of Nevirapine will affect the long-term treatment options for HIV-infected wo= men who participate in the Thai National PMTCT program.<span lang=3DTH style=3D'mso-special-format:lastCR'> </span></div> </p:notes><p:notes id=3D"35" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"64"/> </o:shapelayout><v:shape id=3D"_x0000_s65538" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s6553= 9" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s65539" class=3DN> <div>Prevalence of other resistance mutations at delivery relatively high. </div> <div> </div> At delivery, 7-10% had ZDV resistance mutations; 41% had 3TC<span style=3D'mso-spacerun:yes'>  </span>resistance mutations; and 32% had >= 3 PI resistance mutations. <div> </div> Don’t have information on individual antiretroviral regimens in these pati= ents at this time.</div> </p:notes><p:notes id=3D"36" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"66"/> </o:shapelayout><v:shape id=3D"_x0000_s67586" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s6758= 7" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s67587" class=3DN> <div><b>Coutsoudis A.<span style=3D'mso-spacerun:yes'>  </span>Abstract LbOr6.<span style=3D'mso-spacerun:yes'>   </span>Method of Infant Feeding<= /b> </div> Analysis through age 15 months in S. African Vitamin A trial of infection = by method of infant feeding (never, exclusive for at least first 3 months lif= e, mixed) in 551 mother-infant pairs. <div style=3D'mso-line-spacing:"50 30 0"'> </div> Maternal CD4 count and viral load similar at entry into study.<span style=3D'mso-spacerun:yes'>  </span>Rates of diarrhea, LRTI and thrush in infants did not differ between infants exclusively breastfed for 6 wks to those who switched to mixed at <6 wks of age (re: speaks against reverse causality). <div style=3D'mso-line-spacing:"30 30 0"'> </div> Rate of in utero infection similar in 3 groups.<span style=3D'mso-spacerun:yes'>  </span>Cumulative probability of infection st= ill remained lower among infants exclusively breastfeeding for at least 3 mont= hs infants than those with mixed feeding. <div style=3D'mso-line-spacing:"40 30 0"'> </div> <div>Number deaths by infant feeding: </div> <div>Never:<span style=3D'mso-spacerun:yes'>         </span>7 </div> <div>Exclusive:<span style=3D'mso-spacerun:yes'>   </span>1 </div> <div>Mixed:<span style=3D'mso-spacerun:yes'>       </span>15 </div> <div style=3D'mso-line-spacing:"0 30 0"'> </div> Cox model in which adjustment for treatment assignment, Cd4/8, mode delive= ry, DROM, syphilis, age, water source and other factors had magnitude RR altho= ugh statistical significance no longer present:<br> Exclusive vs mixed:<span style=3D'mso-spacerun:yes'>  </span>RR 0.56 (0.22-1.42). <div> </div> <div><span style=3D'mso-special-format:lastCR'> </span></div> </div> </p:notes><p:notes id=3D"37" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"68"/> </o:shapelayout><v:shape id=3D"_x0000_s69634" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.125pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <p:placeholder type=3D"slideImage"/></v:shape><v:shape id=3D"_x0000_s6963= 5" type=3D"#_x0000_m2050" style=3D'position:absolute;left:71.625pt;top:376.6= 25pt; width:394.375pt;height:356.875pt'> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s69635" class=3DN><b>Nduati R.<span style=3D'mso-spacerun:yes'>  </span>Abstract WeOrC495.<span style=3D'mso-spacerun:yes'>  </span>Kenya Formula/BreastFeeding </b><b>Stu= dy </b>Evaluated maternal mortality among breast (N=3D212) vs formula-feeding (N=3D213) wom= en in trial.<span style=3D'mso-spacerun:yes'>  </span> <div style=3D'mso-line-spacing:"40 30 0"'> </div> Maternal mortality was significantly higher in breast-feeding than formula= -feeding arm, with overall<span style=3D'mso-spacerun:yes'>  </span>3-fold increase= d risk of mortality in breast-feeding arm. <div style=3D'mso-line-spacing:"50 30 0"'> </div> 22% of excess mortality seen by<span style=3D'mso-spacerun:yes'>  </span>6= wks, 55% by 6 months, 72% by 1 ear, and 100% by 18months.<span style=3D'mso-spacerun:yes'>  </span>Attributable risk of mortality from br= eastfeeding was 69%. <div style=3D'mso-line-spacing:"40 30 0"'> </div> Breastfeeding women had more weight loss than formula feeding women. <div style=3D'mso-line-spacing:"20 30 0"'> </div> Mortality was associated with maternal CD4 count, RNA, AIDS illness and we= ight during follow-up. <div style=3D'mso-line-spacing:"40 30 0"'> </div> Infant mortality higher among women who died; among the 24 women who died,= 11 of their infants also died; RR of infant death was 3.1 (95% CI, 1.6-5.9, p=3D0.001) if mother died.</div> </p:notes><p:notes id=3D"46" layout=3D"notes" slots=3D"slideImage,body"> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"88"/> </o:shapelayout><v:shape id=3D"_x0000_s90114" type=3D"#_x0000_m2051" style= =3D'position:absolute; left:45.75pt;top:59.5pt;width:446.25pt;height:297.375pt'> <v:fill o:detectmouseclick=3D"t"/> <v:stroke o:forcedash=3D"t"/> <o:lock v:ext=3D"edit" text=3D"t"/> 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g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 0; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"End of slide show, click to exit.", SCREEN_MODE=3D"Fram= es", gIsEndShow=3D0, NUM_VIS_SLDS=3D44, SCRIPT_HREF=3D"script.js", FULLSCR_= HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0074.htm",1,-1,1),new hrefList(= "slide0016.htm",1,-1,1),new hrefList("slide0013.htm",1,-1,1),new hrefList("= slide0017.htm",1,-1,1),new hrefList("slide0026.htm",1,-1,1),new hrefList("s= lide0027.htm",1,-1,1),new hrefList("slide0029.htm",1,-1,1),new hrefList("sl= ide0028.htm",1,-1,1),new hrefList("slide0032.htm",1,-1,1),new hrefList("sli= de0048.htm",1,-1,1),new hrefList("slide0040.htm",1,-1,1),new hrefList("slid= e0050.htm",1,-1,1),new hrefList("slide0038.htm",1,-1,1),new hrefList("slide= 0034.htm",1,-1,1),new hrefList("slide0049.htm",1,-1,1),new hrefList("slide0= 051.htm",1,-1,1),new hrefList("slide0052.htm",1,-1,1),new hrefList("slide00= 54.htm",1,-1,1),new hrefList("slide0055.htm",1,-1,1),new hrefList("slide005= 6.htm",1,-1,1),new hrefList("slide0059.htm",1,-1,1),new hrefList("slide0060= .htm",1,-1,1),new hrefList("slide0061.htm",1,-1,1),new hrefList("slide0062.= htm",1,-1,1),new hrefList("slide0063.htm",1,-1,1),new hrefList("slide0064.h= tm",1,-1,1),new hrefList("slide0065.htm",1,-1,1),new hrefList("slide0066.ht= m",1,-1,1),new hrefList("slide0071.htm",1,-1,1),new hrefList("slide0035.htm= ",1,-1,1),new hrefList("slide0067.htm",1,-1,1),new hrefList("slide0068.htm"= ,1,-1,1),new hrefList("slide0069.htm",1,-1,1),new hrefList("slide0070.htm",= 1,-1,1),new hrefList("slide0018.htm",1,-1,1),new hrefList("slide0036.htm",1= ,-1,1),new hrefList("slide0037.htm",1,-1,1),new hrefList("slide0041.htm",1,= -1,1),new hrefList("slide0046.htm",1,-1,1),new hrefList("slide0047.htm",1,-= 1,1),new hrefList("slide0044.htm",1,-1,1),new hrefList("slide0045.htm",1,-1= ,1),new hrefList("slide0072.htm",1,-1,1),new hrefList("slide0073.htm",1,-1,= 1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii<GetSldList().mList.length; ii++) { if ( GetSldList().mList[ii].mSldHref =3D=3D href ) return ii+1 } return 1 } function GetHrefObj( sldIdx ){ return GetSldList().mList[sldIdx-1] } function IsFramesMode(){ return ( SCREEN_MODE =3D=3D "Frames" ) } function IsFullScrMode(){ return ( SCREEN_MODE =3D=3D "FullScreen" ) } function GoToNextSld() { ii=3DgCurSld + 1 if( GetHrefObj( ii-1 ).mOrigVis =3D=3D 0 ) { if( ii<=3DGetSldList().mList.length ) { obj=3DGetHrefObj(ii) obj.mVis=3D1 GoToSldNum(ii) return } } else { obj=3DGetHrefObj( ii ) while ( obj && ( obj.mOrigVis =3D=3D 0 ) ) obj=3DGetHrefObj(++ii) if( obj && obj.mOrigVis ) { GoToSldNum(ii) return } } if( gSldStack.length > 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('<html><body dir=3D' + dir + ' bgcolor=3Dblack onload=3Dparent= .SetupEndShow() onunload=3Dparent.Unload()><center><p><font face=3DTahoma c= olor=3Dwhite size=3D2><br><b>' + ENDSHOW_MESG + '</b></font></p></center></= body></html>') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii<arr.length;ii++) { this.mList[ii] =3D new hrefList( arr[ii].mSldHref, arr[ii].mOrigVis, arr[= ii].mAdvDelay, arr[ii].mAdvOnClk ); if( arr[ii].mOrigVis ) this.mList[ii].mSldIdx =3D idx++; } this.mNumVisSlds =3D idx-1; this.fEndShow =3D fEnd; } function GetSldList() { return gSldStack[gSldStack.length-1] } function GetCurSld() { return parent.GetSldList().mList[parent.gCurSld - 1]= } gSldStack =3D new Array(); gSldStack[0] =3D new SldList(gMainDoc,gCurSld,1) function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } /********************************************* Custom Shows implementation When ViewCustomShow() is called, we create a new array that is a subset of the slides in=20 the main doc. This list pushed on a stack so we can return after the end of the custom show. *********************************************/ function ViewCustomShow(idx,fEnd) { if( !IsFullScrMode() ) return; var sldList =3D new Array(); var custShow =3D custShowList[idx-1]; var jj =3D 0; for( ii=3D0;ii<custShow.length;ii++ ) { if( custShow[ii] <=3D gMainDoc.length ) sldList[jj++] =3D gMainDoc[custShow[ii]-1]; } if (sldList.length > 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Next",sPrev=3D"Previous",sEnd=3D"End Show",sFont=3D"Arial",sAr= row=3D"Arrow",sFreeform=3D"Freeform",sRect=3D"Rectangle",sOval=3D"Oval" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( 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onmousedown=3D"BtnOnDown()" onmouseout=3D"BtnOnOut()" onmouseup=3D"BtnOnUp(= )" onkeypress=3D"ExecBtn()" style=3D'display:none;visibility:hidden'> <table style=3D'position:relative;width:70px' align=3Dleft cellpadding=3D0 = cellspacing=3D0> <td nowrap><div title=3D"Show/Hide Outline" id=3D"nb_otl" onfocus=3D"BtnOnOver()" onblur=3D"BtnOnOut()" TABIND= EX=3D11 style=3D'position:absolute;top:0%;left:0%;width:100%;height:100%;cursor:de= fault'> <div id=3D"nb_otlElem" align=3Dcenter style=3D'position:relative;padding:3= px;font-family:Arial; color:buttontext;font-size:9pt'>Outline</div></div> </td> </table> <table style=3D'position:relative' align=3Dcenter cellpadding=3D0 cellspaci= ng=3D0> <td> <div style=3D'position:absolute;left:-18px;width:24px;height:20px;border-s= tyle: solid;border-width:1px;border-color:threedface' onfocus=3D"BtnOnOver()" on= blur=3D"BtnOnOut()" TABINDEX=3D12 id=3D"nb_otlTxtBorder"> <div style=3D'position:absolute;clip:rect(0px, 22px, 18px, 0px)'><img src=3Dbuttons.gif id=3D"nb_otlTxt" title=3D"Expand/Collapse Outline" style=3D'position:relative;left:-157px'></div> </div> </td> </table> </div> <div id=3DOtlObj style=3D'display:none;visibility:hidden;'> <table width=3D"100%" style=3D'font-family:Arial;font-size:9pt'> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>1</font></div> </td> <td width=3D"100%"> <div id=3DPPTP1 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0074.htm');" id=3DPPTL1>Mother-to-child transmission (MTCT) of HIV<br> <br> Isabelle de Vincenzi <br> <br> Training Course in Reproductive Health / Sexual Health Research<br> Geneva 2006</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>2</font></div> </td> <td> <div id=3DPPTP2 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0016.htm');" id=3DPPTL2><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>3</font></div> </td> <td> <div id=3DPPTP3 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0013.htm');" id=3DPPTL3>Prevention of MT= CT through antiretrovirals</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>4</font></div> </td> <td> <div id=3DPPTP4 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0017.htm');" id=3DPPTL4>ARV regimen of p= roven efficacy <br> (through clinical trials)</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>5</font></div> </td> <td> <div id=3DPPTP5 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0026.htm');" id=3DPPTL5>Ivory Coast Shor= t-Course ZDV Trials: Combined Analysis Through 24 Months<br> Witkor S.<span style=3D'mso-spacerun:yes'>  </span>XIII AIDS Conf, July= 2000, Durban S Africa (TuOrB354)</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>6</font></div> </td> <td> <div id=3DPPTP6 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0027.htm');" id=3DPPTL6><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>7</font></div> </td> <td> <div id=3DPPTP7 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0029.htm');" id=3DPPTL7><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>8</font></div> </td> <td> <div id=3DPPTP8 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0028.htm');" id=3DPPTL8>HIVNET 012, Intrapartum/Postpartum Nevirapine vs ZDV:<span style=3D'mso-spacerun:yes'= >  </span>HIV Transmission<br> Owen M.<span style=3D'mso-spacerun:yes'>  </span>XIII AIDS Conf, July 2= 000, Durban S Africa (LbOr01)</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>9</font></div> </td> <td> <div id=3DPPTP9 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0032.htm');" id=3DPPTL9><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>10</font></div> </td> <td> <div id=3DPPTP10 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0048.htm');" id=3DPPTL10>ANRS Abidjan - = 6 wks Tx rates</a></font></div> <div id=3DPPTC10 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>DITRAME (ZDV 36wks-delivery) 12.8%</li> <li>DITRAME+ (ZDV + HIVNET012) <span style=3D'mso-spacerun:yes'>  </spa= n>6.2%</li> <li>DITRAME++ (Combivir + HIVNET012) <span style=3D'mso-spacerun:yes'>  </span>4.8%</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>11</font></div> </td> <td> <div id=3DPPTP11 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0040.htm');" id=3DPPTL11>Thailand Perina= tal Prevention (1)<br> Short-Course AZT Trial Results</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>12</font></div> </td> <td> <div id=3DPPTP12 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0050.htm');" id=3DPPTL12><span style=3D'mso-spacerun:yes'> </span>Perinatal HIV Prevention Trial – Thail= and (2)</a></font></div> <div id=3DPPTC12 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>All women received ZDV from 28weeks</li> <li>All new-borns received 1 week ZDV</li> <li>Randomisation in 3 arms according to SD-NVP given to mother and chil= d, mother only, no NVP:</li> <li>Nevirapine-Nevirapine arm - Tx rate 2.0% (1.2 to 3.4)</li> <li>Nevirapine-Placebo arm – Tx rate 2.8% (1.8 to 4.4)</li> <li><span style=3D'mso-spacerun:yes'> </span>Placebo-Placebo arm – Tx ra= te 6.3% (4.2 to 9.5), stopped at interim analysis</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>13</font></div> </td> <td> <div id=3DPPTP13 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0038.htm');" id=3DPPTL13>ARV Use and HIV Transmission<br> (WITS, USA)</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>14</font></div> </td> <td> <div id=3DPPTP14 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0034.htm');" id=3DPPTL14><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>15</font></div> </td> <td> <div id=3DPPTP15 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0049.htm');" id=3DPPTL15>Infant PEP - Wo= men who have not received an ante-partum regimen</a></font></div> <div id=3DPPTC15 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Wade (NY city) : 6 weeks ZDV started<span style=3D'mso-spacerun:yes'>                               </span> within 48h of birth</li> <li>Gray (SA) : 1 week ZDV or 1 dose NVP</li> <li> (equivalent)</li> <li>Taha-Taha (Malawi): 1 week ZDV + 1 dose NVP (better than NVP alone)</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>16</font></div> </td> <td> <div id=3DPPTP16 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0051.htm');" id=3DPPTL16>Studies of Resi= stance in PMTCT trials using NVP</a></font></div> <div id=3DPPTC16 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>PACTG 316, HIVNET 012,</li> <li>SAINT, HIVNET 023, and Peri-3</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>17</font></div> </td> <td> <div id=3DPPTP17 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0052.htm');" id=3DPPTL17>PACTG 316 Schem= a, Results : SD NVP Did Not Improve Efficacy of Longer or More Complex ARV Regimens<br> Dorenbaum A et al.<span style=3D'mso-spacerun:yes'>  </span>JAMA 2002;288:189-98<span style=3D'mso-spacerun:yes'>  </span>[LMofenson slide= ]</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>18</font></div> </td> <td> <div id=3DPPTP18 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0054.htm');" id=3DPPTL18>Incidence of NVP Resistance at 6 Weeks PP <br> in<span style=3D'mso-spacerun:yes'>  </span>Substudy of Women Receiving= ARV in<span style=3D'mso-spacerun:yes'>  </span>PACTG 316<br> Cunningham C et al.<span style=3D'mso-spacerun:yes'>  </span>J Infect D= is 2002;186:181-8 [L Mofenson slide]</a></font></div> <div id=3DPPTC18 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>16/217 women who did not have NVP resistance at delivery had NVP resistant virus detected at 6 weeks pp:</li> <ul> <li>14/95 (15%) in NVP arm</li> <li>2/122 (2%) in placebo arm (neither had received active drug or open-label NNRTI)</li> </ul> <li>K103N most common (alone in 7 and in combination in 3 women).</li> <li>All women with K103N mutation had mixture of mutant and wild-type vi= rus.</li> <li>Not related to pre pregnancy or antenatal ARV’s; or to delivery CD4, viral load, or other ARV resistance</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>19</font></div> </td> <td> <div id=3DPPTP19 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0055.htm');" id=3DPPTL19> HIVNET 012: Resistance Studies in NVP arm – Sue Eshleman</a></font></div> <div id=3DPPTC19 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Women: 200 mg NVP at onset of labor</li> <li>Infants: 2 mg/kg NVP within 72 hrs of birth</li> <li>Overall transmission rate 6-8 wks=3D 11.8%</li> <li>Overall transmission rate 18 months =3D 15.9%</li> <li>SD NVP Relative Efficacy 42% compared to ZDV</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>20</font></div> </td> <td> <div id=3DPPTP20 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0056.htm');" id=3DPPTL20>NVPR in women 6= -8 weeks after NVP</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>21</font></div> </td> <td> <div id=3DPPTP21 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0059.htm');" id=3DPPTL21>Shift in Specif= ic NNRTI-related Drug Resistance Mutations in 65 Ugandan Women in HIVNET 012<br> Eshleman et al.<span style=3D'mso-spacerun:yes'>  </span>2004 in press<= /a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>22</font></div> </td> <td> <div id=3DPPTP22 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0060.htm');" id=3DPPTL22>HIVNET 012:<span style=3D'mso-spacerun:yes'>  </span>NVPR in infants 6-8 weeks after SD NV= P</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>23</font></div> </td> <td> <div id=3DPPTP23 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0061.htm');" id=3DPPTL23>HIVNET 012: Com= parison of NVPR mutations<br> <span style=3D'mso-spacerun:yes'> </span>in women vs. infants</a></font= ></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>24</font></div> </td> <td> <div id=3DPPTP24 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0062.htm');" id=3DPPTL24>HIVNET 012: NVP= R in late-infected infants</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>25</font></div> </td> <td> <div id=3DPPTP25 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0063.htm');" id=3DPPTL25>Summary: HIVNET= 012 Resistance Data</a></font></div> <div id=3DPPTC25 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <br> <li></li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>26</font></div> </td> <td> <div id=3DPPTP26 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0064.htm');" id=3DPPTL26>Thailand: Peri-3 Study<br> Collaboration Thai MOH and CDC <br> Phase II, Open label</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>27</font></div> </td> <td> <div id=3DPPTP27 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0065.htm');" id=3DPPTL27> Peri-3 Results= and Conclusions</a></font></div> <div id=3DPPTC27 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Short course ZDV starting at 34 weeks plus the 2-dose intrapartum/neonatal NVP regimen was safe and well tolerated</li> <li>Transmission rate was 4.6%; about half that seen with short course Z= DV alone</li> <li>The combined ZDV+ SD NVP regimen appeared more effective in reducing<span style=3D'mso-spacerun:yes'>  </span>perinatal HIV transmission than short course ZDV alone</li> <li>Maternal resistance at 6 wks was 20% (18% NVP and 2% ZDV); Infant NVP resistance was 20%</li> <li>The clinical significance of transient detection of NVP mutation following exposure to SD NVP is unknown and needs to be evaluated</l= i> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>28</font></div> </td> <td> <div id=3DPPTP28 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0066.htm');" id=3DPPTL28>Efficacy of NVP= -based HAART in NVP-exposed and unexposed women</a></font></div> <div id=3DPPTC28 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>After 6 months of HAART:</li> <li> - 68% of the 50 women with at least one mutation,</li> <li> - 80% of the 92 exposed women without mutation and</li> <li> - 85% of the 27 non exposed women had a viral load <400</li> <li>(p for trend =3D 0.057)</li> <li>(viral load <50: 38%, 50%, 74%; p for trend =3D 0.0034).</li> <li>NVP-exposed women who started therapy > 6 mths PP:</li> <li> 91% without mutation and 77% with mutation had a viral load <400= ,</li> <li>Therapy started <6 months PP: 69% without mutation and 58% with mutation had a viral load <400.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>29</font></div> </td> <td> <div id=3DPPTP29 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0071.htm');" id=3DPPTL29>Treatment Optio= ns Preservation Study (TOPS) <br> McIntyre et al (Bangkok, abstract LbOrB09)</a></font></div> <div id=3DPPTC29 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Supplementing NVP SD for the mother and infant with either a 4 or a 7-day course of ZDV + 3TC (given as Combivir®) for the mother and the baby</li> <li>5-fold reduction in NVP resistance after 6 wks of follow-up PP.</li> <li><span style=3D'mso-spacerun:yes'> </span>At interim analysis, 6 wks resistance data available for 61 mothers; Resistance was detected in= :</li> <ul> <li>53.3% of group 1 mothers (NVP only),</li> <li>5.0% in group 2 (NVP + 4 days Combivir) and</li> <li>13.6% in group 3 (NVP + 7 days Combivir),</li> <li>(9.3% of those receiving NVP single-dose + Combivir® irrespective of the duration) (p=3D0.001)</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>30</font></div> </td> <td> <div id=3DPPTP30 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0035.htm');" id=3DPPTL30>PACTG 316:<span style=3D'mso-spacerun:yes'>  </span>Resistance Mutations Present at Deliv= ery in 70 Women with RNA >3,000<br> <span style=3D'mso-spacerun:yes'> </span>Sullivan J.<span style=3D'mso-spacerun:yes'>  </span>XIII AIDS Conf, July 2000, Durban S A= frica (LbOr014)</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>31</font></div> </td> <td> <div id=3DPPTP31 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0067.htm');" id=3DPPTL31>ANRS 075: Open-= Label ZDV/3TC Prophylaxis<br> and ARV Drug Resistance at 6 wks PP (N=3D132) <br> Mandelbrot et al.<span style=3D'mso-spacerun:yes'>  </span>JAMA 2001;285:2083-93 [adapted L Mofenson slide]</a></font></div> <div id=3DPPTC31 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <ul> <li>3TC Resistance (M184V):</li> <ul> <li>Mothers: 39% (mutant 58%; mixed, 42%)</li> <ul> <li>Only 1 (2%) had resistance prior to 3TC dosing</li> <br> <br> </ul> </ul> </ul> <li>Risk factors for maternal 3TC resistance:</li> <ul> <li>CD4 lower</li> <li>HIV RNA higher</li> <li>Longer duration 3TC:</li> <ul> <li>0%<span style=3D'mso-spacerun:yes'>  </span>(0/12) if <1 month = 3TC</li> <li>20% (14/70) if 1-2 months 3TC</li> <li>50% (37/74) if >2 months 3TC</li> </ul> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>32</font></div> </td> <td> <div id=3DPPTP32 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0068.htm');" id=3DPPTL32>PETRA: ZDV or 3= TC Antiretroviral Resistance<br> Giuliano M et al.<span style=3D'mso-spacerun:yes'>  </span>AIDS 2003;17:1570-3 [adapted from L Mofenson slide]</a></font></div> <div id=3DPPTC32 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Virus from 50 women each in arm A and B at 1 week postpartum was genotyped.</li> <li>Arm A:<span style=3D'mso-spacerun:yes'>  </span>6/50 (12%) had M184V= (3TC) and 1/50 (2%) had M41L (ZDV) mutation</li> <li>Transmission unrelated to presence of mutation:</li> <ul> <li>1/11 (9%) if M184V</li> <li>5/39 (13%) if no M184V (NS)</li> </ul> <li>Arm B: 0/50 (0%) women had NRTI mutations.</li> <ul> <br> <br> <br> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>33</font></div> </td> <td> <div id=3DPPTP33 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0069.htm');" id=3DPPTL33>Summary: Acquis= ition of Antiretroviral Resistance in Mothers Following Antiretroviral Prophylaxis= </a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>34</font></div> </td> <td> <div id=3DPPTP34 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0070.htm');" id=3DPPTL34>Summary: ARV Re= sistance at Age 6 Weeks in Infants Infected Despite ARV Prophylaxis</a></font></di= v> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>35</font></div> </td> <td> <div id=3DPPTP35 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0018.htm');" id=3DPPTL35>Balancing the r= isks of breastfeeding and formula feeding</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>36</font></div> </td> <td> <div id=3DPPTP36 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0036.htm');" id=3DPPTL36><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>37</font></div> </td> <td> <div id=3DPPTP37 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0037.htm');" id=3DPPTL37><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>38</font></div> </td> <td> <div id=3DPPTP38 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0041.htm');" id=3DPPTL38>Design of Ongoing/Planned Infant Prophylaxis Trials</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>39</font></div> </td> <td> <div id=3DPPTP39 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0046.htm');" id=3DPPTL39>SIMBA: Stopping Infection from Mother-to-child from Breastfeeding in Africa – Infant Prophylaxis<br> Vyankandondera J et al.<span style=3D'mso-spacerun:yes'>  </span>IAS Me= eting, Paris France 2003</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>40</font></div> </td> <td> <div id=3DPPTP40 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0047.htm');" id=3DPPTL40>SIMBA: MTCT In = Utero, Intrapartum/Early <br> Postpartum & Postnatal (Breast Milk) through 6 Mos</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>41</font></div> </td> <td> <div id=3DPPTP41 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0044.htm');" id=3DPPTL41>New HIV infecti= ons and cumulative MTCT transmission rates by age and treatment group < 500 CD= 4</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>42</font></div> </td> <td> <div id=3DPPTP42 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0045.htm');" id=3DPPTL42>New HIV infecti= ons and cumulative MTCT transmission rates by age and treatment group > 500 CD= 4</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>43</font></div> </td> <td> <div id=3DPPTP43 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0072.htm');" id=3DPPTL43>Is PMTCT solved= ?</a></font></div> <div id=3DPPTC43 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li><span style=3D'mso-spacerun:yes'>   </span><span style=3D'mso-spacerun:yes'> </span>HAART during late pregnancy to all HIV-infected women</li> <li></li> <li>Which HAART regimen for asymptomatic women with high CD4?</li> <li><span style=3D'mso-spacerun:yes'>    </span>(toxicity/adherence/cost/interaction with food&drinks/cold chain…)</li> <li>Risk of viral rebound during breast-feeding versus feasibility/risk/= cost of replacement feeding up to 6 months PP versus risk of transmission= </li> <br> <br> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>44</font></div> </td> <td> <div id=3DPPTP44 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0073.htm');" id=3DPPTL44>Challenge (1)<b= r> Low Program Coverage* (1)</a></font></div> <div id=3DPPTC44 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Few good efforts:</li> <li>CEE/CIS:</li> <ul> <li>Belarus: 87%</li> <li>Ukraine: 49%</li> </ul> <li>LAC:</li> <ul> <li>Uruguay: 97%</li> <li>Belize: 70%</li> <li>Brazil: 33%</li> </ul> <li>SSA</li> <ul> <li>Mauritius: 100%</li> <li>Botswana: 34%</li> <br> <br> </ul> <br> </ul> 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