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Segundo R. León

Socios en Salud, Lima, Peru

Segundo R. León

Segundo R. León, MT (ASCPi), MT&ID
Director of Research, Socios en Salud Sucursal Perú
sleon_ses@pih.org

My professional experience includes being a Professor of Laboratory Medicine at San Marcos National University and Laboratory Coordinator of the Laboratory of Sexual Health at Cayetano Heredia University in Lima and, currently, as Director of Partners in Health’s Peruvian Office, Socios En Salud. I have been working in Peru for over 15 years, mostly performing laboratory-based research and providing support within epidemiological studies. As a well-trained laboratorian, I lead the building of the Laboratory of Sexual Health at Cayetano Heredia University for studying sexual transmitted diseases and HIV. I began my work on HIV and STIs as part of the Peruvian team of the NIMH HIV/STI Collaborative Prevention Trial in collaboration with Peruvian and U.S. researchers to study HIV and STIs in general and most at risk populations and we found high prevalences of this group of infections in vulnerable populations. In addition, I worked for the CPOS study, another NIH-funded trial focused on test the feasibility of improving access to healthcare by using enhanced partner therapy within high-risk communities as are MSM and Trans populations in Lima. My experience also includes epidemiological studies in HPV infection among MSM, field and laboratory validation of rapid single and dual HIV and Syphilis tests and massive DNA extraction from Mycobacteria. I regularly give lectures at Peruvian schools of public health in different universities about my experience.

Publications

  • Herrera MC, Konda KA, Leon SR, Deiss R, Brown B, Calvo GM, Salvatierra HJ, Caceres CF, Klausner JD. Impact of alcohol use on sexual behavior among men who have sex with men and transgender women in Lima, Peru. Drug Alcohol Depend. 2016 Apr 1;161:147-54. doi: 10.1016/j.drugalcdep.2016.01.030. Epub 2016 Feb 16. PubMed PMID: 26896169; PubMed Central PMCID: PMC4807690.
  • Allan-Blitz LT, Leon SR, Bristow CC, Konda KA, Vargas SK, Flores JA, Brown BJ, Caceres CF, Klausner JD. High prevalence of extra-genital chlamydial or gonococcal infections among men who have sex with men and transgender women in Lima, Peru. Int J STD AIDS. 2016 Feb 3. pii: 0956462416630909. [Epub ahead of print] PubMed PMID: 26846151.
  • Bustamante MJ, Konda KA, Joseph Davey D, León SR, Calvo GM, Salvatierra J, Brown B, Caceres CF, Klausner JD. HIV self-testing in Peru: questionable availability, high acceptability but potential low linkage to care among men who have sex with men and transgender women. Int J STD AIDS. 2016 Jan 29. pii:0956462416630674. [Epub ahead of print] PubMed PMID: 26826160.
  • Leon SR, Segura ER, Konda KA, Flores JA, Silva-Santisteban A, Galea JT, Coates TJ, Klausner JD, Caceres CF. High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections in anal and pharyngeal sites among a community-based sample of men who have sex with men and transgender women in Lima, Peru. BMJ Open. 2016 Jan 6;6(1):e008245. doi: 10.1136/bmjopen-2015-008245. PubMed PMID: 26739719; PubMed Central PMCID: PMC4716251.
  • Bristow CC, Leon SR, Huang E, Brown BJ, Ramos LB, Vargas SK, Flores JA, Caceres CF, Klausner JD. Field evaluation of a dual rapid diagnostic test for HIV infection and syphilis in Lima, Peru. Sex Transm Infect. 2016 May;92(3):182-5. doi: 10.1136/sextrans-2015-052326. Epub 2015 Dec 15. PubMed PMID: 26670914; PubMed Central PMCID: PMC4875763.
  • Leon SR, Ramos LB, Vargas SK, Kojima N, Perez DG, Caceres CF, Klausner JD. Laboratory Evaluation of a Dual-Path Platform Assay for Rapid Point-of-Care HIV and Syphilis Testing. J Clin Microbiol. 2016 Feb;54(2):492-4. doi:10.1128/JCM.03152-15. Epub 2015 Dec 9. PubMed PMID: 26659215; PubMed Central PMCID: PMC4733210.
  • Bristow CC, Leon SR, Huang E, Ramos LB, Vargas SK, Flores JA, Konda KA, Caceres CF, Klausner JD. Field Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection in Peru. Sex Transm Dis. 2016 Jan;43(1):57-60. doi: 10.1097/OLQ.0000000000000387. PubMed PMID: 26650998; PubMed Central PMCID: PMC4675040.
  • Galea JT, Kinsler JJ, McLean S, Calvo G, Sánchez H, Leon SR, Brown B. Rectal Douching Prevalence and Practices Among Peruvian Men Who have Sex with Men and Transwomen: Implications for Rectal Microbicides. AIDS Behav. 2015 Oct 12. [Epub ahead of print] PubMed PMID: 26459331.
  • Kojima N, Bristow CC, Maecker H, Rosenberg-Hasson Y, Leon SR, Vargas SK, Konda KA, Caceres CF, Klausner JD. Similarities in the Markers of Inflammation Between Men With Syphilis and Women With Increased Risk of HIV Acquisition. Clin Infect Dis. 2016 Jan 15;62(2):265-6. doi: 10.1093/cid/civ842. Epub 2015 Sep 22. PubMed PMID: 26394671; PubMed Central PMCID: PMC4731406.
  • Castillo R, Konda KA, Leon SR, Silva-Santisteban A, Salazar X, Klausner JD, Coates TJ, Cáceres CF. Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) incidence and associated risk factors among high-risk MSM and male-to-female transgender women in Lima, Peru. J Acquir Immune Defic Syndr. 2015 May 6. [Epub ahead of print] PubMed PMID: 25950207.
  • Galea JT, Kinsler JJ, Galan DB, Calvo G, Sánchez H, Leon SR, Klausner JD, Brown B. Factors associated with visible anogenital warts among hiv-uninfected peruvian men who have sex with men and transwomen: a cross-sectional study. Sex Transm Dis. 2015 Apr;42(4):202-7. doi: 10.1097/OLQ.0000000000000253. PubMed PMID:25763673.
  • Bristow CC, Leon SR, Ramos LB, Vargas SK, Flores JA, Konda KA, Caceres CF, Klausner JD. Laboratory Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection. J Clin Microbiol. 2014 Nov 5. pii: JCM.02763-14. [Epub ahead of print] PubMed PMID: 25378568.
  • Brown B, Davtyan M, Leon SR, Sanchez H, Calvo G, Klausner JD, Galea J. A prospective cohort study characterising the role of anogenital warts in HIV acquisition among men who have sex with men: a study protocol. BMJ Open. 2014 Sep 16;4(9):e005687. doi: 10.1136/bmjopen-2014-005687. PubMed PMID: 25227629; PubMed Central PMCID: PMC4166134.
  • Cabeza J, García PJ, Segura E, García P, Escudero F, La Rosa S, León S, Klausner JD. Feasibility of Chlamydia trachomatis screening and treatment in pregnant women in Lima, Peru: a prospective study in two large urban hospitals. Sex Transm Infect. 2014 Aug 8. pii: sextrans-2014-051531. doi: 10.1136/sextrans-2014-051531. [Epub ahead of print] PubMed PMID: 25107711
  • Deiss RG, Leon SL, Konda KA, Brown B, Segura ER, Galea JT, Caceres CF, Klausner JD. Characterizing the syphilis epidemic among men who have sex with men in Lima, Peru to identify new treatment and control strategies. BMC Infect Dis. 2013 Sep 10;13(1):426
  • Gonzales-Escalante E, Vicente-Taboada W, Champi-Merino R, Soto-Pastrana J,Flores-Paredes W, Lovera-García M, Chuquiray-Valverde N, Bejarano-Cristobal C, Puray-Chávez M, León-Sandoval S. [Metalo-ß-lactamases in clinical isolates of pseudomonas aeruginosa in Lima, Peru]. Rev Peru Med Exp Salud Publica. 2013 Jun;30(2):241-5.
  • Karina Flores and Segundo R. Leon. Diagnostic Accuracy Among 4 Point-of-Care Tests for the Screening of HIV Infection. Lab Medicine 2013 44:172-175
  • Deiss RG, Clark JL, Konda KA, Leon SR, Klausner JD, Caceres CF, Coates TJ. Problem drinking is associated with increased prevalence of sexual risk behaviors among men who have sex with men (MSM) in Lima, Peru. Drug Alcohol Depend. 2013 Sep 1;132(1-2):134-9
  • Maguiña JL, Konda KA, Leon SR, Lescano AG, Clark JL, Hall ER, Klausner JD, Coates TJ, Caceres CF; The NIMH Collaborative HIV/STD Prevention Trial Group. Relationship Between Alcohol Consumption Prior to Sex, Unprotected Sex and Prevalence of STI/HIV Among Socially Marginalized Men in Three Coastal Cities of Peru. AIDS Behav. 2012 Sep 28. [Epub ahead of print] PubMed PMID: 23054035
  • Silva-Santisteban A, Raymond HF, Salazar X, Villayzan J, Leon S, McFarland W, Caceres CF. Understanding the HIV/AIDS epidemic in transgender women of Lima, Peru: results from a sero-epidemiologic study using respondent driven sampling. AIDS Behav. 2012 May;16(4):872-81.
  • Clark JL, Segura ER, Montano SM, Leon SR, Kochel T, Salvatierra HJ, Alcantara J, Cáceres CF, Coates TJ, Klausner JD. Routine laboratory screening for acute and recent HIV infection in Lima, Peru. Sex Transm Infect. 2010 Dec;86(7):545-7.
  • Snowden JM, Konda KA, Leon SR, Giron JM, Escobar G, Coates TJ, Caceres CF, Klausner JD; NIMH HIV/STD Collaborative Intervention Trial. Recent syphilis infection prevalence and risk factors among male low-income populations in coastal Peruvian cities. Sex Transm Dis. 2010 Feb;37(2):75-80.
  • León SR, Konda KA, Klausner JD, Jones FR, Cáceres CF, Coates TJ, et al. Chlamydia trachomatis infection and associated risk factors in a low-income marginalized urban population in coastal Peru. Rev Panam Salud Publica. 2009;26(1):39–45.
  • Clark JL, Lescano AG, Konda KA, Leon SR, Jones FR, Klausner JD, Coates TJ,Caceres CF; NIMH International Collaborative HIV/STD Prevention Trial. Syndromic management and STI control in urban Peru. PLoS One. 2009 Sep 25;4(9):e7201.
  • Clark JL, Konda KA, Segura ER, Salvatierra HJ, Leon SR, Hall ER, Caceres CF, Klausner JD, Coates TJ. Risk factors for the spread of HIV and other sexually transmitted infections among men who have sex with men infected with HIV in Lima, Peru. Sex Transm Infect. 2008 Nov;84(6):449-54.
  • Segundo R. Leon, Kelika A. Konda, Kyle T. Bernstein, et al., “Trichomonas vaginalis Infection and Associated Risk Factors in a Socially-Marginalized Female Population in Coastal Peru,” Infectious Diseases in Obstetrics and Gynecology, vol. 2009, Article ID 752437, 6 pages, 2009. doi:10.1155/2009/752437
  • Cáceres CF, Konda KA, Salazar X, Leon SR, Klausner JD, Lescano AG, Maiorana A, Kegeles S, Jones FR, Coates TJ; The NIMH HIV/STD Collaborative Intervention Trial. New Populations at High Risk of HIV/STIs in Low-income, Urban Coastal Peru. AIDS Behav. 2008 Jul;12(4):544-551
  • Jesse L Clark, Benjamin Espinosa, Segundo R Leon, Eric R Hall, Hector J Salvatierra, Carlos F Cáceres, Jeffrey D Klausner, and Thomas J Coates. Absence of lymphogranuloma venereum infection among high-risk men who have sex with men in Lima, Peru. Int J STD AIDS, Jun 2008; 19: 427 - 428.
  • Clark JL, Konda KA, Munayco CV, Pún M, Lescano AG, Leon SR, Pajuelo J, Suarez-Ognio L, Klausner JD, Coates TJ, Cáceres CF. Prevalence of HIV, herpes simplex virus-2, and syphilis in male sex partners of pregnant women in Peru. BMC Public Health. 2008 Feb 19;8:65.
  • Clark JL, Caceres CF, Lescano AG, Konda KA, Leon SR, Jones FR, Kegeles SM, Klausner JD, Coates TJ; NIMH STD/HIV Collaborative Prevention Trial. Prevalence of same-sex sexual behavior and associated characteristics among low-income urban males in Peru. PLoS ONE. 2007 Aug 22;2(1):e778
  • Mark J Siedner, Mark Pandori, Segundo R Leon, Benjamin J Espinosa, Eric R Hall, Carlos Caceres, Thomas J Coates, Jeffrey D Klausner, and The NIMH Collaborative HIV/STD Prevention Trial Group. Facilitating lymphogranuloma venereum surveillance with the use of real time polymerase chain reaction. Int J STD AIDS, Jul 2007; 18: 506 - 507.
  • Jones FR, Miller G, Gadea N, Meza R, Leon S, Perez J, Lescano AG, Pajuelo J,Caceres CF, Klausner JD, Coates TJ; NIMH Collaborative HIV/STI Prevention Trial Group. Prevalence of bacterial vaginosis among young women in low-income populations of coastal Peru. Int J STD AIDS. 2007 Mar;18(3):188-92.
  • Segundo R. Leon, Juan J. Perez, Rina Meza, Nilda Gadea, Julio A. Cuadros, Carlos F. Caceres, Jeffrey D. Klausner, Thomas J. Coates, Franca R. Jones. The Development and Use of an Automated Laboratory Information Management System (ALIMS) to Reduce Processing Time in a Microbiology Laboratory. Laboratory Medicine. 2006 Dic;37(12): 750-753.
  • Long CM, Klausner JD, Leon S, Jones FR, Giron M, Cuadros J, Pajuelo J, Caceres C, Coates TJ; NIMH Collaborative HIV/STD Prevention Trial Group. Syphilis treatment and HIV infection in a population-based study of persons at high risk for sexually transmitted disease/HIV infection in Lima, Peru. Sex Transm Dis. 2006 Mar;33(3):151-5.
  • Clark JL, Coates TJ, Lescano AG, Castillo R, Meza R, Jones FR, Leon S, Pajuelo J, Caceres CF, Klausner JD. Different positive predictive values of commercially available human immunodeficiency virus enzyme-linked immunosorbent assays. Clin Vaccine Immunol. 2006 Feb;13(2):302-3.
  • Konda KA, Klausner JD, Lescano AG, Leon S, Jones FR, Pajuelo J, Caceres CF, Coates TJ; NIMH Collaborative HIV/STI Prevention Trial Group. The epidemiology of herpes simplex virus type 2 infection in low-income urban populations in coastal Peru. Sex Transm Dis. 2005 Sep;32(9):534-41.
  • Miller GA, Klausner JD, Coates TJ, Meza R, Gaydos CA, Hardick J, Leon S, Caceres CF. Assessment of a rapid antigen detection system for Trichomonas vaginalis infection. Clin Diagn Lab Immunol. 2003 Nov;10(6):1157-8.
  • León, Segundo. Inmunoanálisis Ligado a Enzimas en Membranas de Nitrocelulosa para la Determinación de IgM en el Diagnóstico de Dengue serotipo 1. Anales de la Facultad de Medicina. 1999;60(2): 110-114.

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