Koukolík F. [Epidemiologic autopsy in Alzheimer's disease] Cas Lek Cesk. 1996 Jun 12;135(12):378-81.

BACKGROUND: The prevalence of Alzheimer's disease (AD) in the population older than than 65 yr. has been estimated in industrialized countries at approximately 10% (8.1-12.5%). AD in the Czech republic in the year 1992 in the official statistics (Institute of Health Information and Statistics, UZIS) has been diagnosed in 22 cases of deceased and 175 sick patients. METHODS AND RESULTS: The crude rate of AD diagnosed by the Khachaturyans method among 2,197 autopsies of people aged 65-99 yr. performed at Thomayer University Hospital from 1988-1992 by use of principle of "epidemiologic" autopsy was estimated in this age group at 0.7%/100,000 thousand men/year and 1.4%/100 thousand women/year. Demographically standardized death rate in AD is 285.25/100 thousand in men and 604.24/100 thousand in women. The prevalence of AD in the whole group was 7.46%. The frequency of AD steeply rises with age with the exception of the tenth decade when the increase stops. CONCLUSIONS: AD is therefore one of most frequent diseases in this country too. AD in this republic is probably not being clinically and autoptically adequately diagnosed or its diagnoses do not become part of official statistics.