Osteoporosis

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Osteoporosis: bisphosphonates

Australia

• Royal Australian College of General Practitioners
  • Bisphosphonates

Belgium

• Belgian Bone Club
  • Evidence-based guidelines for the use of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis: a consensus document of the Belgian Bone Club [2009]

Canada

• Canada's Drug Agency
  • Duration of Bisphosphonate Treatment for Patients with Osteoporosis: A Review of Clinical Effectiveness and Guidelines [2019]

• Canadian Family Physician
  • Bisphosphonates: forever or 5 years and stop? [2015]
  • Bisphosphonates for treatment of osteoporosis. Expected benefits, potential harms, and drug holidays [2014]

• Osteoporosis Canada
  • Bisphosphonates

China

• Osteoporosis International
  • Predicting the intervention threshold for initiating osteoporosis treatment among postmenopausal women in China: a cost-effectiveness analysis based on real-world data [2020]

Denmark

• Journal of Clinical Endocrinology & Metabolism
  • Bisphosphonate Use and Risk of Atypical Femoral Fractures: A Danish Case-Cohort Study With Blinded Radiographic Review [2024]

Europe

• European Calcified Tissue Society
  • Medical Management of Patients After Atypical Femur Fractures: a Systematic Review and Recommendations From the European Calcified Tissue Society [2020]

• European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
  • Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report [2010]

France

• International Journal of Environmental Research and Public Health
  • Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France [2021]

• Scientific Reports
  • Adherence with brand versus generic bisphosphonates among osteoporosis patients: a new-user cohort study in the French National Healthcare Insurance database [2020]

High-income countries

• Cochrane Database of Systematic Reviews
  • Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women [2024]

International

• BMJ Open
  • Real-world persistence and adherence with oral bisphosphonates for osteoporosis: a systematic review [2019]

• Cochrane Database of Systematic Reviews
  • Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women [2022]

• European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
  • Novel formulations of oral bisphosphonates in the treatment of osteoporosis [2022]

• Frontiers in Endocrinology
  • The Effect of Bisphosphonates on Fracture Healing Time and Changes in Bone Mass Density: A Meta-Analysis [2021]

• Heliyon
  • Efficacy and safety of zoledronic acid in the treatment of osteoporosis: A meta-analysis of randomized controlled trials [2024]

• International Osteoporosis Foundation
  • International Osteoporosis Foundation and European Calcified Tissue Society Working Group. Recommendations for the screening of adherence to oral bisphosphonates [2017]
  • Bisphosphonates

• Sao Paulo Medical Journal
  • Intravenous zoledronate for postmenopausal women with osteopenia and osteoporosis: a systematic review and metanalysis [2023]

• Science Progress
  • Does alendronate enhance survival rates in osteoporosis patients? A meta-analysis of randomized controlled trials [2025]

New Zealand

• Starship
  • Endocrinology - intravenous bisphosphonate therapy

Norway

• Osteoporosis International
  • Does treatment with bisphosphonates protect against fractures in real life? The HUNT study, Norway [2021]

Republic of Korea

• Journal of Bone Metabolism
  • Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea [2015]
  • Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons [2015]

• Journal of Korean Medical Science
  • Hip and Subtrochanteric or Femoral Shaft Fractures after Bisphosphonate Use in Korean Women, Using Korean National Sample Cohort [2020]

Singapore

• Osteoporosis International
  • Cost-effectiveness of FRAX®-based intervention thresholds for management of osteoporosis in Singaporean women [2021]

Taiwan

• Journal of the Formosan Medical Association
  • The impact of bisphosphonates on mortality and cardiovascular risk among osteoporosis patients after cardiovascular disease [2021]

United Kingdom

• Health Technology Assessment
  • Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study [2024]

• Medicines and Healthcare products Regulatory Agency
  • Bisphosphonates: use and safety

• National Institute for Health and Care Excellence
  • Bisphosphonates for treating osteoporosis [2019]

United States

• American Journal of Medicine
  • Reconsidering the Benefits of Osteoporosis Treatment: The Case of Bisphosphonates [2024]

• American Society for Bone and Mineral Research
  • Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research [2016]
  • Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research [2014]
  • Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research [2007]

• Journal of Bone and Mineral Research
  • Temporal Trends and Factors Associated with Bisphosphonate Discontinuation and Restart [2020]

• Medical Care
  • Duration of Bisphosphonate Drug Holidays and Associated Fracture Risk [2020]

• Osteoporosis International
  • Cost-effectiveness of Five Versus Ten Years of Alendronate Treatment Prior to Drug Holiday for Women with Osteoporosis [2020]

• StatPearls
  • Zoledronate
  • Bisphosphonate
  • Alendronate

Western countries

• BMJ Open
  • Acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis [2020]

{Related topics}

• Topic
  • Osteoporosis: prevention, treatment