TABLE 2: Causes of hypogonadism.
- Primary hypogonadism (hypergonadotropic syndromes)
- Chromosomal abnormalities
- Myotonic dystrophy
- Bilateral anorchia (vanishing testes syndrome)
- Sertoli-cell-only syndrome
- Gonadal toxins (drugs, radiation)
- Orchitis
- Systemic diseases (hepatic, renal, sickle cell disease)
- Defective androgen synthesis or action
- Secondary hypogonadism (hypogonadotropic syndromes)
- Hypogonadotropic eunuchoidism
- Isolated LH deficiency
- Isolated FSH deficiency
- Pituitary disease
- Androgens, estrogens, glucocorticoids (endo/exogenous excess)
- Hyperprolactinemia
- Hemochromatosis