TABLE 1. Etiological factors in premature ovarian failure.
| Congenital defects | Reduced number of germ cells |
| Increased follicular atresia | |
| X chromosome alterations | |
| Enzymatic alterations | 17a -hydroxylase deficiency |
| Galactosemia | |
| Gonadotropin secretion alterations | Secretion of biological inactive forms |
| α or ß subunit defects | |
| Gonadotropin receptor alterations | Resistant ovary syndrome (Savage syndrome) |
| Autoimmune disorders | Isolated |
| Associated with other endocrine disorders | |
| Iatrogenic causes | Radiotherapy |
| Chemotherapy | |
| Ovariectomy | |
| Infectious causes | Viral agents |
| Idiopathic |