Obstetrics, gynecology, andrology, sexual and reproductive health

Menstruation disturbances, female gonadal disorders

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Polycystic ovary syndrome: metformin, insulin sensitizers

 

International

• Cochrane Database of Systematic Reviews
  • Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome [2020]
  • Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome [2020]
  • Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome [2019]
  • Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility [2017]

• International Journal of Endocrinology
  • The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [2020]

• Journal of Clinical Endocrinology & Metabolism
  • Insulin Sensitizers for Improving the Endocrine and Metabolic Profile in Overweight Women With PCOS [2020]

• Medicine
  • The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome [2021]

• Reproductive Health
  • Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis [2021]

• Scientific Reports
  • Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: A systematic review and meta-analysis [2020]

• Therapeutic Advances in Endocrinology and Metabolism
  • Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials [2022]

Taiwan

• International Journal of Environmental Research and Public Health
  • The Risk of Subsequent Miscarriage in Pregnant Women with Prior Polycystic Ovarian Syndrome: A Nationwide Population-Based Study [2021]

United Kingdom

• National Institute for Health and Care Excellence
  • Polycystic ovary syndrome: metformin in women not planning pregnancy [2013]

• Royal College of Obstetricians and Gynaecologists
  • Metformin Therapy for the Management of Infertility in Women with Polycystic Ovary Syndrome [2017]

United States

• American Society for Reproductive Medicine
  • Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline [2017]

• Pediatric Endocrine Society
  • State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS) [2011]

{Related topics}

• Guidelines
  • Polycystic ovary syndrome: treatment