Menstruation disturbances, female gonadal disorders

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Polycystic ovary syndrome: metformin, insulin sensitizers

Canada

• Society of Obstetricians and Gynaecologists of Canada
  • SOGC Position Statement: Inositol for the Management of Polycystic Ovary Syndrome [2025]

International

• American Journal of Obstetrics & Gynecology
  • Preconception and first-trimester metformin on pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis [2025]

• BMC Women's Health
  • Effects of Metformin on CIMT and FMD in PCOS patients: a systematic review and meta-analysis [2024]

• BMJ Open Diabetes Research & Care
  • Major malformations risk following early pregnancy exposure to metformin: a systematic review and meta-analysis [2023]

• Cochrane Database of Systematic Reviews
  • Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome [2020]
  • Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome [2020]
  • Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome [2019]

• Diabetes, Obesity and Metabolism
  • Long-term effects of metformin on offspring health: A review of current evidence and future directions [2025]

• European Journal of Endocrinology
  • The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials [2023]

• Gynecological Endocrinology
  • Correlation between anti-müllerian hormone in polycystic ovarian syndrome with metformin: a systematic review and meta-analysis [2024]

• International Journal of Endocrinology
  • The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [2020]

• Journal of Clinical Endocrinology & Metabolism
  • Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis [2024]
  • Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines [2024]
  • Insulin Sensitizers for Improving the Endocrine and Metabolic Profile in Overweight Women With PCOS [2020]

• Journal of Ovarian Research
  • The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis [2023]

• Medicine
  • The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome [2021]

• Reproductive Biology and Endocrinology
  • Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials [2023]

• Reproductive Health
  • Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis [2021]

• Scientific Reports
  • Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: A systematic review and meta-analysis [2020]

• Therapeutic Advances in Endocrinology and Metabolism
  • Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials [2022]

• Women's Health
  • Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes [2025]

Sweden

• Reproductive Biology and Endocrinology
  • Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study [2022]

Taiwan

• International Journal of Environmental Research and Public Health
  • Prepregnancy Polycystic Ovary Syndrome as a Risk Factor of Subsequent Preterm Labor: A National Population-Based Cohort Study [2022]
  • The Risk of Subsequent Miscarriage in Pregnant Women with Prior Polycystic Ovarian Syndrome: A Nationwide Population-Based Study [2021]

United Kingdom

• National Institute for Health and Care Excellence
  • Polycystic ovary syndrome: metformin in women not planning pregnancy [2013]

United States

• American Society for Reproductive Medicine
  • Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline [2017]

• Pediatric Endocrine Society
  • State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS) [2011]

{Related topics}

• Topic
  • Polycystic ovary syndrome: treatment