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Mouse and human embryonic stem (ES) cells:
cardiac differentiation and cell therapy of heart failure

Marisa Jaconi, PhD
Laboratory of Biology of Aging
Department of Geriatrics
Geneva University Hospitals




  1. He Q, Li J, Bettiol E, Jaconi ME. Embryonic stem cells: new possible therapy for degenerative diseases that affect elderly people. J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):279-87. PMID: 12634295 [PubMed]
  2. Jaconi M. [Embryonic stem cells: new possible therapy of degenerative diseases] Ther Umsch. 2002 Nov;59(11):588-95. German. PMID: 12498051 [PubMed]
  3. Li J, Puceat M, Perez-Terzic C, Mery A, Nakamura K, Michalak M, Krause KH, Jaconi ME. Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol. 2002 Jul 8;158(1):103-13. Epub 2002 Jul 08. PMID: 12105184 [PubMed]
  4. Irminger-Finger I, Leung WC, Li J, Dubois-Dauphin M, Harb J, Feki A, Jefford CE, Soriano JV, Jaconi M, Montesano R, Krause KH. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. Mol Cell. 2001 Dec;8(6):1255-66. PMID: 11779501 [PubMed]
  5. Perez-Terzic C, Gacy AM, Bortolon R, Dzeja PP, Puceat M, Jaconi M, Prendergast FG, Terzic A. Directed inhibition of nuclear import in cellular hypertrophy. J Biol Chem. 2001 Jun 8;276(23):20566-71. Epub 2001 Mar 30. PMID: 11283025 [PubMed]
  6. Meyer N, Jaconi M, Landopoulou A, Fort P, Puceat M. A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. FEBS Lett. 2000 Jul 28;478(1-2):151-8. PMID: 10922488 [PubMed]
  7. Jaconi M, Bony C, Richards SM, Terzic A, Arnaudeau S, Vassort G, Puceat M. Inositol 1,4,5-trisphosphate directs Ca(2+) flow between mitochondria and the Endoplasmic/Sarcoplasmic reticulum: a role in regulating cardiac autonomic Ca(2+) spiking. Mol Biol Cell. 2000 May;11(5):1845-58. PMID: 10793156 [PubMed]
  8. Perez-Terzic C, Gacy AM, Bortolon R, Dzeja PP, Puceat M, Jaconi M, Prendergast FG, Terzic A. Structural plasticity of the cardiac nuclear pore complex in response to regulators of nuclear import. Circ Res. 1999 Jun 11;84(11):1292-301. PMID: 10364567 [PubMed]
  9. Richards SM, Jaconi ME, Vassort G, Puceat M. A spliced variant of AE1 gene encodes a truncated form of Band 3 in heart: the predominant anion exchanger in ventricular myocytes. J Cell Sci. 1999 May;112 ( Pt 10):1519-28. PMID: 10212146 [PubMed]
  10. Perez-Terzic C, Jaconi M, Stehno-Bittel L. Measurement of intracellular calcium concentration using confocal microscopy. Methods Mol Biol. 1999;114:75-91. No abstract available. PMID: 10081011 [PubMed]
  11. Puceat M, Bony C, Jaconi M, Vassort G. Specific activation of adenylyl cyclase V by a purinergic agonist. FEBS Lett. 1998 Jul 17;431(2):189-94. PMID: 9708900 [PubMed]
  12. Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays. 1997 Sep;19(9):787-92. Review. PMID: 9297969 [PubMed]
  13. Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. Curr Biol. 1997 Aug 1;7(8):599-602. PMID: 9259550 [PubMed]
  14. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science. 1996 Sep 27;273(5283):1875-7. PMID: 8791595 [PubMed]
  15. Theler JM, Lew DP, Jaconi ME, Krause KH, Wollheim CB, Schlegel W. Intracellular pattern of cytosolic Ca2+ changes during adhesion and multiple phagocytosis in human neutrophils. Dynamics of intracellular Ca2+ stores. Blood. 1995 Apr 15;85(8):2194-201. PMID: 7718891 [PubMed]
  16. Demaurex N, Rawlings SR, Krause KH, Jaconi ME, Lew PD, Schlegel W. Combination of microfluorimetric monitoring of cytosolic calcium and pH with patch clamp electrophysiological recordings in neutrophil granulocytes. Methods Enzymol. 1994;238:308-20. No abstract available. PMID: 7799797 [PubMed]
  17. Jaconi ME, Lew DP, Monod A, Krause KH. The regulation of store-dependent Ca2+ influx in HL-60 granulocytes involves GTP-sensitive elements. J Biol Chem. 1993 Dec 15;268(35):26075-8. PMID: 8253721 [PubMed]
  18. Varnai P, Demaurex N, Jaconi M, Schlegel W, Lew DP, Krause KH. Highly co-operative Ca2+ activation of intermediate-conductance K+ channels in granulocytes from a human cell line. J Physiol. 1993 Dec;472:373-90. PMID: 7511688 [PubMed]
  19. Demaurex N, Schrenzel J, Jaconi ME, Lew DP, Krause KH. Proton channels, plasma membrane potential, and respiratory burst in human neutrophils. Eur J Haematol. 1993 Nov;51(5):309-12. Review. PMID: 8282093 [PubMed]
  20. Bengtsson T, Jaconi ME, Gustafson M, Magnusson KE, Theler JM, Lew DP, Stendahl O. Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium. Eur J Cell Biol. 1993 Oct;62(1):49-58. PMID: 8269978 [PubMed]
  21. Demaurex N, Grinstein S, Jaconi M, Schlegel W, Lew DP, Krause KH. Proton currents in human granulocytes: regulation by membrane potential and intracellular pH. J Physiol. 1993 Jul;466:329-44. PMID: 7692041 [PubMed]
  22. Lew DP, Jaconi M, Pozzan T. Manipulation of cytosolic free calcium transients during exocytosis in intact human neutrophils. Methods Enzymol. 1993;221:157-73. No abstract available. PMID: 8361373 [PubMed]
  23. Jaconi ME, Theler JM, Schlegel W, Lew PD. Cytosolic free Ca2+ signals in single adherent human neutrophils: generation and functional role. Eur J Pediatr. 1993;152 Suppl 1:S26-32. Review. PMID: 8319724 [PubMed]
  24. Krause KH, Demaurex N, Jaconi M, Lew DP. Ion channels and receptor-mediated Ca2+ influx in neutrophil granulocytes. Blood Cells. 1993;19(1):165-73; discussion 173-5. Review. PMID: 7691267 [PubMed]
  25. Jaconi ME, Theler JM, Schlegel W, Appel RD, Wright SD, Lew PD. Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family. J Cell Biol. 1991 Mar;112(6):1249-57. PMID: 1900302 [PubMed]
  26. Hermann M, Jaconi ME, Dahlgren C, Waldvogel FA, Stendahl O, Lew DP. Neutrophil bactericidal activity against Staphylococcus aureus adherent on biological surfaces. Surface-bound extracellular matrix proteins activate intracellular killing by oxygen-dependent and -independent mechanisms. J Clin Invest. 1990 Sep;86(3):942-51. PMID: 2394841 [PubMed]
  27. Jaconi ME, Lew DP, Carpentier JL, Magnusson KE, Sjogren M, Stendahl O. Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils. J Cell Biol. 1990 May;110(5):1555-64. PMID: 2110568 [PubMed]
  28. Jaconi ME, Rivest RW, Schlegel W, Wollheim CB, Pittet D, Lew PD. Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils. J Biol Chem. 1988 Aug 5;263(22):10557-60. PMID: 3392026 [PubMed]
  29. Rivest RW, Jaconi ME, Gruaz N, Sizonenko PC, Aubert ML. Short-term and long-term effects of melatonin on GnRH-stimulated gonadotropin secretion in pituitaries of sexually maturing rats. Neuroendocrinology. 1987 Nov;46(5):379-86. PMID: 3124012 [PubMed]