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GFMER members pages / Pages des membres de la FGFRM

Paul Bischof

Reproductive biology / Biologie de la reproduction

Paul Bischof


Paul Bischof is a recently retired “Professeur Titulaire” from the Department of Obstetrics and Gynaecology of the University of Geneva. He is a consultant with Viollier laboratories in the field of reproductive medicine. He studied biochemistry in Geneva, obtained his PhD in 1974, and was a Post-doctoral fellow at Ciba-Geigy in Basel (presently Novartis) and later at the Department of Obstetrics and Gynaecology of the University of Aberdeen, Scotland.

He teaches reproductive endocrinology at the universities of Geneva, Claude Bernard (Lyon, France) and Paris-Descartes, he is a member of several editorial boards and scientific societies, a former consultant with WHO, a member of the Swiss FIVNAT committee and the president of the scientific committee of Premup (a French thematic network for research and treatment of prematurity).

His past research interest was in placental proteins and he was the first to characterise and develop a test to measure pregnancy associated plasma protein-A (PAPP-A), a widely used parameter for trisomy 21 risk assessment. His last research dealt with human embryo implantation and he developed an in-vitro model using primary cultures of human placental cells to mimic the behaviour of the human blastocyst. This model is still used to study at the cellular and the molecular level, the regulation by paracrine and endocrine factors of matrix metallo-proteinases the enzymes responsible for the invasive behaviour of embryos at implantation.

Paul is the author of 183 peer reviewed original articles, 9 reviews, 2 books and 30 textbook chapters. He is a Swiss citizen, married and has two children.

Open access online publications

  • Laverrière A, Landau R, Charvet I, Irion O, Bischof P, Morales M, Cohen M. GRP78 as a marker of pre-eclampsia: an exploratory study. Mol. Hum. Reprod. 2009 Sep;15(9):569-574. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19482905
  • Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA meeting 2008 workshops report. Placenta. 2009 Mar;30 Suppl AS4-14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19084270
  • Cohen M, Wuillemin C, Irion O, Bischof P. Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells. Hum. Reprod. 2008 Oct;23(10):2273-2281. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18635530
  • Cohen M, Meisser A, Haenggeli L, Irminger-Finger I, Bischof P. Status of p53 in first-trimester cytotrophoblastic cells. Mol. Hum. Reprod. 2007 Feb;13(2):111-116. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17158854
  • Cohen M, Meisser A, Haenggeli L, Bischof P. Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells. Mol. Hum. Reprod. 2006 Apr;12(4):225-232. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16520344
  • Meisser A, Cohen M, Bischof P. Concentrations of circulating gelatinases (matrix metalloproteinase-2 and -9) are dependent on the conditions of blood collection. Clin. Chem. 2005 Jan;51(1):274-276. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15613733
  • Marzioni D, Tamagnone L, Capparuccia L, Marchini C, Amici A, Todros T, Bischof P, Neidhart S, Grenningloh G, Castellucci M. Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. Dev. Dyn. 2004 Dec;231(4):839-848. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15517571
  • Islami D, Bischof P, Chardonnens D. Modulation of placental vascular endothelial growth factor by leptin and hCG. Mol. Hum. Reprod. 2003 Jul;9(7):395-398. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12802046
  • Cameo P, Bischof P, Calvo JC. Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culture. Biol. Reprod. 2003 Feb;68(2):472-477. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12533410
  • Dong J-C, Dong H, Campana A, Bischof P. Matrix metalloproteinases and their specific tissue inhibitors in menstruation. Reproduction. 2002 May;123(5):621-631. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12006090
  • Islami D, Chardonnens D, Campana A, Bischof P. Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblast. Mol. Hum. Reprod. 2001 Jan;7(1):3-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11134354
  • Mock P, Frydman R, Bellet D, Chassin D, Bischof P, Campana A, Bidart JM. Expression of pro-EPIL peptides encoded by the insulin-like 4 (INSL4) gene in chromosomally abnormal pregnancies. J. Clin. Endocrinol. Metab. 2000 Oct;85(10):3941-3944. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11061561
  • Castellucci M, De Matteis R, Meisser A, Cancello R, Monsurrò V, Islami D, Sarzani R, Marzioni D, Cinti S, Bischof P. Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Mol. Hum. Reprod. 2000 Oct;6(10):951-958. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11006325
  • González RR, Simón C, Caballero-Campo P, Norman R, Chardonnens D, Devoto L, Bischof P. Leptin and reproduction. Hum. Reprod. Update. 2000 Jun;6(3):290-300. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10874574
  • Epiney M, Bertossa C, Weil A, Campana A, Bischof P. CA125 production by the peritoneum: in-vitro and in-vivo studies. Hum. Reprod. 2000 Jun;15(6):1261-1265. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10831552
  • Meisser A, Cameo P, Islami D, Campana A, Bischof P. Effects of interleukin-6 (IL-6) on cytotrophoblastic cells. Mol. Hum. Reprod. 1999 Nov;5(11):1055-1058. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10541568
  • Chardonnens D, Cameo P, Aubert ML, Pralong FP, Islami D, Campana A, Gaillard RC, Bischof P. Modulation of human cytotrophoblastic leptin secretion by interleukin-1alpha and 17beta-oestradiol and its effect on HCG secretion. Mol. Hum. Reprod. 1999 Nov;5(11):1077-1082. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10541571
  • Burguete T, Rabreau M, Fontanges-Darriet M, Roset E, Hager HD, Köppel A, Bischof P, Schlehofer JR. Evidence for infection of the human embryo with adeno-associated virus in pregnancy. Hum. Reprod. 1999 Sep;14(9):2396-2401. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10469719
  • Bersinger NA, Meisser A, Bessou T, Seguin P, Birkhäuser MH, Bischof P. Production and characterization of monoclonal antibodies against pregnancy-associated plasma protein A. Mol. Hum. Reprod. 1999 Jul;5(7):675-681. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10381824
  • Meisser A, Chardonnens D, Campana A, Bischof P. Effects of tumour necrosis factor-alpha, interleukin-1 alpha, macrophage colony stimulating factor and transforming growth factor beta on trophoblastic matrix metalloproteinases. Mol. Hum. Reprod. 1999 Mar;5(3):252-260. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10333360
  • Mock P, Bischof P, Rivest R, Campana A, Chardonnens D. Modulation of human chorionic gonadotrophin bioactivity during the first trimester of pregnancy. Hum. Reprod. 1998 Sep;13(9):2629-2632. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9806297
  • Shoukir Y, Chardonnens D, Campana A, Bischof P, Sakkas D. The rate of development and time of transfer play different roles in influencing the viability of human blastocysts. Hum. Reprod. 1998 Mar;13(3):676-681. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9572433
  • Extermann P, Bischof P, Marguerat P, Mermillod B. Second-trimester maternal serum screening for Down’s syndrome: free beta-human chorionic gonadotrophin (HCG) and alpha-fetoprotein, with or without unconjugated oestriol, compared with total HCG, alpha-fetoprotein and unconjugated oestriol. Hum. Reprod. 1998 Jan;13(1):220-223. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9512261
  • Martin-Du Pan R, Bischof P, de Boccard G, Campana A. Is diclofenac helpful in the diagnosis of partial epididymal obstruction? Hum. Reprod. 1997 Feb;12(2):396-397. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9070735
  • Bischof P, Campana A. A model for implantation of the human blastocyst and early placentation. Hum. Reprod. Update. 1996 Jun;2(3):262-270. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9079419
  • Martelli M, Campana A, Bischof P. Secretion of matrix metalloproteinases by human endometrial cells in vitro. J. Reprod. Fertil. 1993 May;98(1):67-76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8345481
  • Chegini N, Lei ZM, Rao CV, Bischof P. The presence of pregnancy-associated plasma protein-A in human corpora lutea: cellular and subcellular distribution and dependence on reproductive state. Biol. Reprod. 1991 Jan;44(1):201-206. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1707688
  • Weintraub J, Bischof P, Tseng L, Redard M, Vassilakos P. CA 125 is an excretory product of human endometrial glands. Biol. Reprod. 1990 Apr;42(4):721-726. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2346775
  • Bischof P, Germain G, Cedard L. Pregnancy-associated plasma protein-A in pregnant cynomolgus monkeys (Macaca fascicularis): radioimmunoassay, normal levels, effect of RU 486, and preliminary characterization. Biol. Reprod. 1989 Apr;40(4):853-859. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2473787
  • Meisser A, Geinoz A, Bischof P. In vitro effects of pregnancy-associated plasma protein-A: artifacts due to heparin. Biol. Reprod. 1988 Sep;39(2):373-378. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2460147
  • Meisser A, Geinoz A, Bischof P. Interaction of pregnancy-associated plasma protein-A (PAPP-A) with coagulation: a bioassay for PAPP-A. Biol. Reprod. 1985 Dec;33(5):1073-1077. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2416361
  • Bischof P, Haenggeli L, Sizonenko MT, Herrmann W, Sizonenko PC. Radioimmunoassay for the measurement of pregnancy-associated plasma protein-A (PAPP-A) in humans. Biol. Reprod. 1981 Jun;24(5):1076-1081. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6168305
  • Hughes G, Bischof P, Wilson G, Klopper A. Assay of a placental protein to determine fetal risk. Br Med J. 1980 Mar 8;280(6215):671-673. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6153917

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