Expert Working Groups (EWG)

GFMER Global Consultation on WHO Infertility Guidelines
EWG: PCOS

 

Chair: Adam Balen (UK)

Members

• Steve Franks (UK)
• Rick Legro (USA)
• Robert Norman (Australia)
• Chandrika Wijeyeratne (Sri Lanka)

Participants

• Aleksandra Ilievska - Melbourne Medical School, University of Melbourne, Australia
• Amaka Ocheke - Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Jos, Nigeria
• Charles Muteshi - Department of Obstetrics and Gynecology, Aga Khan University Hospital, Nairobi, Kenya
• Confucius Aligo Allison Amba - Martha Primary Health Care Centre, Yei, South Sudan
• Eva Elizabeth Camarena Pulido - Departamento de Ginecología y Obstetricia, Hospital Civil Juan I. Menchaca, Guadalajara, Mexico
• Jayam Kannan - Tamil Nadu Dr. M.G.R. Medical University, Chennai, India
• Lata Jethwani - Jethwani Hospital, Rajkot, India
• Mahmoud Ahmed Mahmoud Abdel-Aleem - Women Health Centre, Assiut University, Egypt
• Muna Bhutta - Al-Iman Hospital, Riyadh, Saudi Arabia
• Nitin Raithatha - Pramukh Swami Medical College, Karamsad, Anand, India

WHO DRAFT PICO Questions:

Population Intervention Comparator Outcome (PICO):
Being developed to find the evidence in order to determine if a Recommendation on best practice can be made by the World Health Organization concerning the following topic.

POLYCYSTIC OVARIAN SYNDROME (PCOS)

(P = women of reproductive age – questions may include exclusion or inclusion criteria)

Should WHO develop a recommendation concerning:

1. the most effective tool/method to assess risk of Type 2 Diabetes?
2. the most effective tool/method to assess depression and anxiety?
3. the most effective tool/method to assess disordered eating?
4. the most effective tool/method to assess psychosexual dysfunction?
5. whether lifestyle interventions (combined compared to minimal or nothing) are effective for improving weight loss, metabolic, reproductive, fertility, quality of life and emotional wellbeing outcomes?
6. the effectiveness of diet compared to exercise for improving weight loss, metabolic, reproductive, fertility, quality of life and emotional wellbeing outcomes?
7. whether diet interventions (compared to no diet or different diets) are effective for improving weight loss, metabolic, fertility, and emotional wellbeing outcomes?
8. the most effective method to deliver dietary information for improving weight loss, quality of life and emotional wellbeing outcomes?
9. whether exercise interventions (compared to no exercise or different exercises) are effective for improving weight loss, metabolic, reproductive, fertility, quality of life and emotional wellbeing outcomes?
10. the effectiveness of lifestyle interventions compared to pharmacological interventions (i.e. metformin and clomiphene citrate) for improving fertility, quality of life and emotional wellbeing outcomes?
11. whether clomiphene citrate is effective for improving fertility outcomes in PCOS patients?
12. whether metformin is effective for improving fertility outcomes in PCOS patients?
13. in women with a BMI <30-32, the effectiveness of metformin compared to clomiphene citrate for improving fertility outcomes?
14. whether gonadotrophins are effective for improving fertility outcomes in PCOS patients?
15. whether aromatase inhibitors are effective for improving fertility outcomes in PCOS patients?
16. whether ovarian surgery is effective for improving fertility outcomes in PCOS patients?
17. the effectiveness of lifestyle interventions compared to bariatric surgery for improving fertility and adverse outcomes in PCOS patients?