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Systematic review and implementation research

Module 4

Systematic review and implementation research

Training course in research methodology and research protocol development 2022

October 12, 2022 - Geneva


Part 1

Question 1

Read the abstract, background and method of the systematic review below.

Gülmezoglu AM, Say L, Betrán AP, Villar J, Piaggio G. WHO systematic review of maternal mortality and morbidity: methodological issues and challenges. BMC Medical Research Methodology. 2004 Jul 5;4(1):16.

Answer the following questions:

1.1 What was the aim of this study?

1.2 What sources were searched to retrieve the relevant articles in the review?

1.3 What were the criteria for inclusion of a study in the review?

1.4 Mention three criteria for exclusion of a study from the review?

Question 2

Read the abstract, introduction and method of the systematic review below.

van Weelden W, Wekker V, de Wit L, Limpens J, Ijäs H, van Wassenaer-Leemhuis AG, Roseboom TJ, van Rijn BB, DeVries JH, Painter RC. Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs. Diabetes Ther. 2018 Oct;9(5):1811-1829. doi: 10.1007/s13300-018-0479-0. Epub 2018 Aug 30. PMID: 30168045; PMCID: PMC6167305.

Answer the following questions:

2.1 What was the aim of the study?

2.2 What Databases were searched to retrieve the related articles?

2.3 What analysis were used for extracted data and qualitative assessment?

Question 3

Read the abstract and method of the implementation research below.

Sterling S, Kline-Simon AH, Satre DD, Jones A, Mertens J, Wong A, Weisner C. Implementation of Screening, Brief Intervention, and Referral to Treatment for Adolescents in Pediatric Primary Care: A Cluster Randomized Trial. JAMA Pediatr. 2015 Nov;169(11):e153145. doi: 10.1001/jamapediatrics.2015.3145. Epub 2015 Nov 2. PMID: 26523821; PMCID: PMC4779618.

Answer the following questions:

3.1 What implementation program was examined in this article?

3.2 What was the objective of the study?

3.3 What were the three SBIRT implementation arms compared?

3.4 What was the primary outcome of the study and what did it include?

Question 4

Read the abstract and method of the implementation research below.

Quanbeck A, Gustafson DH, Marsch LA, Chih M-Y, Kornfield R, McTavish F, Johnson R, Brown RT, Mares M-L, Shah DV. Implementing a Mobile Health System to Integrate the Treatment of Addiction Into Primary Care: A Hybrid Implementation-Effectiveness Study. Journal of Medical Internet Research. 2018 Jan 30;20(1):e8928.

Answer the following questions:

4.1 What were the study objective and research questions?

4.2 What implementation research method was used?

4.3 What was the implementation strategy?

4.4 How did the authors assess the implementation outcome ‘Reach’?

Part 2

Reflect over the topic, question and study design for your research protocol, revise if necessary and submit to your coach for review and feedback.